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O95125

- ZN202_HUMAN

UniProt

O95125 - ZN202_HUMAN

Protein

Zinc finger protein 202

Gene

ZNF202

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 4 (16 May 2006)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri397 – 41923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri425 – 44723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri481 – 50323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri509 – 53123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri537 – 55923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri565 – 58723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri593 – 61523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri621 – 64323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. lipid metabolic process Source: ProtInc
    2. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
    3. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.
    SignaLinkiO95125.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 202
    Alternative name(s):
    Zinc finger protein with KRAB and SCAN domains 10
    Gene namesi
    Name:ZNF202
    Synonyms:ZKSCAN10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:12994. ZNF202.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37574.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 648648Zinc finger protein 202PRO_0000047450Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei466 – 4661Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95125.
    PaxDbiO95125.
    PRIDEiO95125.

    PTM databases

    PhosphoSiteiO95125.

    Expressioni

    Tissue specificityi

    Highly expressed in testis. Also expressed in breast carcinoma cell lines.

    Gene expression databases

    ArrayExpressiO95125.
    BgeeiO95125.
    CleanExiHS_ZNF202.
    GenevestigatoriO95125.

    Interactioni

    Subunit structurei

    Interacts with SDP1.

    Protein-protein interaction databases

    BioGridi113537. 4 interactions.
    IntActiO95125. 2 interactions.
    MINTiMINT-1485656.
    STRINGi9606.ENSP00000337724.

    Structurei

    3D structure databases

    ProteinModelPortaliO95125.
    SMRiO95125. Positions 39-128, 397-644.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 12782SCAN boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini237 – 30872KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri397 – 41923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri425 – 44723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri481 – 50323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri509 – 53123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri537 – 55923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri565 – 58723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri593 – 61523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri621 – 64323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234619.
    HOVERGENiHBG018163.
    InParanoidiO95125.
    KOiK09229.
    OMAiWVPDIQE.
    OrthoDBiEOG7J9VP1.
    PhylomeDBiO95125.
    TreeFamiTF350829.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR001909. Krueppel-associated_box.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PfamiPF01352. KRAB. 1 hit.
    PF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    SSF47353. SSF47353. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Beta (identifier: O95125-1) [UniParc]FASTAAdd to Basket

    Also known as: 2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATAVEPEDQ DLWEEEGILM VKLEDDFTCR PESVLQRDDP VLETSHQNFR    50
    RFRYQEAASP REALIRLREL CHQWLRPERR TKEQILELLV LEQFLTVLPG 100
    ELQSWVRGQR PESGEEAVTL VEGLQKQPRR PRRWVTVHVH GQEVLSEETV 150
    HLGVEPESPN ELQDPVQSST PEQSPEETTQ SPDLGAPAEQ RPHQEEELQT 200
    LQESEVPVPE DPDLPAERSS GDSEMVALLT ALSQGLVTFK DVAVCFSQDQ 250
    WSDLDPTQKE FYGEYVLEED CGIVVSLSFP IPRPDEISQV REEEPWVPDI 300
    QEPQETQEPE ILSFTYTGDR SKDEEECLEQ EDLSLEDIHR PVLGEPEIHQ 350
    TPDWEIVFED NPGRLNERRF GTNISQVNSF VNLRETTPVH PLLGRHHDCS 400
    VCGKSFTCNS HLVRHLRTHT GEKPYKCMEC GKSYTRSSHL ARHQKVHKMN 450
    APYKYPLNRK NLEETSPVTQ AERTPSVEKP YRCDDCGKHF RWTSDLVRHQ 500
    RTHTGEKPFF CTICGKSFSQ KSVLTTHQRI HLGGKPYLCG ECGEDFSEHR 550
    RYLAHRKTHA AEELYLCSEC GRCFTHSAAF AKHLRGHASV RPCRCNECGK 600
    SFSRRDHLVR HQRTHTGEKP FTCPTCGKSF SRGYHLIRHQ RTHSEKTS 648
    Length:648
    Mass (Da):74,720
    Last modified:May 16, 2006 - v4
    Checksum:iE738506D71DAFAE9
    GO
    Isoform Alpha (identifier: O95125-2) [UniParc]FASTAAdd to Basket

    Also known as: 1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-224: Missing.

    Show »
    Length:424
    Mass (Da):48,952
    Checksum:i843C23B240D19DF0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151E → P in CAB82384. (PubMed:17974005)Curated
    Sequence conflicti205 – 2051Missing in CAC21447. 1 PublicationCurated
    Sequence conflicti278 – 2781S → AA1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti154 – 1541V → A.5 Publications
    Corresponds to variant rs1144507 [ dbSNP | Ensembl ].
    VAR_007818
    Natural varianti533 – 5331G → A.1 Publication
    Corresponds to variant rs34111365 [ dbSNP | Ensembl ].
    VAR_023975

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 224224Missing in isoform Alpha. 1 PublicationVSP_006902Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027219 mRNA. Translation: AAC79941.1.
    AF027218 mRNA. Translation: AAC79940.1.
    AJ276177
    , AJ276178, AJ276179, AJ276180, AJ276181, AJ276182 Genomic DNA. Translation: CAC21447.1.
    DQ093962 Genomic DNA. Translation: AAY88738.1.
    EU332869 Genomic DNA. Translation: ABY87558.1.
    BC013382 mRNA. Translation: AAH13382.1.
    AL162031 mRNA. Translation: CAB82384.1.
    CCDSiCCDS8443.1. [O95125-1]
    PIRiT47156.
    RefSeqiNP_003446.2. NM_003455.2. [O95125-1]
    XP_005271716.1. XM_005271659.1. [O95125-1]
    XP_005271717.1. XM_005271660.1. [O95125-1]
    XP_005271718.1. XM_005271661.1. [O95125-1]
    XP_005271719.1. XM_005271662.1. [O95125-1]
    XP_005271720.1. XM_005271663.2. [O95125-1]
    XP_005271721.1. XM_005271664.1. [O95125-2]
    XP_006718963.1. XM_006718900.1. [O95125-1]
    XP_006718964.1. XM_006718901.1. [O95125-1]
    XP_006718965.1. XM_006718902.1. [O95125-1]
    UniGeneiHs.112556.

