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Protein

Dual specificity protein phosphatase 14

Gene

DUSP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei111Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 14 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
MKP-1-like protein tyrosine phosphatase
Short name:
MKP-L
Mitogen-activated protein kinase phosphatase 6
Short name:
MAP kinase phosphatase 6
Short name:
MKP-6
Gene namesi
Name:DUSP14
Synonyms:MKP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17007. DUSP14.

Pathology & Biotechi

Organism-specific databases

DisGeNETi11072.
OpenTargetsiENSG00000276023.
PharmGKBiPA27523.

Chemistry databases

ChEMBLiCHEMBL1764941.

Polymorphism and mutation databases

BioMutaiDUSP14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948221 – 198Dual specificity protein phosphatase 14Add BLAST198

Proteomic databases

EPDiO95147.
PaxDbiO95147.
PeptideAtlasiO95147.
PRIDEiO95147.

PTM databases

DEPODiO95147.
iPTMnetiO95147.
PhosphoSitePlusiO95147.

Expressioni

Gene expression databases

BgeeiENSG00000161326.
CleanExiHS_DUSP14.
ExpressionAtlasiO95147. baseline and differential.
GenevisibleiO95147. HS.

Organism-specific databases

HPAiHPA019911.

Interactioni

Subunit structurei

Interacts with CD28.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SPERTQ8NA613EBI-3922653,EBI-741724

Protein-protein interaction databases

BioGridi116255. 45 interactors.
IntActiO95147. 4 interactors.
STRINGi9606.ENSP00000377910.

Chemistry databases

BindingDBiO95147.

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 31Combined sources5
Beta strandi34 – 37Combined sources4
Helixi39 – 42Combined sources4
Helixi45 – 50Combined sources6
Beta strandi55 – 58Combined sources4
Beta strandi61 – 63Combined sources3
Beta strandi71 – 75Combined sources5
Helixi86 – 89Combined sources4
Helixi90 – 102Combined sources13
Beta strandi107 – 110Combined sources4
Beta strandi112 – 116Combined sources5
Helixi117 – 130Combined sources14
Helixi134 – 144Combined sources11
Helixi152 – 166Combined sources15
Beta strandi173 – 176Combined sources4
Beta strandi179 – 182Combined sources4
Helixi183 – 189Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WGPX-ray1.88A/B2-191[»]
ProteinModelPortaliO95147.
SMRiO95147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95147.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 156Tyrosine-protein phosphataseAdd BLAST66

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1718. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiO95147.
KOiK14165.
OMAiYLMKFHS.
OrthoDBiEOG091G0249.
PhylomeDBiO95147.
TreeFamiTF316009.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR020417. Atypical_DUSP.
IPR020420. Atypical_DUSP_famB.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PRINTSiPR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

O95147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA
60 70 80 90 100
RGITCIVNAT IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV
110 120 130 140 150
SRKHGATLVH CAAGVSRSAT LCIAYLMKFH NVCLLEAYNW VKARRPVIRP
160 170 180 190
NVGFWRQLID YERQLFGKST VKMVQTPYGI VPDVYEKESR HLMPYWGI
Length:198
Mass (Da):22,255
Last modified:May 1, 1999 - v1
Checksum:i6AAFAE1B3A24F9AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038844 mRNA. Translation: AAD02105.1.
AF120032 mRNA. Translation: AAF28861.1.
BC000370 mRNA. Translation: AAH00370.1.
BC001894 mRNA. Translation: AAH01894.1.
BC004448 mRNA. Translation: AAH04448.1.
CCDSiCCDS11320.1.
RefSeqiNP_008957.1. NM_007026.3.
XP_005257034.1. XM_005256977.3.
XP_011522536.1. XM_011524234.1.
UniGeneiHs.91448.

Genome annotation databases

EnsembliENST00000613659; ENSP00000484091; ENSG00000276023.
ENST00000614294; ENSP00000478406; ENSG00000275932.
ENST00000614411; ENSP00000477653; ENSG00000276023.
ENST00000617516; ENSP00000478595; ENSG00000276023.
ENST00000632468; ENSP00000487886; ENSG00000275932.
ENST00000633870; ENSP00000488882; ENSG00000275932.
GeneIDi11072.
KEGGihsa:11072.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDUS14_HUMAN
AccessioniPrimary (citable) accession number: O95147
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: June 7, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families