Reviewed, UniProtKB/Swiss-Prot O95147 (DUS14_HUMAN)

Names and origin

Protein names

Recommended name:
    Dual specificity protein phosphatase 14
    EC=3.1.3.48
    EC=3.1.3.16
Alternative name(s):
    Mitogen-activated protein kinase phosphatase 6
      Short name=MAP kinase phosphatase 6
      Short name=MKP-6
    MKP-1-like protein tyrosine phosphatase
      Short name=MKP-L

Gene names

Name:	DUSP14
Synonyms:	MKP6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subunit structure	Interacts with CD28.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Dual specificity protein phosphatase 14		PRO_0000094822
Regions
	Domain	91 – 156	66	Tyrosine-protein phosphatase
Sites
	Active site	111	1	Phosphocysteine intermediate By similarity
Amino acid modifications
	Modified residue	7	1	Phosphoserine
	Modified residue	8	1	Phosphothreonine

Sequences

	Sequence		Length	Mass (Da)
	O95147-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 6AAFAE1B3A24F9AA	FASTA	198	22,255
	10 20 30 40 50 60 MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT 70 80 90 100 110 120 IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT 130 140 150 160 170 180 LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI 190 VPDVYEKESR HLMPYWGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MKP-L, a novel MKP-1 like protein tyrosine phosphatase." Yuan Y., Suphapeetiporn K., Sun H. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6." Marti F., Krause A., Post N.H., Lyddane C., Dupont B., Sadelain M., King P.D. J. Immunol. 166:197-206(2001) [PubMed: 11123293] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND THR-8, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF038844 mRNA. Translation: AAD02105.1.
AF120032 mRNA. Translation: AAF28861.1.
BC000370 mRNA. Translation: AAH00370.1.
BC001894 mRNA. Translation: AAH01894.1.
BC004448 mRNA. Translation: AAH04448.1.

IPI

IPI00013031.

RefSeq

NP_008957.1.

UniGene

Hs.91448

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WGP	X-ray	1.88	A/B	2-191	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

O95147.

PTM databases

PhosphoSite

O95147.

Proteomic databases

PeptideAtlas

O95147.

PRIDE

O95147.

Genome annotation databases

Ensembl

ENST00000292964; ENSP00000292964; ENSG00000161326; Homo sapiens. [Genome view]
ENST00000394386; ENSP00000377910; ENSG00000161326; Homo sapiens. [Genome view]
ENST00000394389; ENSP00000377912; ENSG00000161326; Homo sapiens. [Genome view]

GeneID

11072.

KEGG

hsa:11072.

UCSC

uc002hnx.2. human.

Organism-specific databases

CTD

11072.

GeneCards

GC17P032924.

H-InvDB

HIX0013746.

HGNC

HGNC:17007. DUSP14.

HPA

HPA019911.

MIM

606618. gene.

PharmGKB

PA27523.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG15835.

HOGENOM

HBG717377.

HOVERGEN

O95147.

InParanoid

O95147.

OMA

PYGVVPD.

OrthoDB

EOG90043R.

PhylomeDB

O95147.

Enzyme and pathway databases

BRENDA

3.1.3.16. 247.
3.1.3.48. 247.

Gene expression databases

ArrayExpress

O95147.

Bgee

O95147.

CleanEx

HS_DUSP14.

Genevestigator

O95147.

GermOnline

ENSG00000161326. Homo sapiens.

Family and domain databases

InterPro

IPR000387. Dual-sp/Tyr_phosphatase.
IPR020417. Dual-sp_phosphatase.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020420. Dual-sp_phosphatase_famB.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR016130. Tyr_Pase_AS.
[Graphical view]

Pfam

PF00782. DSPc. 1 hit.
[Graphical view]

PRINTS

PR01908. ADSPHPHTASE.
PR01910. ADSPHPHTASEB.

SMART

SM00195. DSPc. 1 hit.
[Graphical view]

PROSITE

PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

42090.

SOURCE

Search...

Entry information

Entry name

DUS14_HUMAN

Accession

Primary (citable) accession number: O95147

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 1, 1999
Last modified:	February 9, 2010
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.