    Genome annotation databases

    EnsembliENST00000336139; ENSP00000337724; ENSG00000166261. [O95125-1]
    ENST00000529691; ENSP00000433881; ENSG00000166261. [O95125-1]
    ENST00000530393; ENSP00000432504; ENSG00000166261. [O95125-1]
    GeneIDi7753.
    KEGGihsa:7753.
    UCSCiuc001pzc.1. human. [O95125-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027219 mRNA. Translation: AAC79941.1 .
    AF027218 mRNA. Translation: AAC79940.1 .
    AJ276177
    , AJ276178 , AJ276179 , AJ276180 , AJ276181 , AJ276182 Genomic DNA. Translation: CAC21447.1 .
    DQ093962 Genomic DNA. Translation: AAY88738.1 .
    EU332869 Genomic DNA. Translation: ABY87558.1 .
    BC013382 mRNA. Translation: AAH13382.1 .
    AL162031 mRNA. Translation: CAB82384.1 .
    CCDSi CCDS8443.1. [O95125-1 ]
    PIRi T47156.
    RefSeqi NP_003446.2. NM_003455.2. [O95125-1 ]
    XP_005271716.1. XM_005271659.1. [O95125-1 ]
    XP_005271717.1. XM_005271660.1. [O95125-1 ]
    XP_005271718.1. XM_005271661.1. [O95125-1 ]
    XP_005271719.1. XM_005271662.1. [O95125-1 ]
    XP_005271720.1. XM_005271663.2. [O95125-1 ]
    XP_005271721.1. XM_005271664.1. [O95125-2 ]
    XP_006718963.1. XM_006718900.1. [O95125-1 ]
    XP_006718964.1. XM_006718901.1. [O95125-1 ]
    XP_006718965.1. XM_006718902.1. [O95125-1 ]
    UniGenei Hs.112556.

    3D structure databases

    ProteinModelPortali O95125.
    SMRi O95125. Positions 39-128, 397-644.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113537. 4 interactions.
    IntActi O95125. 2 interactions.
    MINTi MINT-1485656.
    STRINGi 9606.ENSP00000337724.

    PTM databases

    PhosphoSitei O95125.

    Proteomic databases

    MaxQBi O95125.
    PaxDbi O95125.
    PRIDEi O95125.

    Protocols and materials databases

    DNASUi 7753.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336139 ; ENSP00000337724 ; ENSG00000166261 . [O95125-1 ]
    ENST00000529691 ; ENSP00000433881 ; ENSG00000166261 . [O95125-1 ]
    ENST00000530393 ; ENSP00000432504 ; ENSG00000166261 . [O95125-1 ]
    GeneIDi 7753.
    KEGGi hsa:7753.
    UCSCi uc001pzc.1. human. [O95125-1 ]

    Organism-specific databases

    CTDi 7753.
    GeneCardsi GC11M123594.
    HGNCi HGNC:12994. ZNF202.
    MIMi 603430. gene.
    neXtProti NX_O95125.
    PharmGKBi PA37574.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234619.
    HOVERGENi HBG018163.
    InParanoidi O95125.
    KOi K09229.
    OMAi WVPDIQE.
    OrthoDBi EOG7J9VP1.
    PhylomeDBi O95125.
    TreeFami TF350829.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.
    SignaLinki O95125.

    Miscellaneous databases

    ChiTaRSi ZNF202. human.
    GeneWikii ZNF202.
    GenomeRNAii 7753.
    NextBioi 30008.
    PROi O95125.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95125.
    Bgeei O95125.
    CleanExi HS_ZNF202.
    Genevestigatori O95125.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR001909. Krueppel-associated_box.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    Pfami PF01352. KRAB. 1 hit.
    PF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    SSF47353. SSF47353. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins."
      Monaco C., Helmer Citterich M., Caprini E., Vorechovsky I., Russo G., Croce C.M., Barbanti-Brodano G., Negrini M.
      Genomics 52:358-362(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), VARIANT ALA-154.
      Tissue: Testis.
    2. "Genomic sequence analysis of the ZNF202 gene: relevance for lipid parameters."
      Langmann T., Porsch-Oezcueruemez M., Heimerl S., Andrikovics H., Schmitz G.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-154.
    3. SeattleSNPs variation discovery resource
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-154 AND ALA-533.
    4. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-154.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA), VARIANT ALA-154.
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-648 (ISOFORM BETA).
      Tissue: Mammary cancer.
    7. Cited for: CHARACTERIZATION.
    8. "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux."
      Porsch-Oezcueruemez M., Langmann T., Heimerl S., Borsukova H., Kaminski W.E., Drobnik W., Honer C., Schumacher C., Schmitz G.
      J. Biol. Chem. 276:12427-12433(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE FUNCTION.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN202_HUMAN
    AccessioniPrimary (citable) accession number: O95125
    Secondary accession number(s): B0LPH9
    , Q4JG21, Q9H1B9, Q9NSM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 139 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3