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Protein

Sciellin

Gene

SCEL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

GO - Molecular functioni

GO - Biological processi

  • embryo development Source: UniProtKB
  • epidermis development Source: UniProtKB
  • keratinocyte differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sciellin
Gene namesi
Name:SCEL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:10573. SCEL.

Subcellular locationi

  • Cytoplasm
  • Membrane

  • Note: May become cross-linked to membrane proteins by transglutaminase.

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34986.

Polymorphism and mutation databases

BioMutaiSCEL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 688688SciellinPRO_0000075903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831N6-acetyllysineBy similarity
Modified residuei289 – 2891PhosphoserineBy similarity
Modified residuei389 – 3891PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95171.
PaxDbiO95171.
PeptideAtlasiO95171.
PRIDEiO95171.

PTM databases

iPTMnetiO95171.
PhosphoSiteiO95171.

Expressioni

Tissue specificityi

Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail.

Gene expression databases

BgeeiO95171.
CleanExiHS_SCEL.
ExpressionAtlasiO95171. baseline and differential.
GenevisibleiO95171. HS.

Organism-specific databases

HPAiHPA039737.
HPA040154.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FXR2P511163EBI-7543896,EBI-740459
GOLGA2Q083794EBI-7543896,EBI-618309
KIFC3Q9BVG83EBI-7543896,EBI-2125614
MTUS2Q5JR593EBI-7543896,EBI-742948
NMIQ132874EBI-7543896,EBI-372942
NMIQ8WTW23EBI-7543896,EBI-10174268
TSGA10Q9BZW73EBI-7543896,EBI-744794

Protein-protein interaction databases

BioGridi114324. 10 interactions.
IntActiO95171. 9 interactions.
MINTiMINT-3975264.
STRINGi9606.ENSP00000302579.

Structurei

3D structure databases

ProteinModelPortaliO95171.
SMRiO95171. Positions 620-684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati251 – 266161Add
BLAST
Repeati267 – 286202Add
BLAST
Repeati287 – 306203Add
BLAST
Repeati307 – 326204Add
BLAST
Repeati327 – 346205Add
BLAST
Repeati347 – 366206Add
BLAST
Repeati367 – 386207Add
BLAST
Repeati387 – 406208Add
BLAST
Repeati407 – 426209Add
BLAST
Repeati427 – 4462010Add
BLAST
Repeati447 – 4651911Add
BLAST
Repeati466 – 4841912Add
BLAST
Repeati485 – 5042013Add
BLAST
Repeati505 – 5231914Add
BLAST
Repeati524 – 5432015Add
BLAST
Repeati544 – 5632016Add
BLAST
Domaini619 – 68567LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 56331316 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410INGG. Eukaryota.
ENOG4111UEX. LUCA.
GeneTreeiENSGT00530000063872.
HOGENOMiHOG000294069.
HOVERGENiHBG023141.
InParanoidiO95171.
OMAiPKDGYQE.
OrthoDBiEOG72C52Z.
PhylomeDBiO95171.
TreeFamiTF335114.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95171-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNVTLRKMS PTGNEMKSTT QGTTRKQQDF HEVNKRRTFL QDNSWIKKRP
60 70 80 90 100
EEEKDENYGR VVLNRHNSHD ALDRKVNERD VPKATISRYS SDDTLDRISD
110 120 130 140 150
RNDAAKTYKA NTLDNQLTNR SMSMFRSLEV TKLQPGGSLN ANTSNTIAST
160 170 180 190 200
SATTPVKKKR QSWFPPPPPG YNASSSTGTR RREPGVHPPI PPKPSSPVSS
210 220 230 240 250
PNQLRQDNRQ IHPPKPGVYT ETNRSAERNI RSQDLDNIVK VATSLQRSDK
260 270 280 290 300
GEELDNLIKM NKSLNRNQGL DSLFRANPKV EEREKRAKSL ESLIYMSTRT
310 320 330 340 350
DKDGKGIQSL GSPIKVNQRT DKNEKGRQNL ESVAKVNARM NKTSRRSEDL
360 370 380 390 400
DNATEVNPKG HENTTGKKDL DGLIKVDPET NKNITRGQSL DNLIKVTPEV
410 420 430 440 450
KRSNQGSKDL NNFIKVYPGT EKSTEGGQSL DSLIKVTPER NRTNQGNQDL
460 470 480 490 500
ENLIKVIPSA NKSSEQGLDE HINVSPKAVK NTDGKQDLDK LIKVNPEIFT
510 520 530 540 550
NNQRNQDLAN LIKVNPAVIR NNQSQDLDNL IKVKPSALRN TNRDQNLENL
560 570 580 590 600
IEVNSHVSEN KNGSSNTGAK QAGPQDTVVY TRTYVENSKS PKDGYQENIS
610 620 630 640 650
GKYIQTVYST SDRSVIERDM CTYCRKPLGV ETKMILDELQ ICCHSTCFKC
660 670 680
EICKQPLENL QAGDSIWIYR QTIHCEPCYS KIMAKWIP
Length:688
Mass (Da):77,552
Last modified:December 16, 2008 - v2
Checksum:iB97F62DD560B57C3
GO
Isoform 2 (identifier: O95171-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-251: RSQDLDNIVKVATSLQRSDKG → S

Show »
Length:668
Mass (Da):75,326
Checksum:i119DB006BB85EC13
GO
Isoform 3 (identifier: O95171-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-181: Missing.
     367-386: Missing.

