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Protein

Battenin

Gene

CLN3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BatteninUniRule annotation
Gene namesi
Name:CLN3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2074. CLN3.

Subcellular locationi

  • Lysosome membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6825HelicalUniRule annotationAdd
BLAST
Transmembranei74 – 9118HelicalUniRule annotationAdd
BLAST
Transmembranei98 – 12225HelicalUniRule annotationAdd
BLAST
Transmembranei179 – 19618HelicalUniRule annotationAdd
BLAST
Transmembranei242 – 26322HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 28820HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiO95086. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliO95086.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the battenin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000003249.
HOGENOMiHOG000164765.
HOVERGENiHBG017297.

Family and domain databases

InterProiIPR003492. Battenin_disease_Cln3.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10981. PTHR10981. 2 hits.
PfamiPF02487. CLN3. 2 hits.
[Graphical view]
PRINTSiPR01315. BATTENIN.
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

O95086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAAHDILS HKRTSGNQSH VDPGPTPIPH NSSSRFDCNS VSTAAVLLAD
60 70 80 90 100
ILPTLVIKLL APLGLHLLPY SPRVLVSGIC AAGSFVLVAF SHSVGTSLCG
110 120 130 140 150
VVFASISSGL GEVTFLSLTA FYPSYFLLLT SPEAQDPGGE EEAESAARQP
160 170 180 190 200
LIRTEAPESK PGSSSSLSLR ERWTVFKGLL WYIVPLVVVY FAEYFINQGL
210 220 230 240 250
FELLFFWNTS LSHAQQYRWY QMLYQAGVFA SRSSLRCCRI RFTWALALLQ
260 270 280 290 300
CLNLVFLLAD VWFGFLPSIY LVFLIILYEG LLGGAAYVNT FHNIALETSD
310 320 330
EHREFAMAAT CISDTLGISL SGLLALPLHD FLCQLS
Length:336
Mass (Da):36,842
Last modified:May 1, 1999 - v1
Checksum:i8B78EB74349314BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138894 Genomic DNA. No translation available.
AF015595 mRNA. Translation: AAD01557.1.
UniGeneiHs.534667.

Genome annotation databases

EnsembliENST00000359984; ENSP00000353073; ENSG00000188603.
UCSCiuc002dpq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138894 Genomic DNA. No translation available.
AF015595 mRNA. Translation: AAD01557.1.
UniGeneiHs.534667.

3D structure databases

ProteinModelPortaliO95086.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359984; ENSP00000353073; ENSG00000188603.
UCSCiuc002dpq.2. human.

Organism-specific databases

HGNCiHGNC:2074. CLN3.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000003249.
HOGENOMiHOG000164765.
HOVERGENiHBG017297.

Gene expression databases

ExpressionAtlasiO95086. baseline and differential.

Family and domain databases

InterProiIPR003492. Battenin_disease_Cln3.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR10981. PTHR10981. 2 hits.
PfamiPF02487. CLN3. 2 hits.
[Graphical view]
PRINTSiPR01315. BATTENIN.
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Unique alternative spliced transcripts associated with the 56 chromosome haplotype allele of the Batten disease gene, CLN3."
    LaFauci G., Papini M., Pullarkat R., Rubenstein R.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Ensembl
    Submitted (NOV-2014) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "N-terminome analysis of the human mitochondrial proteome."
    Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.
    Proteomics 15:2519-2524(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiO95086_HUMAN
AccessioniPrimary (citable) accession number: O95086
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: March 16, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.