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Reviewed, UniProtKB/Swiss-Prot O95166 (GBRAP_HUMAN)

Last modified November 25, 2008. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Gamma-aminobutyric acid receptor-associated protein
Alternative name(s):
    GABA(A) receptor-associated protein
    MM46
Gene names
Name: GABARAP
Synonyms: FLC3B
ORF Names: HT004
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton By similarity.

Subunit structure

Interacts with GPHN and NSF By similarity. Interacts with GABRG2, beta-tubulin and ULK1.

Subcellular location

Intracytoplasmic membraneBy similarity. CytoplasmcytoskeletonBy similarity. Golgi apparatus membraneBy similarity. Note= Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules By similarity.

Tissue specificity

Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

Sequence similarities

Belongs to the MAP1 LC3 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ULK1O753851EBI-712001,EBI-908831

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 117117Gamma-aminobutyric acid receptor-associated protein
PRO_0000212363

Regions

Region1 – 2222Interaction with beta-tubulin
Region36 – 11782Interaction with GPHN By similarity
Region36 – 6833Interaction with GABRG2 Potential

Secondary structure

................. 117
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O95166-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: BC0B84B8A51C1E32

FASTA11713,918
        10         20         30         40         50         60 
MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 

        70         80         90        100        110 
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL 

« Hide

References

« Hide 'large scale' references
[1]"GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton."
Wang H., Bedford F.K., Brandon N.J., Moss S.J., Olsen R.W.
Nature 397:69-72(1999) [PubMed: 9892355] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH GABRG2 AND BETA-TUBULIN.
Tissue: Brain.
[2]"Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."
Okazaki N., Yan J., Yuasa S., Ueno T., Kominami E., Masuho Y., Koga H., Muramatsu M.-A.
Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed: 11146101] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ULK1.
Tissue: Frontal cortex.
[3]Iijima M., Mitsui Y.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]Ye M., Fu G., Wu J., Zhou J., Zhang Q., Shen Y., Kan L., He K., Gu B., Chen S., Mao M., Chen Z.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hypothalamus.
[6]"The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein."
Knight D., Harris R., McAlister M.S.B., Phelan J.P., Geddes S., Moss S.J., Driscoll P.C., Keep N.H.
J. Biol. Chem. 277:5556-5561(2002) [PubMed: 11729197] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS), INTERACTION WITH GABRG2; TUBULIN ALPHA AND TUBULIN BETA.
[7]"Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biolgoical funcrion and its regulation."
Stangler T., Mayr L.M., Willbold D.
J. Biol. Chem. 277:13363-13366(2002) [PubMed: 11875056] [Abstract]
Cited for: STRUCTURE BY NMR.
[8]"1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein."
Kouno T., Miura K., Kanematsu T., Shirakawa M., Hirata M., Kawano K.
J. Biomol. NMR 22:97-98(2002) [PubMed: 11885988] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF161586 mRNA. Translation: AAD47641.1.
AB030711 mRNA. Translation: BAB21549.1.
AF044671 mRNA. Translation: AAD02337.1.
AF067171 mRNA. Translation: AAD32455.1.
AF183425 mRNA. Translation: AAG09694.1.
RefSeqNP_009209.1.
UniGeneHs.647421

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1GNUX-ray1.75A1-117[»]
1KLVNMR-A1-117[»]
1KM7NMR-A1-117[»]
1KOTNMR-A1-117[»]
3D32X-ray1.30A/B1-117[»]
ModBaseSearch...

Protein-protein interaction databases

IntActO95166.

PTM databases

PhosphoSiteO95166.

Genome annotation databases

EnsemblENSG00000170296. Homo sapiens. [Contig view]
GeneID11337.
KEGGhsa:11337.

Organism-specific databases

H-InvDBHIX0013108.
HGNCHGNC:4067. GABARAP.
MIM605125. gene.
PharmGKBPA28480.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMO95166.
HOVERGENO95166.

Gene expression databases

ArrayExpressO95166.
CleanExHS_GABARAP.
GermOnlineENSG00000170296. Homo sapiens.

Family and domain databases

InterProIPR004241. MAP1_LC3.
[Graphical view]
PANTHERPTHR10969. MAP1_LC3. 1 hit.
PfamPF02991. MAP1_LC3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubO95166.
NextBio43075.
SOURCESearch...

Entry information

Entry nameGBRAP_HUMAN
AccessionPrimary (citable) accession number: O95166
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 1999
Last modified: November 25, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents