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Protein

Sphingosine 1-phosphate receptor 2

Gene

S1PR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • G-protein coupled receptor binding Source: UniProtKB
  • integrin binding Source: UniProtKB
  • lipid binding Source: ProtInc
  • sphingosine-1-phosphate receptor activity Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • activation of MAPK activity Source: ProtInc
  • filopodium assembly Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • negative regulation of excitatory postsynaptic potential Source: Ensembl
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of establishment of endothelial barrier Source: UniProtKB
  • positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
  • sphingosine-1-phosphate signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiO95136.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 2
Short name:
S1P receptor 2
Short name:
S1P2
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 5
Sphingosine 1-phosphate receptor Edg-5
Short name:
S1P receptor Edg-5
Gene namesi
Name:S1PR2
Synonyms:EDG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3169. S1PR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularBy similarityAdd
BLAST
Transmembranei35 – 5925Helical; Name=1By similarityAdd
BLAST
Topological domaini60 – 667CytoplasmicBy similarity
Transmembranei67 – 9529Helical; Name=2By similarityAdd
BLAST
Topological domaini96 – 10914ExtracellularBy similarityAdd
BLAST
Transmembranei110 – 12819Helical; Name=3By similarityAdd
BLAST
Topological domaini129 – 14719CytoplasmicBy similarityAdd
BLAST
Transmembranei148 – 17326Helical; Name=4By similarityAdd
BLAST
Topological domaini174 – 18916ExtracellularBy similarityAdd
BLAST
Transmembranei190 – 21021Helical; Name=5By similarityAdd
BLAST
Topological domaini211 – 23323CytoplasmicBy similarityAdd
BLAST
Transmembranei234 – 25522Helical; Name=6By similarityAdd
BLAST
Topological domaini256 – 27116ExtracellularBy similarityAdd
BLAST
Transmembranei272 – 29221Helical; Name=7By similarityAdd
BLAST
Topological domaini293 – 35361CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402353.

Chemistry

ChEMBLiCHEMBL2363041.
GuidetoPHARMACOLOGYi276.

Polymorphism and mutation databases

BioMutaiS1PR2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Sphingosine 1-phosphate receptor 2PRO_0000069427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Lipidationi305 – 3051S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95136.
PRIDEiO95136.

PTM databases

iPTMnetiO95136.
PhosphoSiteiO95136.

Expressioni

Gene expression databases

BgeeiO95136.
CleanExiHS_S1PR2.
ExpressionAtlasiO95136. baseline and differential.
GenevisibleiO95136. HS.

Organism-specific databases

HPAiHPA014307.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB4P161442EBI-10634606,EBI-948678

GO - Molecular functioni

  • G-protein coupled receptor binding Source: UniProtKB
  • integrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114708. 20 interactions.
DIPiDIP-60682N.
IntActiO95136. 2 interactions.
STRINGi9606.ENSP00000466933.

Chemistry

BindingDBiO95136.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZTImodel-A1-353[»]
ProteinModelPortaliO95136.
SMRiO95136. Positions 6-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHTX. Eukaryota.
ENOG41100F8. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiO95136.
KOiK04292.
OMAiDYACPVR.
PhylomeDBiO95136.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLYSEYLN PNKVQEHYNY TKETLETQET TSRQVASAFI VILCCAIVVE
60 70 80 90 100
NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGSVTLRL
110 120 130 140 150
TPVQWFAREG SAFITLSASV FSLLAIAIER HVAIAKVKLY GSDKSCRMLL
160 170 180 190 200
LIGASWLISL VLGGLPILGW NCLGHLEACS TVLPLYAKHY VLCVVTIFSI
210 220 230 240 250
ILLAIVALYV RIYCVVRSSH ADMAAPQTLA LLKTVTIVLG VFIVCWLPAF
260 270 280 290 300
SILLLDYACP VHSCPILYKA HYFFAVSTLN SLLNPVIYTW RSRDLRREVL
310 320 330 340 350
RPLQCWRPGV GVQGRRRGGT PGHHLLPLRS SSSLERGMHM PTSPTFLEGN

TVV
Length:353
Mass (Da):38,867
Last modified:November 7, 2003 - v2
Checksum:i8E37084284ABF7E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131F → S in AAC98919 (PubMed:10617617).Curated
Sequence conflicti318 – 3181G → V in AAC98919 (PubMed:10617617).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034780 mRNA. Translation: AAC98919.1.
AY262688 Genomic DNA. Translation: AAP20652.1.
BC069598 mRNA. Translation: AAH69598.1.
CCDSiCCDS12229.1.
RefSeqiNP_004221.3. NM_004230.3.
UniGeneiHs.655405.

Genome annotation databases

EnsembliENST00000590320; ENSP00000466933; ENSG00000267534.
GeneIDi9294.
KEGGihsa:9294.
UCSCiuc002mnl.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034780 mRNA. Translation: AAC98919.1.
AY262688 Genomic DNA. Translation: AAP20652.1.
BC069598 mRNA. Translation: AAH69598.1.
CCDSiCCDS12229.1.
RefSeqiNP_004221.3. NM_004230.3.
UniGeneiHs.655405.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZTImodel-A1-353[»]
ProteinModelPortaliO95136.
SMRiO95136. Positions 6-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114708. 20 interactions.
DIPiDIP-60682N.
IntActiO95136. 2 interactions.
STRINGi9606.ENSP00000466933.

Chemistry

BindingDBiO95136.
ChEMBLiCHEMBL2363041.
GuidetoPHARMACOLOGYi276.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95136.
PhosphoSiteiO95136.

Polymorphism and mutation databases

BioMutaiS1PR2.

Proteomic databases

PaxDbiO95136.
PRIDEiO95136.

Protocols and materials databases

DNASUi9294.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000590320; ENSP00000466933; ENSG00000267534.
GeneIDi9294.
KEGGihsa:9294.
UCSCiuc002mnl.3. human.

Organism-specific databases

CTDi9294.
GeneCardsiS1PR2.
HGNCiHGNC:3169. S1PR2.
HPAiHPA014307.
MIMi605111. gene.
neXtProtiNX_O95136.
PharmGKBiPA162402353.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHTX. Eukaryota.
ENOG41100F8. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiO95136.
KOiK04292.
OMAiDYACPVR.
PhylomeDBiO95136.

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiO95136.

Miscellaneous databases

ChiTaRSiS1PR2. human.
GeneWikiiS1PR2.
GenomeRNAii9294.
PROiO95136.
SOURCEiSearch...

Gene expression databases

BgeeiO95136.
CleanExiHS_S1PR2.
ExpressionAtlasiO95136. baseline and differential.
GenevisibleiO95136. HS.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5."
    An S., Zheng Y., Bleu T.
    J. Biol. Chem. 275:288-296(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiS1PR2_HUMAN
AccessioniPrimary (citable) accession number: O95136
Secondary accession number(s): Q86UN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: June 8, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.