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Protein

Homeobox protein Nkx-2.2

Gene

NKX2-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi128 – 187HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-210745. Regulation of gene expression in beta cells.
R-HSA-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.2
Alternative name(s):
Homeobox protein NK-2 homolog B
Gene namesi
Name:NKX2-2
Synonyms:NKX2.2, NKX2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125820.5.
HGNCiHGNC:7835. NKX2-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4821.
OpenTargetsiENSG00000125820.
PharmGKBiPA31642.

Polymorphism and mutation databases

BioMutaiNKX2-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489291 – 273Homeobox protein Nkx-2.2Add BLAST273

Proteomic databases

PaxDbiO95096.
PeptideAtlasiO95096.
PRIDEiO95096.

PTM databases

iPTMnetiO95096.
PhosphoSitePlusiO95096.

Expressioni

Gene expression databases

BgeeiENSG00000125820.
CleanExiHS_NKX2-2.
GenevisibleiO95096. HS.

Organism-specific databases

HPAiHPA003468.

Interactioni

Subunit structurei

Interacts with OLIG2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110886. 2 interactors.
IntActiO95096. 1 interactor.
STRINGi9606.ENSP00000366347.

Structurei

3D structure databases

ProteinModelPortaliO95096.
SMRiO95096.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The homeodomain is essential for interaction with OLIG2.By similarity

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842. Eukaryota.
ENOG410XR21. LUCA.
GeneTreeiENSGT00870000136367.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiO95096.
KOiK08029.
OMAiGKPCHTL.
OrthoDBiEOG091G0LZ2.
PhylomeDBiO95096.
TreeFamiTF351204.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O95096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ
60 70 80 90 100
GALDAVQSLP LKNPFYDSSD NPYTRWLAST EGLQYSLHGL AAGAPPQDSS
110 120 130 140 150
SKSPEPSADE SPDNDKETPG GGGDAGKKRK RRVLFSKAQT YELERRFRQQ
160 170 180 190 200
RYLSAPEREH LASLIRLTPT QVKIWFQNHR YKMKRARAEK GMEVTPLPSP
210 220 230 240 250
RRVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ SLQHMQYNAQ
260 270
YSSASTPQYP TAHPLVQAQQ WTW
Length:273
Mass (Da):30,133
Last modified:May 1, 1999 - v1
Checksum:i91BDA220BAFA63D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019415, AF019414 Genomic DNA. Translation: AAC83132.1.
AL133325 Genomic DNA. No translation available.
BC075092 mRNA. Translation: AAH75092.1.
BC075093 mRNA. Translation: AAH75093.1.
CCDSiCCDS13145.1.
RefSeqiNP_002500.1. NM_002509.3.
UniGeneiHs.516922.

Genome annotation databases

EnsembliENST00000377142; ENSP00000366347; ENSG00000125820.
GeneIDi4821.
KEGGihsa:4821.
UCSCiuc002wsi.4. human.

Similar proteinsi

Entry informationi

Entry nameiNKX22_HUMAN
AccessioniPrimary (citable) accession number: O95096
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: September 27, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families