NKX2-2

Functionⁱ

Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	128 – 187	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

chromatin binding Source: UniProtKB
proximal promoter sequence-specific DNA binding Source: UniProtKB
RNA polymerase II transcription factor activity, sequence-specific DNA binding
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
transcription coactivator activity Source: UniProtKB
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

astrocyte differentiation Source: Ensembl
brain development
Source: ProtInc
Traceable author statementⁱ
- 1346742
digestive tract development Source: Ensembl
endocrine pancreas development Source: Reactome
negative regulation of neuron differentiation Source: Ensembl
neuron fate specification Source: Ensembl
oligodendrocyte development Source: Ensembl
optic nerve development Source: Ensembl
pancreatic A cell fate commitment Source: Ensembl
pancreatic PP cell fate commitment Source: Ensembl
positive regulation of DNA binding transcription factor activity Source: UniProtKB
positive regulation of neuron differentiation Source: Ensembl
positive regulation of oligodendrocyte differentiation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
response to glucose Source: Ensembl
response to progesterone Source: Ensembl
smoothened signaling pathway Source: Ensembl
spinal cord motor neuron differentiation Source: Ensembl
spinal cord oligodendrocyte cell fate specification Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW
type B pancreatic cell development Source: Ensembl
type B pancreatic cell fate commitment Source: Ensembl
ventral spinal cord interneuron fate determination Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745. Regulation of gene expression in beta cells. R-HSA-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Reactomeⁱ

R-HSA-210745. Regulation of gene expression in beta cells.
R-HSA-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Nkx-2.2 Alternative name(s): Homeobox protein NK-2 homolog B
Gene namesⁱ	Name:NKX2-2 Synonyms:NKX2.2, NKX2B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125820.5.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7835. NKX2-2.
MIMⁱ	604612. gene.
neXtProtⁱ	NX_O95096.

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4821.
Open Targets More...OpenTargetsⁱ	ENSG00000125820.
PharmGKBⁱ	PA31642.

Polymorphism and mutation databases

BioMutaⁱ	NKX2-2.

BioMutaⁱ

NKX2-2.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048929	1 – 273	Homeobox protein Nkx-2.2Add BLAST		273

Proteomic databases

PaxDbⁱ	O95096.
PeptideAtlas More...PeptideAtlasⁱ	O95096.
PRIDEⁱ	O95096.

PTM databases

iPTMnetⁱ	O95096.
PhosphoSitePlusⁱ	O95096.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000125820.
CleanExⁱ	HS_NKX2-2.
Genevisibleⁱ	O95096. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003468.

HPAⁱ

HPA003468.

Interactionⁱ

Subunit structureⁱ

Interacts with OLIG2.By similarity

GO - Molecular functionⁱ

transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110886. 2 interactors.
IntActⁱ	O95096. 1 interactor.
Molecular INTeraction database More...MINTⁱ	O95096.
STRINGⁱ	9606.ENSP00000366347.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95096.
SMRⁱ	O95096.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The homeodomain is essential for interaction with OLIG2.By similarity

Sequence similaritiesⁱ

Belongs to the NK-2 homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0842. Eukaryota. ENOG410XR21. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144003.
HOGENOMⁱ	HOG000231923.
HOVERGENⁱ	HBG006689.
InParanoidⁱ	O95096.
KEGG Orthology (KO) More...KOⁱ	K08029.
OMAⁱ	HHLVQAQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LZ2.
PhylomeDBⁱ	O95096.
TreeFamⁱ	TF351204.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086. homeodomain. 1 hit.
InterProⁱ	View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR020479. Homeobox_metazoa.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit.
PRINTSⁱ	PR00024. HOMEOBOX.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

O95096-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ 
        60         70         80         90        100
GALDAVQSLP LKNPFYDSSD NPYTRWLAST EGLQYSLHGL AAGAPPQDSS 
       110        120        130        140        150
SKSPEPSADE SPDNDKETPG GGGDAGKKRK RRVLFSKAQT YELERRFRQQ 
       160        170        180        190        200
RYLSAPEREH LASLIRLTPT QVKIWFQNHR YKMKRARAEK GMEVTPLPSP 
       210        220        230        240        250
RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ SLQHMQYNAQ 
       260        270 
YSSASTPQYP TAHPLVQAQQ WTW

Length:273

Mass (Da):30,133

Last modified:May 1, 1999 - v1

Checksum:ⁱ91BDA220BAFA63D1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF019415, AF019414 Genomic DNA. Translation: AAC83132.1. AL133325 Genomic DNA. No translation available. BC075092 mRNA. Translation: AAH75092.1. BC075093 mRNA. Translation: AAH75093.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13145.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_002500.1. NM_002509.3.
UniGeneⁱ	Hs.516922.

