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Protein

Neurexophilin-2

Gene

NXPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.Curated

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-2
Gene namesi
Name:NXPH2
Synonyms:NPH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:8076. NXPH2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31864.

Polymorphism and mutation databases

BioMutaiNXPH2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 264242Neurexophilin-2PRO_0000020063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO95156.
PaxDbiO95156.
PeptideAtlasiO95156.
PRIDEiO95156.

PTM databases

iPTMnetiO95156.
PhosphoSiteiO95156.

Expressioni

Tissue specificityi

Expressed in brain and kidney.

Gene expression databases

BgeeiO95156.
CleanExiHS_NXPH2.
GenevisibleiO95156. HS.

Organism-specific databases

HPAiHPA034759.

Interactioni

Protein-protein interaction databases

BioGridi116410. 20 interactions.
STRINGi9606.ENSP00000272641.

Structurei

3D structure databases

ProteinModelPortaliO95156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 9068IIAdd
BLAST
Regioni91 – 16979IIIAdd
BLAST
Regioni170 – 1789IV (linker domain)
Regioni179 – 26486V (Cys-rich)Add
BLAST

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410INCH. Eukaryota.
ENOG410ZJUS. LUCA.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiO95156.
KOiK16657.
OMAiHLAYADS.
OrthoDBiEOG7SBNPB.
PhylomeDBiO95156.
TreeFamiTF333047.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRPLPLVV VPGLLQLLFC DSKEVVHATE GLDWEDKDAP GTLVGNVVHS
60 70 80 90 100
RIISPLRLFV KQSPVPKPGP MAYADSMENF WDWLANITEI QEPLARTKRR
110 120 130 140 150
PIVKTGKFKK MFGWGDFHSN IKTVKLNLLI TGKIVDHGNG TFSVYFRHNS
160 170 180 190 200
TGLGNVSVSL VPPSKVVEFE VSPQSTLETK ESKSFNCRIE YEKTDRAKKT
210 220 230 240 250
ALCNFDPSKI CYQEQTQSHV SWLCSKPFKV ICIYIAFYSV DYKLVQKVCP
260
DYNYHSETPY LSSG
Length:264
Mass (Da):29,938
Last modified:February 1, 2005 - v2
Checksum:iE793B5AD69FD0E71
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 126PLVVVP → ARVLVT in AAD02280 (PubMed:9570794).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162675 mRNA. Translation: BAD11132.1.
AC092620 Genomic DNA. No translation available.
AC092837 Genomic DNA. No translation available.
AC110421 Genomic DNA. No translation available.
BC101462 mRNA. Translation: AAI01463.1.
BC101463 mRNA. Translation: AAI01464.1.
BC104741 mRNA. Translation: AAI04742.1.
AF043467 mRNA. Translation: AAD02280.1.
CCDSiCCDS46421.1.
RefSeqiNP_009157.1. NM_007226.2.
UniGeneiHs.435019.

Genome annotation databases

EnsembliENST00000272641; ENSP00000272641; ENSG00000144227.
GeneIDi11249.
KEGGihsa:11249.
UCSCiuc002tvi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162675 mRNA. Translation: BAD11132.1.
AC092620 Genomic DNA. No translation available.
AC092837 Genomic DNA. No translation available.
AC110421 Genomic DNA. No translation available.
BC101462 mRNA. Translation: AAI01463.1.
BC101463 mRNA. Translation: AAI01464.1.
BC104741 mRNA. Translation: AAI04742.1.
AF043467 mRNA. Translation: AAD02280.1.
CCDSiCCDS46421.1.
RefSeqiNP_009157.1. NM_007226.2.
UniGeneiHs.435019.

3D structure databases

ProteinModelPortaliO95156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116410. 20 interactions.
STRINGi9606.ENSP00000272641.

PTM databases

iPTMnetiO95156.
PhosphoSiteiO95156.

Polymorphism and mutation databases

BioMutaiNXPH2.

Proteomic databases

EPDiO95156.
PaxDbiO95156.
PeptideAtlasiO95156.
PRIDEiO95156.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272641; ENSP00000272641; ENSG00000144227.
GeneIDi11249.
KEGGihsa:11249.
UCSCiuc002tvi.4. human.

Organism-specific databases

CTDi11249.
GeneCardsiNXPH2.
HGNCiHGNC:8076. NXPH2.
HPAiHPA034759.
MIMi604635. gene.
neXtProtiNX_O95156.
PharmGKBiPA31864.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INCH. Eukaryota.
ENOG410ZJUS. LUCA.
GeneTreeiENSGT00390000015950.
HOGENOMiHOG000261694.
HOVERGENiHBG052706.
InParanoidiO95156.
KOiK16657.
OMAiHLAYADS.
OrthoDBiEOG7SBNPB.
PhylomeDBiO95156.
TreeFamiTF333047.

Miscellaneous databases

GenomeRNAii11249.
PROiO95156.
SOURCEiSearch...

Gene expression databases

BgeeiO95156.
CleanExiHS_NXPH2.
GenevisibleiO95156. HS.

Family and domain databases

InterProiIPR010450. Nxph.
IPR026845. NXPH/NXPE.
[Graphical view]
PANTHERiPTHR17103. PTHR17103. 1 hit.
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
PIRSFiPIRSF038019. Neurexophilin. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a full-length human neurexophilin2 gene."
    Kawasaki A., Ohira M., Miyazaki K., Nakagawara A.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Neuroblastoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Neurexophilins form a conserved family of neuropeptide-like glycoproteins."
    Missler M., Suedhof T.C.
    J. Neurosci. 18:3630-3638(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-264.

Entry informationi

Entry nameiNXPH2_HUMAN
AccessioniPrimary (citable) accession number: O95156
Secondary accession number(s): B7WP24, Q494R1, Q75QC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 2005
Last modified: July 6, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.