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O95167

- NDUA3_HUMAN

UniProt

O95167 - NDUA3_HUMAN

Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Gene

NDUFA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
    3. respiratory electron transport chain Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
    Alternative name(s):
    Complex I-B9
    Short name:
    CI-B9
    NADH-ubiquinone oxidoreductase B9 subunit
    Gene namesi
    Name:NDUFA3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:7686. NDUFA3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome
    3. mitochondrial respiratory chain complex I Source: UniProtKB
    4. mitochondrion Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31492.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 8483NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3PRO_0000118793Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiO95167.
    PeptideAtlasiO95167.
    PRIDEiO95167.

    PTM databases

    PhosphoSiteiO95167.

    Expressioni

    Gene expression databases

    ArrayExpressiO95167.
    BgeeiO95167.
    CleanExiHS_NDUFA3.
    GenevestigatoriO95167.

    Organism-specific databases

    HPAiHPA046976.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits.1 Publication

    Protein-protein interaction databases

    BioGridi110776. 2 interactions.
    STRINGi9606.ENSP00000398290.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I NDUFA3 subunit family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46010.
    HOGENOMiHOG000015319.
    HOVERGENiHBG006495.
    KOiK03947.
    OMAiYSIMINK.
    PhylomeDBiO95167.
    TreeFamiTF333021.

    Family and domain databases

    InterProiIPR026626. NDUFA3.
    [Graphical view]
    PANTHERiPTHR15221. PTHR15221. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95167-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARVGAFLK NAWDKEPVLV VSFVVGGLAV ILPPLSPYFK YSVMINKATP   50
    YNYPVPVRDD GNMPDVPSHP QDPQGPSLEW LKKL 84
    Length:84
    Mass (Da):9,279
    Last modified:May 1, 1999 - v1
    Checksum:i38B27A96D7A05D31
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti62 – 621N → D in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036175

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044955 mRNA. Translation: AAD05420.1.
    AF070653 mRNA. Translation: AAD20959.1.
    BC022369 mRNA. Translation: AAH22369.1.
    BC061644 mRNA. Translation: AAH61644.1.
    CCDSiCCDS12877.1.
    PIRiJE0379.
    RefSeqiNP_004533.1. NM_004542.3.
    UniGeneiHs.198269.

    Genome annotation databases

    EnsembliENST00000419113; ENSP00000398290; ENSG00000170906.
    ENST00000485876; ENSP00000418438; ENSG00000170906.
    GeneIDi4696.
    KEGGihsa:4696.
    UCSCiuc002qde.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044955 mRNA. Translation: AAD05420.1 .
    AF070653 mRNA. Translation: AAD20959.1 .
    BC022369 mRNA. Translation: AAH22369.1 .
    BC061644 mRNA. Translation: AAH61644.1 .
    CCDSi CCDS12877.1.
    PIRi JE0379.
    RefSeqi NP_004533.1. NM_004542.3.
    UniGenei Hs.198269.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110776. 2 interactions.
    STRINGi 9606.ENSP00000398290.

    Chemistry

    ChEMBLi CHEMBL2363065.
    DrugBanki DB00157. NADH.

    PTM databases

    PhosphoSitei O95167.

    Proteomic databases

    PaxDbi O95167.
    PeptideAtlasi O95167.
    PRIDEi O95167.

    Protocols and materials databases

    DNASUi 4696.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000419113 ; ENSP00000398290 ; ENSG00000170906 .
    ENST00000485876 ; ENSP00000418438 ; ENSG00000170906 .
    GeneIDi 4696.
    KEGGi hsa:4696.
    UCSCi uc002qde.3. human.

    Organism-specific databases

    CTDi 4696.
    GeneCardsi GC19P054590.
    HGNCi HGNC:7686. NDUFA3.
    HPAi HPA046976.
    MIMi 603832. gene.
    neXtProti NX_O95167.
    PharmGKBi PA31492.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46010.
    HOGENOMi HOG000015319.
    HOVERGENi HBG006495.
    KOi K03947.
    OMAi YSIMINK.
    PhylomeDBi O95167.
    TreeFami TF333021.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    GenomeRNAii 4696.
    NextBioi 18110.
    PROi O95167.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95167.
    Bgeei O95167.
    CleanExi HS_NDUFA3.
    Genevestigatori O95167.

    Family and domain databases

    InterProi IPR026626. NDUFA3.
    [Graphical view ]
    PANTHERi PTHR15221. PTHR15221. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
      Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M.
      Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas and Prostate.
    4. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
      Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
      J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-62.

    Entry informationi

    Entry nameiNDUA3_HUMAN
    AccessioniPrimary (citable) accession number: O95167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3