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Protein

Arf-GAP domain and FG repeat-containing protein 2

Gene

AGFG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri47 – 7024C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP domain and FG repeat-containing protein 2
Alternative name(s):
HIV-1 Rev-binding protein-like protein
Rev/Rex activation domain-binding protein related
Short name:
RAB-R
Gene namesi
Name:AGFG2
Synonyms:HRBL, RABR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:5177. AGFG2.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29451.

Polymorphism and mutation databases

BioMutaiAGFG2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Arf-GAP domain and FG repeat-containing protein 2PRO_0000204828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO95081.
MaxQBiO95081.
PaxDbiO95081.
PeptideAtlasiO95081.
PRIDEiO95081.

PTM databases

iPTMnetiO95081.
PhosphoSiteiO95081.

Expressioni

Gene expression databases

BgeeiENSG00000106351.
CleanExiHS_AGFG2.
ExpressionAtlasiO95081. baseline and differential.
GenevisibleiO95081. HS.

Organism-specific databases

HPAiHPA019689.

Interactioni

Subunit structurei

Interacts with EPS15R.By similarity

Protein-protein interaction databases

BioGridi109504. 10 interactions.
IntActiO95081. 2 interactions.
MINTiMINT-6630281.
STRINGi9606.ENSP00000300176.

Structurei

3D structure databases

ProteinModelPortaliO95081.
SMRiO95081. Positions 44-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 153127Arf-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi367 – 42761Pro-richAdd
BLAST

Domaini

Contains FG repeats and 4 N-P-F repeats.

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri47 – 7024C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0702. Eukaryota.
ENOG41122WA. LUCA.
GeneTreeiENSGT00560000077249.
HOGENOMiHOG000253009.
HOVERGENiHBG006551.
InParanoidiO95081.
OMAiGPSFGMS.
OrthoDBiEOG091G09LC.
PhylomeDBiO95081.
TreeFamiTF325357.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC
60 70 80 90 100
AQRGVTYVDI TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ
110 120 130 140 150
SRGNEVCRKI WLGLFDARTS LVPDSRDPQK VKEFLQEKYE KKRWYVPPDQ
160 170 180 190 200
VKGPTYTKGS ASTPVQGSIP EGKPLRTLLG DPAPSLSVAA STSSQPVSQS
210 220 230 240 250
HARTSQARST QPPPHSSVKK ASTDLLADIG GDPFAAPQMA PAFAAFPAFG
260 270 280 290 300
GQTPSQGGFA NFDAFSSGPS SSVFGSLPPA GQASFQAQPT PAGSSQGTPF
310 320 330 340 350
GATPLAPASQ PNSLADVGSF LGPGVPAAGV PSSLFGMAGQ VPPLQSVTMG
360 370 380 390 400
GGGGSSTGLA FGAFTNPFTA PAAQSPLPST NPFQPNGLAP GPGFGMSSAG
410 420 430 440 450
PGFPQAVPPT GAFASSFPAP LFPPQTPLVQ QQNGSSFGDL GSAKLGQRPL
460 470 480
SQPAGISTNP FMTGPSSSPF ASKPPTTNPF L
Length:481
Mass (Da):48,963
Last modified:June 21, 2004 - v2
Checksum:iA89202A0F0924FE2
GO
Isoform 2 (identifier: O95081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-155: YVPPDQVKGPT → PDTFPRRLCQL
     157-481: Missing.

Show »
Length:156
Mass (Da):17,344
Checksum:i3FB8EBEDE73DD1EB
GO

Sequence cautioni

The sequence AAC78803 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961V → L in AAD01550 (PubMed:9303539).Curated
Sequence conflicti124 – 1241D → N in AAD01550 (PubMed:9303539).Curated
Sequence conflicti206 – 2061Q → H in AAC78803 (PubMed:9799793).Curated
Sequence conflicti349 – 3491M → T in AAH17329 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti365 – 3651T → N.
Corresponds to variant rs34731997 [ dbSNP | Ensembl ].
VAR_050566

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei145 – 15511YVPPDQVKGPT → PDTFPRRLCQL in isoform 2. 1 PublicationVSP_010667Add
BLAST
Alternative sequencei157 – 481325Missing in isoform 2. 1 PublicationVSP_010668Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015042 mRNA. Translation: AAD01550.1.
BC009393 mRNA. Translation: AAH09393.1.
BC017329 mRNA. Translation: AAH17329.1.
AF053356 Genomic DNA. Translation: AAC78803.1. Sequence problems.
CCDSiCCDS5697.1. [O95081-1]
RefSeqiNP_006067.3. NM_006076.4. [O95081-1]
UniGeneiHs.521083.

Genome annotation databases

EnsembliENST00000300176; ENSP00000300176; ENSG00000106351. [O95081-1]
GeneIDi3268.
KEGGihsa:3268.
UCSCiuc003uvf.4. human. [O95081-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015042 mRNA. Translation: AAD01550.1.
BC009393 mRNA. Translation: AAH09393.1.
BC017329 mRNA. Translation: AAH17329.1.
AF053356 Genomic DNA. Translation: AAC78803.1. Sequence problems.
CCDSiCCDS5697.1. [O95081-1]
RefSeqiNP_006067.3. NM_006076.4. [O95081-1]
UniGeneiHs.521083.

3D structure databases

ProteinModelPortaliO95081.
SMRiO95081. Positions 44-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109504. 10 interactions.
IntActiO95081. 2 interactions.
MINTiMINT-6630281.
STRINGi9606.ENSP00000300176.

PTM databases

iPTMnetiO95081.
PhosphoSiteiO95081.

Polymorphism and mutation databases

BioMutaiAGFG2.

Proteomic databases

EPDiO95081.
MaxQBiO95081.
PaxDbiO95081.
PeptideAtlasiO95081.
PRIDEiO95081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300176; ENSP00000300176; ENSG00000106351. [O95081-1]
GeneIDi3268.
KEGGihsa:3268.
UCSCiuc003uvf.4. human. [O95081-1]

Organism-specific databases

CTDi3268.
GeneCardsiAGFG2.
HGNCiHGNC:5177. AGFG2.
HPAiHPA019689.
MIMi604019. gene.
neXtProtiNX_O95081.
PharmGKBiPA29451.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0702. Eukaryota.
ENOG41122WA. LUCA.
GeneTreeiENSGT00560000077249.
HOGENOMiHOG000253009.
HOVERGENiHBG006551.
InParanoidiO95081.
OMAiGPSFGMS.
OrthoDBiEOG091G09LC.
PhylomeDBiO95081.
TreeFamiTF325357.

Miscellaneous databases

GeneWikiiHRBL.
GenomeRNAii3268.
PROiO95081.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106351.
CleanExiHS_AGFG2.
ExpressionAtlasiO95081. baseline and differential.
GenevisibleiO95081. HS.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGFG2_HUMAN
AccessioniPrimary (citable) accession number: O95081
Secondary accession number(s): O75429, Q96AB9, Q96GL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.