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Protein

Serine protease 23

Gene

PRSS23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei175 – 1751Charge relay systemPROSITE-ProRule annotation
Active sitei240 – 2401Charge relay systemPROSITE-ProRule annotation
Active sitei316 – 3161Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.309.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 23 (EC:3.4.21.-)
Alternative name(s):
Putative secreted protein Zsig13
Gene namesi
Name:PRSS23
Synonyms:ZSIG13
ORF Names:UNQ270/PRO307
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14370. PRSS23.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleus Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952846.

Polymorphism and mutation databases

BioMutaiPRSS23.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 383364Serine protease 23PRO_0000027847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Modified residuei109 – 1091Phosphoserine; by FAM20C1 Publication
Disulfide bondi160 ↔ 176By similarity
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO95084.
PaxDbiO95084.
PeptideAtlasiO95084.
PRIDEiO95084.
TopDownProteomicsiO95084-1. [O95084-1]

PTM databases

iPTMnetiO95084.
PhosphoSiteiO95084.

Expressioni

Gene expression databases

BgeeiENSG00000150687.
CleanExiHS_PRSS23.
ExpressionAtlasiO95084. baseline and differential.
GenevisibleiO95084. HS.

Organism-specific databases

HPAiHPA030591.

Interactioni

Protein-protein interaction databases

BioGridi116279. 45 interactions.
IntActiO95084. 36 interactions.
MINTiMINT-1370120.
STRINGi9606.ENSP00000280258.

Structurei

3D structure databases

ProteinModelPortaliO95084.
SMRiO95084. Positions 152-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF0G. Eukaryota.
ENOG410ZRQ7. LUCA.
GeneTreeiENSGT00390000000155.
HOGENOMiHOG000059661.
HOVERGENiHBG053702.
InParanoidiO95084.
KOiK09627.
OMAiHDGKNYV.
OrthoDBiEOG091G0BVQ.
PhylomeDBiO95084.
TreeFamiTF329011.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95084-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK
60 70 80 90 100
PDFGAEAKLE VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ
110 120 130 140 150
VGIYILSSSG DGAQHRDSGS SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF
160 170 180 190 200
STSVKLSTGC TGTLVAEKHV LTAAHCIHDG KTYVKGTQKL RVGFLKPKFK
210 220 230 240 250
DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND IGMDYDYALL
260 270 280 290 300
ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE
310 320 330 340 350
TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG
360 370 380
SPQDFNVAVR ITPLKYAQIC YWIKGNYLDC REG
Length:383
Mass (Da):43,001
Last modified:May 1, 1999 - v1
Checksum:i46EB6C11ABFD5E8F
GO
Isoform 2 (identifier: O95084-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-80: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,642
Checksum:i54D3D95CF6B3A526
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei49 – 8032Missing in isoform 2. 1 PublicationVSP_056628Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015287 mRNA. Translation: AAD01553.1.
AF193611 mRNA. Translation: AAF07186.1.
AL136914 mRNA. Translation: CAB66848.1.
AY359033 mRNA. Translation: AAQ89392.1.
CR456824 mRNA. Translation: CAG33105.1.
AK304301 mRNA. Translation: BAG65155.1.
AK315562 mRNA. Translation: BAG37938.1.
AP000654 Genomic DNA. No translation available.
AP001528 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW75145.1.
BC001278 mRNA. Translation: AAH01278.1.
CCDSiCCDS8278.1. [O95084-1]
RefSeqiNP_001280107.1. NM_001293178.1.
NP_001280108.1. NM_001293179.1. [O95084-1]
NP_001280109.1. NM_001293180.1. [O95084-1]
UniGeneiHs.25338.
Hs.729257.

Genome annotation databases

EnsembliENST00000280258; ENSP00000280258; ENSG00000150687. [O95084-1]
GeneIDi11098.
KEGGihsa:11098.
UCSCiuc001pcb.4. human. [O95084-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015287 mRNA. Translation: AAD01553.1.
AF193611 mRNA. Translation: AAF07186.1.
AL136914 mRNA. Translation: CAB66848.1.
AY359033 mRNA. Translation: AAQ89392.1.
CR456824 mRNA. Translation: CAG33105.1.
AK304301 mRNA. Translation: BAG65155.1.
AK315562 mRNA. Translation: BAG37938.1.
AP000654 Genomic DNA. No translation available.
AP001528 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW75145.1.
BC001278 mRNA. Translation: AAH01278.1.
CCDSiCCDS8278.1. [O95084-1]
RefSeqiNP_001280107.1. NM_001293178.1.
NP_001280108.1. NM_001293179.1. [O95084-1]
NP_001280109.1. NM_001293180.1. [O95084-1]
UniGeneiHs.25338.
Hs.729257.

3D structure databases

ProteinModelPortaliO95084.
SMRiO95084. Positions 152-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116279. 45 interactions.
IntActiO95084. 36 interactions.
MINTiMINT-1370120.
STRINGi9606.ENSP00000280258.

Protein family/group databases

MEROPSiS01.309.

PTM databases

iPTMnetiO95084.
PhosphoSiteiO95084.

Polymorphism and mutation databases

BioMutaiPRSS23.

Proteomic databases

MaxQBiO95084.
PaxDbiO95084.
PeptideAtlasiO95084.
PRIDEiO95084.
TopDownProteomicsiO95084-1. [O95084-1]

Protocols and materials databases

DNASUi11098.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280258; ENSP00000280258; ENSG00000150687. [O95084-1]
GeneIDi11098.
KEGGihsa:11098.
UCSCiuc001pcb.4. human. [O95084-1]

Organism-specific databases

CTDi11098.
GeneCardsiPRSS23.
HGNCiHGNC:14370. PRSS23.
HPAiHPA030591.
neXtProtiNX_O95084.
PharmGKBiPA134952846.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF0G. Eukaryota.
ENOG410ZRQ7. LUCA.
GeneTreeiENSGT00390000000155.
HOGENOMiHOG000059661.
HOVERGENiHBG053702.
InParanoidiO95084.
KOiK09627.
OMAiHDGKNYV.
OrthoDBiEOG091G0BVQ.
PhylomeDBiO95084.
TreeFamiTF329011.

Miscellaneous databases

ChiTaRSiPRSS23. human.
GeneWikiiPRSS23.
GenomeRNAii11098.
PROiO95084.

Gene expression databases

BgeeiENSG00000150687.
CleanExiHS_PRSS23.
ExpressionAtlasiO95084. baseline and differential.
GenevisibleiO95084. HS.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRS23_HUMAN
AccessioniPrimary (citable) accession number: O95084
Secondary accession number(s): B2RDJ1, B4E2J3, Q6IBI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.