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Protein

Neurexophilin-2

Gene

NXPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.Curated

GO - Molecular functioni

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-2
Gene namesi
Name:NXPH2
Synonyms:NPH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144227.4
HGNCiHGNC:8076 NXPH2
MIMi604635 gene
neXtProtiNX_O95156

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11249
OpenTargetsiENSG00000144227
PharmGKBiPA31864

Polymorphism and mutation databases

BioMutaiNXPH2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002006323 – 264Neurexophilin-2Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO95156
PeptideAtlasiO95156
PRIDEiO95156

PTM databases

iPTMnetiO95156
PhosphoSitePlusiO95156

Expressioni

Tissue specificityi

Expressed in brain and kidney.

Gene expression databases

BgeeiENSG00000144227
CleanExiHS_NXPH2
GenevisibleiO95156 HS

Organism-specific databases

HPAiHPA034759

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116410, 20 interactors
STRINGi9606.ENSP00000272641

Structurei

3D structure databases

ProteinModelPortaliO95156
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 90IIAdd BLAST68
Regioni91 – 169IIIAdd BLAST79
Regioni170 – 178IV (linker domain)9
Regioni179 – 264V (Cys-rich)Add BLAST86

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410INCH Eukaryota
ENOG410ZJUS LUCA
GeneTreeiENSGT00390000015950
HOGENOMiHOG000261694
HOVERGENiHBG052706
InParanoidiO95156
KOiK16657
OMAiVPKPGHL
OrthoDBiEOG091G0GC5
PhylomeDBiO95156
TreeFamiTF333047

Family and domain databases

InterProiView protein in InterPro
IPR010450 Nxph
IPR026845 NXPH/NXPE
PANTHERiPTHR17103 PTHR17103, 1 hit
PfamiView protein in Pfam
PF06312 Neurexophilin, 1 hit
PIRSFiPIRSF038019 Neurexophilin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRPLPLVV VPGLLQLLFC DSKEVVHATE GLDWEDKDAP GTLVGNVVHS
60 70 80 90 100
RIISPLRLFV KQSPVPKPGP MAYADSMENF WDWLANITEI QEPLARTKRR
110 120 130 140 150
PIVKTGKFKK MFGWGDFHSN IKTVKLNLLI TGKIVDHGNG TFSVYFRHNS
160 170 180 190 200
TGLGNVSVSL VPPSKVVEFE VSPQSTLETK ESKSFNCRIE YEKTDRAKKT
210 220 230 240 250
ALCNFDPSKI CYQEQTQSHV SWLCSKPFKV ICIYIAFYSV DYKLVQKVCP
260
DYNYHSETPY LSSG
Length:264
Mass (Da):29,938
Last modified:February 1, 2005 - v2
Checksum:iE793B5AD69FD0E71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 12PLVVVP → ARVLVT in AAD02280 (PubMed:9570794).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162675 mRNA Translation: BAD11132.1
AC092620 Genomic DNA No translation available.
AC092837 Genomic DNA No translation available.
AC110421 Genomic DNA No translation available.
BC101462 mRNA Translation: AAI01463.1
BC101463 mRNA Translation: AAI01464.1
BC104741 mRNA Translation: AAI04742.1
AF043467 mRNA Translation: AAD02280.1
CCDSiCCDS46421.1
RefSeqiNP_009157.1, NM_007226.2
UniGeneiHs.435019

Genome annotation databases

EnsembliENST00000272641; ENSP00000272641; ENSG00000144227
GeneIDi11249
KEGGihsa:11249
UCSCiuc002tvi.4 human

Similar proteinsi

Entry informationi

Entry nameiNXPH2_HUMAN
AccessioniPrimary (citable) accession number: O95156
Secondary accession number(s): B7WP24, Q494R1, Q75QC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health