SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O95167

- NDUA3_HUMAN

UniProt

O95167 - NDUA3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Gene
NDUFA3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  3. respiratory electron transport chain Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Alternative name(s):
Complex I-B9
Short name:
CI-B9
NADH-ubiquinone oxidoreductase B9 subunit
Gene namesi
Name:NDUFA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:7686. NDUFA3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial respiratory chain complex I Source: UniProtKB
  4. mitochondrion Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 8483NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
PRO_0000118793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO95167.
PeptideAtlasiO95167.
PRIDEiO95167.

PTM databases

PhosphoSiteiO95167.

Expressioni

Gene expression databases

ArrayExpressiO95167.
BgeeiO95167.
CleanExiHS_NDUFA3.
GenevestigatoriO95167.

Organism-specific databases

HPAiHPA046976.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

BioGridi110776. 2 interactions.
STRINGi9606.ENSP00000398290.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46010.
HOGENOMiHOG000015319.
HOVERGENiHBG006495.
KOiK03947.
OMAiYSIMINK.
PhylomeDBiO95167.
TreeFamiTF333021.

Family and domain databases

InterProiIPR026626. NDUFA3.
[Graphical view]
PANTHERiPTHR15221. PTHR15221. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95167-1 [UniParc]FASTAAdd to Basket

« Hide

MAARVGAFLK NAWDKEPVLV VSFVVGGLAV ILPPLSPYFK YSVMINKATP   50
YNYPVPVRDD GNMPDVPSHP QDPQGPSLEW LKKL 84
Length:84
Mass (Da):9,279
Last modified:May 1, 1999 - v1
Checksum:i38B27A96D7A05D31
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621N → D in a breast cancer sample; somatic mutation. 1 Publication
VAR_036175

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044955 mRNA. Translation: AAD05420.1.
AF070653 mRNA. Translation: AAD20959.1.
BC022369 mRNA. Translation: AAH22369.1.
BC061644 mRNA. Translation: AAH61644.1.
CCDSiCCDS12877.1.
PIRiJE0379.
RefSeqiNP_004533.1. NM_004542.3.
UniGeneiHs.198269.

Genome annotation databases

EnsembliENST00000419113; ENSP00000398290; ENSG00000170906.
ENST00000485876; ENSP00000418438; ENSG00000170906.
ENST00000571050; ENSP00000461139; ENSG00000273426.
ENST00000573732; ENSP00000459774; ENSG00000273426.
ENST00000603070; ENSP00000473873; ENSG00000271016.
ENST00000605308; ENSP00000474381; ENSG00000271016.
ENST00000608551; ENSP00000476522; ENSG00000273453.
ENST00000608578; ENSP00000476315; ENSG00000273052.
ENST00000608754; ENSP00000476931; ENSG00000273126.
ENST00000608992; ENSP00000476773; ENSG00000273052.
ENST00000609149; ENSP00000476328; ENSG00000272553.
ENST00000609197; ENSP00000476524; ENSG00000273095.
ENST00000609226; ENSP00000477121; ENSG00000273427.
ENST00000609444; ENSP00000476973; ENSG00000273453.
ENST00000609560; ENSP00000476674; ENSG00000273095.
ENST00000609753; ENSP00000476406; ENSG00000273126.
ENST00000609826; ENSP00000476665; ENSG00000273178.
ENST00000609960; ENSP00000477477; ENSG00000272553.
ENST00000610124; ENSP00000477347; ENSG00000273178.
ENST00000610231; ENSP00000476626; ENSG00000273427.
GeneIDi4696.
KEGGihsa:4696.
UCSCiuc002qde.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF044955 mRNA. Translation: AAD05420.1 .
AF070653 mRNA. Translation: AAD20959.1 .
BC022369 mRNA. Translation: AAH22369.1 .
BC061644 mRNA. Translation: AAH61644.1 .
CCDSi CCDS12877.1.
PIRi JE0379.
RefSeqi NP_004533.1. NM_004542.3.
UniGenei Hs.198269.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110776. 2 interactions.
STRINGi 9606.ENSP00000398290.

Chemistry

ChEMBLi CHEMBL2363065.
DrugBanki DB00157. NADH.

PTM databases

PhosphoSitei O95167.

Proteomic databases

PaxDbi O95167.
PeptideAtlasi O95167.
PRIDEi O95167.

Protocols and materials databases

DNASUi 4696.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000419113 ; ENSP00000398290 ; ENSG00000170906 .
ENST00000485876 ; ENSP00000418438 ; ENSG00000170906 .
ENST00000571050 ; ENSP00000461139 ; ENSG00000273426 .
ENST00000573732 ; ENSP00000459774 ; ENSG00000273426 .
ENST00000603070 ; ENSP00000473873 ; ENSG00000271016 .
ENST00000605308 ; ENSP00000474381 ; ENSG00000271016 .
ENST00000608551 ; ENSP00000476522 ; ENSG00000273453 .
ENST00000608578 ; ENSP00000476315 ; ENSG00000273052 .
ENST00000608754 ; ENSP00000476931 ; ENSG00000273126 .
ENST00000608992 ; ENSP00000476773 ; ENSG00000273052 .
ENST00000609149 ; ENSP00000476328 ; ENSG00000272553 .
ENST00000609197 ; ENSP00000476524 ; ENSG00000273095 .
ENST00000609226 ; ENSP00000477121 ; ENSG00000273427 .
ENST00000609444 ; ENSP00000476973 ; ENSG00000273453 .
ENST00000609560 ; ENSP00000476674 ; ENSG00000273095 .
ENST00000609753 ; ENSP00000476406 ; ENSG00000273126 .
ENST00000609826 ; ENSP00000476665 ; ENSG00000273178 .
ENST00000609960 ; ENSP00000477477 ; ENSG00000272553 .
ENST00000610124 ; ENSP00000477347 ; ENSG00000273178 .
ENST00000610231 ; ENSP00000476626 ; ENSG00000273427 .
GeneIDi 4696.
KEGGi hsa:4696.
UCSCi uc002qde.3. human.

Organism-specific databases

CTDi 4696.
GeneCardsi GC19P054590.
HGNCi HGNC:7686. NDUFA3.
HPAi HPA046976.
MIMi 603832. gene.
neXtProti NX_O95167.
PharmGKBi PA31492.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46010.
HOGENOMi HOG000015319.
HOVERGENi HBG006495.
KOi K03947.
OMAi YSIMINK.
PhylomeDBi O95167.
TreeFami TF333021.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

GenomeRNAii 4696.
NextBioi 18110.
PROi O95167.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95167.
Bgeei O95167.
CleanExi HS_NDUFA3.
Genevestigatori O95167.

Family and domain databases

InterProi IPR026626. NDUFA3.
[Graphical view ]
PANTHERi PTHR15221. PTHR15221. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
    Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M.
    Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Prostate.
  4. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-62.

Entry informationi

Entry nameiNDUA3_HUMAN
AccessioniPrimary (citable) accession number: O95167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi