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O95073 (FSBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibrinogen silencer-binding protein
Gene names
Name:FSBP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1. Ref.5

Subunit structure

Interacts with APBA1 (via PDZ 1 and 2 domains). Ref.5

Subcellular location

Nucleus Ref.5.

Tissue specificity

Expressed in multiple tissues including brain. Ref.5

Miscellaneous

Intragenic, in the second intron of RAB54B gene.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay Ref.5. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95073-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95073-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Fibrinogen silencer-binding protein
PRO_0000087352

Natural variations

Alternative sequence1 – 141141Missing in isoform 2.
VSP_010774
Natural variant2261R → K. Ref.2
Corresponds to variant rs3136422 [ dbSNP | Ensembl ].
VAR_019301

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 3CC89EC32A377B2F

FASTA29934,768
        10         20         30         40         50         60 
MVGKARSSNF TLSEKLDLLK LVKPYVKILE EHTNKHSVIV EKNRCWDIIA VNYNAIGVDR 

        70         80         90        100        110        120 
PPRTAQGLRT LYKRLKEYAK QELLQQKETQ SDFKSNISEP TKKVMEMIPQ ISSFCLVRDR 

       130        140        150        160        170        180 
NHIQSANLDE EAQAGTSSLQ VMLDHHPVAI TVEVKQEEDI KPPPPLVLNS QQSDTLEQRE 

       190        200        210        220        230        240 
EHELVHVMER SLSPSLSSVD MRMTSSPSSI PRRDDFFRHE SGEHFRSLLG YDPQILQMLK 

       250        260        270        280        290 
EEHQIILENQ KNFGLYVQEK RDGLKRRQQL EEELLRAKIE VEKLKAIRLR HDLPEYNSL 

« Hide

Isoform 2 [UniParc].

Checksum: 974DA0DC61B99879
Show »

FASTA15818,626

References

« Hide 'large scale' references
[1]"A novel transcription repressor that down-regulates the expression of the gamma chain of human fibrinogen."
Hu C.-H., Cao Z., Chung D.W., Davie E.W.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]SeattleSNPs variation discovery resource
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-226.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[4]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter."
Lau K.F., Perkinton M.S., Rodriguez L., McLoughlin D.M., Miller C.C.
NeuroReport 21:761-766(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH APBA1.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007866 mRNA. Translation: AAD09313.1.
AF487652 Genomic DNA. Translation: AAL96666.1.
AC023632 Genomic DNA. No translation available.
BC033710 mRNA. Translation: AAH33710.2.
RefSeqNP_001192191.1. NM_001205262.2.
NP_001243070.1. NM_001256141.1.
UniGeneHs.30561.
Hs.744229.

3D structure databases

ProteinModelPortalO95073.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117321. 25 interactions.
IntActO95073. 4 interactions.
STRING9606.ENSP00000420405.

Proteomic databases

PaxDbO95073.
PRIDEO95073.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000481490; ENSP00000420405; ENSG00000265817. [O95073-1]
GeneID100861412.
25788.
KEGGhsa:100861412.
hsa:25788.
UCSCuc003ygm.3. human. [O95073-1]

Organism-specific databases

CTD100861412.
25788.
GeneCardsGC08M095400.
HGNCHGNC:43653. FSBP.
HPAHPA026509.
neXtProtNX_O95073.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28734.
HOGENOMHOG000112654.
HOVERGENHBG051662.
InParanoidO95073.
KOK10877.
OMACWDIIAD.
PhylomeDBO95073.
TreeFamTF331896.

Gene expression databases

BgeeO95073.
GenevestigatorO95073.

Family and domain databases

InterProIPR028002. Myb_DNA-bind_5.
[Graphical view]
PfamPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRAD54B.
NextBio46945.
PROO95073.

Entry information

Entry nameFSBP_HUMAN
AccessionPrimary (citable) accession number: O95073
Secondary accession number(s): Q8N4S5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM