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O95166

- GBRAP_HUMAN

UniProt

O95166 - GBRAP_HUMAN

Protein

Gamma-aminobutyric acid receptor-associated protein

Gene

GABARAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei116 – 1172Cleavage; by ATG4B

    GO - Molecular functioni

    1. beta-tubulin binding Source: UniProtKB
    2. GABA receptor binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
    3. microtubule cytoskeleton organization Source: Ensembl
    4. protein targeting Source: ProtInc
    5. synaptic transmission Source: ProtInc

    Keywords - Biological processi

    Apoptosis, Autophagy, Protein transport, Transport

    Protein family/group databases

    TCDBi1.A.9.5.2. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein
    Alternative name(s):
    GABA(A) receptor-associated protein
    MM46
    Gene namesi
    Name:GABARAP
    Synonyms:FLC3B
    ORF Names:HT004
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4067. GABARAP.

    Subcellular locationi

    Endomembrane system By similarity. Cytoplasmcytoskeleton By similarity. Golgi apparatus membrane By similarity. Cytoplasmic vesicleautophagosome 4 Publications
    Note: Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules By similarity. Localizes also to discrete punctae along the ciliary axoneme By similarity.By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. autophagic vacuole Source: UniProtKB
    3. autophagic vacuole membrane Source: UniProtKB
    4. axoneme Source: UniProtKB
    5. cell body Source: Ensembl
    6. cytoplasmic vesicle Source: UniProtKB-KW
    7. Golgi membrane Source: UniProtKB-SubCell
    8. lysosome Source: Ensembl
    9. microtubule Source: UniProtKB-KW
    10. microtubule associated complex Source: Ensembl
    11. perinuclear region of cytoplasm Source: Ensembl
    12. plasma membrane Source: ProtInc
    13. smooth endoplasmic reticulum Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi49 – 502YL → AA: Inhibits interaction with TECPR2.
    Mutagenesisi67 – 671R → A: No effect on interaction with TECPR2. 1 Publication
    Mutagenesisi116 – 1161G → A: Impairs localization at the autophagosomal membrane. 1 Publication

    Organism-specific databases

    PharmGKBiPA28480.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116Gamma-aminobutyric acid receptor-associated proteinPRO_0000212363Add
    BLAST
    Propeptidei117 – 1171Removed in mature formPRO_0000423065

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi116 – 1161Phosphatidylethanolamine amidated glycine1 Publication

    Post-translational modificationi

    The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II.1 Publication

    Keywords - PTMi

    Lipoprotein

    Proteomic databases

    MaxQBiO95166.
    PaxDbiO95166.
    PRIDEiO95166.

    PTM databases

    PhosphoSiteiO95166.

    Miscellaneous databases

    PMAP-CutDBO95166.

    Expressioni

    Tissue specificityi

    Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.2 Publications

    Gene expression databases

    BgeeiO95166.
    CleanExiHS_GABARAP.
    GenevestigatoriO95166.

    Interactioni

    Subunit structurei

    Interacts with GPHN and NSF By similarity. Interacts with ATG3, ATG7, ATG13, RB1CC1, GABRG2, beta-tubulin and ULK1. Interacts with CALR. Interacts with DDX47. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1. Interacts with MAPK15. Interacts with TECPR2 and PCM1.By similarity17 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATG2AQ2TAZ02EBI-712001,EBI-2514077
    ATG3Q9NT625EBI-712001,EBI-988094
    ATG4BQ9Y4P18EBI-712001,EBI-712014
    ATG5Q9H1Y02EBI-712001,EBI-1047414
    ATG7O953528EBI-712001,EBI-987834
    Bnip3lQ9Z2F72EBI-712001,EBI-1774669From a different organism.
    CALRP277974EBI-712001,EBI-1049597
    DDX47Q9H0S43EBI-712001,EBI-2515241
    DYX1C1Q8WXU24EBI-712001,EBI-2946907
    FNBP1Q96RU32EBI-712001,EBI-1111248
    FNIP1Q8TF405EBI-712001,EBI-2946919
    FYCO1Q9BQS82EBI-712001,EBI-2869338
    GBASO753235EBI-712001,EBI-307133
    HADHAP409395EBI-712001,EBI-356720
    IPO5O004106EBI-712001,EBI-356424
    KBTBD6Q86V973EBI-712001,EBI-2514778
    KBTBD7Q8WVZ92EBI-712001,EBI-473695
    NBR1Q145965EBI-712001,EBI-742698
    NCOA7Q8NI084EBI-712001,EBI-80799
    NEDD4P469346EBI-712001,EBI-726944
    NEK9Q8TD195EBI-712001,EBI-1044009
    NSMAFQ926362EBI-712001,EBI-2947053
    RASSF1Q9NS232EBI-712001,EBI-367363
    RASSF5Q8WWW02EBI-712001,EBI-367390
    SQSTM1Q1350110EBI-712001,EBI-307104
    STBD1O952105EBI-712001,EBI-2947137
    STK3Q131882EBI-712001,EBI-992580
    STK4Q130432EBI-712001,EBI-367376
    TBC1D15Q8TC075EBI-712001,EBI-1048247
    TBC1D2BQ9UPU72EBI-712001,EBI-2947180
    TECPR2O150402EBI-712001,EBI-2946991
    UBA5Q9GZZ92EBI-712001,EBI-747805

    Protein-protein interaction databases

    BioGridi116465. 43 interactions.
    DIPiDIP-35050N.
    IntActiO95166. 474 interactions.
    MINTiMINT-206256.
    STRINGi9606.ENSP00000306866.

    Structurei

    Secondary structure

    1
    117
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 85
    Helixi11 – 2414
    Beta strandi28 – 358
    Beta strandi47 – 526
    Helixi57 – 6812
    Beta strandi77 – 804
    Beta strandi87 – 904
    Helixi91 – 988
    Beta strandi101 – 1033
    Beta strandi105 – 1117

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GNUX-ray1.75A1-117[»]
    1KLVNMR-A1-117[»]
    1KM7NMR-A1-117[»]
    1KOTNMR-A1-117[»]
    3D32X-ray1.30A/B1-117[»]
    3DOWX-ray2.30A1-117[»]
    3WIMX-ray2.60A1-117[»]
    ProteinModelPortaliO95166.
    SMRiO95166. Positions 1-116.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95166.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2222Interaction with beta-tubulinAdd
    BLAST
    Regioni36 – 11782Interaction with GPHNBy similarityAdd
    BLAST
    Regioni36 – 6833Interaction with GABRG2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATG8 family.Curated

    Phylogenomic databases

    eggNOGiNOG263746.
    HOGENOMiHOG000232034.
    HOVERGENiHBG051706.
    InParanoidiO95166.
    KOiK08341.
    OMAiTTMGQLY.
    OrthoDBiEOG70KGRK.
    PhylomeDBiO95166.
    TreeFamiTF314556.

    Family and domain databases

    InterProiIPR004241. Atg8_like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10969. PTHR10969. 1 hit.
    PfamiPF02991. Atg8. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95166-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL    50
    VPSDLTVGQF YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE 100
    EDFFLYIAYS DESVYGL 117
    Length:117
    Mass (Da):13,918
    Last modified:May 1, 1999 - v1
    Checksum:iBC0B84B8A51C1E32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161586 mRNA. Translation: AAD47641.1.
    AB030711 mRNA. Translation: BAB21549.1.
    AF044671 mRNA. Translation: AAD02337.1.
    AF067171 mRNA. Translation: AAD32455.1.
    AF183425 mRNA. Translation: AAG09694.1.
    CCDSiCCDS11092.1.
    RefSeqiNP_009209.1. NM_007278.1.
    UniGeneiHs.647421.

    Genome annotation databases

    EnsembliENST00000302386; ENSP00000306866; ENSG00000170296.
    GeneIDi11337.
    KEGGihsa:11337.
    UCSCiuc002gfb.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161586 mRNA. Translation: AAD47641.1 .
    AB030711 mRNA. Translation: BAB21549.1 .
    AF044671 mRNA. Translation: AAD02337.1 .
    AF067171 mRNA. Translation: AAD32455.1 .
    AF183425 mRNA. Translation: AAG09694.1 .
    CCDSi CCDS11092.1.
    RefSeqi NP_009209.1. NM_007278.1.
    UniGenei Hs.647421.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GNU X-ray 1.75 A 1-117 [» ]
    1KLV NMR - A 1-117 [» ]
    1KM7 NMR - A 1-117 [» ]
    1KOT NMR - A 1-117 [» ]
    3D32 X-ray 1.30 A/B 1-117 [» ]
    3DOW X-ray 2.30 A 1-117 [» ]
    3WIM X-ray 2.60 A 1-117 [» ]
    ProteinModelPortali O95166.
    SMRi O95166. Positions 1-116.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116465. 43 interactions.
    DIPi DIP-35050N.
    IntActi O95166. 474 interactions.
    MINTi MINT-206256.
    STRINGi 9606.ENSP00000306866.

    Protein family/group databases

    TCDBi 1.A.9.5.2. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    PTM databases

    PhosphoSitei O95166.

    Proteomic databases

    MaxQBi O95166.
    PaxDbi O95166.
    PRIDEi O95166.

    Protocols and materials databases

    DNASUi 11337.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302386 ; ENSP00000306866 ; ENSG00000170296 .
    GeneIDi 11337.
    KEGGi hsa:11337.
    UCSCi uc002gfb.3. human.

    Organism-specific databases

    CTDi 11337.
    GeneCardsi GC17M007143.
    HGNCi HGNC:4067. GABARAP.
    MIMi 605125. gene.
    neXtProti NX_O95166.
    PharmGKBi PA28480.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263746.
    HOGENOMi HOG000232034.
    HOVERGENi HBG051706.
    InParanoidi O95166.
    KOi K08341.
    OMAi TTMGQLY.
    OrthoDBi EOG70KGRK.
    PhylomeDBi O95166.
    TreeFami TF314556.

