O95158 (NXPH4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurexophilin-4

Gene names

Name:	NXPH4
Synonyms:	NPH4
ORF Names:	UNQ1928/PRO4403

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors Potential.
Subcellular location	Secreted Potential.
Tissue specificity	Expressed in brain, spleen, and testis.
Post-translational modification	May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells By similarity.
Sequence similarities	Belongs to the neurexophilin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Repeat Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Non-traceable author statement Ref.4. Source: UniProtKB
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 308	285	Neurexophilin-4		PRO_0000020068
Regions
	Region	24 – 84	61	II
	Region	85 – 163	79	III
	Region	164 – 224	61	IV (linker domain)
	Region	225 – 308	84	V (Cys-rich)
Amino acid modifications
	Glycosylation	72	1	N-linked (GlcNAc...) Potential
	Glycosylation	133	1	N-linked (GlcNAc...) Potential
	Glycosylation	143	1	N-linked (GlcNAc...) Potential
	Glycosylation	149	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	56	1	S → T in AAH36679. Ref.3
	Sequence conflict	226 – 227	2	KE → RG in AAD02282. Ref.4
	Sequence conflict	296	1	P → Q in AAH36679. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O95158 [UniParc]. Last modified March 15, 2005. Version 3. Checksum: C18780A422AF6F6D	FASTA	308	33,065
	10 20 30 40 50 60 MRLLPEWFLL LFGPWLLRKA VSAQIPESGR PQYLGLRPAA AGAGAPGQQL PEPRSSDGLG 70 80 90 100 110 120 VGRAWSWAWP TNHTGALARA GAAGALPAQR TKRKPSIKAA RAKKIFGWGD FYFRVHTLKF 130 140 150 160 170 180 SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL SVSIVPPSKR VEFGGVWLPG PVPHPLQSTL 190 200 210 220 230 240 ALEGVLPGLG PPLGMAAAAA GPGLGGSLGG ALAGPLGGAL GVPGAKESRA FNCHVEYEKT 250 260 270 280 290 300 NRARKHRPCL YDPSQVCFTE HTQSQAAWLC AKPFKVICIF VSFLSFDYKL VQKVCPDYNF QSEHPYFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Neurexophilins form a conserved family of neuropeptide-like glycoproteins." Missler M., Suedhof T.C. J. Neurosci. 18:3630-3638(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 225-308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358614 mRNA. Translation: AAQ88977.1. AK290949 mRNA. Translation: BAF83638.1. BC036679 mRNA. Translation: AAH36679.1. BC053581 mRNA. Translation: AAH53581.1. AF043469 mRNA. Translation: AAD02282.1.
IPI	IPI00293723.
RefSeq	NP_009155.1. NM_007224.3.
UniGene	Hs.740567.
3D structure databases
ProteinModelPortal	O95158.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000333593.
PTM databases
PhosphoSite	O95158.
Proteomic databases
PaxDb	O95158.
PRIDE	O95158.
Protocols and materials databases
DNASU	11247.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000349394; ENSP00000333593; ENSG00000182379.
GeneID	11247.
KEGG	hsa:11247.
UCSC	uc010srf.2. human.
Organism-specific databases
CTD	11247.
GeneCards	GC12P057610.
HGNC	HGNC:8078. NXPH4.
MIM	604637. gene.
neXtProt	NX_O95158.
PharmGKB	PA31866.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG81037.
HOGENOM	HOG000261694.
HOVERGEN	HBG052706.
InParanoid	O95158.
OMA	ESGRPQY.
OrthoDB	EOG4ZS94S.
PhylomeDB	O95158.
Gene expression databases
ArrayExpress	O95158.
Bgee	O95158.
CleanEx	HS_NXPH4.
Genevestigator	O95158.
GermOnline	ENSG00000182379. Homo sapiens.
Family and domain databases
InterPro	IPR010450. Neurexophilin. IPR026845. NXPH/NXPE. [Graphical view]
PANTHER	PTHR17103. PTHR17103. 1 hit.
Pfam	PF06312. Neurexophilin. 2 hits. [Graphical view]
PIRSF	PIRSF038019. Neurexophilin. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	NXPH4. human.
GenomeRNAi	11247.
NextBio	42796.
SOURCE	Search...

Entry information

Entry name

NXPH4_HUMAN

Accession

Primary (citable) accession number: O95158
Secondary accession number(s): A8K4I4, Q7Z6L3, Q8N462

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	March 15, 2005
Last modified:	April 3, 2013
This is version 98 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.