Reviewed, UniProtKB/Swiss-Prot O95081 (AGFG2_HUMAN)

Names and origin

Protein names

Recommended name:
    Arf-GAP domain and FG repeats-containing protein 2
Alternative name(s):
    HIV-1 Rev-binding protein-like protein
    Rev/Rex activation domain-binding protein related
      Short name=RAB-R

Gene names

Name:	AGFG2
Synonyms:	HRBL, RABR

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with EPS15R By similarity.
Domain	Contains FG repeats and 4 N-P-F repeats.
Sequence similarities	Contains 1 Arf-GAP domain.
Sequence caution	The sequence AAC78803.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of ARF GTPase activity Inferred from electronic annotation. Source: InterPro
Molecular function	ARF GTPase activator activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95081-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95081-2)

The sequence of this isoform differs from the canonical sequence as follows:
     145-155: YVPPDQVKGPT → PDTFPRRLCQL
     157-481: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Arf-GAP domain and FG repeats-containing protein 2		PRO_0000204828
Regions
	Domain	27 – 153	127	Arf-GAP
	Zinc finger	47 – 70	24	C4-type
	Compositional bias	367 – 427	61	Pro-rich
Amino acid modifications
	Modified residue	173	1	N6-acetyllysine Ref.4
Natural variations
	Alternative sequence	145 – 155	11	YVPPDQVKGPT → PDTFPRRLCQL in isoform 2.		VSP_010667
	Alternative sequence	157 – 481	325	Missing in isoform 2.		VSP_010668
	Natural variant	365	1	T → N: dbSNP rs34731997.		VAR_050566
Experimental info
	Sequence conflict	96	1	V → L in AAD01550. Ref.1
	Sequence conflict	124	1	D → N in AAD01550. Ref.1
	Sequence conflict	206	1	Q → H in AAC78803. Ref.3
	Sequence conflict	349	1	M → T in AAH17329. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 21, 2004. Version 2. Checksum: A89202A0F0924FE2	FASTA	481	48,963
	10 20 30 40 50 60 MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC AQRGVTYVDI 70 80 90 100 110 120 TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ SRGNEVCRKI WLGLFDARTS 130 140 150 160 170 180 LVPDSRDPQK VKEFLQEKYE KKRWYVPPDQ VKGPTYTKGS ASTPVQGSIP EGKPLRTLLG 190 200 210 220 230 240 DPAPSLSVAA STSSQPVSQS HARTSQARST QPPPHSSVKK ASTDLLADIG GDPFAAPQMA 250 260 270 280 290 300 PAFAAFPAFG GQTPSQGGFA NFDAFSSGPS SSVFGSLPPA GQASFQAQPT PAGSSQGTPF 310 320 330 340 350 360 GATPLAPASQ PNSLADVGSF LGPGVPAAGV PSSLFGMAGQ VPPLQSVTMG GGGGSSTGLA 370 380 390 400 410 420 FGAFTNPFTA PAAQSPLPST NPFQPNGLAP GPGFGMSSAG PGFPQAVPPT GAFASSFPAP 430 440 450 460 470 480 LFPPQTPLVQ QQNGSSFGDL GSAKLGQRPL SQPAGISTNP FMTGPSSSPF ASKPPTTNPF L
	Isoform 2. Checksum: 3FB8EBEDE73DD1EB	FASTA	156	17,344
	10 20 30 40 50 60 MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC AQRGVTYVDI 70 80 90 100 110 120 TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ SRGNEVCRKI WLGLFDARTS 130 140 150 LVPDSRDPQK VKEFLQEKYE KKRWPDTFPR RLCQLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module." Salcini A.E., Confalonieri S., Doria M., Santolini E., Tassi E., Minenkova O., Cesareni G., Pelicci P.G., Di Fiore P.P. Genes Dev. 11:2239-2249(1997) [PubMed: 9303539] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Placenta.
[3]	"Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes." Gloeckner G., Scherer S., Schattevoy R., Boright A.P., Weber J., Tsui L.-C., Rosenthal A. Genome Res. 8:1060-1073(1998) [PubMed: 9799793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-481.
[4]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-173, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF015042 mRNA. Translation: AAD01550.1. BC009393 mRNA. Translation: AAH09393.1. BC017329 mRNA. Translation: AAH17329.1. AF053356 Genomic DNA. Translation: AAC78803.1. Sequence problems.
IPI	IPI00418238. IPI00418239.
RefSeq	NP_006067.3.
UniGene	Hs.521083
3D structure databases
SMR	O95081. Positions 31-152.
ModBase	Search...
Protein-protein interaction databases
STRING	O95081.
PTM databases
PhosphoSite	O95081.
Proteomic databases
PRIDE	O95081.
Genome annotation databases
Ensembl	ENST00000300176; ENSP00000300176; ENSG00000106351; Homo sapiens. [Genome view]
GeneID	3268.
KEGG	hsa:3268.
UCSC	uc003uvf.1. human. uc003uvg.1. human.
Organism-specific databases
CTD	3268.
GeneCards	GC07P099976.
H-InvDB	HIX0006923.
HGNC	HGNC:5177. AGFG2.
HPA	HPA019689.
MIM	604019. gene.
PharmGKB	PA29451.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O95081.
HOVERGEN	O95081.
OMA	QPAGIST
OrthoDB	EOG9DFS7G
Gene expression databases
ArrayExpress	O95081.
Bgee	O95081.
CleanEx	HS_AGFG2.
Genevestigator	O95081.
GermOnline	ENSG00000106351. Homo sapiens.
Family and domain databases
InterPro	IPR001164. ArfGAP. [Graphical view]
Pfam	PF01412. ArfGap. 1 hit. [Graphical view]
PRINTS	PR00405. REVINTRACTNG.
SMART	SM00105. ArfGap. 1 hit. [Graphical view]
PROSITE	PS50115. ARFGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	12977.
SOURCE	Search...

Entry information

Entry name

AGFG2_HUMAN

Accession

Primary (citable) accession number: O95081
Secondary accession number(s): O75429, Q96AB9, Q96GL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2004
Last sequence update:	June 21, 2004
Last modified:	November 24, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.