    Miscellaneous databases

    ChiTaRSi GABARAP. human.
    EvolutionaryTracei O95166.
    GeneWikii GABARAP.
    GenomeRNAii 11337.
    NextBioi 43075.
    PMAP-CutDB O95166.
    PROi O95166.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95166.
    CleanExi HS_GABARAP.
    Genevestigatori O95166.

    Family and domain databases

    InterProi IPR004241. Atg8_like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10969. PTHR10969. 1 hit.
    Pfami PF02991. Atg8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton."
      Wang H., Bedford F.K., Brandon N.J., Moss S.J., Olsen R.W.
      Nature 397:69-72(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH GABRG2 AND BETA-TUBULIN.
      Tissue: Brain.
    2. "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."
      Okazaki N., Yan J., Yuasa S., Ueno T., Kominami E., Masuho Y., Koga H., Muramatsu M.-A.
      Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ULK1.
      Tissue: Frontal cortex.
    3. Iijima M., Mitsui Y.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Ye M., Fu G., Wu J., Zhou J., Zhang Q., Shen Y., Kan L., He K., Gu B., Chen S., Mao M., Chen Z.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hypothalamus.
    6. "The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."
      Tanida I., Tanida-Miyake E., Ueno T., Kominami E.
      J. Biol. Chem. 276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG7.
    7. "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
      Tanida I., Tanida-Miyake E., Komatsu M., Ueno T., Kominami E.
      J. Biol. Chem. 277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG3.
    8. "GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3."
      Tanida I., Komatsu M., Ueno T., Kominami E.
      Biochem. Biophys. Res. Commun. 300:637-644(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIPIDATION AT GLY-116, INTERACTION WITH ATG3 AND ATG7, SUBCELLULAR LOCATION.
    9. "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation."
      Kabeya Y., Mizushima N., Yamamoto A., Oshitani-Okamoto S., Ohsumi Y., Yoshimori T.
      J. Cell Sci. 117:2805-2812(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-116.
    10. "GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47)."
      Lee J.H., Rho S.B., Chun T.
      Biotechnol. Lett. 27:623-628(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DDX47.
    11. "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."
      Pankiv S., Clausen T.H., Lamark T., Brech A., Bruun J.A., Outzen H., Overvatn A., Bjorkoy G., Johansen T.
      J. Biol. Chem. 282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SQSTM1, SUBCELLULAR LOCATION.
    12. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TP53INP2.
    13. "Network organization of the human autophagy system."
      Behrends C., Sowa M.E., Gygi S.P., Harper J.W.
      Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TECPR2, MUTAGENESIS OF 49-TYR-LEU-50 AND ARG-67.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation."
      Itoh T., Kanno E., Uemura T., Waguri S., Fukuda M.
      J. Cell Biol. 192:839-853(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TBC1D25.
    16. Cited for: INTERACTION WITH MAPK15.
    17. "TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."
      Seillier M., Peuget S., Gayet O., Gauthier C., N'guessan P., Monte M., Carrier A., Iovanna J.L., Dusetti N.J.
      Cell Death Differ. 19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TP53INP1.
    18. "ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs."
      Alemu E.A., Lamark T., Torgersen K.M., Birgisdottir A.B., Larsen K.B., Jain A., Olsvik H., Overvatn A., Kirkin V., Johansen T.
      J. Biol. Chem. 287:39275-39290(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG13; RB1CC1 AND ULK1.
    19. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
      Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A., Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U., Palacin M., Johansen T., Zorzano A.
      PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TP53INP1 AND TP53INP2.
    20. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
      Tang Z., Lin M.G., Stowe T.R., Chen S., Zhu M., Stearns T., Franco B., Zhong Q.
      Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION PCM1.
    21. "The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein."
      Knight D., Harris R., McAlister M.S.B., Phelan J.P., Geddes S., Moss S.J., Driscoll P.C., Keep N.H.
      J. Biol. Chem. 277:5556-5561(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS), INTERACTION WITH GABRG2; TUBULIN ALPHA AND TUBULIN BETA.
    22. "Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biological function and its regulation."
      Stangler T., Mayr L.M., Willbold D.
      J. Biol. Chem. 277:13363-13366(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    23. "1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein."
      Kouno T., Miura K., Kanematsu T., Shirakawa M., Hirata M., Kawano K.
      J. Biomol. NMR 22:97-98(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    24. Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS).
    25. "Structural framework of the GABARAP-calreticulin interface --implications for substrate binding to endoplasmic reticulum chaperones."
      Thielmann Y., Weiergraber O.H., Mohrluder J., Willbold D.
      FEBS J. 276:1140-1152(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH CALR, INTERACTION WITH CALR.

    Entry informationi

    Entry nameiGBRAP_HUMAN
    AccessioniPrimary (citable) accession number: O95166
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3