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O95125

- ZN202_HUMAN

UniProt

O95125 - ZN202_HUMAN

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Protein

Zinc finger protein 202

Gene

ZNF202

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri397 – 41923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. lipid metabolic process Source: ProtInc
  2. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  3. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.
SignaLinkiO95125.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 202
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 10
Gene namesi
Name:ZNF202
Synonyms:ZKSCAN10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:12994. ZNF202.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37574.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Zinc finger protein 202PRO_0000047450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei466 – 4661Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95125.
PaxDbiO95125.
PRIDEiO95125.

PTM databases

PhosphoSiteiO95125.

Expressioni

Tissue specificityi

Highly expressed in testis. Also expressed in breast carcinoma cell lines.

Gene expression databases

BgeeiO95125.
CleanExiHS_ZNF202.
ExpressionAtlasiO95125. baseline and differential.
GenevestigatoriO95125.

Interactioni

Subunit structurei

Interacts with SDP1.

Protein-protein interaction databases

BioGridi113537. 4 interactions.
IntActiO95125. 2 interactions.
MINTiMINT-1485656.
STRINGi9606.ENSP00000337724.

Structurei

3D structure databases

ProteinModelPortaliO95125.
SMRiO95125. Positions 39-128, 397-644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 12782SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini237 – 30872KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri397 – 41923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117556.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiO95125.
KOiK09229.
OMAiWVPDIQE.
OrthoDBiEOG7J9VP1.
PhylomeDBiO95125.
TreeFamiTF350829.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Beta (identifier: O95125-1) [UniParc]FASTAAdd to Basket

Also known as: 2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR
60 70 80 90 100
RFRYQEAASP REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG
110 120 130 140 150
ELQSWVRGQR PESGEEAVTL VEGLQKQPRR PRRWVTVHVH GQEVLSEETV
160 170 180 190 200
HLGVEPESPN ELQDPVQSST PEQSPEETTQ SPDLGAPAEQ RPHQEEELQT
210 220 230 240 250
LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK DVAVCFSQDQ
260 270 280 290 300
WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI
310 320 330 340 350
QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ
360 370 380 390 400
TPDWEIVFED NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS
410 420 430 440 450
VCGKSFTCNS HLVRHLRTHT GEKPYKCMEC GKSYTRSSHL ARHQKVHKMN
460 470 480 490 500
APYKYPLNRK NLEETSPVTQ AERTPSVEKP YRCDDCGKHF RWTSDLVRHQ
510 520 530 540 550
RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG ECGEDFSEHR
560 570 580 590 600
RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK
610 620 630 640
SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS
Length:648
Mass (Da):74,720
Last modified:May 16, 2006 - v4
Checksum:iE738506D71DAFAE9
GO
Isoform Alpha (identifier: O95125-2) [UniParc]FASTAAdd to Basket

Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.

Show »
Length:424
Mass (Da):48,952
Checksum:i843C23B240D19DF0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151E → P in CAB82384. (PubMed:17974005)Curated
Sequence conflicti205 – 2051Missing in CAC21447. 1 PublicationCurated
Sequence conflicti278 – 2781S → AA1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541V → A.5 Publications
Corresponds to variant rs1144507 [ dbSNP | Ensembl ].
VAR_007818
Natural varianti533 – 5331G → A.1 Publication
Corresponds to variant rs34111365 [ dbSNP | Ensembl ].
VAR_023975

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 224224Missing in isoform Alpha. 1 PublicationVSP_006902Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027219 mRNA. Translation: AAC79941.1.
AF027218 mRNA. Translation: AAC79940.1.
AJ276177
, AJ276178, AJ276179, AJ276180, AJ276181, AJ276182 Genomic DNA. Translation: CAC21447.1.
DQ093962 Genomic DNA. Translation: AAY88738.1.
EU332869 Genomic DNA. Translation: ABY87558.1.
BC013382 mRNA. Translation: AAH13382.1.
AL162031 mRNA. Translation: CAB82384.1.
CCDSiCCDS8443.1. [O95125-1]
PIRiT47156.
RefSeqiNP_003446.2. NM_003455.2. [O95125-1]
XP_005271716.1. XM_005271659.1. [O95125-1]
XP_005271717.1. XM_005271660.1. [O95125-1]
XP_005271718.1. XM_005271661.1. [O95125-1]
XP_005271719.1. XM_005271662.1. [O95125-1]
XP_005271720.1. XM_005271663.2. [O95125-1]
XP_005271721.1. XM_005271664.1. [O95125-2]
XP_006718963.1. XM_006718900.1. [O95125-1]
XP_006718964.1. XM_006718901.1. [O95125-1]
XP_006718965.1. XM_006718902.1. [O95125-1]
UniGeneiHs.112556.

Genome annotation databases

EnsembliENST00000336139; ENSP00000337724; ENSG00000166261. [O95125-1]
ENST00000529691; ENSP00000433881; ENSG00000166261. [O95125-1]
ENST00000530393; ENSP00000432504; ENSG00000166261. [O95125-1]
GeneIDi7753.
KEGGihsa:7753.
UCSCiuc001pzc.1. human. [O95125-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027219 mRNA. Translation: AAC79941.1 .
AF027218 mRNA. Translation: AAC79940.1 .
AJ276177
, AJ276178 , AJ276179 , AJ276180 , AJ276181 , AJ276182 Genomic DNA. Translation: CAC21447.1 .
DQ093962 Genomic DNA. Translation: AAY88738.1 .
EU332869 Genomic DNA. Translation: ABY87558.1 .
BC013382 mRNA. Translation: AAH13382.1 .
AL162031 mRNA. Translation: CAB82384.1 .
CCDSi CCDS8443.1. [O95125-1 ]
PIRi T47156.
RefSeqi NP_003446.2. NM_003455.2. [O95125-1 ]
XP_005271716.1. XM_005271659.1. [O95125-1 ]
XP_005271717.1. XM_005271660.1. [O95125-1 ]
XP_005271718.1. XM_005271661.1. [O95125-1 ]
XP_005271719.1. XM_005271662.1. [O95125-1 ]
XP_005271720.1. XM_005271663.2. [O95125-1 ]
XP_005271721.1. XM_005271664.1. [O95125-2 ]
XP_006718963.1. XM_006718900.1. [O95125-1 ]
XP_006718964.1. XM_006718901.1. [O95125-1 ]
XP_006718965.1. XM_006718902.1. [O95125-1 ]
UniGenei Hs.112556.

3D structure databases

ProteinModelPortali O95125.
SMRi O95125. Positions 39-128, 397-644.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113537. 4 interactions.
IntActi O95125. 2 interactions.
MINTi MINT-1485656.
STRINGi 9606.ENSP00000337724.

PTM databases

PhosphoSitei O95125.

Proteomic databases

MaxQBi O95125.
PaxDbi O95125.
PRIDEi O95125.

Protocols and materials databases

DNASUi 7753.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336139 ; ENSP00000337724 ; ENSG00000166261 . [O95125-1 ]
ENST00000529691 ; ENSP00000433881 ; ENSG00000166261 . [O95125-1 ]
ENST00000530393 ; ENSP00000432504 ; ENSG00000166261 . [O95125-1 ]
GeneIDi 7753.
KEGGi hsa:7753.
UCSCi uc001pzc.1. human. [O95125-1 ]

Organism-specific databases

CTDi 7753.
GeneCardsi GC11M123594.
HGNCi HGNC:12994. ZNF202.
MIMi 603430. gene.
neXtProti NX_O95125.
PharmGKBi PA37574.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00750000117556.
HOGENOMi HOG000234619.
HOVERGENi HBG018163.
InParanoidi O95125.
KOi K09229.
OMAi WVPDIQE.
OrthoDBi EOG7J9VP1.
PhylomeDBi O95125.
TreeFami TF350829.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.
SignaLinki O95125.

Miscellaneous databases

ChiTaRSi ZNF202. human.
GeneWikii ZNF202.
GenomeRNAii 7753.
NextBioi 30008.
PROi O95125.
SOURCEi Search...

Gene expression databases

Bgeei O95125.
CleanExi HS_ZNF202.
ExpressionAtlasi O95125. baseline and differential.
Genevestigatori O95125.

Family and domain databases

Gene3Di 3.30.160.60. 8 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
Pfami PF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins."
    Monaco C., Helmer Citterich M., Caprini E., Vorechovsky I., Russo G., Croce C.M., Barbanti-Brodano G., Negrini M.
    Genomics 52:358-362(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), VARIANT ALA-154.
    Tissue: Testis.
  2. "Genomic sequence analysis of the ZNF202 gene: relevance for lipid parameters."
    Langmann T., Porsch-Oezcueruemez M., Heimerl S., Andrikovics H., Schmitz G.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-154.
  3. SeattleSNPs variation discovery resource
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-154 AND ALA-533.
  4. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-154.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA), VARIANT ALA-154.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-648 (ISOFORM BETA).
    Tissue: Mammary cancer.
  7. Cited for: CHARACTERIZATION.
  8. "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux."
    Porsch-Oezcueruemez M., Langmann T., Heimerl S., Borsukova H., Kaminski W.E., Drobnik W., Honer C., Schumacher C., Schmitz G.
    J. Biol. Chem. 276:12427-12433(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN202_HUMAN
AccessioniPrimary (citable) accession number: O95125
Secondary accession number(s): B0LPH9
, Q4JG21, Q9H1B9, Q9NSM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3