Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O95158 (NXPH4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurexophilin-4
Gene names
Name:NXPH4
Synonyms:NPH4
ORF Names:UNQ1928/PRO4403
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors Potential.

Subcellular location

Secreted Potential.

Tissue specificity

Expressed in brain, spleen, and testis.

Post-translational modification

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells By similarity.

Sequence similarities

Belongs to the neurexophilin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Non-traceable author statement Ref.4. Source: UniProtKB

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 308285Neurexophilin-4
PRO_0000020068

Regions

Region24 – 8461II
Region85 – 16379III
Region164 – 22461IV (linker domain)
Region225 – 30884V (Cys-rich)

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict561S → T in AAH36679. Ref.3
Sequence conflict226 – 2272KE → RG in AAD02282. Ref.4
Sequence conflict2961P → Q in AAH36679. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O95158 [UniParc].

Last modified March 15, 2005. Version 3.
Checksum: C18780A422AF6F6D

FASTA30833,065
        10         20         30         40         50         60 
MRLLPEWFLL LFGPWLLRKA VSAQIPESGR PQYLGLRPAA AGAGAPGQQL PEPRSSDGLG 

        70         80         90        100        110        120 
VGRAWSWAWP TNHTGALARA GAAGALPAQR TKRKPSIKAA RAKKIFGWGD FYFRVHTLKF 

       130        140        150        160        170        180 
SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL SVSIVPPSKR VEFGGVWLPG PVPHPLQSTL 

       190        200        210        220        230        240 
ALEGVLPGLG PPLGMAAAAA GPGLGGSLGG ALAGPLGGAL GVPGAKESRA FNCHVEYEKT 

       250        260        270        280        290        300 
NRARKHRPCL YDPSQVCFTE HTQSQAAWLC AKPFKVICIF VSFLSFDYKL VQKVCPDYNF 


QSEHPYFG 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Neurexophilins form a conserved family of neuropeptide-like glycoproteins."
Missler M., Suedhof T.C.
J. Neurosci. 18:3630-3638(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 225-308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358614 mRNA. Translation: AAQ88977.1.
AK290949 mRNA. Translation: BAF83638.1.
BC036679 mRNA. Translation: AAH36679.1.
BC053581 mRNA. Translation: AAH53581.1.
AF043469 mRNA. Translation: AAD02282.1.
CCDSCCDS8933.1.
RefSeqNP_009155.1. NM_007224.3.
UniGeneHs.745023.

3D structure databases

ProteinModelPortalO95158.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000333593.

PTM databases

PhosphoSiteO95158.

Proteomic databases

MaxQBO95158.
PaxDbO95158.
PRIDEO95158.

Protocols and materials databases

DNASU11247.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000349394; ENSP00000333593; ENSG00000182379.
GeneID11247.
KEGGhsa:11247.
UCSCuc010srf.2. human.

Organism-specific databases

CTD11247.
GeneCardsGC12P057610.
HGNCHGNC:8078. NXPH4.
MIM604637. gene.
neXtProtNX_O95158.
PharmGKBPA31866.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81037.
HOGENOMHOG000261694.
HOVERGENHBG052706.
InParanoidO95158.
OMAQIPESGR.
OrthoDBEOG7V4B0M.
PhylomeDBO95158.
TreeFamTF333047.

Gene expression databases

ArrayExpressO95158.
BgeeO95158.
CleanExHS_NXPH4.
GenevestigatorO95158.

Family and domain databases

InterProIPR010450. Neurexophilin.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERPTHR17103. PTHR17103. 1 hit.
PfamPF06312. Neurexophilin. 2 hits.
[Graphical view]
PIRSFPIRSF038019. Neurexophilin. 1 hit.
ProtoNetSearch...

Other

ChiTaRSNXPH4. human.
GenomeRNAi11247.
NextBio42796.
PROO95158.
SOURCESearch...

Entry information

Entry nameNXPH4_HUMAN
AccessionPrimary (citable) accession number: O95158
Secondary accession number(s): A8K4I4, Q7Z6L3, Q8N462
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM