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Protein

Serine protease 23

Gene

PRSS23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175Charge relay systemPROSITE-ProRule annotation1
Active sitei240Charge relay systemPROSITE-ProRule annotation1
Active sitei316Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-HSA-8957275. Post-translational protein phosphorylation.

Protein family/group databases

MEROPSiS01.309.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 23 (EC:3.4.21.-)
Alternative name(s):
Putative secreted protein Zsig13
Gene namesi
Name:PRSS23
Synonyms:ZSIG13
ORF Names:UNQ270/PRO307
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14370. PRSS23.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11098.
OpenTargetsiENSG00000150687.
PharmGKBiPA134952846.

Polymorphism and mutation databases

BioMutaiPRSS23.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002784720 – 383Serine protease 23Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei109Phosphoserine; by FAM20C1 Publication1
Disulfide bondi160 ↔ 176By similarity
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO95084.
MaxQBiO95084.
PaxDbiO95084.
PeptideAtlasiO95084.
PRIDEiO95084.
TopDownProteomicsiO95084-1. [O95084-1]

PTM databases

iPTMnetiO95084.
PhosphoSitePlusiO95084.

Expressioni

Gene expression databases

BgeeiENSG00000150687.
CleanExiHS_PRSS23.
ExpressionAtlasiO95084. baseline and differential.
GenevisibleiO95084. HS.

Organism-specific databases

HPAiHPA030591.

Interactioni

Protein-protein interaction databases

BioGridi116279. 45 interactors.
IntActiO95084. 36 interactors.
MINTiMINT-1370120.
STRINGi9606.ENSP00000280258.

Structurei

3D structure databases

ProteinModelPortaliO95084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF0G. Eukaryota.
ENOG410ZRQ7. LUCA.
GeneTreeiENSGT00390000000155.
HOGENOMiHOG000059661.
HOVERGENiHBG053702.
InParanoidiO95084.
KOiK09627.
OMAiHDGKNYV.
OrthoDBiEOG091G0BVQ.
PhylomeDBiO95084.
TreeFamiTF329011.

Family and domain databases

InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS00134. TRYPSIN_HIS. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95084-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK
60 70 80 90 100
PDFGAEAKLE VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ
110 120 130 140 150
VGIYILSSSG DGAQHRDSGS SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF
160 170 180 190 200
STSVKLSTGC TGTLVAEKHV LTAAHCIHDG KTYVKGTQKL RVGFLKPKFK
210 220 230 240 250
DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND IGMDYDYALL
260 270 280 290 300
ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE
310 320 330 340 350
TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG
360 370 380
SPQDFNVAVR ITPLKYAQIC YWIKGNYLDC REG
Length:383
Mass (Da):43,001
Last modified:May 1, 1999 - v1
Checksum:i46EB6C11ABFD5E8F
GO
Isoform 2 (identifier: O95084-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-80: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,642
Checksum:i54D3D95CF6B3A526
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05662849 – 80Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015287 mRNA. Translation: AAD01553.1.
AF193611 mRNA. Translation: AAF07186.1.
AL136914 mRNA. Translation: CAB66848.1.
AY359033 mRNA. Translation: AAQ89392.1.
CR456824 mRNA. Translation: CAG33105.1.
AK304301 mRNA. Translation: BAG65155.1.
AK315562 mRNA. Translation: BAG37938.1.
AP000654 Genomic DNA. No translation available.
AP001528 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW75145.1.
BC001278 mRNA. Translation: AAH01278.1.
CCDSiCCDS8278.1. [O95084-1]
RefSeqiNP_001280107.1. NM_001293178.1.
NP_001280108.1. NM_001293179.1. [O95084-1]
NP_001280109.1. NM_001293180.1. [O95084-1]
UniGeneiHs.25338.
Hs.729257.

Genome annotation databases

EnsembliENST00000280258; ENSP00000280258; ENSG00000150687. [O95084-1]
GeneIDi11098.
KEGGihsa:11098.
UCSCiuc001pcb.4. human. [O95084-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRS23_HUMAN
AccessioniPrimary (citable) accession number: O95084
Secondary accession number(s): B2RDJ1, B4E2J3, Q6IBI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families