Genome annotation databases

Ensemblⁱ	ENST00000377142; ENSP00000366347; ENSG00000125820.
GeneIDⁱ	4821.
KEGGⁱ	hsa:4821.
UCSC genome browser More...UCSCⁱ	uc002wsi.4. human.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O95096	H2QK20 G7PH38 F7HHQ2 G3QYG3 A0A0D9RF98 A0A2K6KRS2 A0A2K5NK46 A0A2K6R2L3 A0A096NVR7 A0A2K5XKB5 +1	Pan troglodytes (Chimpanzee) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca mulatta (Rhesus macaque) Gorilla gorilla gorilla (Western lowland gorilla) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Papio anubis (Olive baboon) Mandrillus leucophaeus (Drill) (Papio leucophaeus)	273	UniRef100_O95096	Cluster: Homeobox protein Nkx-2.2	12

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O95096	P42586 Q3URZ4 Q9JKR0 UPI0003C91E63 UPI0001550A1B G3SQC5 I3MY45 UPI0002C45E26 UPI0003314ADD UPI00045DB660 +84	Mus musculus (Mouse) Tupaia chinensis (Chinese tree shrew) Vicugna pacos (Alpaca) (Lama pacos) Loxodonta africana (African elephant) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) Trichechus manatus latirostris (Florida manatee) Sorex araneus (Eurasian common shrew) (European shrew) Orycteropus afer afer Eptesicus fuscus (Big brown bat) (Vespertilio fuscus) Manis javanica (Malayan pangolin) (Sunda pangolin) And more	273	UniRef90_P42586	Cluster: Homeobox protein Nkx-2.2	95

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O95096	P42586 Q3URZ4 Q9JKR0 UPI0003C91E63 UPI0001550A1B UPI0004D07CE4 UPI00042AA783 A0A2K5E245 UPI000579E7E9 G3SQC5 +162	Mus musculus (Mouse) Tupaia chinensis (Chinese tree shrew) Vicugna pacos (Alpaca) (Lama pacos) Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Aotus nancymaae (Ma's night monkey) Camelus bactrianus (Bactrian camel) Loxodonta africana (African elephant) Oryctolagus cuniculus (Rabbit) Ochotona princeps (Southern American pika) And more	273	UniRef50_P42586	Cluster: Homeobox protein Nkx-2.2	173

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF019415, AF019414 Genomic DNA. Translation: AAC83132.1. AL133325 Genomic DNA. No translation available. BC075092 mRNA. Translation: AAH75092.1. BC075093 mRNA. Translation: AAH75093.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13145.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_002500.1. NM_002509.3.
UniGeneⁱ	Hs.516922.

3D structure databases

ProteinModelPortalⁱ	O95096.
SMRⁱ	O95096.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110886. 2 interactors.
IntActⁱ	O95096. 1 interactor.
Molecular INTeraction database More...MINTⁱ	O95096.
STRINGⁱ	9606.ENSP00000366347.

PTM databases

iPTMnetⁱ	O95096.
PhosphoSitePlusⁱ	O95096.

Polymorphism and mutation databases

BioMutaⁱ	NKX2-2.

BioMutaⁱ

NKX2-2.

Proteomic databases

PaxDbⁱ	O95096.
PeptideAtlas More...PeptideAtlasⁱ	O95096.
PRIDEⁱ	O95096.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4821.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377142; ENSP00000366347; ENSG00000125820.
GeneIDⁱ	4821.
KEGGⁱ	hsa:4821.
UCSC genome browser More...UCSCⁱ	uc002wsi.4. human.

Organism-specific databases

CTDⁱ	4821.
DisGeNET More...DisGeNETⁱ	4821.
EuPathDBⁱ	HostDB:ENSG00000125820.5.
GeneCardsⁱ	NKX2-2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7835. NKX2-2.
Human Protein Atlas More...HPAⁱ	HPA003468.
MIMⁱ	604612. gene.
neXtProtⁱ	NX_O95096.
Open Targets More...OpenTargetsⁱ	ENSG00000125820.
PharmGKBⁱ	PA31642.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0842. Eukaryota. ENOG410XR21. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144003.
HOGENOMⁱ	HOG000231923.
HOVERGENⁱ	HBG006689.
InParanoidⁱ	O95096.
KEGG Orthology (KO) More...KOⁱ	K08029.
OMAⁱ	HHLVQAQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LZ2.
PhylomeDBⁱ	O95096.
TreeFamⁱ	TF351204.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745. Regulation of gene expression in beta cells. R-HSA-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Reactomeⁱ

R-HSA-210745. Regulation of gene expression in beta cells.
R-HSA-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Miscellaneous databases

ChiTaRSⁱ	NKX2-2. human.
GeneWikiⁱ	NKX2-2.
GenomeRNAiⁱ	4821.
Protein Ontology More...PROⁱ	PR:O95096.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125820.
CleanExⁱ	HS_NKX2-2.
Genevisibleⁱ	O95096. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086. homeodomain. 1 hit.
InterProⁱ	View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR020479. Homeobox_metazoa.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit.
PRINTSⁱ	PR00024. HOMEOBOX.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NKX22_HUMAN
Accessionⁱ	O95096Primary (citable) accession number: O95096
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	May 1, 1999
	Last modified:	March 28, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95096 (NKX22_HUMAN)

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Homeobox protein Nkx-2.2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