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Protein

Neurexophilin-3

Gene

NXPH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-3
Gene namesi
Name:NXPH3
Synonyms:KIAA1159, NPH3
ORF Names:UNQ687/PRO1327
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000182575.7.
HGNCiHGNC:8077. NXPH3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182575.
PharmGKBiPA31865.

Polymorphism and mutation databases

BioMutaiNXPH3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000002006523 – 252Neurexophilin-3Add BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO95157.
PeptideAtlasiO95157.
PRIDEiO95157.

PTM databases

iPTMnetiO95157.
PhosphoSitePlusiO95157.

Expressioni

Tissue specificityi

Highest level in brain.

Gene expression databases

BgeeiENSG00000182575.
CleanExiHS_NXPH3.
ExpressionAtlasiO95157. baseline and differential.
GenevisibleiO95157. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116409. 9 interactors.
IntActiO95157. 5 interactors.
MINTiMINT-7241304.
STRINGi9606.ENSP00000329295.

Structurei

3D structure databases

ProteinModelPortaliO95157.
SMRiO95157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 75IIAdd BLAST53
Regioni76 – 157IIIAdd BLAST82
Regioni158 – 166IV (linker domain)9
Regioni167 – 252V (Cys-rich)Add BLAST86

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4V. Eukaryota.
ENOG410Y975. LUCA.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiO95157.
KOiK16658.
PhylomeDBiO95157.
TreeFamiTF333047.

Family and domain databases

InterProiView protein in InterPro
IPR010450. Nxph.
IPR026845. NXPH/NXPE.
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiView protein in Pfam
PF06312. Neurexophilin. 1 hit.
PIRSFiPIRSF038019. Neurexophilin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTRCCFVF LVQGSLYLVI CGQDDGPPGS EDPERDDHEG QPRPRVPRKR
60 70 80 90 100
GHISPKSRPM ANSTLLGLLA PPGEAWGILG QPPNRPNHSP PPSAKVKKIF
110 120 130 140 150
GWGDFYSNIK TVALNLLVTG KIVDHGNGTF SVHFQHNATG QGNISISLVP
160 170 180 190 200
PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE KVERGRRTSL CTHDPAKICS
210 220 230 240 250
RDHAQSSATW SCSQPFKVVC VYIAFYSTDY RLVQKVCPDY NYHSDTPYYP

SG
Length:252
Mass (Da):28,127
Last modified:July 11, 2002 - v3
Checksum:i74D2B3D5A89D221F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178E → G in AAH22541 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358526 mRNA. Translation: AAQ88890.1.
AL834282 mRNA. Translation: CAD38956.2.
CH471109 Genomic DNA. Translation: EAW94676.1.
BC022541 mRNA. Translation: AAH22541.1.
AB032985 mRNA. Translation: BAA86473.1.
AF043468 mRNA. Translation: AAD02281.1.
CCDSiCCDS11550.1.
RefSeqiNP_009156.2. NM_007225.2.
UniGeneiHs.55069.

Genome annotation databases

EnsembliENST00000328741; ENSP00000329295; ENSG00000182575.
GeneIDi11248.
KEGGihsa:11248.
UCSCiuc002ipa.4. human.

Similar proteinsi

Entry informationi

Entry nameiNXPH3_HUMAN
AccessioniPrimary (citable) accession number: O95157
Secondary accession number(s): Q8NDC3, Q8TBF6, Q9ULR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 11, 2002
Last modified: September 27, 2017
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families