O95167 (NDUA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Alternative name(s):
Complex I-B9
Short name=CI-B9
NADH-ubiquinone oxidoreductase B9 subunit

Gene names

Name:

NDUFA3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	84 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subunit structure	Complex I is composed of 45 different subunits. Ref.4
Subcellular location	Mitochondrion inner membrane; Single-pass membrane protein.
Sequence similarities	Belongs to the complex I NDUFA3 subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial electron transport, NADH to ubiquinone Non-traceable author statement Ref.1. Source: UniProtKB small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial respiratory chain complex I Inferred from direct assay Ref.4. Source: UniProtKB
Molecular_function	NADH dehydrogenase (ubiquinone) activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 84	83	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3		PRO_0000118793
Regions
	Transmembrane	19 – 39	21	Helical; Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
Natural variations
	Natural variant	62	1	N → D in a breast cancer sample; somatic mutation. Ref.6		VAR_036175

Sequences

	Sequence		Length	Mass (Da)
	O95167 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 38B27A96D7A05D31	FASTA	84	9,279
	10 20 30 40 50 60 MAARVGAFLK NAWDKEPVLV VSFVVGGLAV ILPPLSPYFK YSVMINKATP YNYPVPVRDD 70 80 GNMPDVPSHP QDPQGPSLEW LKKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed." Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M. Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Prostate.
[4]	"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification." Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A. J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract] Cited for: MASS SPECTROMETRY, IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-62.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF044955 mRNA. Translation: AAD05420.1. AF070653 mRNA. Translation: AAD20959.1. BC022369 mRNA. Translation: AAH22369.1. BC061644 mRNA. Translation: AAH61644.1.
IPI	IPI00028881.
PIR	JE0379.
RefSeq	NP_004533.1. NM_004542.3.
UniGene	Hs.198269.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000398290.
PTM databases
PhosphoSite	O95167.
Proteomic databases
PaxDb	O95167.
PeptideAtlas	O95167.
PRIDE	O95167.
Protocols and materials databases
DNASU	4696.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000417328; ENSP00000410363; ENSG00000170906. ENST00000419113; ENSP00000398290; ENSG00000170906. ENST00000485876; ENSP00000418438; ENSG00000170906. ENST00000571050; ENSP00000461139; ENSG00000267842. ENST00000571297; ENSP00000458855; ENSG00000267842. ENST00000573732; ENSP00000459774; ENSG00000267842. ENST00000594423; ENSP00000472538; ENSG00000268841. ENST00000594450; ENSP00000470981; ENSG00000268007. ENST00000594995; ENSP00000471459; ENSG00000268627. ENST00000595849; ENSP00000473206; ENSG00000269435. ENST00000595942; ENSP00000472974; ENSG00000268007. ENST00000596791; ENSP00000471580; ENSG00000268165. ENST00000596980; ENSP00000469198; ENSG00000268408. ENST00000597174; ENSP00000470349; ENSG00000268627. ENST00000597613; ENSP00000470559; ENSG00000268165. ENST00000597720; ENSP00000470330; ENSG00000268841. ENST00000598250; ENSP00000470264; ENSG00000268408. ENST00000598373; ENSP00000469927; ENSG00000269435. ENST00000598403; ENSP00000470556; ENSG00000268408. ENST00000598631; ENSP00000472906; ENSG00000267907. ENST00000599424; ENSP00000470985; ENSG00000268841. ENST00000599455; ENSP00000471287; ENSG00000267907. ENST00000599763; ENSP00000473149; ENSG00000268627. ENST00000599777; ENSP00000470612; ENSG00000268007. ENST00000599878; ENSP00000469653; ENSG00000268165. ENST00000600325; ENSP00000469303; ENSG00000267907. ENST00000601497; ENSP00000470223; ENSG00000269435.
GeneID	4696.
KEGG	hsa:4696.
UCSC	uc002qde.3. human.
Organism-specific databases
CTD	4696.
GeneCards	GC19P054590.
HGNC	HGNC:7686. NDUFA3.
HPA	HPA046976.
MIM	603832. gene.
neXtProt	NX_O95167.
PharmGKB	PA31492.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46010.
HOGENOM	HOG000015319.
HOVERGEN	HBG006495.
KO	K03947.
OMA	KYSSMIN.
PhylomeDB	O95167.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	O95167.
Bgee	O95167.
CleanEx	HS_NDUFA3.
Genevestigator	O95167.
GermOnline	ENSG00000170906. Homo sapiens.
Family and domain databases
InterPro	IPR026626. NDUFA3. [Graphical view]
PANTHER	PTHR15221. PTHR15221. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00157. NADH.
GenomeRNAi	4696.
NextBio	18110.
SOURCE	Search...

Entry information

Entry name

NDUA3_HUMAN

Accession

Primary (citable) accession number: O95167

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.