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O95158

- NXPH4_HUMAN

UniProt

O95158 - NXPH4_HUMAN

Protein

Neurexophilin-4

Gene

NXPH4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.Curated

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurexophilin-4
    Gene namesi
    Name:NXPH4
    Synonyms:NPH4
    ORF Names:UNQ1928/PRO4403
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:8078. NXPH4.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31866.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 308285Neurexophilin-4PRO_0000020068Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO95158.
    PaxDbiO95158.
    PRIDEiO95158.

    PTM databases

    PhosphoSiteiO95158.

    Expressioni

    Tissue specificityi

    Expressed in brain, spleen, and testis.

    Gene expression databases

    ArrayExpressiO95158.
    BgeeiO95158.
    CleanExiHS_NXPH4.
    GenevestigatoriO95158.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000333593.

    Structurei

    3D structure databases

    ProteinModelPortaliO95158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 8461IIAdd
    BLAST
    Regioni85 – 16379IIIAdd
    BLAST
    Regioni164 – 22461IV (linker domain)Add
    BLAST
    Regioni225 – 30884V (Cys-rich)Add
    BLAST

    Sequence similaritiesi

    Belongs to the neurexophilin family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG81037.
    HOGENOMiHOG000261694.
    HOVERGENiHBG052706.
    InParanoidiO95158.
    OMAiQIPESGR.
    OrthoDBiEOG7V4B0M.
    PhylomeDBiO95158.
    TreeFamiTF333047.

    Family and domain databases

    InterProiIPR010450. Neurexophilin.
    IPR026845. NXPH/NXPE.
    [Graphical view]
    PANTHERiPTHR17103. PTHR17103. 1 hit.
    PfamiPF06312. Neurexophilin. 2 hits.
    [Graphical view]
    PIRSFiPIRSF038019. Neurexophilin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95158-1 [UniParc]FASTAAdd to Basket

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    MRLLPEWFLL LFGPWLLRKA VSAQIPESGR PQYLGLRPAA AGAGAPGQQL    50
    PEPRSSDGLG VGRAWSWAWP TNHTGALARA GAAGALPAQR TKRKPSIKAA 100
    RAKKIFGWGD FYFRVHTLKF SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL 150
    SVSIVPPSKR VEFGGVWLPG PVPHPLQSTL ALEGVLPGLG PPLGMAAAAA 200
    GPGLGGSLGG ALAGPLGGAL GVPGAKESRA FNCHVEYEKT NRARKHRPCL 250
    YDPSQVCFTE HTQSQAAWLC AKPFKVICIF VSFLSFDYKL VQKVCPDYNF 300
    QSEHPYFG 308
    Length:308
    Mass (Da):33,065
    Last modified:March 15, 2005 - v3
    Checksum:iC18780A422AF6F6D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561S → T in AAH36679. (PubMed:15489334)Curated
    Sequence conflicti226 – 2272KE → RG in AAD02282. (PubMed:9570794)Curated
    Sequence conflicti296 – 2961P → Q in AAH36679. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358614 mRNA. Translation: AAQ88977.1.
    AK290949 mRNA. Translation: BAF83638.1.
    BC036679 mRNA. Translation: AAH36679.1.
    BC053581 mRNA. Translation: AAH53581.1.
    AF043469 mRNA. Translation: AAD02282.1.
    CCDSiCCDS8933.1.
    RefSeqiNP_009155.1. NM_007224.3.
    UniGeneiHs.745023.

    Genome annotation databases

    EnsembliENST00000349394; ENSP00000333593; ENSG00000182379.
    GeneIDi11247.
    KEGGihsa:11247.
    UCSCiuc010srf.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358614 mRNA. Translation: AAQ88977.1 .
    AK290949 mRNA. Translation: BAF83638.1 .
    BC036679 mRNA. Translation: AAH36679.1 .
    BC053581 mRNA. Translation: AAH53581.1 .
    AF043469 mRNA. Translation: AAD02282.1 .
    CCDSi CCDS8933.1.
    RefSeqi NP_009155.1. NM_007224.3.
    UniGenei Hs.745023.

    3D structure databases

    ProteinModelPortali O95158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000333593.

    PTM databases

    PhosphoSitei O95158.

    Proteomic databases

    MaxQBi O95158.
    PaxDbi O95158.
    PRIDEi O95158.

    Protocols and materials databases

    DNASUi 11247.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349394 ; ENSP00000333593 ; ENSG00000182379 .
    GeneIDi 11247.
    KEGGi hsa:11247.
    UCSCi uc010srf.2. human.

    Organism-specific databases

    CTDi 11247.
    GeneCardsi GC12P057610.
    HGNCi HGNC:8078. NXPH4.
    MIMi 604637. gene.
    neXtProti NX_O95158.
    PharmGKBi PA31866.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81037.
    HOGENOMi HOG000261694.
    HOVERGENi HBG052706.
    InParanoidi O95158.
    OMAi QIPESGR.
    OrthoDBi EOG7V4B0M.
    PhylomeDBi O95158.
    TreeFami TF333047.

    Miscellaneous databases

    ChiTaRSi NXPH4. human.
    GenomeRNAii 11247.
    NextBioi 42796.
    PROi O95158.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95158.
    Bgeei O95158.
    CleanExi HS_NXPH4.
    Genevestigatori O95158.

    Family and domain databases

    InterProi IPR010450. Neurexophilin.
    IPR026845. NXPH/NXPE.
    [Graphical view ]
    PANTHERi PTHR17103. PTHR17103. 1 hit.
    Pfami PF06312. Neurexophilin. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF038019. Neurexophilin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Neurexophilins form a conserved family of neuropeptide-like glycoproteins."
      Missler M., Suedhof T.C.
      J. Neurosci. 18:3630-3638(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 225-308.

    Entry informationi

    Entry nameiNXPH4_HUMAN
    AccessioniPrimary (citable) accession number: O95158
    Secondary accession number(s): A8K4I4, Q7Z6L3, Q8N462
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3