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Protein

Ubiquitin-like protein 3

Gene

UBL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 3
Alternative name(s):
Membrane-anchored ubiquitin-fold protein
Short name:
HsMUB
Short name:
MUB
Protein HCG-1
Gene namesi
Name:UBL3
Synonyms:PNSC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:12504. UBL3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intracellular Source: LIFEdb
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37151.

Polymorphism and mutation databases

BioMutaiUBL3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Ubiquitin-like protein 3PRO_0000114862Add
BLAST
Propeptidei115 – 1173Removed in mature formCuratedPRO_0000248183

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi113 – 1131S-palmitoyl cysteine1 Publication
Modified residuei114 – 1141Cysteine methyl esterCurated
Lipidationi114 – 1141S-geranylgeranyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiO95164.
MaxQBiO95164.
PaxDbiO95164.
PeptideAtlasiO95164.
PRIDEiO95164.

PTM databases

iPTMnetiO95164.
PhosphoSiteiO95164.
SwissPalmiO95164.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiO95164.
CleanExiHS_UBL3.
ExpressionAtlasiO95164. baseline and differential.
GenevisibleiO95164. HS.

Organism-specific databases

HPAiHPA053772.
HPA058781.

Interactioni

Protein-protein interaction databases

BioGridi111413. 2 interactions.
MINTiMINT-4713639.
STRINGi9606.ENSP00000370055.

Structurei

Secondary structure

1
117
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 156Combined sources
Beta strandi21 – 266Combined sources
Helixi32 – 409Combined sources
Helixi55 – 573Combined sources
Beta strandi58 – 669Combined sources
Helixi74 – 763Combined sources
Beta strandi82 – 909Combined sources
Beta strandi95 – 995Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GOWNMR-A2-117[»]
ProteinModelPortaliO95164.
SMRiO95164. Positions 2-117.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95164.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8879Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IVZB. Eukaryota.
ENOG4111N2D. LUCA.
GeneTreeiENSGT00390000004952.
HOGENOMiHOG000253908.
HOVERGENiHBG054980.
InParanoidiO95164.
OMAiMHLVTRE.
OrthoDBiEOG7KSXBW.
PhylomeDBiO95164.
TreeFamiTF314489.

Family and domain databases

InterProiIPR017000. MUB.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PIRSFiPIRSF032572. MUB. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNVPADMI NLRLILVSGK TKEFLFSPND SASDIAKHVY DNWPMDWEEE
60 70 80 90 100
QVSSPNILRL IYQGRFLHGN VTLGALKLPF GKTTVMHLVA RETLPEPNSQ
110
GQRNREKTGE SNCCVIL
Length:117
Mass (Da):13,157
Last modified:May 1, 1999 - v1
Checksum:i4EB1375D9C0B029F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101I → V in CAG38489 (Ref. 4) Curated
Sequence conflicti28 – 281P → H in AAH44582 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044221 mRNA. Translation: AAD02323.1.
AL080177 mRNA. Translation: CAB45762.1.
AK311846 mRNA. Translation: BAG34788.1.
AK056580 mRNA. Translation: BAG51754.1.
CR533458 mRNA. Translation: CAG38489.1.
AL158193, AL139188 Genomic DNA. Translation: CAH73447.1.
AL139188, AL158193 Genomic DNA. Translation: CAI17023.1.
CH471075 Genomic DNA. Translation: EAX08446.1.
BC044582 mRNA. Translation: AAH44582.1.
BC059385 mRNA. Translation: AAH59385.1.
CCDSiCCDS9334.1.
PIRiT12498.
RefSeqiNP_009037.1. NM_007106.3.
UniGeneiHs.145575.

Genome annotation databases

EnsembliENST00000380680; ENSP00000370055; ENSG00000122042.
GeneIDi5412.
KEGGihsa:5412.
UCSCiuc001usp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044221 mRNA. Translation: AAD02323.1.
AL080177 mRNA. Translation: CAB45762.1.
AK311846 mRNA. Translation: BAG34788.1.
AK056580 mRNA. Translation: BAG51754.1.
CR533458 mRNA. Translation: CAG38489.1.
AL158193, AL139188 Genomic DNA. Translation: CAH73447.1.
AL139188, AL158193 Genomic DNA. Translation: CAI17023.1.
CH471075 Genomic DNA. Translation: EAX08446.1.
BC044582 mRNA. Translation: AAH44582.1.
BC059385 mRNA. Translation: AAH59385.1.
CCDSiCCDS9334.1.
PIRiT12498.
RefSeqiNP_009037.1. NM_007106.3.
UniGeneiHs.145575.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GOWNMR-A2-117[»]
ProteinModelPortaliO95164.
SMRiO95164. Positions 2-117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111413. 2 interactions.
MINTiMINT-4713639.
STRINGi9606.ENSP00000370055.

PTM databases

iPTMnetiO95164.
PhosphoSiteiO95164.
SwissPalmiO95164.

Polymorphism and mutation databases

BioMutaiUBL3.

Proteomic databases

EPDiO95164.
MaxQBiO95164.
PaxDbiO95164.
PeptideAtlasiO95164.
PRIDEiO95164.

Protocols and materials databases

DNASUi5412.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380680; ENSP00000370055; ENSG00000122042.
GeneIDi5412.
KEGGihsa:5412.
UCSCiuc001usp.4. human.

Organism-specific databases

CTDi5412.
GeneCardsiUBL3.
HGNCiHGNC:12504. UBL3.
HPAiHPA053772.
HPA058781.
MIMi604711. gene.
neXtProtiNX_O95164.
PharmGKBiPA37151.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVZB. Eukaryota.
ENOG4111N2D. LUCA.
GeneTreeiENSGT00390000004952.
HOGENOMiHOG000253908.
HOVERGENiHBG054980.
InParanoidiO95164.
OMAiMHLVTRE.
OrthoDBiEOG7KSXBW.
PhylomeDBiO95164.
TreeFamiTF314489.

Miscellaneous databases

ChiTaRSiUBL3. human.
EvolutionaryTraceiO95164.
GeneWikiiUBL3.
GenomeRNAii5412.
PROiO95164.
SOURCEiSearch...

Gene expression databases

BgeeiO95164.
CleanExiHS_UBL3.
ExpressionAtlasiO95164. baseline and differential.
GenevisibleiO95164. HS.

Family and domain databases

InterProiIPR017000. MUB.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PIRSFiPIRSF032572. MUB. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene."
    Chadwick B.P., Kidd T., Sgouros J., Ish-Horowicz D., Frischauf A.-M.
    Gene 233:189-195(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Corpus callosum and Tongue.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "MUBS: a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation."
    Downes B.P., Saracco S.A., Lee S.S., Crowell D.N., Vierstra R.D.
    J. Biol. Chem. 281:27145-27157(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE, ISOPRENYLATION AT CYS-114 IN VITRO.
  9. "Solution structure of a membrane-anchored ubiquitin-fold (MUB) protein from Homo sapiens."
    de la Cruz N.B., Peterson F.C., Lytle B.L., Volkman B.F.
    Protein Sci. 16:1479-1484(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2-117.

Entry informationi

Entry nameiUBL3_HUMAN
AccessioniPrimary (citable) accession number: O95164
Secondary accession number(s): B2R4J1
, Q5RL72, Q5VZS0, Q6FIG8, Q96SG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.