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Protein

Sphingosine 1-phosphate receptor 2

Gene

S1PR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • G-protein coupled receptor binding Source: UniProtKB
  • integrin binding Source: UniProtKB
  • lipid binding Source: ProtInc
  • sphingosine-1-phosphate receptor activity Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • activation of MAPK activity Source: ProtInc
  • filopodium assembly Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • negative regulation of excitatory postsynaptic potential Source: Ensembl
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of establishment of endothelial barrier Source: UniProtKB
  • positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
  • sphingosine-1-phosphate signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175898-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiO95136.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 2
Short name:
S1P receptor 2
Short name:
S1P2
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 5
Sphingosine 1-phosphate receptor Edg-5
Short name:
S1P receptor Edg-5
Gene namesi
Name:S1PR2
Synonyms:EDG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3169. S1PR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 59Helical; Name=1By similarityAdd BLAST25
Topological domaini60 – 66CytoplasmicBy similarity7
Transmembranei67 – 95Helical; Name=2By similarityAdd BLAST29
Topological domaini96 – 109ExtracellularBy similarityAdd BLAST14
Transmembranei110 – 128Helical; Name=3By similarityAdd BLAST19
Topological domaini129 – 147CytoplasmicBy similarityAdd BLAST19
Transmembranei148 – 173Helical; Name=4By similarityAdd BLAST26
Topological domaini174 – 189ExtracellularBy similarityAdd BLAST16
Transmembranei190 – 210Helical; Name=5By similarityAdd BLAST21
Topological domaini211 – 233CytoplasmicBy similarityAdd BLAST23
Transmembranei234 – 255Helical; Name=6By similarityAdd BLAST22
Topological domaini256 – 271ExtracellularBy similarityAdd BLAST16
Transmembranei272 – 292Helical; Name=7By similarityAdd BLAST21
Topological domaini293 – 353CytoplasmicBy similarityAdd BLAST61

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 68 (DFNB68)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:610419
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076391108R → P in DFNB68. 1 Publication1
Natural variantiVAR_076392140Y → C in DFNB68. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi9294.
MIMi610419. phenotype.
OpenTargetsiENSG00000267534.
PharmGKBiPA162402353.

Chemistry databases

ChEMBLiCHEMBL2955.
GuidetoPHARMACOLOGYi276.

Polymorphism and mutation databases

BioMutaiS1PR2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694271 – 353Sphingosine 1-phosphate receptor 2Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Lipidationi305S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

EPDiO95136.
PaxDbiO95136.
PeptideAtlasiO95136.
PRIDEiO95136.

PTM databases

iPTMnetiO95136.
PhosphoSitePlusiO95136.

Expressioni

Gene expression databases

BgeeiENSG00000267534.
CleanExiHS_S1PR2.
ExpressionAtlasiO95136. baseline and differential.
GenevisibleiO95136. HS.

Organism-specific databases

HPAiHPA014307.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB4P161442EBI-10634606,EBI-948678

GO - Molecular functioni

  • G-protein coupled receptor binding Source: UniProtKB
  • integrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114708. 20 interactors.
DIPiDIP-60682N.
IntActiO95136. 2 interactors.
STRINGi9606.ENSP00000466933.

Chemistry databases

BindingDBiO95136.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZTImodel-A1-353[»]
ProteinModelPortaliO95136.
SMRiO95136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHTX. Eukaryota.
ENOG41100F8. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiO95136.
KOiK04292.
OMAiDYACPVR.
OrthoDBiEOG091G0DD4.
PhylomeDBiO95136.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLYSEYLN PNKVQEHYNY TKETLETQET TSRQVASAFI VILCCAIVVE
60 70 80 90 100
NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGSVTLRL
110 120 130 140 150
TPVQWFAREG SAFITLSASV FSLLAIAIER HVAIAKVKLY GSDKSCRMLL
160 170 180 190 200
LIGASWLISL VLGGLPILGW NCLGHLEACS TVLPLYAKHY VLCVVTIFSI
210 220 230 240 250
ILLAIVALYV RIYCVVRSSH ADMAAPQTLA LLKTVTIVLG VFIVCWLPAF
260 270 280 290 300
SILLLDYACP VHSCPILYKA HYFFAVSTLN SLLNPVIYTW RSRDLRREVL
310 320 330 340 350
RPLQCWRPGV GVQGRRRGGT PGHHLLPLRS SSSLERGMHM PTSPTFLEGN

TVV
Length:353
Mass (Da):38,867
Last modified:November 7, 2003 - v2
Checksum:i8E37084284ABF7E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113F → S in AAC98919 (PubMed:10617617).Curated1
Sequence conflicti318G → V in AAC98919 (PubMed:10617617).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076391108R → P in DFNB68. 1 Publication1
Natural variantiVAR_076392140Y → C in DFNB68. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034780 mRNA. Translation: AAC98919.1.
AY262688 Genomic DNA. Translation: AAP20652.1.
BC069598 mRNA. Translation: AAH69598.1.
CCDSiCCDS12229.1.
RefSeqiNP_004221.3. NM_004230.3.
UniGeneiHs.655405.

Genome annotation databases

EnsembliENST00000590320; ENSP00000466933; ENSG00000267534.
GeneIDi9294.
KEGGihsa:9294.
UCSCiuc002mnl.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034780 mRNA. Translation: AAC98919.1.
AY262688 Genomic DNA. Translation: AAP20652.1.
BC069598 mRNA. Translation: AAH69598.1.
CCDSiCCDS12229.1.
RefSeqiNP_004221.3. NM_004230.3.
UniGeneiHs.655405.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZTImodel-A1-353[»]
ProteinModelPortaliO95136.
SMRiO95136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114708. 20 interactors.
DIPiDIP-60682N.
IntActiO95136. 2 interactors.
STRINGi9606.ENSP00000466933.

Chemistry databases

BindingDBiO95136.
ChEMBLiCHEMBL2955.
GuidetoPHARMACOLOGYi276.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95136.
PhosphoSitePlusiO95136.

Polymorphism and mutation databases

BioMutaiS1PR2.

Proteomic databases

EPDiO95136.
PaxDbiO95136.
PeptideAtlasiO95136.
PRIDEiO95136.

Protocols and materials databases

DNASUi9294.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000590320; ENSP00000466933; ENSG00000267534.
GeneIDi9294.
KEGGihsa:9294.
UCSCiuc002mnl.3. human.

Organism-specific databases

CTDi9294.
DisGeNETi9294.
GeneCardsiS1PR2.
HGNCiHGNC:3169. S1PR2.
HPAiHPA014307.
MIMi605111. gene.
610419. phenotype.
neXtProtiNX_O95136.
OpenTargetsiENSG00000267534.
PharmGKBiPA162402353.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHTX. Eukaryota.
ENOG41100F8. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiO95136.
KOiK04292.
OMAiDYACPVR.
OrthoDBiEOG091G0DD4.
PhylomeDBiO95136.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175898-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiO95136.

Miscellaneous databases

ChiTaRSiS1PR2. human.
GeneWikiiS1PR2.
GenomeRNAii9294.
PROiO95136.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000267534.
CleanExiHS_S1PR2.
ExpressionAtlasiO95136. baseline and differential.
GenevisibleiO95136. HS.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR2_HUMAN
AccessioniPrimary (citable) accession number: O95136
Secondary accession number(s): Q86UN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.