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Protein

Neurexophilin-4

Gene

NXPH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.Curated

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-4
Gene namesi
Name:NXPH4
Synonyms:NPH4
ORF Names:UNQ1928/PRO4403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:8078. NXPH4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31866.

Polymorphism and mutation databases

BioMutaiNXPH4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 308285Neurexophilin-4PRO_0000020068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO95158.
PaxDbiO95158.
PRIDEiO95158.

PTM databases

PhosphoSiteiO95158.

Expressioni

Tissue specificityi

Expressed in brain, spleen, and testis.

Gene expression databases

BgeeiO95158.
CleanExiHS_NXPH4.
ExpressionAtlasiO95158. baseline and differential.
GenevisibleiO95158. HS.

Interactioni

Protein-protein interaction databases

BioGridi116408. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliO95158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 8461IIAdd
BLAST
Regioni85 – 16379IIIAdd
BLAST
Regioni164 – 22461IV (linker domain)Add
BLAST
Regioni225 – 30884V (Cys-rich)Add
BLAST

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG81037.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiO95158.
OMAiQIPESGR.
OrthoDBiEOG7V4B0M.
PhylomeDBiO95158.
TreeFamiTF333047.

Family and domain databases

InterProiIPR010450. Neurexophilin.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLPEWFLL LFGPWLLRKA VSAQIPESGR PQYLGLRPAA AGAGAPGQQL
60 70 80 90 100
PEPRSSDGLG VGRAWSWAWP TNHTGALARA GAAGALPAQR TKRKPSIKAA
110 120 130 140 150
RAKKIFGWGD FYFRVHTLKF SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL
160 170 180 190 200
SVSIVPPSKR VEFGGVWLPG PVPHPLQSTL ALEGVLPGLG PPLGMAAAAA
210 220 230 240 250
GPGLGGSLGG ALAGPLGGAL GVPGAKESRA FNCHVEYEKT NRARKHRPCL
260 270 280 290 300
YDPSQVCFTE HTQSQAAWLC AKPFKVICIF VSFLSFDYKL VQKVCPDYNF

QSEHPYFG
Length:308
Mass (Da):33,065
Last modified:March 15, 2005 - v3
Checksum:iC18780A422AF6F6D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561S → T in AAH36679 (PubMed:15489334).Curated
Sequence conflicti226 – 2272KE → RG in AAD02282 (PubMed:9570794).Curated
Sequence conflicti296 – 2961P → Q in AAH36679 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358614 mRNA. Translation: AAQ88977.1.
AK290949 mRNA. Translation: BAF83638.1.
BC036679 mRNA. Translation: AAH36679.1.
BC053581 mRNA. Translation: AAH53581.1.
AF043469 mRNA. Translation: AAD02282.1.
CCDSiCCDS8933.1.
RefSeqiNP_009155.1. NM_007224.3.
UniGeneiHs.745023.

Genome annotation databases

EnsembliENST00000349394; ENSP00000333593; ENSG00000182379.
GeneIDi11247.
KEGGihsa:11247.
UCSCiuc010srf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358614 mRNA. Translation: AAQ88977.1.
AK290949 mRNA. Translation: BAF83638.1.
BC036679 mRNA. Translation: AAH36679.1.
BC053581 mRNA. Translation: AAH53581.1.
AF043469 mRNA. Translation: AAD02282.1.
CCDSiCCDS8933.1.
RefSeqiNP_009155.1. NM_007224.3.
UniGeneiHs.745023.

3D structure databases

ProteinModelPortaliO95158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116408. 3 interactions.

PTM databases

PhosphoSiteiO95158.

Polymorphism and mutation databases

BioMutaiNXPH4.

Proteomic databases

MaxQBiO95158.
PaxDbiO95158.
PRIDEiO95158.

Protocols and materials databases

DNASUi11247.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349394; ENSP00000333593; ENSG00000182379.
GeneIDi11247.
KEGGihsa:11247.
UCSCiuc010srf.2. human.

Organism-specific databases

CTDi11247.
GeneCardsiGC12P057610.
HGNCiHGNC:8078. NXPH4.
MIMi604637. gene.
neXtProtiNX_O95158.
PharmGKBiPA31866.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG81037.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiO95158.
OMAiQIPESGR.
OrthoDBiEOG7V4B0M.
PhylomeDBiO95158.
TreeFamiTF333047.

Miscellaneous databases

ChiTaRSiNXPH4. human.
GenomeRNAii11247.
NextBioi42796.
PROiO95158.
SOURCEiSearch...

Gene expression databases

BgeeiO95158.
CleanExiHS_NXPH4.
ExpressionAtlasiO95158. baseline and differential.
GenevisibleiO95158. HS.

Family and domain databases

InterProiIPR010450. Neurexophilin.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Neurexophilins form a conserved family of neuropeptide-like glycoproteins."
    Missler M., Suedhof T.C.
    J. Neurosci. 18:3630-3638(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 225-308.

Entry informationi

Entry nameiNXPH4_HUMAN
AccessioniPrimary (citable) accession number: O95158
Secondary accession number(s): A8K4I4, Q7Z6L3, Q8N462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 15, 2005
Last modified: June 24, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.