Note: No experimental confirmation available.
Show »
Length:646
Mass (Da):72,843
Checksum:iBDA3D0960363AEFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371R → G in BAH13533 (PubMed:14702039).Curated
Sequence conflicti124 – 1241M → V in AAH47536 (PubMed:15489334).Curated
Sequence conflicti201 – 2011P → T in AAH47536 (PubMed:15489334).Curated
Sequence conflicti337 – 3371N → D in AAC78461 (PubMed:9813070).Curated
Sequence conflicti340 – 3401M → T in AAC78461 (PubMed:9813070).Curated
Sequence conflicti680 – 6801S → P in BAD96440 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti336 – 3361V → L.
Corresponds to variant rs34164479 [ dbSNP | Ensembl ].
VAR_047920
Natural varianti386 – 3861R → K.
Corresponds to variant rs2274016 [ dbSNP | Ensembl ].
VAR_047921
Natural varianti480 – 4801K → R.
Corresponds to variant rs8002725 [ dbSNP | Ensembl ].
VAR_047922

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei160 – 18122Missing in isoform 3. 1 PublicationVSP_045288Add
BLAST
Alternative sequencei231 – 25121RSQDL…RSDKG → S in isoform 2. 2 PublicationsVSP_035980Add
BLAST
Alternative sequencei367 – 38620Missing in isoform 3. 1 PublicationVSP_045289Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045941 mRNA. Translation: AAC78461.1.
AK301659 mRNA. Translation: BAH13533.1.
AK222720 mRNA. Translation: BAD96440.1.
AL137140 Genomic DNA. Translation: CAH70475.1.
AL137140 Genomic DNA. Translation: CAH70476.1.
CH471093 Genomic DNA. Translation: EAW80568.1.
CH471093 Genomic DNA. Translation: EAW80569.1.
BC047536 mRNA. Translation: AAH47536.1.
CCDSiCCDS53877.1. [O95171-3]
CCDS9458.1. [O95171-2]
CCDS9459.1. [O95171-1]
RefSeqiNP_001154178.1. NM_001160706.1. [O95171-3]
NP_003834.3. NM_003843.3. [O95171-2]
NP_659001.2. NM_144777.2. [O95171-1]
UniGeneiHs.534699.

Genome annotation databases

EnsembliENST00000349847; ENSP00000302579; ENSG00000136155. [O95171-1]
ENST00000377246; ENSP00000366454; ENSG00000136155. [O95171-2]
ENST00000535157; ENSP00000437895; ENSG00000136155. [O95171-3]
GeneIDi8796.
KEGGihsa:8796.
UCSCiuc001vki.4. human. [O95171-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045941 mRNA. Translation: AAC78461.1.
AK301659 mRNA. Translation: BAH13533.1.
AK222720 mRNA. Translation: BAD96440.1.
AL137140 Genomic DNA. Translation: CAH70475.1.
AL137140 Genomic DNA. Translation: CAH70476.1.
CH471093 Genomic DNA. Translation: EAW80568.1.
CH471093 Genomic DNA. Translation: EAW80569.1.
BC047536 mRNA. Translation: AAH47536.1.
CCDSiCCDS53877.1. [O95171-3]
CCDS9458.1. [O95171-2]
CCDS9459.1. [O95171-1]
RefSeqiNP_001154178.1. NM_001160706.1. [O95171-3]
NP_003834.3. NM_003843.3. [O95171-2]
NP_659001.2. NM_144777.2. [O95171-1]
UniGeneiHs.534699.

3D structure databases

ProteinModelPortaliO95171.
SMRiO95171. Positions 620-684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114324. 10 interactions.
IntActiO95171. 9 interactions.
MINTiMINT-3975264.
STRINGi9606.ENSP00000302579.

PTM databases

iPTMnetiO95171.
PhosphoSiteiO95171.

Polymorphism and mutation databases

BioMutaiSCEL.

Proteomic databases

MaxQBiO95171.
PaxDbiO95171.
PeptideAtlasiO95171.
PRIDEiO95171.

Protocols and materials databases

DNASUi8796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349847; ENSP00000302579; ENSG00000136155. [O95171-1]
ENST00000377246; ENSP00000366454; ENSG00000136155. [O95171-2]
ENST00000535157; ENSP00000437895; ENSG00000136155. [O95171-3]
GeneIDi8796.
KEGGihsa:8796.
UCSCiuc001vki.4. human. [O95171-1]

Organism-specific databases

CTDi8796.
GeneCardsiSCEL.
HGNCiHGNC:10573. SCEL.
HPAiHPA039737.
HPA040154.
MIMi604112. gene.
neXtProtiNX_O95171.
PharmGKBiPA34986.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INGG. Eukaryota.
ENOG4111UEX. LUCA.
GeneTreeiENSGT00530000063872.
HOGENOMiHOG000294069.
HOVERGENiHBG023141.
InParanoidiO95171.
OMAiPKDGYQE.
OrthoDBiEOG72C52Z.
PhylomeDBiO95171.
TreeFamiTF335114.

Miscellaneous databases

GeneWikiiSCEL_(gene).
GenomeRNAii8796.
PROiO95171.
SOURCEiSearch...

Gene expression databases

BgeeiO95171.
CleanExiHS_SCEL.
ExpressionAtlasiO95171. baseline and differential.
GenevisibleiO95171. HS.

Family and domain databases

Gene3Di2.10.110.10. 1 hit.
InterProiIPR001781. Znf_LIM.
[Graphical view]
SMARTiSM00132. LIM. 1 hit.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope."
    Champliaud M.-F., Burgeson R.E., Jin W., Baden H.P., Olson P.F.
    J. Biol. Chem. 273:31547-31554(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 463-477 AND 655-670.
    Tissue: Foreskin.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Esophagus.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiSCEL_HUMAN
AccessioniPrimary (citable) accession number: O95171
Secondary accession number(s): B7Z797
, F5H651, Q53H61, Q5W0S8, Q5W0S9, Q86X00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 16, 2008
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.