Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibrinogen silencer-binding protein

Gene

FSBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen silencer-binding protein
Gene namesi
Name:FSBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:43653. FSBP.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiFSBP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Fibrinogen silencer-binding proteinPRO_0000087352Add
BLAST

Proteomic databases

PaxDbiO95073.
PRIDEiO95073.

Expressioni

Tissue specificityi

Expressed in multiple tissues including brain.1 Publication

Gene expression databases

BgeeiO95073.
ExpressionAtlasiO95073. baseline.
GenevisibleiO95073. HS.

Organism-specific databases

HPAiHPA026509.

Interactioni

Subunit structurei

Interacts with APBA1 (via PDZ 1 and 2 domains).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1059030,EBI-1059030
Q9H6143EBI-1059030,EBI-10249899
ANKRD36BP1Q96IX93EBI-1059030,EBI-744859
ATPAF2Q8N5M13EBI-1059030,EBI-1166928
CDC23Q9UJX23EBI-1059030,EBI-396137
ENKD1Q9H0I23EBI-1059030,EBI-744099
FLJ13057Q53SE73EBI-1059030,EBI-10172181
PLCG2P168852EBI-10696047,EBI-617403
PRKAA1Q131313EBI-1059030,EBI-1181405
SH2D2AQ9NP313EBI-10696047,EBI-490630
SUMO1P631653EBI-1059030,EBI-80140
TCEANCQ8N8B73EBI-1059030,EBI-954696

Protein-protein interaction databases

BioGridi117321. 33 interactions.
IntActiO95073. 15 interactions.
STRINGi9606.ENSP00000420405.

Structurei

3D structure databases

ProteinModelPortaliO95073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG28734.
GeneTreeiENSGT00390000008778.
HOGENOMiHOG000112654.
HOVERGENiHBG051662.
InParanoidiO95073.
KOiK10877.
OMAiCWDIIAD.
PhylomeDBiO95073.
TreeFamiTF331896.

Family and domain databases

InterProiIPR028002. Myb_DNA-bind_5.
[Graphical view]
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95073-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGKARSSNF TLSEKLDLLK LVKPYVKILE EHTNKHSVIV EKNRCWDIIA
60 70 80 90 100
VNYNAIGVDR PPRTAQGLRT LYKRLKEYAK QELLQQKETQ SDFKSNISEP
110 120 130 140 150
TKKVMEMIPQ ISSFCLVRDR NHIQSANLDE EAQAGTSSLQ VMLDHHPVAI
160 170 180 190 200
TVEVKQEEDI KPPPPLVLNS QQSDTLEQRE EHELVHVMER SLSPSLSSVD
210 220 230 240 250
MRMTSSPSSI PRRDDFFRHE SGEHFRSLLG YDPQILQMLK EEHQIILENQ
260 270 280 290
KNFGLYVQEK RDGLKRRQQL EEELLRAKIE VEKLKAIRLR HDLPEYNSL
Length:299
Mass (Da):34,768
Last modified:May 1, 1999 - v1
Checksum:i3CC89EC32A377B2F
GO
Isoform 2 (identifier: O95073-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,626
Checksum:i974DA0DC61B99879
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti226 – 2261R → K.1 Publication
Corresponds to variant rs3136422 [ dbSNP | Ensembl ].
VAR_019301

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 141141Missing in isoform 2. 1 PublicationVSP_010774Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007866 mRNA. Translation: AAD09313.1.
AF487652 Genomic DNA. Translation: AAL96666.1.
AC023632 Genomic DNA. No translation available.
BC033710 mRNA. Translation: AAH33710.2.
CCDSiCCDS59106.1. [O95073-1]
RefSeqiNP_001192191.1. NM_001205262.2.
NP_001243070.1. NM_001256141.1. [O95073-1]
UniGeneiHs.30561.
Hs.744229.

Genome annotation databases

EnsembliENST00000481490; ENSP00000420405; ENSG00000265817.
GeneIDi100861412.
25788.
KEGGihsa:100861412.
hsa:25788.
UCSCiuc003ygm.3. human. [O95073-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007866 mRNA. Translation: AAD09313.1.
AF487652 Genomic DNA. Translation: AAL96666.1.
AC023632 Genomic DNA. No translation available.
BC033710 mRNA. Translation: AAH33710.2.
CCDSiCCDS59106.1. [O95073-1]
RefSeqiNP_001192191.1. NM_001205262.2.
NP_001243070.1. NM_001256141.1. [O95073-1]
UniGeneiHs.30561.
Hs.744229.

3D structure databases

ProteinModelPortaliO95073.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117321. 33 interactions.
IntActiO95073. 15 interactions.
STRINGi9606.ENSP00000420405.

Polymorphism and mutation databases

BioMutaiFSBP.

Proteomic databases

PaxDbiO95073.
PRIDEiO95073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000481490; ENSP00000420405; ENSG00000265817.
GeneIDi100861412.
25788.
KEGGihsa:100861412.
hsa:25788.
UCSCiuc003ygm.3. human. [O95073-1]

Organism-specific databases

CTDi100861412.
25788.
GeneCardsiGC08M095400.
HGNCiHGNC:43653. FSBP.
HPAiHPA026509.
MIMi616306. gene.
neXtProtiNX_O95073.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28734.
GeneTreeiENSGT00390000008778.
HOGENOMiHOG000112654.
HOVERGENiHBG051662.
InParanoidiO95073.
KOiK10877.
OMAiCWDIIAD.
PhylomeDBiO95073.
TreeFamiTF331896.

Miscellaneous databases

GeneWikiiRAD54B.
NextBioi46945.
PROiO95073.
SOURCEiSearch...

Gene expression databases

BgeeiO95073.
ExpressionAtlasiO95073. baseline.
GenevisibleiO95073. HS.

Family and domain databases

InterProiIPR028002. Myb_DNA-bind_5.
[Graphical view]
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel transcription repressor that down-regulates the expression of the gamma chain of human fibrinogen."
    Hu C.-H., Cao Z., Chung D.W., Davie E.W.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. SeattleSNPs variation discovery resource
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-226.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter."
    Lau K.F., Perkinton M.S., Rodriguez L., McLoughlin D.M., Miller C.C.
    NeuroReport 21:761-766(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH APBA1.

Entry informationi

Entry nameiFSBP_HUMAN
AccessioniPrimary (citable) accession number: O95073
Secondary accession number(s): Q8N4S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Intragenic, in the second intron of RAB54B gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.