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O95150

- TNF15_HUMAN

UniProt

O95150 - TNF15_HUMAN

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Protein

Tumor necrosis factor ligand superfamily member 15

Gene

TNFSF15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei71 – 722Cleavage
Sitei187 – 1871Important for binding TNFRSF6B
Sitei190 – 1901Important for binding TNFRSF6B

GO - Molecular functioni

  1. receptor binding Source: ProtInc

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. activation of NF-kappaB-inducing kinase activity Source: MGI
  3. cytokine metabolic process Source: MGI
  4. immune response Source: InterPro
  5. positive regulation of cytokine secretion Source: Ensembl
  6. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 15
Alternative name(s):
TNF ligand-related molecule 1
Vascular endothelial cell growth inhibitor
Cleaved into the following 2 chains:
Gene namesi
Name:TNFSF15
Synonyms:TL1, VEGI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:11931. TNFSF15.

Subcellular locationi

Membrane 2 Publications; Single-pass type II membrane protein 2 Publications

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti186. Primary biliary cirrhosis.
PharmGKBiPA36623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Tumor necrosis factor ligand superfamily member 15, membrane formPRO_0000185505Add
BLAST
Chaini72 – 251180Tumor necrosis factor ligand superfamily member 15, secreted formPRO_0000333234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi162 ↔ 2021 Publication
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95150.
PRIDEiO95150.

Expressioni

Tissue specificityi

Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.4 Publications

Inductioni

Up-regulated by IL1A/interleukin-1 alpha and TNF.2 Publications

Gene expression databases

BgeeiO95150.
CleanExiHS_TNFSF15.
ExpressionAtlasiO95150. baseline and differential.
GenevestigatoriO95150.

Organism-specific databases

HPAiHPA012948.

Interactioni

Subunit structurei

Homotrimer.2 Publications

Protein-protein interaction databases

BioGridi115291. 2 interactions.
DIPiDIP-59562N.
STRINGi9606.ENSP00000363157.

Structurei

Secondary structure

1
251
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi96 – 1016
Beta strandi111 – 1133
Beta strandi120 – 1234
Beta strandi127 – 1293
Beta strandi133 – 1353
Beta strandi138 – 1403
Beta strandi145 – 15612
Beta strandi161 – 1644
Turni167 – 1693
Beta strandi175 – 18410
Beta strandi186 – 1883
Beta strandi192 – 2009
Beta strandi204 – 2063
Beta strandi209 – 22012
Beta strandi225 – 2317
Helixi233 – 2353
Turni241 – 2433
Beta strandi244 – 2507

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O0OX-ray3.00A/B/C72-251[»]
2QE3X-ray2.50A72-251[»]
2RE9X-ray2.10A/B/C72-251[»]
2RJKX-ray2.30A72-251[»]
2RJLX-ray2.05A72-251[»]
3K51X-ray2.45A72-251[»]
3MI8X-ray2.95A72-251[»]
ProteinModelPortaliO95150.
SMRiO95150. Positions 88-251.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95150.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini57 – 251195ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40368.
GeneTreeiENSGT00530000062992.
HOGENOMiHOG000060140.
HOVERGENiHBG067254.
InParanoidiO95150.
KOiK05478.
OMAiTSECGEI.
OrthoDBiEOG7V4B0Q.
PhylomeDBiO95150.
TreeFamiTF332169.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR006052. TNF_dom.
IPR008064. TNFSF15.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR11471:SF24. PTHR11471:SF24. 1 hit.
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95150) [UniParc]FASTAAdd to Basket

Also known as: TL1A, VEGI-251

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEDLGLSFG ETASVEMLPE HGSCRPKARS SSARWALTCC LVLLPFLAGL
60 70 80 90 100
TTYLLVSQLR AQGEACVQFQ ALKGQEFAPS HQQVYAPLRA DGDKPRAHLT
110 120 130 140 150
VVRQTPTQHF KNQFPALHWE HELGLAFTKN RMNYTNKFLL IPESGDYFIY
160 170 180 190 200
SQVTFRGMTS ECSEIRQAGR PNKPDSITVV ITKVTDSYPE PTQLLMGTKS
210 220 230 240 250
VCEVGSNWFQ PIYLGAMFSL QEGDKLMVNV SDISLVDYTK EDKTFFGAFL

L
Length:251
Mass (Da):28,087
Last modified:May 20, 2008 - v2
Checksum:i65ED70E367E3446D
GO
Isoform 2 (identifier: O95150-2) [UniParc]FASTAAdd to Basket

Also known as: VEGI-192

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: MAEDLGLSFG...EFAPSHQQVY → MQLTKGRLHFSHPLSHTKHISPFVTD

Show »
Length:192
Mass (Da):21,857
Checksum:iCC7D2E73CEF5A53A
GO
Isoform 3 (identifier: O95150-3) [UniParc]FASTAAdd to Basket

Also known as: VEGI-174

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-100: APSHQQVYAPLRADGDKPRAHLT → MRRFLSKVYSFPMRKLILFLVFP

Note: No experimental confirmation available.

Show »
Length:174
Mass (Da):20,131
Checksum:iCCB83BA7EE673B98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341R → H in AAI04463. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101F → L.
Corresponds to variant rs16931745 [ dbSNP | Ensembl ].
VAR_043130

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585MAEDL…HQQVY → MQLTKGRLHFSHPLSHTKHI SPFVTD in isoform 2. 1 PublicationVSP_033492Add
BLAST
Alternative sequencei1 – 7777Missing in isoform 3. 1 PublicationVSP_033493Add
BLAST
Alternative sequencei78 – 10023APSHQ…RAHLT → MRRFLSKVYSFPMRKLILFL VFP in isoform 3. 1 PublicationVSP_033494Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039390 mRNA. Translation: AAD08783.1.
AY434464 mRNA. Translation: AAR98573.1.
AF520785 mRNA. Translation: AAM77366.1.
AK291642 mRNA. Translation: BAF84331.1.
AL390240 Genomic DNA. Translation: CAH73730.1.
AL390240 Genomic DNA. Translation: CAH73731.1.
CH471090 Genomic DNA. Translation: EAW87431.1.
BC069435 mRNA. Translation: AAH69435.1.
BC074940 mRNA. Translation: AAH74940.1.
BC074941 mRNA. Translation: AAH74941.1.
BC104462 mRNA. Translation: AAI04463.1.
BC104463 mRNA. Translation: AAI04464.1.
CCDSiCCDS6809.1. [O95150-1]
RefSeqiNP_001191273.1. NM_001204344.1. [O95150-2]
NP_005109.2. NM_005118.3. [O95150-1]
UniGeneiHs.23349.

Genome annotation databases

EnsembliENST00000374045; ENSP00000363157; ENSG00000181634. [O95150-1]
GeneIDi9966.
KEGGihsa:9966.
UCSCiuc004bjg.3. human. [O95150-2]
uc004bjh.3. human. [O95150-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039390 mRNA. Translation: AAD08783.1 .
AY434464 mRNA. Translation: AAR98573.1 .
AF520785 mRNA. Translation: AAM77366.1 .
AK291642 mRNA. Translation: BAF84331.1 .
AL390240 Genomic DNA. Translation: CAH73730.1 .
AL390240 Genomic DNA. Translation: CAH73731.1 .
CH471090 Genomic DNA. Translation: EAW87431.1 .
BC069435 mRNA. Translation: AAH69435.1 .
BC074940 mRNA. Translation: AAH74940.1 .
BC074941 mRNA. Translation: AAH74941.1 .
BC104462 mRNA. Translation: AAI04463.1 .
BC104463 mRNA. Translation: AAI04464.1 .
CCDSi CCDS6809.1. [O95150-1 ]
RefSeqi NP_001191273.1. NM_001204344.1. [O95150-2 ]
NP_005109.2. NM_005118.3. [O95150-1 ]
UniGenei Hs.23349.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2O0O X-ray 3.00 A/B/C 72-251 [» ]
2QE3 X-ray 2.50 A 72-251 [» ]
2RE9 X-ray 2.10 A/B/C 72-251 [» ]
2RJK X-ray 2.30 A 72-251 [» ]
2RJL X-ray 2.05 A 72-251 [» ]
3K51 X-ray 2.45 A 72-251 [» ]
3MI8 X-ray 2.95 A 72-251 [» ]
ProteinModelPortali O95150.
SMRi O95150. Positions 88-251.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115291. 2 interactions.
DIPi DIP-59562N.
STRINGi 9606.ENSP00000363157.

Proteomic databases

PaxDbi O95150.
PRIDEi O95150.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374045 ; ENSP00000363157 ; ENSG00000181634 . [O95150-1 ]
GeneIDi 9966.
KEGGi hsa:9966.
UCSCi uc004bjg.3. human. [O95150-2 ]
uc004bjh.3. human. [O95150-1 ]

Organism-specific databases

CTDi 9966.
GeneCardsi GC09M117551.
HGNCi HGNC:11931. TNFSF15.
HPAi HPA012948.
MIMi 604052. gene.
neXtProti NX_O95150.
Orphaneti 186. Primary biliary cirrhosis.
PharmGKBi PA36623.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40368.
GeneTreei ENSGT00530000062992.
HOGENOMi HOG000060140.
HOVERGENi HBG067254.
InParanoidi O95150.
KOi K05478.
OMAi TSECGEI.
OrthoDBi EOG7V4B0Q.
PhylomeDBi O95150.
TreeFami TF332169.

Miscellaneous databases

EvolutionaryTracei O95150.
GeneWikii Vascular_endothelial_growth_inhibitor.
GenomeRNAii 9966.
NextBioi 37610.
PROi O95150.
SOURCEi Search...

Gene expression databases

Bgeei O95150.
CleanExi HS_TNFSF15.
ExpressionAtlasi O95150. baseline and differential.
Genevestigatori O95150.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR006053. TNF.
IPR006052. TNF_dom.
IPR008064. TNFSF15.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
PANTHERi PTHR11471:SF24. PTHR11471:SF24. 1 hit.
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PRINTSi PR01234. TNECROSISFCT.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo."
    Zhai Y., Ni J., Jiang G.-W., Lu J., Xing L., Lincoln C., Carter K.C., Janat F., Kozak D., Xu S., Rojas L., Aggarwal B.B., Ruben S., Li L.-Y., Gentz R., Yu G.-L.
    FASEB J. 13:181-189(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Umbilical vein.
  2. "A novel secreted splice variant of vascular endothelial cell growth inhibitor."
    Chew L.-J., Pan H., Yu J., Tian S., Huang W.-Q., Zhang J.Y., Pang S., Li L.-Y.
    FASEB J. 16:742-744(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, INTERACTION WITH TNFRSF25 AND TNFRSF6B, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING, INDUCTION, TISSUE SPECIFICITY.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells."
    Tan K.B., Harrop J., Reddy M., Young P., Terrett J., Emery J., Moore G., Truneh A.
    Gene 204:35-46(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM 3), TISSUE SPECIFICITY.
  9. "VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth."
    Haridas V., Shrivastava A., Su J., Yu G.-L., Ni J., Liu D., Chen S.-F., Ni Y., Ruben S.M., Gentz R., Aggarwal B.B.
    Oncogene 18:6496-6504(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "X-ray crystal structure of TNF ligand family member TL1A at 2.1A."
    Jin T., Guo F., Kim S., Howard A., Zhang Y.-Z.
    Biochem. Biophys. Res. Commun. 364:1-6(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 71-251, DISULFIDE BOND, SUBUNIT.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 72-251 IN COMPLEX WITH TNFRSF6B.

Entry informationi

Entry nameiTNF15_HUMAN
AccessioniPrimary (citable) accession number: O95150
Secondary accession number(s): Q3SX69
, Q5VJK8, Q5VWH1, Q8NFE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3