UniProtKB - O95096 (NKX22_HUMAN)
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Protein
Homeobox protein Nkx-2.2
Gene
NKX2-2
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 128 – 187 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- proximal promoter sequence-specific DNA binding Source: UniProtKB
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
- transcription coactivator activity Source: UniProtKB
- transcription factor binding Source: Ensembl
GO - Biological processi
- astrocyte differentiation Source: Ensembl
- brain development Source: ProtInc
- digestive tract development Source: Ensembl
- endocrine pancreas development Source: Reactome
- negative regulation of neuron differentiation Source: Ensembl
- neuron fate specification Source: Ensembl
- oligodendrocyte development Source: Ensembl
- optic nerve development Source: Ensembl
- pancreatic A cell fate commitment Source: Ensembl
- pancreatic PP cell fate commitment Source: Ensembl
- positive regulation of DNA binding transcription factor activity Source: UniProtKB
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- response to glucose Source: Ensembl
- response to progesterone Source: Ensembl
- smoothened signaling pathway Source: Ensembl
- spinal cord motor neuron differentiation Source: Ensembl
- spinal cord oligodendrocyte cell fate specification Source: Ensembl
- transcription, DNA-templated Source: UniProtKB-KW
- type B pancreatic cell development Source: Ensembl
- type B pancreatic cell fate commitment Source: Ensembl
- ventral spinal cord interneuron fate determination Source: Ensembl
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-HSA-210745. Regulation of gene expression in beta cells. R-HSA-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells. |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Nkx-2.2Alternative name(s): Homeobox protein NK-2 homolog B |
Gene namesi | Name:NKX2-2 Synonyms:NKX2.2, NKX2B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000125820.5. |
HGNCi | HGNC:7835. NKX2-2. |
MIMi | 604612. gene. |
neXtProti | NX_O95096. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 4821. |
OpenTargetsi | ENSG00000125820. |
PharmGKBi | PA31642. |
Polymorphism and mutation databases
BioMutai | NKX2-2. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048929 | 1 – 273 | Homeobox protein Nkx-2.2Add BLAST | 273 |
Proteomic databases
PaxDbi | O95096. |
PeptideAtlasi | O95096. |
PRIDEi | O95096. |
PTM databases
iPTMneti | O95096. |
PhosphoSitePlusi | O95096. |
Expressioni
Gene expression databases
Bgeei | ENSG00000125820. |
CleanExi | HS_NKX2-2. |
Genevisiblei | O95096. HS. |
Organism-specific databases
HPAi | HPA003468. |
Interactioni
Subunit structurei
Interacts with OLIG2.By similarity
GO - Molecular functioni
- transcription factor binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 110886. 2 interactors. |
IntActi | O95096. 1 interactor. |
MINTi | O95096. |
STRINGi | 9606.ENSP00000366347. |
Structurei
3D structure databases
ProteinModelPortali | O95096. |
SMRi | O95096. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domaini
The homeodomain is essential for interaction with OLIG2.By similarity
Sequence similaritiesi
Belongs to the NK-2 homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0842. Eukaryota. ENOG410XR21. LUCA. |
GeneTreei | ENSGT00910000144003. |
HOGENOMi | HOG000231923. |
HOVERGENi | HBG006689. |
InParanoidi | O95096. |
KOi | K08029. |
OMAi | HHLVQAQ. |
OrthoDBi | EOG091G0LZ2. |
PhylomeDBi | O95096. |
TreeFami | TF351204. |
Family and domain databases
CDDi | cd00086. homeodomain. 1 hit. |
InterProi | View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR020479. Homeobox_metazoa. |
Pfami | View protein in Pfam PF00046. Homeobox. 1 hit. |
PRINTSi | PR00024. HOMEOBOX. |
SMARTi | View protein in SMART SM00389. HOX. 1 hit. |
SUPFAMi | SSF46689. SSF46689. 1 hit. |
PROSITEi | View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
O95096-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ
60 70 80 90 100
GALDAVQSLP LKNPFYDSSD NPYTRWLAST EGLQYSLHGL AAGAPPQDSS
110 120 130 140 150
SKSPEPSADE SPDNDKETPG GGGDAGKKRK RRVLFSKAQT YELERRFRQQ
160 170 180 190 200
RYLSAPEREH LASLIRLTPT QVKIWFQNHR YKMKRARAEK GMEVTPLPSP
210 220 230 240 250
RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ SLQHMQYNAQ
260 270
YSSASTPQYP TAHPLVQAQQ WTW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019415, AF019414 Genomic DNA. Translation: AAC83132.1. AL133325 Genomic DNA. No translation available. BC075092 mRNA. Translation: AAH75092.1. BC075093 mRNA. Translation: AAH75093.1. |
CCDSi | CCDS13145.1. |
RefSeqi | NP_002500.1. NM_002509.3. |
UniGenei | Hs.516922. |
Genome annotation databases
Ensembli | ENST00000377142; ENSP00000366347; ENSG00000125820. |
GeneIDi | 4821. |
KEGGi | hsa:4821. |
UCSCi | uc002wsi.4. human. |
Similar proteinsi
Entry informationi
Entry namei | NKX22_HUMAN | |
Accessioni | O95096Primary (citable) accession number: O95096 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1999 | |
Last modified: | March 28, 2018 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |