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Protein

Neurexophilin-4

Gene

NXPH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.Curated

GO - Molecular functioni

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-4
Gene namesi
Name:NXPH4
Synonyms:NPH4
ORF Names:UNQ1928/PRO4403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000182379.9
HGNCiHGNC:8078 NXPH4
MIMi604637 gene
neXtProtiNX_O95158

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182379
PharmGKBiPA31866

Polymorphism and mutation databases

BioMutaiNXPH4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002006824 – 308Neurexophilin-4Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO95158
PaxDbiO95158
PeptideAtlasiO95158
PRIDEiO95158

PTM databases

PhosphoSitePlusiO95158

Expressioni

Tissue specificityi

Expressed in brain, spleen, and testis.

Gene expression databases

BgeeiENSG00000182379
CleanExiHS_NXPH4
ExpressionAtlasiO95158 baseline and differential
GenevisibleiO95158 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116408, 10 interactors
STRINGi9606.ENSP00000333593

Structurei

3D structure databases

ProteinModelPortaliO95158
SMRiO95158
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 84IIAdd BLAST61
Regioni85 – 163IIIAdd BLAST79
Regioni164 – 224IV (linker domain)Add BLAST61
Regioni225 – 308V (Cys-rich)Add BLAST84

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHZT Eukaryota
ENOG4111F7U LUCA
GeneTreeiENSGT00390000015950
HOGENOMiHOG000261694
HOVERGENiHBG052706
InParanoidiO95158
OMAiQIPESGR
OrthoDBiEOG091G0GC5
PhylomeDBiO95158
TreeFamiTF333047

Family and domain databases

InterProiView protein in InterPro
IPR010450 Nxph
IPR026845 NXPH/NXPE
PANTHERiPTHR17103 PTHR17103, 1 hit
PfamiView protein in Pfam
PF06312 Neurexophilin, 2 hits
PIRSFiPIRSF038019 Neurexophilin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLPEWFLL LFGPWLLRKA VSAQIPESGR PQYLGLRPAA AGAGAPGQQL
60 70 80 90 100
PEPRSSDGLG VGRAWSWAWP TNHTGALARA GAAGALPAQR TKRKPSIKAA
110 120 130 140 150
RAKKIFGWGD FYFRVHTLKF SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL
160 170 180 190 200
SVSIVPPSKR VEFGGVWLPG PVPHPLQSTL ALEGVLPGLG PPLGMAAAAA
210 220 230 240 250
GPGLGGSLGG ALAGPLGGAL GVPGAKESRA FNCHVEYEKT NRARKHRPCL
260 270 280 290 300
YDPSQVCFTE HTQSQAAWLC AKPFKVICIF VSFLSFDYKL VQKVCPDYNF

QSEHPYFG
Length:308
Mass (Da):33,065
Last modified:March 15, 2005 - v3
Checksum:iC18780A422AF6F6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56S → T in AAH36679 (PubMed:15489334).Curated1
Sequence conflicti226 – 227KE → RG in AAD02282 (PubMed:9570794).Curated2
Sequence conflicti296P → Q in AAH36679 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358614 mRNA Translation: AAQ88977.1
AK290949 mRNA Translation: BAF83638.1
BC036679 mRNA Translation: AAH36679.1
BC053581 mRNA Translation: AAH53581.1
AF043469 mRNA Translation: AAD02282.1
CCDSiCCDS8933.1
RefSeqiNP_009155.1, NM_007224.3
UniGeneiHs.745023

Genome annotation databases

EnsembliENST00000349394; ENSP00000333593; ENSG00000182379
GeneIDi11247
KEGGihsa:11247
UCSCiuc010srf.2 human

Similar proteinsi

Entry informationi

Entry nameiNXPH4_HUMAN
AccessioniPrimary (citable) accession number: O95158
Secondary accession number(s): A8K4I4, Q7Z6L3, Q8N462
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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