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O95125 (ZN202_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 202
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 10
Gene names
Name:ZNF202
Synonyms:ZKSCAN10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease. Ref.8

Subunit structure

Interacts with SDP1.

Subcellular location

Nucleus.

Tissue specificity

Highly expressed in testis. Also expressed in breast carcinoma cell lines.

Sequence similarities

Contains 8 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Contains 1 SCAN box domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Beta (identifier: O95125-1)

Also known as: 2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Alpha (identifier: O95125-2)

Also known as: 1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 648648Zinc finger protein 202
PRO_0000047450

Regions

Domain46 – 12782SCAN box
Domain237 – 30872KRAB
Zinc finger397 – 41923C2H2-type 1
Zinc finger425 – 44723C2H2-type 2
Zinc finger481 – 50323C2H2-type 3
Zinc finger509 – 53123C2H2-type 4
Zinc finger537 – 55923C2H2-type 5
Zinc finger565 – 58723C2H2-type 6
Zinc finger593 – 61523C2H2-type 7
Zinc finger621 – 64323C2H2-type 8

Amino acid modifications

Modified residue4661Phosphoserine Ref.9

Natural variations

Alternative sequence1 – 224224Missing in isoform Alpha.
VSP_006902
Natural variant1541V → A. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5
Corresponds to variant rs1144507 [ dbSNP | Ensembl ].
VAR_007818
Natural variant5331G → A. Ref.3
Corresponds to variant rs34111365 [ dbSNP | Ensembl ].
VAR_023975

Experimental info

Sequence conflict151E → P in CAB82384. Ref.6
Sequence conflict2051Missing in CAC21447. Ref.2
Sequence conflict2781S → AA Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform Beta (2) [UniParc].

Last modified May 16, 2006. Version 4.
Checksum: E738506D71DAFAE9

FASTA64874,720
        10         20         30         40         50         60 
MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR RFRYQEAASP 

        70         80         90        100        110        120 
REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG ELQSWVRGQR PESGEEAVTL 

       130        140        150        160        170        180 
VEGLQKQPRR PRRWVTVHVH GQEVLSEETV HLGVEPESPN ELQDPVQSST PEQSPEETTQ 

       190        200        210        220        230        240 
SPDLGAPAEQ RPHQEEELQT LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK 

       250        260        270        280        290        300 
DVAVCFSQDQ WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI 

       310        320        330        340        350        360 
QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ TPDWEIVFED 

       370        380        390        400        410        420 
NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS VCGKSFTCNS HLVRHLRTHT 

       430        440        450        460        470        480 
GEKPYKCMEC GKSYTRSSHL ARHQKVHKMN APYKYPLNRK NLEETSPVTQ AERTPSVEKP 

       490        500        510        520        530        540 
YRCDDCGKHF RWTSDLVRHQ RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG 

       550        560        570        580        590        600 
ECGEDFSEHR RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK 

       610        620        630        640 
SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS 

« Hide

Isoform Alpha (1) [UniParc].

Checksum: 843C23B240D19DF0
Show »

FASTA42448,952

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins."
Monaco C., Helmer Citterich M., Caprini E., Vorechovsky I., Russo G., Croce C.M., Barbanti-Brodano G., Negrini M.
Genomics 52:358-362(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), VARIANT ALA-154.
Tissue: Testis.
[2]"Genomic sequence analysis of the ZNF202 gene: relevance for lipid parameters."
Langmann T., Porsch-Oezcueruemez M., Heimerl S., Andrikovics H., Schmitz G.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-154.
[3]SeattleSNPs variation discovery resource
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-154 AND ALA-533.
[4]NHLBI resequencing and genotyping service (RS&G)
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-154.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA), VARIANT ALA-154.
Tissue: Brain.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-648 (ISOFORM BETA).
Tissue: Mammary cancer.
[7]"A broad role for the zinc finger protein ZNF202 in human lipid metabolism."
Wagner S., Hess M.A., Ormonde-Hanson P., Malandro J., Hu H., Chen M., Kehrer R., Frodsham M., Schumacher C., Beluch M., Honer C., Skolnick M., Ballinger D., Bowen B.R.
J. Biol. Chem. 275:15685-15690(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[8]"The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux."
Porsch-Oezcueruemez M., Langmann T., Heimerl S., Borsukova H., Kaminski W.E., Drobnik W., Honer C., Schumacher C., Schmitz G.
J. Biol. Chem. 276:12427-12433(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION.
[9]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF027219 mRNA. Translation: AAC79941.1.
AF027218 mRNA. Translation: AAC79940.1.
AJ276177 expand/collapse EMBL AC list , AJ276178, AJ276179, AJ276180, AJ276181, AJ276182 Genomic DNA. Translation: CAC21447.1.
DQ093962 Genomic DNA. Translation: AAY88738.1.
EU332869 Genomic DNA. Translation: ABY87558.1.
BC013382 mRNA. Translation: AAH13382.1.
AL162031 mRNA. Translation: CAB82384.1.
CCDSCCDS8443.1. [O95125-1]
PIRT47156.
RefSeqNP_003446.2. NM_003455.2. [O95125-1]
XP_005271716.1. XM_005271659.1. [O95125-1]
XP_005271717.1. XM_005271660.1. [O95125-1]
XP_005271718.1. XM_005271661.1. [O95125-1]
XP_005271719.1. XM_005271662.1. [O95125-1]
XP_005271720.1. XM_005271663.2. [O95125-1]
XP_005271721.1. XM_005271664.1. [O95125-2]
XP_006718963.1. XM_006718900.1. [O95125-1]
XP_006718964.1. XM_006718901.1. [O95125-1]
XP_006718965.1. XM_006718902.1. [O95125-1]
UniGeneHs.112556.

3D structure databases

ProteinModelPortalO95125.
SMRO95125. Positions 39-128, 397-644.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113537. 4 interactions.
IntActO95125. 2 interactions.
MINTMINT-1485656.
STRING9606.ENSP00000337724.

PTM databases

PhosphoSiteO95125.

Proteomic databases

MaxQBO95125.
PaxDbO95125.
PRIDEO95125.

Protocols and materials databases

DNASU7753.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336139; ENSP00000337724; ENSG00000166261. [O95125-1]
ENST00000529691; ENSP00000433881; ENSG00000166261. [O95125-1]
ENST00000530393; ENSP00000432504; ENSG00000166261. [O95125-1]
GeneID7753.
KEGGhsa:7753.
UCSCuc001pzc.1. human. [O95125-1]

Organism-specific databases

CTD7753.
GeneCardsGC11M123594.
HGNCHGNC:12994. ZNF202.
MIM603430. gene.
neXtProtNX_O95125.
PharmGKBPA37574.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234619.
HOVERGENHBG018163.
InParanoidO95125.
KOK09229.
OMAWVPDIQE.
OrthoDBEOG7J9VP1.
PhylomeDBO95125.
TreeFamTF350829.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.
SignaLinkO95125.

Gene expression databases

ArrayExpressO95125.
BgeeO95125.
CleanExHS_ZNF202.
GenevestigatorO95125.

Family and domain databases

Gene3D3.30.160.60. 8 hits.
InterProIPR027775. C2H2_Znf_fam.
IPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERPTHR10032. PTHR10032. 1 hit.
PfamPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF202. human.
GeneWikiZNF202.
GenomeRNAi7753.
NextBio30008.
PROO95125.
SOURCESearch...

Entry information

Entry nameZN202_HUMAN
AccessionPrimary (citable) accession number: O95125
Secondary accession number(s): B0LPH9 expand/collapse secondary AC list , Q4JG21, Q9H1B9, Q9NSM4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM