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Reviewed, UniProtKB/Swiss-Prot O95180 (CAC1H_HUMAN)

Last modified June 16, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Voltage-dependent T-type calcium channel subunit alpha-1H
Alternative name(s):
    Voltage-gated calcium channel subunit alpha Cav3.2
    Low-voltage-activated calcium channel alpha1 3.2 subunit
Gene names
Name: CACNA1H
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2353 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific.

Domain

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Post-translational modification

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.

Involvement in disease

Defects in CACNA1H are a cause of susceptibility to idiopathic generalized epilepsy type 6 (IGE6) [MIM:611942]. IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. IGE6 is a polygenic and multifactorial disease. Ref.10

Sequence similarities

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

Sequence caution

The sequence AAK61268.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAC42094.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95180-1)

Also known as: A1H-a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95180-2)

Also known as: A1H-b;

The sequence of this isoform differs from the canonical sequence as follows:
     1587-1592: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23532353Voltage-dependent T-type calcium channel subunit alpha-1H
PRO_0000053954

Regions

Topological domain1 – 100100Cytoplasmic Potential
Transmembrane101 – 11919S1 of repeat I Potential
Topological domain120 – 13920Extracellular Potential
Transmembrane140 – 16021S2 of repeat I Potential
Topological domain161 – 1699Cytoplasmic Potential
Transmembrane170 – 18415S3 of repeat I Potential
Topological domain185 – 1939Extracellular Potential
Transmembrane194 – 21219S4 of repeat I Potential
Topological domain213 – 23220Cytoplasmic Potential
Transmembrane233 – 25321S5 of repeat I Potential
Topological domain254 – 394141Extracellular Potential
Transmembrane395 – 41925S6 of repeat I Potential
Topological domain420 – 793374Cytoplasmic Potential
Transmembrane794 – 81421S1 of repeat II Potential
Topological domain815 – 82713Extracellular Potential
Transmembrane828 – 84922S2 of repeat II Potential
Topological domain850 – 8556Cytoplasmic Potential
Transmembrane856 – 87419S3 of repeat II Potential
Topological domain875 – 8828Extracellular Potential
Transmembrane883 – 90624S4 of repeat II Potential
Topological domain907 – 91711Cytoplasmic Potential
Transmembrane918 – 93821S5 of repeat II Potential
Topological domain939 – 99052Extracellular Potential
Transmembrane991 – 101525S6 of repeat II Potential
Topological domain1016 – 1290275Cytoplasmic Potential
Transmembrane1291 – 131323S1 of repeat III Potential
Topological domain1314 – 133118Extracellular Potential
Transmembrane1332 – 135221S2 of repeat III Potential
Topological domain1353 – 136210Cytoplasmic Potential
Transmembrane1363 – 138220S3 of repeat III Potential
Topological domain1383 – 139614Extracellular Potential
Transmembrane1397 – 141822S4 of repeat III Potential
Topological domain1419 – 142810Cytoplasmic Potential
Transmembrane1429 – 145224S5 of repeat III Potential
Topological domain1453 – 152977Extracellular Potential
Transmembrane1530 – 155526S6 of repeat III Potential
Topological domain1556 – 161661Cytoplasmic Potential
Transmembrane1617 – 163721S1 of repeat IV Potential
Topological domain1638 – 165114Extracellular Potential
Transmembrane1652 – 167322S2 of repeat IV Potential
Topological domain1674 – 16807Cytoplasmic Potential
Transmembrane1681 – 169919S3 of repeat IV Potential
Topological domain1700 – 171314Extracellular Potential
Transmembrane1714 – 173724S4 of repeat IV Potential
Topological domain1738 – 175114Cytoplasmic Potential
Transmembrane1752 – 177221S5 of repeat IV Potential
Topological domain1773 – 183563Extracellular Potential
Transmembrane1836 – 186328S6 of repeat IV Potential
Topological domain1864 – 2353490Cytoplasmic Potential
Repeat87 – 422336I
Repeat779 – 1018240II
Repeat1281 – 1558278III
Repeat1602 – 1863262IV
Compositional bias520 – 53011Poly-His
Compositional bias1107 – 11104Poly-Ser
Compositional bias1583 – 15864Poly-Arg

Sites

Site3781Calcium ion selectivity and permeability By similarity
Site9741Calcium ion selectivity and permeability By similarity
Site15041Calcium ion selectivity and permeability By similarity
Site18081Calcium ion selectivity and permeability By similarity

Amino acid modifications

Modified residue7831Phosphoserine Ref.9
Modified residue11911Phosphothreonine Ref.8
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation14661N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1587 – 15926Missing in isoform 2.
VSP_000949
Natural variant1611F → L in IGE6. Ref.10
VAR_045935
Natural variant2821E → K in IGE6. Ref.10
VAR_045936
Natural variant3131M → V: dbSNP rs36117280. Ref.10 Ref.5 Ref.6
VAR_045937
Natural variant4561C → S in IGE6. Ref.10
VAR_045938
Natural variant4991G → S in IGE6. Ref.10
VAR_045939
Natural variant6401P → L Ref.10 Ref.7
VAR_045940
Natural variant6481P → L in IGE6. Ref.10
VAR_045941
Natural variant6641V → A: dbSNP rs4984636. Ref.10 Ref.1 Ref.4
VAR_045942
Natural variant6841P → S Ref.10
VAR_045943
Natural variant7441R → Q in IGE6. Ref.10
VAR_045944
Natural variant7481A → V in IGE6. Ref.10
VAR_045945
Natural variant7731G → D in IGE6. Ref.10
VAR_045946
Natural variant7841G → S in IGE6. Ref.10
VAR_045947
Natural variant7881R → C: dbSNP rs3751664. Ref.10
VAR_045948
Natural variant8121V → M: dbSNP rs28365119.
VAR_045949
Natural variant8311V → M in IGE6. Ref.10
VAR_045950
Natural variant8481G → S in IGE6. Ref.10
VAR_045951
Natural variant14631D → N in IGE6. Ref.10
VAR_045952
Natural variant19741E → G: dbSNP rs3751886.
VAR_033698
Natural variant20321R → H: dbSNP rs1054644.
VAR_048744
Natural variant20601R → H: dbSNP rs1054644. Ref.10 Ref.5
VAR_045953
Natural variant20771R → H: dbSNP rs1054645. Ref.10 Ref.7 Ref.3
VAR_045954
Natural variant21731P → S Ref.10
VAR_045955

Experimental info

Sequence conflict71A → S in AC120498. Ref.5
Sequence conflict311E → K in AC120498. Ref.5
Sequence conflict551A → S in AC120498. Ref.5
Sequence conflict941L → V in AC120498. Ref.5
Sequence conflict2151S → T in CAC42094. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A1H-a) [UniParc].

Last modified September 19, 2002. Version 4.
Checksum: E13E270635173D98

FASTA2,353259,163
        10         20         30         40         50         60 
MTEGARAADE VRVPLGAPPP GPAALVGASP ESPGAPGREA ERGSELGVSP SESPAAERGA 

        70         80         90        100        110        120 
ELGADEEQRV PYPALAATVF FCLGQTTRPR SWCLRLVCNP WFEHVSMLVI MLNCVTLGMF 

       130        140        150        160        170        180 
RPCEDVECGS ERCNILEAFD AFIFAFFAVE MVIKMVALGL FGQKCYLGDT WNRLDFFIVV 

       190        200        210        220        230        240 
AGMMEYSLDG HNVSLSAIRT VRVLRPLRAI NRVPSMRILV TLLLDTLPML GNVLLLCFFV 

       250        260        270        280        290        300 
FFIFGIVGVQ LWAGLLRNRC FLDSAFVRNN NLTFLRPYYQ TEEGEENPFI CSSRRDNGMQ 

       310        320        330        340        350        360 
KCSHIPGRRE LRMPCTLGWE AYTQPQAEGV GAARNACINW NQYYNVCRSG DSNPHNGAIN 

       370        380        390        400        410        420 
FDNIGYAWIA IFQVITLEGW VDIMYYVMDA HSFYNFIYFI LLIIVGSFFM INLCLVVIAT 

       430        440        450        460        470        480 
QFSETKQRES QLMREQRARH LSNDSTLASF SEPGSCYEEL LKYVGHIFRK VKRRSLRLYA 

       490        500        510        520        530        540 
RWQSRWRKKV DPSAVQGQGP GHRQRRAGRH TASVHHLVYH HHHHHHHHYH FSHGSPRRPG 

       550        560        570        580        590        600 
PEPGACDTRL VRAGAPPSPP SPGRGPPDAE SVHSIYHADC HIEGPQERAR VAHAAATAAA 

       610        620        630        640        650        660 
SLRLATGLGT MNYPTILPSG VGSGKGSTSP GPKGKWAGGP PGTGGHGPLS LNSPDPYEKI 

       670        680        690        700        710        720 
PHVVGEHGLG QAPGHLSGLS VPCPLPSPPA GTLTCELKSC PYCTRALEDP EGELSGSESG 

       730        740        750        760        770        780 
DSDGRGVYEF TQDVRHGDRW DPTRPPRATD TPGPGPGSPQ RRAQQRAAPG EPGWMGRLWV 

       790        800        810        820        830        840 
TFSGKLRRIV DSKYFSRGIM MAILVNTLSM GVEYHEQPEE LTNALEISNI VFTSMFALEM 

       850        860        870        880        890        900 
LLKLLACGPL GYIRNPYNIF DGIIVVISVW EIVGQADGGL SVLRTFRLLR VLKLVRFLPA 

       910        920        930        940        950        960 
LRRQLVVLVK TMDNVATFCT LLMLFIFIFS ILGMHLFGCK FSLKTDTGDT VPDRKNFDSL 

       970        980        990       1000       1010       1020 
LWAIVTVFQI LTQEDWNVVL YNGMASTSSW AALYFVALMT FGNYVLFNLL VAILVEGFQA 

      1030       1040       1050       1060       1070       1080 
EGDANRSDTD EDKTSVHFEE DFHKLRELQT TELKMCSLAV TPNGHLEGRG SLSPPLIMCT 

      1090       1100       1110       1120       1130       1140 
AATPMPTPKS SPFLDAAPSL PDSRRGSSSS GDPPLGDQKP PASLRSSPCA PWGPSGAWSS 

      1150       1160       1170       1180       1190       1200 
RRSSWSSLGR APSLKRRGQC GERESLLSGE GKGSTDDEAE DGRAAPGPRA TPLRRAESLD 

      1210       1220       1230       1240       1250       1260 
PRPLRPAALP PTKCRDRDGQ VVALPSDFFL RIDSHREDAA ELDDDSEDSC CLRLHKVLEP 

      1270       1280       1290       1300       1310       1320 
YKPQWCRSRE AWALYLFSPQ NRFRVSCQKV ITHKMFDHVV LVFIFLNCVT IALERPDIDP 

      1330       1340       1350       1360       1370       1380 
GSTERVFLSV SNYIFTAIFV AEMMVKVVAL GLLSGEHAYL QSSWNLLDGL LVLVSLVDIV 

      1390       1400       1410       1420       1430       1440 
VAMASAGGAK ILGVLRVLRL LRTLRPLRVI SRAPGLKLVV ETLISSLRPI GNIVLICCAF 

      1450       1460       1470       1480       1490       1500 
FIIFGILGVQ LFKGKFYYCE GPDTRNISTK AQCRAAHYRW VRRKYNFDNL GQALMSLFVL 

      1510       1520       1530       1540       1550       1560 
SSKDGWVNIM YDGLDAVGVD QQPVQNHNPW MLLYFISFLL IVSFFVLNMF VGVVVENFHK 

      1570       1580       1590       1600       1610       1620 
CRQHQEAEEA RRREEKRLRR LERRRRSTFP SPEAQRRPYY ADYSPTRRSI HSLCTSHYLD 

      1630       1640       1650       1660       1670       1680 
LFITFIICVN VITMSMEHYN QPKSLDEALK YCNYVFTIVF VFEAALKLVA FGFRRFFKDR 

      1690       1700       1710       1720       1730       1740 
WNQLDLAIVL LSLMGITLEE IEMSAALPIN PTIIRIMRVL RIARVLKLLK MATGMRALLD 

      1750       1760       1770       1780       1790       1800 
TVVQALPQVG NLGLLFMLLF FIYAALGVEL FGRLECSEDN PCEGLSRHAT FSNFGMAFLT 

      1810       1820       1830       1840       1850       1860 
LFRVSTGDNW NGIMKDTLRE CSREDKHCLS YLPALSPVYF VTFVLVAQFV LVNVVVAVLM 

      1870       1880       1890       1900       1910       1920 
KHLEESNKEA REDAELDAEI ELEMAQGPGS ARRVDADRPP LPQESPGARD APNLVARKVS 

      1930       1940       1950       1960       1970       1980 
VSRMLSLPND SYMFRPVVPA SAPHPRPLQE VEMETYGAGT PLGSVASVHS PPAESCASLQ 

      1990       2000       2010       2020       2030       2040 
IPLAVSSPAR SGEPLHALSP RGTARSPSLS RLLCRQEAVH TDSLEGKIDS PRDTLDPAEP 

      2050       2060       2070       2080       2090       2100 
GEKTPVRPVT QGGSLQSPPR SPRPASVRTR KHTFGQRCVS SRPAAPGGEE AEASDPADEE 

      2110       2120       2130       2140       2150       2160 
VSHITSSACP WQPTAEPHGP EASPVAGGER DLRRLYSVDA QGFLDKPGRA DEQWRPSAEL 

      2170       2180       2190       2200       2210       2220 
GSGEPGEAKA WGPEAEPALG ARRKKKMSPP CISVEPPAED EGSARPSAAE GGSTTLRRRT 

      2230       2240       2250       2260       2270       2280 
PSCEATPHRD SLEPTEGSGA GGDPAAKGER WGQASCRAEH LTVPSFAFEP LDLGVPSGDP 

      2290       2300       2310       2320       2330       2340 
FLDGSHSVTP ESRASSSGAI VPLEPPESEP PMPVGDPPEK RRGLYLTVPQ CPLEKPGSPS 

      2350 
ATPAPGGGAD DPV 

« Hide

Isoform 2 (A1H-b).

