Reviewed, UniProtKB/Swiss-Prot O95155 (UBE4B_HUMAN)

Names and origin

Protein names

Recommended name:
    Ubiquitin conjugation factor E4 B
Alternative name(s):
    Ubiquitin fusion degradation protein 2
    Homozygously deleted in neuroblastoma 1

Gene names

Name:	UBE4B
Synonyms:	HDNB1, KIAA0684, UFD2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1302 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 By similarity.
Subunit structure	Interacts with Vcp By similarity.
Subcellular location	CytoplasmBy similarity.
Tissue specificity	Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.
Post-translational modification	Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.
Sequence similarities	Belongs to the ubiquitin conjugation factor E4 family. Contains 1 U-box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	apoptosis Ref.1 Inferred from direct assay. Source: UniProtKB protein ubiquitination during ubiquitin-dependent protein catabolic process Ref.1 Traceable author statement. Source: UniProtKB response to UV Ref.1 Inferred from direct assay. Source: UniProtKB
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin ligase complex Ref.1 Traceable author statement. Source: UniProtKB
Molecular function	enzyme binding Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95155-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95155-2)

The sequence of this isoform differs from the canonical sequence as follows:
     270-398: Missing.

Isoform 3 (identifier: O95155-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     270-398: Missing.
     1234-1234: D → GKWTH

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1302	1302	Ubiquitin conjugation factor E4 B		PRO_0000194993
Regions
	Domain	1231 – 1293	63	U-box
Sites
	Site	109 – 110	2	Cleavage; by caspase-3 and caspase-7
	Site	123 – 124	2	Cleavage; by caspase-6 and granzyme B
Amino acid modifications
	Modified residue	31	1	Phosphoserine By similarity
	Modified residue	101	1	Phosphoserine By similarity
	Modified residue	105	1	Phosphoserine
	Modified residue	803	1	Phosphoserine
	Modified residue	1265	1	Phosphoserine
Natural variations
	Alternative sequence	1 – 116	116	Missing in isoform 3.		VSP_007101
	Alternative sequence	270 – 398	129	Missing in isoform 2 and isoform 3.		VSP_007102
	Alternative sequence	1234	1	D → GKWTH in isoform 3.		VSP_007103
Experimental info
	Mutagenesis	109	1	D → A: Abolishes cleavage by caspase-3 and caspase-7
	Mutagenesis	121	1	D → A: Abolishes cleavage by caspase-6. No effect on cleavage by granzyme B
	Mutagenesis	123	1	D → A: Abolishes cleavage by caspase-6 and granzyme B

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 6BAA80984B03E43B	FASTA	1,302	146,185
	10 20 30 40 50 60 MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM 70 80 90 100 110 120 TPATSPIGAS GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV 130 140 150 160 170 180 DVDSGIENME VDENDRREKR SLSDKEPSSG PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL 190 200 210 220 230 240 SSLSAQFKQN PKEVFSDFKD LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIAAAARSPD 250 260 270 280 290 300 RNLLLNTGSN PGTSPMFCSV ASFGASSLSS LYESSPAPTP SFWSSVPVMG PSLASPSRAA 310 320 330 340 350 360 SQLAVPSTPL SPHSAASGTA AGSQPSSPRY RPYTVTHPWA SSGVSILSSS PSPPALASSP 370 380 390 400 410 420 QAVPASSSRQ RPSSTGPPLP PASPSATSRR PSSLRISPSL GASGGASNWD SYSDHFTIET 430 440 450 460 470 480 CKETDMLNYL IECFDRVGIE EKKAPKMCSQ PAVSQLLSNI RSQCISHTAL VLQGSLTQPR 490 500 510 520 530 540 SLQQPSFLVP YMLCRNLPYG FIQELVRTTH QDEEVFKQIF IPILQGLALA AKECSLDSDY 550 560 570 580 590 600 FKYPLMALGE LCETKFGKTH PVCNLVASLR LWLPKSLSPG CGRELQRLSY LGAFFSFSVF 610 620 630 640 650 660 AEDDVKVVEK YFSGPAITLE NTRVVSQSLQ HYLELGRQEL FKILHSILLN GETREAALSY 670 680 690 700 710 720 MAAVVNANMK KAQMQTDDRL VSTDGFMLNF LWVLQQLSTK IKLETVDPTY IFHPRCRITL 730 740 750 760 770 780 PNDETRVNAT MEDVNDWLTE LYGDQPPFSE PKFPTECFFL TLHAHHLSIL PSCRRYIRRL 790 800 810 820 830 840 RAIRELNRTV EDLKNNESQW KDSPLATRHR EMLKRCKTQL KKLVRCKACA DAGLLDESFL 850 860 870 880 890 900 RRCLNFYGLL IQLLLRILDP AYPDITLPLN SDVPKVFAAL PEFYVEDVAE FLFFIVQYSP 910 920 930 940 950 960 QALYEPCTQD IVMFLVVMLC NQNYIRNPYL VAKLVEVMFM TNPAVQPRTQ KFFEMIENHP 970 980 990 1000 1010 1020 LSTKLLVPSL MKFYTDVEHT GATSEFYDKF TIRYHISTIF KSLWQNIAHH GTFMEEFNSG 1030 1040 1050 1060 1070 1080 KQFVRYINML INDTTFLLDE SLESLKRIHE VQEEMKNKEQ WDQLPRDQQQ ARQSQLAQDE 1090 1100 1110 1120 1130 1140 RVSRSYLALA TETVDMFHIL TKQVQKPFLR PELGPRLAAM LNFNLQQLCG PKCRDLKVEN 1150 1160 1170 1180 1190 1200 PEKYGFEPKK LLDQLTDIYL QLDCARFAKA IADDQRSYSK ELFEEVISKM RKAGIKSTIA 1210 1220 1230 1240 1250 1260 IEKFKLLAEK VEEIVAKNAR AEIDYSDAPD EFRDPLMDTL MTDPVRLPSG TIMDRSIILR 1270 1280 1290 1300 HLLNSPTDPF NRQTLTESML EPVPELKEQI QAWMREKQNS DH
	Isoform 2 [UniParc]. Checksum: EBFE3FA2270B72B3		1,173	133,275
	10 20 30 40 50 60 MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM 70 80 90 100 110 120 TPATSPIGAS GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV 130 140 150 160 170 180 DVDSGIENME VDENDRREKR SLSDKEPSSG PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL 190 200 210 220 230 240 SSLSAQFKQN PKEVFSDFKD LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIAAAARSPD 250 260 270 280 290 300 RNLLLNTGSN PGTSPMFCSV ASFGASSLSS LGASGGASNW DSYSDHFTIE TCKETDMLNY 310 320 330 340 350 360 LIECFDRVGI EEKKAPKMCS QPAVSQLLSN IRSQCISHTA LVLQGSLTQP RSLQQPSFLV 370 380 390 400 410 420 PYMLCRNLPY GFIQELVRTT HQDEEVFKQI FIPILQGLAL AAKECSLDSD YFKYPLMALG 430 440 450 460 470 480 ELCETKFGKT HPVCNLVASL RLWLPKSLSP GCGRELQRLS YLGAFFSFSV FAEDDVKVVE 490 500 510 520 530 540 KYFSGPAITL ENTRVVSQSL QHYLELGRQE LFKILHSILL NGETREAALS YMAAVVNANM 550 560 570 580 590 600 KKAQMQTDDR LVSTDGFMLN FLWVLQQLST KIKLETVDPT YIFHPRCRIT LPNDETRVNA 610 620 630 640 650 660 TMEDVNDWLT ELYGDQPPFS EPKFPTECFF LTLHAHHLSI LPSCRRYIRR LRAIRELNRT 670 680 690 700 710 720 VEDLKNNESQ WKDSPLATRH REMLKRCKTQ LKKLVRCKAC ADAGLLDESF LRRCLNFYGL 730 740 750 760 770 780 LIQLLLRILD PAYPDITLPL NSDVPKVFAA LPEFYVEDVA EFLFFIVQYS PQALYEPCTQ 790 800 810 820 830 840 DIVMFLVVML CNQNYIRNPY LVAKLVEVMF MTNPAVQPRT QKFFEMIENH PLSTKLLVPS 850 860 870 880 890 900 LMKFYTDVEH TGATSEFYDK FTIRYHISTI FKSLWQNIAH HGTFMEEFNS GKQFVRYINM 910 920 930 940 950 960 LINDTTFLLD ESLESLKRIH EVQEEMKNKE QWDQLPRDQQ QARQSQLAQD ERVSRSYLAL 970 980 990 1000 1010 1020 ATETVDMFHI LTKQVQKPFL RPELGPRLAA MLNFNLQQLC GPKCRDLKVE NPEKYGFEPK 1030 1040 1050 1060 1070 1080 KLLDQLTDIY LQLDCARFAK AIADDQRSYS KELFEEVISK MRKAGIKSTI AIEKFKLLAE 1090 1100 1110 1120 1130 1140 KVEEIVAKNA RAEIDYSDAP DEFRDPLMDT LMTDPVRLPS GTIMDRSIIL RHLLNSPTDP 1150 1160 1170 FNRQTLTESM LEPVPELKEQ IQAWMREKQN SDH
	Isoform 3 [UniParc]. Checksum: B4A29F16FFB1BD46		1,061	121,820
	10 20 30 40 50 60 MSQVDVDSGI ENMEVDENDR REKRSLSDKE PSSGPEVSEE QALQLVCKIF RVSWKDRDRD 70 80 90 100 110 120 VIFLSSLSAQ FKQNPKEVFS DFKDLIGQIL MEVLMMSTQT RDENPFASLT ATSQPIAAAA 130 140 150 160 170 180 RSPDRNLLLN TGSNPGTSPM FCSVASFGAS SLSSLGASGG ASNWDSYSDH FTIETCKETD 190 200 210 220 230 240 MLNYLIECFD RVGIEEKKAP KMCSQPAVSQ LLSNIRSQCI SHTALVLQGS LTQPRSLQQP 250 260 270 280 290 300 SFLVPYMLCR NLPYGFIQEL VRTTHQDEEV FKQIFIPILQ GLALAAKECS LDSDYFKYPL 310 320 330 340 350 360 MALGELCETK FGKTHPVCNL VASLRLWLPK SLSPGCGREL QRLSYLGAFF SFSVFAEDDV 370 380 390 400 410 420 KVVEKYFSGP AITLENTRVV SQSLQHYLEL GRQELFKILH SILLNGETRE AALSYMAAVV 430 440 450 460 470 480 NANMKKAQMQ TDDRLVSTDG FMLNFLWVLQ QLSTKIKLET VDPTYIFHPR CRITLPNDET 490 500 510 520 530 540 RVNATMEDVN DWLTELYGDQ PPFSEPKFPT ECFFLTLHAH HLSILPSCRR YIRRLRAIRE 550 560 570 580 590 600 LNRTVEDLKN NESQWKDSPL ATRHREMLKR CKTQLKKLVR CKACADAGLL DESFLRRCLN 610 620 630 640 650 660 FYGLLIQLLL RILDPAYPDI TLPLNSDVPK VFAALPEFYV EDVAEFLFFI VQYSPQALYE 670 680 690 700 710 720 PCTQDIVMFL VVMLCNQNYI RNPYLVAKLV EVMFMTNPAV QPRTQKFFEM IENHPLSTKL 730 740 750 760 770 780 LVPSLMKFYT DVEHTGATSE FYDKFTIRYH ISTIFKSLWQ NIAHHGTFME EFNSGKQFVR 790 800 810 820 830 840 YINMLINDTT FLLDESLESL KRIHEVQEEM KNKEQWDQLP RDQQQARQSQ LAQDERVSRS 850 860 870 880 890 900 YLALATETVD MFHILTKQVQ KPFLRPELGP RLAAMLNFNL QQLCGPKCRD LKVENPEKYG 910 920 930 940 950 960 FEPKKLLDQL TDIYLQLDCA RFAKAIADDQ RSYSKELFEE VISKMRKAGI KSTIAIEKFK 970 980 990 1000 1010 1020 LLAEKVEEIV AKNARAEIDY SDAPDEFRGK WTHPLMDTLM TDPVRLPSGT IMDRSIILRH 1030 1040 1050 1060 LLNSPTDPFN RQTLTESMLE PVPELKEQIQ AWMREKQNSD H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis." Mahoney J.A., Odin J.A., White S.M., Shaffer D., Koff A., Casciola-Rosen L., Rosen A. Biochem. J. 361:587-595(2002) [PubMed: 11802788] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, MUTAGENESIS OF ASP-109; ASP-121 AND ASP-123, CLEAVAGE BY CASPASES.
[2]	"Molecular cloning and expression analysis of five novel genes in chromosome 1p36." Onyango P., Lubyova B., Gardellin P., Kurzbauer R., Weith A. Genomics 50:187-198(1998) [PubMed: 9653645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line." Ohira M., Kageyama H., Mihara M., Furuta S., Machida T., Shishikura T., Takayasu H., Islam A., Nakamura Y., Takahashi M., Tomioka N., Sakiyama S., Kaneko Y., Toyoda A., Hattori M., Sakaki Y., Ohki M., Horii A. , Soeda E., Inazawa J., Seki N., Kuma H., Nozawa I., Nakagawara A. Oncogene 19:4302-4307(2000) [PubMed: 10980605] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Substantia nigra.
[4]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[5]	Ohara O., Suyama M., Nagase T., Ishikawa K. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Cerebellum.
[8]	"Full-insert sequence of mapped XREF EST." Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1112-1302.
[9]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, MASS SPECTROMETRY. Tissue: Epithelium.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803 AND SER-1265, MASS SPECTROMETRY. Tissue: Epithelium.
[11]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1265, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF331520 mRNA. Translation: AAK69622.1. AF043117 mRNA. Translation: AAD02233.1. AB028839 mRNA. Translation: BAB40446.1. AB014584 mRNA. Translation: BAA31659.3. Different initiation. AL590639, AL096841 Genomic DNA. Translation: CAI14687.1. AL590639, AL096841 Genomic DNA. Translation: CAI14688.1. AL096841, AL590639 Genomic DNA. Translation: CAI21859.1. AL096841, AL590639 Genomic DNA. Translation: CAI21860.1. BC093696 mRNA. Translation: AAH93696.1. AF091093 mRNA. Translation: AAC72962.1. Sequence problems.
PIR	T00358.
RefSeq	NP_001099032.1. NP_006039.2.
UniGene	Hs.632370
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	O95155.
Genome annotation databases
Ensembl	ENSG00000130939. Homo sapiens. [Contig view]
GeneID	10277.
KEGG	hsa:10277.
Organism-specific databases
H-InvDB	HIX0023150.
HGNC	HGNC:12500. UBE4B.
PharmGKB	PA37148.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	O95155.
Gene expression databases
ArrayExpress	O95155.
CleanEx	HS_UBE4B.
GermOnline	ENSG00000130939. Homo sapiens.
Family and domain databases
InterPro	IPR003613. Ubox. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF04564. U-box. 1 hit. [Graphical view]
SMART	SM00504. Ubox. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	38932.

Entry information

Entry name

UBE4B_HUMAN

Accession

Primary (citable) accession number: O95155
Secondary accession number(s): O75169 , O95338, Q5SZ12, Q5SZ16, Q96QD4, Q9BYI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	May 1, 1999
Last modified:	November 25, 2008
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)