Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95147

- DUS14_HUMAN

UniProt

O95147 - DUS14_HUMAN

Protein

Dual specificity protein phosphatase 14

Gene

DUSP14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei111 – 1111Phosphocysteine intermediate1 PublicationPROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB
    3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    4. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 14 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    MKP-1-like protein tyrosine phosphatase
    Short name:
    MKP-L
    Mitogen-activated protein kinase phosphatase 6
    Short name:
    MAP kinase phosphatase 6
    Short name:
    MKP-6
    Gene namesi
    Name:DUSP14
    Synonyms:MKP6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:17007. DUSP14.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27523.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Dual specificity protein phosphatase 14PRO_0000094822Add
    BLAST

    Proteomic databases

    MaxQBiO95147.
    PaxDbiO95147.
    PeptideAtlasiO95147.
    PRIDEiO95147.

    PTM databases

    PhosphoSiteiO95147.

    Expressioni

    Gene expression databases

    ArrayExpressiO95147.
    BgeeiO95147.
    CleanExiHS_DUSP14.
    GenevestigatoriO95147.

    Organism-specific databases

    HPAiHPA019911.

    Interactioni

    Subunit structurei

    Interacts with CD28.1 Publication

    Protein-protein interaction databases

    BioGridi116255. 6 interactions.
    IntActiO95147. 1 interaction.
    STRINGi9606.ENSP00000292964.

    Structurei

    Secondary structure

    1
    198
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 315
    Beta strandi34 – 374
    Helixi39 – 424
    Helixi45 – 506
    Beta strandi55 – 584
    Beta strandi61 – 633
    Beta strandi71 – 755
    Helixi86 – 894
    Helixi90 – 10213
    Beta strandi107 – 1104
    Beta strandi112 – 1165
    Helixi117 – 13014
    Helixi134 – 14411
    Helixi152 – 16615
    Beta strandi173 – 1764
    Beta strandi179 – 1824
    Helixi183 – 1897

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WGPX-ray1.88A/B2-191[»]
    ProteinModelPortaliO95147.
    SMRiO95147. Positions 24-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95147.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 15666Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000233766.
    HOVERGENiHBG051422.
    InParanoidiO95147.
    KOiK14165.
    OMAiYLMKFHS.
    OrthoDBiEOG7PK90H.
    PhylomeDBiO95147.
    TreeFamiTF316009.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95147-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA    50
    RGITCIVNAT IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV 100
    SRKHGATLVH CAAGVSRSAT LCIAYLMKFH NVCLLEAYNW VKARRPVIRP 150
    NVGFWRQLID YERQLFGKST VKMVQTPYGI VPDVYEKESR HLMPYWGI 198
    Length:198
    Mass (Da):22,255
    Last modified:May 1, 1999 - v1
    Checksum:i6AAFAE1B3A24F9AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038844 mRNA. Translation: AAD02105.1.
    AF120032 mRNA. Translation: AAF28861.1.
    BC000370 mRNA. Translation: AAH00370.1.
    BC001894 mRNA. Translation: AAH01894.1.
    BC004448 mRNA. Translation: AAH04448.1.
    CCDSiCCDS11320.1.
    RefSeqiNP_008957.1. NM_007026.3.
    XP_005257034.1. XM_005256977.1.
    XP_006725363.1. XM_006725300.1.
    UniGeneiHs.91448.

    Genome annotation databases

    GeneIDi11072.
    KEGGihsa:11072.
    UCSCiuc002hnx.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038844 mRNA. Translation: AAD02105.1 .
    AF120032 mRNA. Translation: AAF28861.1 .
    BC000370 mRNA. Translation: AAH00370.1 .
    BC001894 mRNA. Translation: AAH01894.1 .
    BC004448 mRNA. Translation: AAH04448.1 .
    CCDSi CCDS11320.1.
    RefSeqi NP_008957.1. NM_007026.3.
    XP_005257034.1. XM_005256977.1.
    XP_006725363.1. XM_006725300.1.
    UniGenei Hs.91448.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WGP X-ray 1.88 A/B 2-191 [» ]
    ProteinModelPortali O95147.
    SMRi O95147. Positions 24-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116255. 6 interactions.
    IntActi O95147. 1 interaction.
    STRINGi 9606.ENSP00000292964.

    Chemistry

    BindingDBi O95147.
    ChEMBLi CHEMBL1764941.

    PTM databases

    PhosphoSitei O95147.

    Proteomic databases

    MaxQBi O95147.
    PaxDbi O95147.
    PeptideAtlasi O95147.
    PRIDEi O95147.

    Protocols and materials databases

    DNASUi 11072.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11072.
    KEGGi hsa:11072.
    UCSCi uc002hnx.2. human.

    Organism-specific databases

    CTDi 11072.
    GeneCardsi GC17P035850.
    HGNCi HGNC:17007. DUSP14.
    HPAi HPA019911.
    MIMi 606618. gene.
    neXtProti NX_O95147.
    PharmGKBi PA27523.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000233766.
    HOVERGENi HBG051422.
    InParanoidi O95147.
    KOi K14165.
    OMAi YLMKFHS.
    OrthoDBi EOG7PK90H.
    PhylomeDBi O95147.
    TreeFami TF316009.

    Miscellaneous databases

    EvolutionaryTracei O95147.
    GenomeRNAii 11072.
    NextBioi 42090.
    PROi O95147.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95147.
    Bgeei O95147.
    CleanExi HS_DUSP14.
    Genevestigatori O95147.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020420. Atypical_DUSP_famB.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01910. ADSPHPHTASEB.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MKP-L, a novel MKP-1 like protein tyrosine phosphatase."
      Yuan Y., Suphapeetiporn K., Sun H.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6."
      Marti F., Krause A., Post N.H., Lyddane C., Dupont B., Sadelain M., King P.D.
      J. Immunol. 166:197-206(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Overproduction, purification and structure determination of human dual-specificity phosphatase 14."
      Lountos G.T., Tropea J.E., Cherry S., Waugh D.S.
      Acta Crystallogr. D 65:1013-1020(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 2-191 IN COMPLEX WITH PHOSPHATE, ACTIVE SITE, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiDUS14_HUMAN
    AccessioniPrimary (citable) accession number: O95147
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3