Checksum: 927BBE328438142A
Show »

FASTA2,347258,546

References

« Hide 'large scale' references
[1]"Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family."
Cribbs L.L., Lee J.-H., Yang J., Satin J., Zhang Y., Daud A.N., Barclay J., Wiliamson M.P., Fox M., Rees M., Perez-Reyes E.
Circ. Res. 83:103-109(1998) [PubMed: 9670923] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-664.
Tissue: Heart.
[2]Cribbs L.L., Lee J.-H., Yang J., Daud A.N., Perez-Reyes E.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Structure and functional characterization of a novel human low-voltage activated calcium channel."
Williams M.E., Washburn M.S., Hans M., Urrutia A., Brust P.F., Prodanovich P., Harpold M.M., Stauderman K.A.
J. Neurochem. 72:791-799(1999) [PubMed: 9930755] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT HIS-2077.
Tissue: Thyroid carcinoma.
[4]"Identification and localization of T-type voltage-operated calcium channel subunits in human male germ cells. Expression of multiple isoforms."
Jagannathan S., Punt E.L., Gu Y., Arnoult C., Sakkas D., Barratt C.L., Publicover S.J.
J. Biol. Chem. 277:8449-8456(2002) [PubMed: 11751928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ALA-664.
Tissue: Testis.
[5]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-313 AND HIS-2060.
[6]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed: 15616553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-313.
[7]"Organization and alternative splicing of CACNA1H."
Mittman S., Agnew W.S.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 424-661 AND 838-2373 (ISOFORM 1), VARIANTS LEU-640 AND HIS-2077.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1191, MASS SPECTROMETRY.
Tissue: Epithelium.
[9]"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.
Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-783, MASS SPECTROMETRY.
[10]"Association between genetic variation of CACNA1H and childhood absence epilepsy."
Chen Y., Lu J., Pan H., Zhang Y., Wu H., Xu K., Liu X., Jiang Y., Bao X., Yao Z., Ding K., Lo W.H., Qiang B., Chan P., Shen Y., Wu X.
Ann. Neurol. 54:239-243(2003) [PubMed: 12891677] [Abstract]
Cited for: VARIANTS IGE6 LEU-161; LYS-282; SER-456; SER-499; LEU-648; GLN-744; VAL-748; ASP-773; SER-784; MET-831; SER-848 AND ASN-1463, VARIANTS VAL-313; LEU-640; ALA-664; SER-684; CYS-788; HIS-2060; HIS-2077 AND SER-2173.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF051946 mRNA. Translation: AAC67239.3.
AF073931 mRNA. Translation: AAD17668.1.
AJ420779 mRNA. Translation: CAD12646.1.
AE006466 Genomic DNA. Translation: AAK61268.1. Sequence problems.
AL031703 Genomic DNA. Translation: CAC42094.1. Sequence problems.
AC120498 Genomic DNA. No translation available.
AF223562 Genomic DNA. Translation: AAF60162.1.
AF223563 Genomic DNA. Translation: AAF60163.1.
IPIIPI00028915.
IPI00288892.
RefSeqNP_001005407.1.
NP_066921.2.
UniGeneHs.459642

3D structure databases

ModBaseSearch...

Protein family/group databases

TCDB1.A.1.11.5. voltage-gated ion channel (VIC) superfamily.

PTM databases

PhosphoSiteO95180.

Proteomic databases

PRIDEO95180.

Genome annotation databases

EnsemblENSG00000196557. Homo sapiens. [Contig view]
GeneID8912.
KEGGhsa:8912.

Organism-specific databases

GeneCardsGC16P001147.
H-InvDBHIX0038538.
HGNCHGNC:1395. CACNA1H.
MIM607904. gene.
611942. phenotype.
PharmGKBPA380.
GenAtlasSearch...

Phylogenomic databases

HOVERGENO95180.
OMAO95180. FFLRIDS.

Gene expression databases

BgeeO95180.
CleanExHS_CACNA1H.
GermOnlineENSG00000196557. Homo sapiens.

Family and domain databases

InterProIPR005821. Ion_trans.
IPR005445. VDCC_T_a1su.
[Graphical view]
PfamPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSPR01629. TVDCCALPHA1.
ProtoNetSearch...

Other Resources

DrugBankDB04841. Flunarizine.
DB01388. Mibefradil.
NextBio33494.
SOURCESearch...

Entry information

Entry nameCAC1H_HUMAN
AccessionPrimary (citable) accession number: O95180
Secondary accession number(s): O95802 expand/collapse secondary AC list , Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 19, 2002
Last modified: June 16, 2009
This is version 87 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents