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Reviewed, UniProtKB/Swiss-Prot O95147 (DUS14_HUMAN)

Last modified February 9, 2010. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dual specificity protein phosphatase 14
    EC=3.1.3.48
    EC=3.1.3.16
Alternative name(s):
    Mitogen-activated protein kinase phosphatase 6
      Short name=MAP kinase phosphatase 6
      Short name=MKP-6
    MKP-1-like protein tyrosine phosphatase
      Short name=MKP-L
Gene names
Name: DUSP14
Synonyms: MKP6
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphoprotein + H2O = a protein + phosphate.

Subunit structure

Interacts with CD28.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Dual specificity protein phosphatase 14
PRO_0000094822

Regions

Domain91 – 15666Tyrosine-protein phosphatase

Sites

Active site1111Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue71Phosphoserine
Modified residue81Phosphothreonine

Sequences

Sequence LengthMass (Da)Tools
O95147-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 6AAFAE1B3A24F9AA

FASTA19822,255
        10         20         30         40         50         60 
MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT 

        70         80         90        100        110        120 
IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT 

       130        140        150        160        170        180 
LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI 

       190 
VPDVYEKESR HLMPYWGI 

« Hide

References

« Hide 'large scale' references
[1]"MKP-L, a novel MKP-1 like protein tyrosine phosphatase."
Yuan Y., Suphapeetiporn K., Sun H.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6."
Marti F., Krause A., Post N.H., Lyddane C., Dupont B., Sadelain M., King P.D.
J. Immunol. 166:197-206(2001) [PubMed: 11123293] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND THR-8, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038844 mRNA. Translation: AAD02105.1.
AF120032 mRNA. Translation: AAF28861.1.
BC000370 mRNA. Translation: AAH00370.1.
BC001894 mRNA. Translation: AAH01894.1.
BC004448 mRNA. Translation: AAH04448.1.
IPIIPI00013031.
RefSeqNP_008957.1.
UniGeneHs.91448

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2WGPX-ray1.88A/B2-191[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGO95147.

PTM databases

PhosphoSiteO95147.

Proteomic databases

PeptideAtlasO95147.
PRIDEO95147.

Genome annotation databases

EnsemblENST00000292964; ENSP00000292964; ENSG00000161326; Homo sapiens. [Genome view]
ENST00000394386; ENSP00000377910; ENSG00000161326; Homo sapiens. [Genome view]
ENST00000394389; ENSP00000377912; ENSG00000161326; Homo sapiens. [Genome view]
GeneID11072.
KEGGhsa:11072.
UCSCuc002hnx.2. human.

Organism-specific databases

CTD11072.
GeneCardsGC17P032924.
H-InvDBHIX0013746.
HGNCHGNC:17007. DUSP14.
HPAHPA019911.
MIM606618. gene.
PharmGKBPA27523.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG15835.
HOGENOMHBG717377.
HOVERGENO95147.
InParanoidO95147.
OMAPYGVVPD.
OrthoDBEOG90043R.
PhylomeDBO95147.

Enzyme and pathway databases

BRENDA3.1.3.16. 247.
3.1.3.48. 247.

Gene expression databases

ArrayExpressO95147.
BgeeO95147.
CleanExHS_DUSP14.
GenevestigatorO95147.
GermOnlineENSG00000161326. Homo sapiens.

Family and domain databases

InterProIPR000387. Dual-sp/Tyr_phosphatase.
IPR020417. Dual-sp_phosphatase.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020420. Dual-sp_phosphatase_famB.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio42090.
SOURCESearch...

Entry information

Entry nameDUS14_HUMAN
AccessionPrimary (citable) accession number: O95147
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: February 9, 2010
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents