Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O95136 (S1PR2_HUMAN)

Last modified June 16, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Sphingosine 1-phosphate receptor 2
      Short name=S1P receptor 2
      Short name=S1P2
Alternative name(s):
    Sphingosine 1-phosphate receptor Edg-5
      Short name=S1P receptor Edg-5
    Endothelial differentiation G-protein coupled receptor 5
Gene names
Name: S1PR2
Synonyms: EDG5
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Sphingosine 1-phosphate receptor 2
PRO_0000069427

Regions

Topological domain1 – 3434Extracellular By similarity
Transmembrane35 – 59251 By similarity
Topological domain60 – 667Cytoplasmic By similarity
Transmembrane67 – 95292 By similarity
Topological domain96 – 10914Extracellular By similarity
Transmembrane110 – 128193 By similarity
Topological domain129 – 14719Cytoplasmic By similarity
Transmembrane148 – 173264 By similarity
Topological domain174 – 18916Extracellular By similarity
Transmembrane190 – 210215 By similarity
Topological domain211 – 23323Cytoplasmic By similarity
Transmembrane234 – 255226 By similarity
Topological domain256 – 27116Extracellular By similarity
Transmembrane272 – 292217 By similarity
Topological domain293 – 35361Cytoplasmic By similarity

Amino acid modifications

Modified residue3331Phosphoserine By similarity
Lipidation3051S-palmitoyl cysteine By similarity
Glycosylation191N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1131F → S in AAC98919. Ref.1
Sequence conflict3181G → V in AAC98919. Ref.1

Secondary structure

1 ............................................. 353
Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
O95136-1 [UniParc].

Last modified November 7, 2003. Version 2.
Checksum: 8E37084284ABF7E8

FASTA35338,867
        10         20         30         40         50         60 
MGSLYSEYLN PNKVQEHYNY TKETLETQET TSRQVASAFI VILCCAIVVE NLLVLIAVAR 

        70         80         90        100        110        120 
NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGSVTLRL TPVQWFAREG SAFITLSASV 

       130        140        150        160        170        180 
FSLLAIAIER HVAIAKVKLY GSDKSCRMLL LIGASWLISL VLGGLPILGW NCLGHLEACS 

       190        200        210        220        230        240 
TVLPLYAKHY VLCVVTIFSI ILLAIVALYV RIYCVVRSSH ADMAAPQTLA LLKTVTIVLG 

       250        260        270        280        290        300 
VFIVCWLPAF SILLLDYACP VHSCPILYKA HYFFAVSTLN SLLNPVIYTW RSRDLRREVL 

       310        320        330        340        350 
RPLQCWRPGV GVQGRRRGGT PGHHLLPLRS SSSLERGMHM PTSPTFLEGN TVV

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5."
An S., Zheng Y., Bleu T.
J. Biol. Chem. 275:288-296(2000) [PubMed: 10617617] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AF034780 mRNA. Translation: AAC98919.1.
AY262688 Genomic DNA. Translation: AAP20652.1.
BC069598 mRNA. Translation: AAH69598.1.
IPIIPI00003501.
RefSeqNP_004221.3.
UniGeneHs.655405

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1ZTImodel-A1-353[»]
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEO95136.

Genome annotation databases

EnsemblENSG00000175898. Homo sapiens. [Contig view]
GeneID9294.
KEGGhsa:9294.

Organism-specific databases

GeneCardsGC19M010193.
H-InvDBHIX0039949.
HGNCHGNC:3169. S1PR2.
HPAHPA014307.
MIM605111. gene.
PharmGKBPA27609.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO95136.
HOVERGENO95136.
OMAO95136. REGSAFI.

Enzyme and pathway databases

Pathway_Interaction_DBs1p_s1p2_pathway. S1P2 pathway.
s1p_s1p3_pathway. S1P3 pathway.
s1p_meta_pathway. Sphingosine 1-phosphate (S1P) pathway.

Gene expression databases

ArrayExpressO95136.
BgeeO95136.
CleanExHS_S1PR2.
GermOnlineENSG00000175898. Homo sapiens.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR004063. EDG5_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERPTHR22750:SF17. EDG5_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio34823.
SOURCESearch...

Hide | Top

Entry information

Entry nameS1PR2_HUMAN
AccessionPrimary (citable) accession number: O95136
Secondary accession number(s): Q86UN8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents