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Protein

Neurexophilin-3

Gene

NXPH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).By similarity

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-3
Gene namesi
Name:NXPH3
Synonyms:KIAA1159, NPH3
ORF Names:UNQ687/PRO1327
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:8077. NXPH3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31865.

Polymorphism and mutation databases

BioMutaiNXPH3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 252230Neurexophilin-3PRO_0000020065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO95157.
PRIDEiO95157.

PTM databases

PhosphoSiteiO95157.

Expressioni

Tissue specificityi

Highest level in brain.

Gene expression databases

BgeeiO95157.
CleanExiHS_NXPH3.
ExpressionAtlasiO95157. baseline and differential.
GenevisibleiO95157. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005191EBI-1752913,EBI-375543
CRKP461081EBI-1752913,EBI-886
NCK1P163331EBI-1752913,EBI-389883
SRCP129311EBI-1752913,EBI-621482

Protein-protein interaction databases

BioGridi116409. 8 interactions.
IntActiO95157. 5 interactions.
MINTiMINT-7241304.
STRINGi9606.ENSP00000329295.

Structurei

3D structure databases

ProteinModelPortaliO95157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 7553IIAdd
BLAST
Regioni76 – 15782IIIAdd
BLAST
Regioni158 – 1669IV (linker domain)
Regioni167 – 25286V (Cys-rich)Add
BLAST

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4V. Eukaryota.
ENOG410Y975. LUCA.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiO95157.
KOiK16658.
OrthoDBiEOG7K0ZCR.
PhylomeDBiO95157.
TreeFamiTF333047.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTRCCFVF LVQGSLYLVI CGQDDGPPGS EDPERDDHEG QPRPRVPRKR
60 70 80 90 100
GHISPKSRPM ANSTLLGLLA PPGEAWGILG QPPNRPNHSP PPSAKVKKIF
110 120 130 140 150
GWGDFYSNIK TVALNLLVTG KIVDHGNGTF SVHFQHNATG QGNISISLVP
160 170 180 190 200
PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE KVERGRRTSL CTHDPAKICS
210 220 230 240 250
RDHAQSSATW SCSQPFKVVC VYIAFYSTDY RLVQKVCPDY NYHSDTPYYP

SG
Length:252
Mass (Da):28,127
Last modified:July 11, 2002 - v3
Checksum:i74D2B3D5A89D221F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781E → G in AAH22541 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358526 mRNA. Translation: AAQ88890.1.
AL834282 mRNA. Translation: CAD38956.2.
CH471109 Genomic DNA. Translation: EAW94676.1.
BC022541 mRNA. Translation: AAH22541.1.
AB032985 mRNA. Translation: BAA86473.1.
AF043468 mRNA. Translation: AAD02281.1.
CCDSiCCDS11550.1.
RefSeqiNP_009156.2. NM_007225.2.
UniGeneiHs.55069.

Genome annotation databases

EnsembliENST00000328741; ENSP00000329295; ENSG00000182575.
GeneIDi11248.
KEGGihsa:11248.
UCSCiuc002ipa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358526 mRNA. Translation: AAQ88890.1.
AL834282 mRNA. Translation: CAD38956.2.
CH471109 Genomic DNA. Translation: EAW94676.1.
BC022541 mRNA. Translation: AAH22541.1.
AB032985 mRNA. Translation: BAA86473.1.
AF043468 mRNA. Translation: AAD02281.1.
CCDSiCCDS11550.1.
RefSeqiNP_009156.2. NM_007225.2.
UniGeneiHs.55069.

3D structure databases

ProteinModelPortaliO95157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116409. 8 interactions.
IntActiO95157. 5 interactions.
MINTiMINT-7241304.
STRINGi9606.ENSP00000329295.

PTM databases

PhosphoSiteiO95157.

Polymorphism and mutation databases

BioMutaiNXPH3.

Proteomic databases

PaxDbiO95157.
PRIDEiO95157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328741; ENSP00000329295; ENSG00000182575.
GeneIDi11248.
KEGGihsa:11248.
UCSCiuc002ipa.4. human.

Organism-specific databases

CTDi11248.
GeneCardsiNXPH3.
HGNCiHGNC:8077. NXPH3.
MIMi604636. gene.
neXtProtiNX_O95157.
PharmGKBiPA31865.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK4V. Eukaryota.
ENOG410Y975. LUCA.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiO95157.
KOiK16658.
OrthoDBiEOG7K0ZCR.
PhylomeDBiO95157.
TreeFamiTF333047.

Miscellaneous databases

GeneWikiiNXPH3.
GenomeRNAii11248.
NextBioi42802.
PROiO95157.
SOURCEiSearch...

Gene expression databases

BgeeiO95157.
CleanExiHS_NXPH3.
ExpressionAtlasiO95157. baseline and differential.
GenevisibleiO95157. HS.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hypothalamus.
  5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-252.
    Tissue: Brain.
  6. "Neurexophilins form a conserved family of neuropeptide-like glycoproteins."
    Missler M., Suedhof T.C.
    J. Neurosci. 18:3630-3638(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-252.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-37.

Entry informationi

Entry nameiNXPH3_HUMAN
AccessioniPrimary (citable) accession number: O95157
Secondary accession number(s): Q8NDC3, Q8TBF6, Q9ULR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 11, 2002
Last modified: March 16, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.