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O95166 (GBRAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-aminobutyric acid receptor-associated protein
Alternative name(s):
GABA(A) receptor-associated protein
MM46
Gene names
Name:GABARAP
Synonyms:FLC3B
ORF Names:HT004
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton By similarity.

Subunit structure

Interacts with GPHN and NSF By similarity. Interacts with GABRG2, beta-tubulin and ULK1. Interacts with CALR. Ref.1 Ref.2 Ref.7 Ref.11

Subcellular location

Endomembrane system By similarity. Cytoplasm › cytoskeleton By similarity. Golgi apparatus membrane By similarity. Note: Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules By similarity.

Tissue specificity

Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Ref.1 Ref.2

Sequence similarities

Belongs to the MAP1 LC3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 117117Gamma-aminobutyric acid receptor-associated protein
PRO_0000212363

Regions

Region1 – 2222Interaction with beta-tubulin
Region36 – 11782Interaction with GPHN By similarity
Region36 – 6833Interaction with GABRG2 Potential

Secondary structure

1 ................. 117
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O95166 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: BC0B84B8A51C1E32

FASTA11713,918
        10         20         30         40         50         60 
MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 

        70         80         90        100        110 
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

« Hide

References

« Hide 'large scale' references
[1]"GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton."
Wang H., Bedford F.K., Brandon N.J., Moss S.J., Olsen R.W.
Nature 397:69-72(1999) [PubMed: 9892355] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH GABRG2 AND BETA-TUBULIN.
Tissue: Brain.
[2]"Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."
Okazaki N., Yan J., Yuasa S., Ueno T., Kominami E., Masuho Y., Koga H., Muramatsu M.-A.
Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed: 11146101] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ULK1.
Tissue: Frontal cortex.
[3]Iijima M., Mitsui Y.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]Ye M., Fu G., Wu J., Zhou J., Zhang Q., Shen Y., Kan L., He K., Gu B., Chen S., Mao M., Chen Z.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hypothalamus.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein."
Knight D., Harris R., McAlister M.S.B., Phelan J.P., Geddes S., Moss S.J., Driscoll P.C., Keep N.H.
J. Biol. Chem. 277:5556-5561(2002) [PubMed: 11729197] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS), INTERACTION WITH GABRG2; TUBULIN ALPHA AND TUBULIN BETA.
[8]"Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biolgoical funcrion and its regulation."
Stangler T., Mayr L.M., Willbold D.
J. Biol. Chem. 277:13363-13366(2002) [PubMed: 11875056] [Abstract]
Cited for: STRUCTURE BY NMR.
[9]"1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein."
Kouno T., Miura K., Kanematsu T., Shirakawa M., Hirata M., Kawano K.
J. Biomol. NMR 22:97-98(2002) [PubMed: 11885988] [Abstract]
Cited for: STRUCTURE BY NMR.
[10]"Ligand binding mode of GABAA receptor-associated protein."
Weiergraber O.H., Stangler T., Thielmann Y., Mohrluder J., Wiesehan K., Willbold D.
J. Mol. Biol. 381:1320-1331(2008) [PubMed: 18638487] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS).
[11]"Structural framework of the GABARAP-calreticulin interface--implications for substrate binding to endoplasmic reticulum chaperones."
Thielmann Y., Weiergraber O.H., Mohrluder J., Willbold D.
FEBS J. 276:1140-1152(2009) [PubMed: 19154346] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH CALR, INTERACTION WITH CALR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF161586 mRNA. Translation: AAD47641.1.
AB030711 mRNA. Translation: BAB21549.1.
AF044671 mRNA. Translation: AAD02337.1.
AF067171 mRNA. Translation: AAD32455.1.
AF183425 mRNA. Translation: AAG09694.1.
IPIIPI00027253.
RefSeqNP_009209.1. NM_007278.1.
UniGeneHs.647421.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GNUX-ray1.75A1-117[»]
1KLVNMR-A1-117[»]
1KM7NMR-A1-117[»]
1KOTNMR-A1-117[»]
3D32X-ray1.30A/B1-117[»]
3DOWX-ray2.30A1-117[»]
ProteinModelPortalO95166.
SMRO95166. Positions 1-116.
ModBaseSearch...

Protein-protein interaction databases

IntActO95166. 471 interactions.
MINTMINT-206256.
STRINGO95166.

Protein family/group databases

TCDB1.A.9.5.2. neurotransmitter receptor, cys loop, ligand-gated ion channel (LIC) family.

Proteomic databases

PRIDEO95166.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302386; ENSP00000306866; ENSG00000170296.
GeneID11337.
KEGGhsa:11337.
UCSCuc002gfb.1. human.

Organism-specific databases

CTD11337.
GeneCardsGC17M007143.
H-InvDBHIX0013108.
HGNCHGNC:4067. GABARAP.
MIM605125. gene.
neXtProtNX_O95166.
PharmGKBPA28480.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20108.
HOGENOMHBG592694.
HOVERGENHBG051706.
InParanoidO95166.
OMATTMGQLY.
OrthoDBEOG4T4CWW.
PhylomeDBO95166.

Gene expression databases

ArrayExpressO95166.
BgeeO95166.
CleanExHS_GABARAP.
GenevestigatorO95166.
GermOnlineENSG00000170296. Homo sapiens.

Family and domain databases

InterProIPR004241. Atg8_ubiquitin-like.
[Graphical view]
KOK08341.
PANTHERPTHR10969. MAP1_LC3. 1 hit.
PfamPF02991. Atg8. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio43075.
PMAP-CutDBO95166.
SOURCESearch...

Entry information

Entry nameGBRAP_HUMAN
AccessionPrimary (citable) accession number: O95166
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents