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O95150

- TNF15_HUMAN

UniProt

O95150 - TNF15_HUMAN

Protein

Tumor necrosis factor ligand superfamily member 15

Gene

TNFSF15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.4 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei71 – 722Cleavage
    Sitei187 – 1871Important for binding TNFRSF6B
    Sitei190 – 1901Important for binding TNFRSF6B

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
    2. activation of NF-kappaB-inducing kinase activity Source: MGI
    3. cytokine metabolic process Source: MGI
    4. immune response Source: InterPro
    5. positive regulation of cytokine secretion Source: Ensembl
    6. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 15
    Alternative name(s):
    TNF ligand-related molecule 1
    Vascular endothelial cell growth inhibitor
    Cleaved into the following 2 chains:
    Gene namesi
    Name:TNFSF15
    Synonyms:TL1, VEGI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:11931. TNFSF15.

    Subcellular locationi

    Membrane 2 Publications; Single-pass type II membrane protein 2 Publications

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti186. Primary biliary cirrhosis.
    PharmGKBiPA36623.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 251251Tumor necrosis factor ligand superfamily member 15, membrane formPRO_0000185505Add
    BLAST
    Chaini72 – 251180Tumor necrosis factor ligand superfamily member 15, secreted formPRO_0000333234Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi162 ↔ 2021 Publication
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95150.
    PRIDEiO95150.

    Expressioni

    Tissue specificityi

    Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.4 Publications

    Inductioni

    Up-regulated by IL1A/interleukin-1 alpha and TNF.2 Publications

    Gene expression databases

    ArrayExpressiO95150.
    BgeeiO95150.
    CleanExiHS_TNFSF15.
    GenevestigatoriO95150.

    Organism-specific databases

    HPAiHPA012948.

    Interactioni

    Subunit structurei

    Homotrimer.2 Publications

    Protein-protein interaction databases

    BioGridi115291. 2 interactions.
    DIPiDIP-59562N.
    STRINGi9606.ENSP00000363157.

    Structurei

    Secondary structure

    1
    251
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi96 – 1016
    Beta strandi111 – 1133
    Beta strandi120 – 1234
    Beta strandi127 – 1293
    Beta strandi133 – 1353
    Beta strandi138 – 1403
    Beta strandi145 – 15612
    Beta strandi161 – 1644
    Turni167 – 1693
    Beta strandi175 – 18410
    Beta strandi186 – 1883
    Beta strandi192 – 2009
    Beta strandi204 – 2063
    Beta strandi209 – 22012
    Beta strandi225 – 2317
    Helixi233 – 2353
    Turni241 – 2433
    Beta strandi244 – 2507

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2O0OX-ray3.00A/B/C72-251[»]
    2QE3X-ray2.50A72-251[»]
    2RE9X-ray2.10A/B/C72-251[»]
    2RJKX-ray2.30A72-251[»]
    2RJLX-ray2.05A72-251[»]
    3K51X-ray2.45A72-251[»]
    3MI8X-ray2.95A72-251[»]
    ProteinModelPortaliO95150.
    SMRiO95150. Positions 88-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95150.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini57 – 251195ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40368.
    HOGENOMiHOG000060140.
    HOVERGENiHBG067254.
    InParanoidiO95150.
    KOiK05478.
    OMAiTSECGEI.
    OrthoDBiEOG7V4B0Q.
    PhylomeDBiO95150.
    TreeFamiTF332169.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR006052. TNF_dom.
    IPR008064. TNFSF15.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PANTHERiPTHR11471:SF24. PTHR11471:SF24. 1 hit.
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95150-1) [UniParc]FASTAAdd to Basket

    Also known as: TL1A, VEGI-251

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEDLGLSFG ETASVEMLPE HGSCRPKARS SSARWALTCC LVLLPFLAGL    50
    TTYLLVSQLR AQGEACVQFQ ALKGQEFAPS HQQVYAPLRA DGDKPRAHLT 100
    VVRQTPTQHF KNQFPALHWE HELGLAFTKN RMNYTNKFLL IPESGDYFIY 150
    SQVTFRGMTS ECSEIRQAGR PNKPDSITVV ITKVTDSYPE PTQLLMGTKS 200
    VCEVGSNWFQ PIYLGAMFSL QEGDKLMVNV SDISLVDYTK EDKTFFGAFL 250
    L 251
    Length:251
    Mass (Da):28,087
    Last modified:May 20, 2008 - v2
    Checksum:i65ED70E367E3446D
    GO
    Isoform 2 (identifier: O95150-2) [UniParc]FASTAAdd to Basket

    Also known as: VEGI-192

    The sequence of this isoform differs from the canonical sequence as follows:
         1-85: MAEDLGLSFG...EFAPSHQQVY → MQLTKGRLHFSHPLSHTKHISPFVTD

    Show »
    Length:192
    Mass (Da):21,857
    Checksum:iCC7D2E73CEF5A53A
    GO
    Isoform 3 (identifier: O95150-3) [UniParc]FASTAAdd to Basket

    Also known as: VEGI-174

    The sequence of this isoform differs from the canonical sequence as follows:
         1-77: Missing.
         78-100: APSHQQVYAPLRADGDKPRAHLT → MRRFLSKVYSFPMRKLILFLVFP

    Note: No experimental confirmation available.

    Show »
    Length:174
    Mass (Da):20,131
    Checksum:iCCB83BA7EE673B98
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341R → H in AAI04463. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101F → L.
    Corresponds to variant rs16931745 [ dbSNP | Ensembl ].
    VAR_043130

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8585MAEDL…HQQVY → MQLTKGRLHFSHPLSHTKHI SPFVTD in isoform 2. 1 PublicationVSP_033492Add
    BLAST
    Alternative sequencei1 – 7777Missing in isoform 3. 1 PublicationVSP_033493Add
    BLAST
    Alternative sequencei78 – 10023APSHQ…RAHLT → MRRFLSKVYSFPMRKLILFL VFP in isoform 3. 1 PublicationVSP_033494Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039390 mRNA. Translation: AAD08783.1.
    AY434464 mRNA. Translation: AAR98573.1.
    AF520785 mRNA. Translation: AAM77366.1.
    AK291642 mRNA. Translation: BAF84331.1.
    AL390240 Genomic DNA. Translation: CAH73730.1.
    AL390240 Genomic DNA. Translation: CAH73731.1.
    CH471090 Genomic DNA. Translation: EAW87431.1.
    BC069435 mRNA. Translation: AAH69435.1.
    BC074940 mRNA. Translation: AAH74940.1.
    BC074941 mRNA. Translation: AAH74941.1.
    BC104462 mRNA. Translation: AAI04463.1.
    BC104463 mRNA. Translation: AAI04464.1.
    CCDSiCCDS6809.1. [O95150-1]
    RefSeqiNP_001191273.1. NM_001204344.1. [O95150-2]
    NP_005109.2. NM_005118.3. [O95150-1]
    UniGeneiHs.23349.

    Genome annotation databases

    EnsembliENST00000374045; ENSP00000363157; ENSG00000181634. [O95150-1]
    GeneIDi9966.
    KEGGihsa:9966.
    UCSCiuc004bjg.3. human. [O95150-2]
    uc004bjh.3. human. [O95150-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039390 mRNA. Translation: AAD08783.1 .
    AY434464 mRNA. Translation: AAR98573.1 .
    AF520785 mRNA. Translation: AAM77366.1 .
    AK291642 mRNA. Translation: BAF84331.1 .
    AL390240 Genomic DNA. Translation: CAH73730.1 .
    AL390240 Genomic DNA. Translation: CAH73731.1 .
    CH471090 Genomic DNA. Translation: EAW87431.1 .
    BC069435 mRNA. Translation: AAH69435.1 .
    BC074940 mRNA. Translation: AAH74940.1 .
    BC074941 mRNA. Translation: AAH74941.1 .
    BC104462 mRNA. Translation: AAI04463.1 .
    BC104463 mRNA. Translation: AAI04464.1 .
    CCDSi CCDS6809.1. [O95150-1 ]
    RefSeqi NP_001191273.1. NM_001204344.1. [O95150-2 ]
    NP_005109.2. NM_005118.3. [O95150-1 ]
    UniGenei Hs.23349.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2O0O X-ray 3.00 A/B/C 72-251 [» ]
    2QE3 X-ray 2.50 A 72-251 [» ]
    2RE9 X-ray 2.10 A/B/C 72-251 [» ]
    2RJK X-ray 2.30 A 72-251 [» ]
    2RJL X-ray 2.05 A 72-251 [» ]
    3K51 X-ray 2.45 A 72-251 [» ]
    3MI8 X-ray 2.95 A 72-251 [» ]
    ProteinModelPortali O95150.
    SMRi O95150. Positions 88-251.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115291. 2 interactions.
    DIPi DIP-59562N.
    STRINGi 9606.ENSP00000363157.

    Proteomic databases

    PaxDbi O95150.
    PRIDEi O95150.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374045 ; ENSP00000363157 ; ENSG00000181634 . [O95150-1 ]
    GeneIDi 9966.
    KEGGi hsa:9966.
    UCSCi uc004bjg.3. human. [O95150-2 ]
    uc004bjh.3. human. [O95150-1 ]

    Organism-specific databases

    CTDi 9966.
    GeneCardsi GC09M117551.
    HGNCi HGNC:11931. TNFSF15.
    HPAi HPA012948.
    MIMi 604052. gene.
    neXtProti NX_O95150.
    Orphaneti 186. Primary biliary cirrhosis.
    PharmGKBi PA36623.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40368.
    HOGENOMi HOG000060140.
    HOVERGENi HBG067254.
    InParanoidi O95150.
    KOi K05478.
    OMAi TSECGEI.
    OrthoDBi EOG7V4B0Q.
    PhylomeDBi O95150.
    TreeFami TF332169.

    Miscellaneous databases

    EvolutionaryTracei O95150.
    GeneWikii Vascular_endothelial_growth_inhibitor.
    GenomeRNAii 9966.
    NextBioi 37610.
    PROi O95150.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95150.
    Bgeei O95150.
    CleanExi HS_TNFSF15.
    Genevestigatori O95150.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR006052. TNF_dom.
    IPR008064. TNFSF15.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    PANTHERi PTHR11471:SF24. PTHR11471:SF24. 1 hit.
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo."
      Zhai Y., Ni J., Jiang G.-W., Lu J., Xing L., Lincoln C., Carter K.C., Janat F., Kozak D., Xu S., Rojas L., Aggarwal B.B., Ruben S., Li L.-Y., Gentz R., Yu G.-L.
      FASEB J. 13:181-189(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Umbilical vein.
    2. "A novel secreted splice variant of vascular endothelial cell growth inhibitor."
      Chew L.-J., Pan H., Yu J., Tian S., Huang W.-Q., Zhang J.Y., Pang S., Li L.-Y.
      FASEB J. 16:742-744(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, INTERACTION WITH TNFRSF25 AND TNFRSF6B, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING, INDUCTION, TISSUE SPECIFICITY.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    5. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells."
      Tan K.B., Harrop J., Reddy M., Young P., Terrett J., Emery J., Moore G., Truneh A.
      Gene 204:35-46(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORM 3), TISSUE SPECIFICITY.
    9. "VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth."
      Haridas V., Shrivastava A., Su J., Yu G.-L., Ni J., Liu D., Chen S.-F., Ni Y., Ruben S.M., Gentz R., Aggarwal B.B.
      Oncogene 18:6496-6504(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "X-ray crystal structure of TNF ligand family member TL1A at 2.1A."
      Jin T., Guo F., Kim S., Howard A., Zhang Y.-Z.
      Biochem. Biophys. Res. Commun. 364:1-6(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 71-251, DISULFIDE BOND, SUBUNIT.
    11. Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 72-251 IN COMPLEX WITH TNFRSF6B.

    Entry informationi

    Entry nameiTNF15_HUMAN
    AccessioniPrimary (citable) accession number: O95150
    Secondary accession number(s): Q3SX69
    , Q5VJK8, Q5VWH1, Q8NFE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3