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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

Gene

NDUFB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciZFISH:HS01679-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Alternative name(s):
Complex I-AGGG
Short name:
CI-AGGG
NADH-ubiquinone oxidoreductase AGGG subunit
Gene namesi
Name:NDUFB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:7697. NDUFB2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4708.
OpenTargetsiENSG00000090266.
PharmGKBiPA31503.

Chemistry databases

ChEMBLiCHEMBL2363065.

Polymorphism and mutation databases

BioMutaiNDUFB2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionCombined sources1 PublicationAdd BLAST33
ChainiPRO_000002004234 – 105NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialAdd BLAST72

Proteomic databases

EPDiO95178.
MaxQBiO95178.
PaxDbiO95178.
PeptideAtlasiO95178.
PRIDEiO95178.
TopDownProteomicsiO95178.

PTM databases

iPTMnetiO95178.
PhosphoSitePlusiO95178.

Expressioni

Gene expression databases

BgeeiENSG00000090266.
CleanExiHS_NDUFB2.
ExpressionAtlasiO95178. baseline and differential.
GenevisibleiO95178. HS.

Organism-specific databases

HPAiHPA051377.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

BioGridi110788. 1 interactor.
IntActiO95178. 2 interactors.
STRINGi9606.ENSP00000247866.

Structurei

3D structure databases

ProteinModelPortaliO95178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB2 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410J0BK. Eukaryota.
ENOG41128HF. LUCA.
GeneTreeiENSGT00390000004044.
HOGENOMiHOG000252974.
HOVERGENiHBG006499.
InParanoidiO95178.
KOiK03958.
OMAiFSATMWF.
OrthoDBiEOG091G0YSW.
PhylomeDBiO95178.
TreeFamiTF316619.

Family and domain databases

InterProiIPR026627. NDUFB2.
[Graphical view]
PANTHERiPTHR15223. PTHR15223. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALTRLASF ARVGGRLFRS GCARTAGDGG VRHAGGGVHI EPRYRQFPQL
60 70 80 90 100
TRSQVFQSEF FSGLMWFWIL WRFWHDSEEV LGHFPYPDPS QWTDEELGIP

PDDED
Length:105
Mass (Da):12,058
Last modified:May 1, 1999 - v1
Checksum:i5698368608CDC16F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050639 mRNA. Translation: AAD05428.1.
AF067166 mRNA. Translation: AAD32450.1.
CR542121 mRNA. Translation: CAG46918.1.
BC001168 mRNA. No translation available.
CCDSiCCDS5862.1.
PIRiJE0384.
RefSeqiNP_004537.1. NM_004546.2.
UniGeneiHs.655788.

Genome annotation databases

EnsembliENST00000247866; ENSP00000247866; ENSG00000090266.
ENST00000465506; ENSP00000419357; ENSG00000090266.
ENST00000476279; ENSP00000419087; ENSG00000090266.
GeneIDi4708.
KEGGihsa:4708.
UCSCiuc003vwa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050639 mRNA. Translation: AAD05428.1.
AF067166 mRNA. Translation: AAD32450.1.
CR542121 mRNA. Translation: CAG46918.1.
BC001168 mRNA. No translation available.
CCDSiCCDS5862.1.
PIRiJE0384.
RefSeqiNP_004537.1. NM_004546.2.
UniGeneiHs.655788.

3D structure databases

ProteinModelPortaliO95178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110788. 1 interactor.
IntActiO95178. 2 interactors.
STRINGi9606.ENSP00000247866.

Chemistry databases

ChEMBLiCHEMBL2363065.

PTM databases

iPTMnetiO95178.
PhosphoSitePlusiO95178.

Polymorphism and mutation databases

BioMutaiNDUFB2.

Proteomic databases

EPDiO95178.
MaxQBiO95178.
PaxDbiO95178.
PeptideAtlasiO95178.
PRIDEiO95178.
TopDownProteomicsiO95178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247866; ENSP00000247866; ENSG00000090266.
ENST00000465506; ENSP00000419357; ENSG00000090266.
ENST00000476279; ENSP00000419087; ENSG00000090266.
GeneIDi4708.
KEGGihsa:4708.
UCSCiuc003vwa.4. human.

Organism-specific databases

CTDi4708.
DisGeNETi4708.
GeneCardsiNDUFB2.
HGNCiHGNC:7697. NDUFB2.
HPAiHPA051377.
MIMi603838. gene.
neXtProtiNX_O95178.
OpenTargetsiENSG00000090266.
PharmGKBiPA31503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0BK. Eukaryota.
ENOG41128HF. LUCA.
GeneTreeiENSGT00390000004044.
HOGENOMiHOG000252974.
HOVERGENiHBG006499.
InParanoidiO95178.
KOiK03958.
OMAiFSATMWF.
OrthoDBiEOG091G0YSW.
PhylomeDBiO95178.
TreeFamiTF316619.

Enzyme and pathway databases

BioCyciZFISH:HS01679-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNDUFB2. human.
GeneWikiiNDUFB2.
GenomeRNAii4708.
PROiO95178.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090266.
CleanExiHS_NDUFB2.
ExpressionAtlasiO95178. baseline and differential.
GenevisibleiO95178. HS.

Family and domain databases

InterProiIPR026627. NDUFB2.
[Graphical view]
PANTHERiPTHR15223. PTHR15223. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB2_HUMAN
AccessioniPrimary (citable) accession number: O95178
Secondary accession number(s): Q6FGI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.