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O95167 (NDUA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Alternative name(s):
Complex I-B9
Short name=CI-B9
NADH-ubiquinone oxidoreductase B9 subunit
Gene names
Name:NDUFA3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length84 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subunit structure

Complex I is composed of 45 different subunits. Ref.4

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein.

Sequence similarities

Belongs to the complex I NDUFA3 subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 8483NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
PRO_0000118793

Regions

Transmembrane19 – 3921Helical; Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Natural variant621N → D in a breast cancer sample; somatic mutation. Ref.6
VAR_036175

Sequences

Sequence LengthMass (Da)Tools
O95167 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 38B27A96D7A05D31

FASTA849,279
        10         20         30         40         50         60 
MAARVGAFLK NAWDKEPVLV VSFVVGGLAV ILPPLSPYFK YSVMINKATP YNYPVPVRDD 

        70         80 
GNMPDVPSHP QDPQGPSLEW LKKL 

« Hide

References

« Hide 'large scale' references
[1]"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M.
Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas and Prostate.
[4]"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-62.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF044955 mRNA. Translation: AAD05420.1.
AF070653 mRNA. Translation: AAD20959.1.
BC022369 mRNA. Translation: AAH22369.1.
BC061644 mRNA. Translation: AAH61644.1.
CCDSCCDS12877.1.
PIRJE0379.
RefSeqNP_004533.1. NM_004542.3.
UniGeneHs.198269.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110776. 2 interactions.
STRING9606.ENSP00000398290.

Chemistry

ChEMBLCHEMBL2363065.
DrugBankDB00157. NADH.

PTM databases

PhosphoSiteO95167.

Proteomic databases

PaxDbO95167.
PeptideAtlasO95167.
PRIDEO95167.

Protocols and materials databases

DNASU4696.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000419113; ENSP00000398290; ENSG00000170906.
ENST00000485876; ENSP00000418438; ENSG00000170906.
ENST00000571050; ENSP00000461139; ENSG00000273426.
ENST00000573732; ENSP00000459774; ENSG00000273426.
ENST00000603070; ENSP00000473873; ENSG00000271016.
ENST00000605308; ENSP00000474381; ENSG00000271016.
ENST00000608551; ENSP00000476522; ENSG00000273453.
ENST00000608578; ENSP00000476315; ENSG00000273052.
ENST00000608754; ENSP00000476931; ENSG00000273126.
ENST00000608992; ENSP00000476773; ENSG00000273052.
ENST00000609149; ENSP00000476328; ENSG00000272553.
ENST00000609197; ENSP00000476524; ENSG00000273095.
ENST00000609226; ENSP00000477121; ENSG00000273427.
ENST00000609444; ENSP00000476973; ENSG00000273453.
ENST00000609560; ENSP00000476674; ENSG00000273095.
ENST00000609753; ENSP00000476406; ENSG00000273126.
ENST00000609826; ENSP00000476665; ENSG00000273178.
ENST00000609960; ENSP00000477477; ENSG00000272553.
ENST00000610124; ENSP00000477347; ENSG00000273178.
ENST00000610231; ENSP00000476626; ENSG00000273427.
GeneID4696.
KEGGhsa:4696.
UCSCuc002qde.3. human.

Organism-specific databases

CTD4696.
GeneCardsGC19P054590.
HGNCHGNC:7686. NDUFA3.
HPAHPA046976.
MIM603832. gene.
neXtProtNX_O95167.
PharmGKBPA31492.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46010.
HOGENOMHOG000015319.
HOVERGENHBG006495.
KOK03947.
OMAYSIMINK.
PhylomeDBO95167.
TreeFamTF333021.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressO95167.
BgeeO95167.
CleanExHS_NDUFA3.
GenevestigatorO95167.

Family and domain databases

InterProIPR026626. NDUFA3.
[Graphical view]
PANTHERPTHR15221. PTHR15221. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi4696.
NextBio18110.
PROO95167.
SOURCESearch...

Entry information

Entry nameNDUA3_HUMAN
AccessionPrimary (citable) accession number: O95167
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM