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Protein

Zinc finger protein 202

Gene

ZNF202

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri397 – 419C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • lipid metabolic process Source: ProtInc
  • negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.
SignaLinkiO95125.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 202
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 10
Gene namesi
Name:ZNF202
Synonyms:ZKSCAN10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12994. ZNF202.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7753.
OpenTargetsiENSG00000166261.
PharmGKBiPA37574.

Polymorphism and mutation databases

BioMutaiZNF202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474501 – 648Zinc finger protein 202Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki454Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki460Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei466PhosphoserineCombined sources1
Cross-linki507Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki521Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO95125.
MaxQBiO95125.
PaxDbiO95125.
PeptideAtlasiO95125.
PRIDEiO95125.

PTM databases

iPTMnetiO95125.
PhosphoSitePlusiO95125.

Expressioni

Tissue specificityi

Highly expressed in testis. Also expressed in breast carcinoma cell lines.

Gene expression databases

BgeeiENSG00000166261.
CleanExiHS_ZNF202.
ExpressionAtlasiO95125. baseline and differential.
GenevisibleiO95125. HS.

Organism-specific databases

HPAiHPA061946.

Interactioni

Subunit structurei

Interacts with SDP1.

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1625EBI-751960,EBI-10171697

Protein-protein interaction databases

BioGridi113537. 13 interactors.
IntActiO95125. 11 interactors.
MINTiMINT-1485656.
STRINGi9606.ENSP00000337724.

Structurei

3D structure databases

ProteinModelPortaliO95125.
SMRiO95125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 127SCAN boxPROSITE-ProRule annotationAdd BLAST82
Domaini237 – 308KRABPROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri397 – 419C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiO95125.
KOiK09229.
OMAiEDQDLWE.
OrthoDBiEOG091G034X.
PhylomeDBiO95125.
TreeFamiTF350829.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 3 hits.
InterProiView protein in InterPro
IPR027775. C2H2_Znf_fam_sub.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: O95125-1) [UniParc]FASTAAdd to basket
Also known as: 2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR
60 70 80 90 100
RFRYQEAASP REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG
110 120 130 140 150
ELQSWVRGQR PESGEEAVTL VEGLQKQPRR PRRWVTVHVH GQEVLSEETV
160 170 180 190 200
HLGVEPESPN ELQDPVQSST PEQSPEETTQ SPDLGAPAEQ RPHQEEELQT
210 220 230 240 250
LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK DVAVCFSQDQ
260 270 280 290 300
WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI
310 320 330 340 350
QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ
360 370 380 390 400
TPDWEIVFED NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS
410 420 430 440 450
VCGKSFTCNS HLVRHLRTHT GEKPYKCMEC GKSYTRSSHL ARHQKVHKMN
460 470 480 490 500
APYKYPLNRK NLEETSPVTQ AERTPSVEKP YRCDDCGKHF RWTSDLVRHQ
510 520 530 540 550
RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG ECGEDFSEHR
560 570 580 590 600
RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK
610 620 630 640
SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS
Length:648
Mass (Da):74,720
Last modified:May 16, 2006 - v4
Checksum:iE738506D71DAFAE9
GO
Isoform Alpha (identifier: O95125-2) [UniParc]FASTAAdd to basket
Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.

Show »
Length:424
Mass (Da):48,952
Checksum:i843C23B240D19DF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15E → P in CAB82384 (PubMed:17974005).Curated1
Sequence conflicti205Missing in CAC21447 (Ref. 2) Curated1
Sequence conflicti278S → AA (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007818154V → A5 PublicationsCorresponds to variant dbSNP:rs1144507Ensembl.1
Natural variantiVAR_023975533G → A1 PublicationCorresponds to variant dbSNP:rs34111365Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0069021 – 224Missing in isoform Alpha. 1 PublicationAdd BLAST224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027219 mRNA. Translation: AAC79941.1.
AF027218 mRNA. Translation: AAC79940.1.
AJ276177
, AJ276178, AJ276179, AJ276180, AJ276181, AJ276182 Genomic DNA. Translation: CAC21447.1.
DQ093962 Genomic DNA. Translation: AAY88738.1.
EU332869 Genomic DNA. Translation: ABY87558.1.
BC013382 mRNA. Translation: AAH13382.1.
AL162031 mRNA. Translation: CAB82384.1.
CCDSiCCDS8443.1. [O95125-1]
PIRiT47156.
RefSeqiNP_001288708.1. NM_001301779.1. [O95125-1]
NP_001288709.1. NM_001301780.1. [O95125-1]
NP_001288748.1. NM_001301819.1. [O95125-2]
NP_003446.2. NM_003455.3. [O95125-1]
XP_005271716.1. XM_005271659.1. [O95125-1]
XP_005271717.1. XM_005271660.1. [O95125-1]
XP_005271718.1. XM_005271661.1. [O95125-1]
XP_005271721.1. XM_005271664.1. [O95125-2]
XP_006718964.1. XM_006718901.2. [O95125-1]
XP_011541274.1. XM_011542972.1. [O95125-1]
XP_011541275.1. XM_011542973.1. [O95125-1]
XP_011541277.1. XM_011542975.1. [O95125-1]
XP_011541278.1. XM_011542976.1. [O95125-2]
XP_016873757.1. XM_017018268.1. [O95125-1]
UniGeneiHs.112556.

Genome annotation databases

EnsembliENST00000336139; ENSP00000337724; ENSG00000166261. [O95125-1]
ENST00000529691; ENSP00000433881; ENSG00000166261. [O95125-1]
ENST00000530393; ENSP00000432504; ENSG00000166261. [O95125-1]
GeneIDi7753.
KEGGihsa:7753.
UCSCiuc001pzd.2. human. [O95125-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN202_HUMAN
AccessioniPrimary (citable) accession number: O95125
Secondary accession number(s): B0LPH9
, Q4JG21, Q9H1B9, Q9NSM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 16, 2006
Last modified: August 30, 2017
This is version 167 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot