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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Gene

NDUFA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Alternative name(s):
Complex I-B9
Short name:
CI-B9
NADH-ubiquinone oxidoreductase B9 subunit
Gene namesi
Name:NDUFA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7686. NDUFA3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: Reactome
  • mitochondrial respiratory chain complex I Source: UniProtKB
  • mitochondrion Source: UniProtKB

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170906.
PharmGKBiPA31492.

Chemistry databases

ChEMBLiCHEMBL2363065.
DrugBankiDB00157. NADH.

Polymorphism and mutation databases

BioMutaiNDUFA3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001187932 – 84NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO95167.
PaxDbiO95167.
PeptideAtlasiO95167.
PRIDEiO95167.
TopDownProteomicsiO95167.

PTM databases

iPTMnetiO95167.
PhosphoSitePlusiO95167.

Expressioni

Gene expression databases

BgeeiENSG00000170906.
CleanExiHS_NDUFA3.
ExpressionAtlasiO95167. baseline and differential.
GenevisibleiO95167. HS.

Organism-specific databases

HPAiHPA046976.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

BioGridi110776. 27 interactors.
IntActiO95167. 6 interactors.
STRINGi9606.ENSP00000398290.

Structurei

3D structure databases

SMRiO95167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA3 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J189. Eukaryota.
ENOG411212S. LUCA.
GeneTreeiENSGT00390000004322.
HOGENOMiHOG000015319.
HOVERGENiHBG006495.
InParanoidiO95167.
KOiK03947.
OMAiKYSSMIN.
OrthoDBiEOG091G13PK.
PhylomeDBiO95167.
TreeFamiTF333021.

Family and domain databases

InterProiView protein in InterPro
IPR026626. NDUFA3.
PANTHERiPTHR15221. PTHR15221. 1 hit.
PfamiView protein in Pfam
PF14987. NADHdh_A3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARVGAFLK NAWDKEPVLV VSFVVGGLAV ILPPLSPYFK YSVMINKATP
60 70 80
YNYPVPVRDD GNMPDVPSHP QDPQGPSLEW LKKL
Length:84
Mass (Da):9,279
Last modified:May 1, 1999 - v1
Checksum:i38B27A96D7A05D31
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03617562N → D in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044955 mRNA. Translation: AAD05420.1.
AF070653 mRNA. Translation: AAD20959.1.
BC022369 mRNA. Translation: AAH22369.1.
BC061644 mRNA. Translation: AAH61644.1.
CCDSiCCDS12877.1.
PIRiJE0379.
RefSeqiNP_004533.1. NM_004542.3.
XP_016882322.1. XM_017026833.1.
UniGeneiHs.198269.

Genome annotation databases

EnsembliENST00000419113; ENSP00000398290; ENSG00000170906.
ENST00000485876; ENSP00000418438; ENSG00000170906.
ENST00000620289; ENSP00000477783; ENSG00000276061.
ENST00000622523; ENSP00000483683; ENSG00000276061.
GeneIDi4696.
KEGGihsa:4696.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNDUA3_HUMAN
AccessioniPrimary (citable) accession number: O95167
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families