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O95073

- FSBP_HUMAN

UniProt

O95073 - FSBP_HUMAN

Protein

Fibrinogen silencer-binding protein

Gene

FSBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibrinogen silencer-binding protein
    Gene namesi
    Name:FSBP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:43653. FSBP.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Fibrinogen silencer-binding proteinPRO_0000087352Add
    BLAST

    Proteomic databases

    PaxDbiO95073.
    PRIDEiO95073.

    Expressioni

    Tissue specificityi

    Expressed in multiple tissues including brain.1 Publication

    Gene expression databases

    BgeeiO95073.
    GenevestigatoriO95073.

    Organism-specific databases

    HPAiHPA026509.

    Interactioni

    Subunit structurei

    Interacts with APBA1 (via PDZ 1 and 2 domains).1 Publication

    Protein-protein interaction databases

    BioGridi117321. 25 interactions.
    IntActiO95073. 4 interactions.
    STRINGi9606.ENSP00000420405.

    Structurei

    3D structure databases

    ProteinModelPortaliO95073.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG28734.
    HOGENOMiHOG000112654.
    HOVERGENiHBG051662.
    InParanoidiO95073.
    KOiK10877.
    OMAiCWDIIAD.
    PhylomeDBiO95073.
    TreeFamiTF331896.

    Family and domain databases

    InterProiIPR028002. Myb_DNA-bind_5.
    [Graphical view]
    PfamiPF13873. Myb_DNA-bind_5. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95073-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVGKARSSNF TLSEKLDLLK LVKPYVKILE EHTNKHSVIV EKNRCWDIIA    50
    VNYNAIGVDR PPRTAQGLRT LYKRLKEYAK QELLQQKETQ SDFKSNISEP 100
    TKKVMEMIPQ ISSFCLVRDR NHIQSANLDE EAQAGTSSLQ VMLDHHPVAI 150
    TVEVKQEEDI KPPPPLVLNS QQSDTLEQRE EHELVHVMER SLSPSLSSVD 200
    MRMTSSPSSI PRRDDFFRHE SGEHFRSLLG YDPQILQMLK EEHQIILENQ 250
    KNFGLYVQEK RDGLKRRQQL EEELLRAKIE VEKLKAIRLR HDLPEYNSL 299
    Length:299
    Mass (Da):34,768
    Last modified:May 1, 1999 - v1
    Checksum:i3CC89EC32A377B2F
    GO
    Isoform 2 (identifier: O95073-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-141: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:158
    Mass (Da):18,626
    Checksum:i974DA0DC61B99879
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti226 – 2261R → K.1 Publication
    Corresponds to variant rs3136422 [ dbSNP | Ensembl ].
    VAR_019301

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 141141Missing in isoform 2. 1 PublicationVSP_010774Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007866 mRNA. Translation: AAD09313.1.
    AF487652 Genomic DNA. Translation: AAL96666.1.
    AC023632 Genomic DNA. No translation available.
    BC033710 mRNA. Translation: AAH33710.2.
    CCDSiCCDS59106.1. [O95073-1]
    RefSeqiNP_001192191.1. NM_001205262.2.
    NP_001243070.1. NM_001256141.1. [O95073-1]
    UniGeneiHs.30561.
    Hs.744229.

    Genome annotation databases

    EnsembliENST00000481490; ENSP00000420405; ENSG00000265817. [O95073-1]
    GeneIDi100861412.
    25788.
    KEGGihsa:100861412.
    hsa:25788.
    UCSCiuc003ygm.3. human. [O95073-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007866 mRNA. Translation: AAD09313.1 .
    AF487652 Genomic DNA. Translation: AAL96666.1 .
    AC023632 Genomic DNA. No translation available.
    BC033710 mRNA. Translation: AAH33710.2 .
    CCDSi CCDS59106.1. [O95073-1 ]
    RefSeqi NP_001192191.1. NM_001205262.2.
    NP_001243070.1. NM_001256141.1. [O95073-1 ]
    UniGenei Hs.30561.
    Hs.744229.

    3D structure databases

    ProteinModelPortali O95073.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117321. 25 interactions.
    IntActi O95073. 4 interactions.
    STRINGi 9606.ENSP00000420405.

    Proteomic databases

    PaxDbi O95073.
    PRIDEi O95073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000481490 ; ENSP00000420405 ; ENSG00000265817 . [O95073-1 ]
    GeneIDi 100861412.
    25788.
    KEGGi hsa:100861412.
    hsa:25788.
    UCSCi uc003ygm.3. human. [O95073-1 ]

    Organism-specific databases

    CTDi 100861412.
    25788.
    GeneCardsi GC08M095400.
    HGNCi HGNC:43653. FSBP.
    HPAi HPA026509.
    neXtProti NX_O95073.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28734.
    HOGENOMi HOG000112654.
    HOVERGENi HBG051662.
    InParanoidi O95073.
    KOi K10877.
    OMAi CWDIIAD.
    PhylomeDBi O95073.
    TreeFami TF331896.

    Miscellaneous databases

    GeneWikii RAD54B.
    NextBioi 46945.
    PROi O95073.

    Gene expression databases

    Bgeei O95073.
    Genevestigatori O95073.

    Family and domain databases

    InterProi IPR028002. Myb_DNA-bind_5.
    [Graphical view ]
    Pfami PF13873. Myb_DNA-bind_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel transcription repressor that down-regulates the expression of the gamma chain of human fibrinogen."
      Hu C.-H., Cao Z., Chung D.W., Davie E.W.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. SeattleSNPs variation discovery resource
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-226.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    4. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter."
      Lau K.F., Perkinton M.S., Rodriguez L., McLoughlin D.M., Miller C.C.
      NeuroReport 21:761-766(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH APBA1.

    Entry informationi

    Entry nameiFSBP_HUMAN
    AccessioniPrimary (citable) accession number: O95073
    Secondary accession number(s): Q8N4S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Intragenic, in the second intron of RAB54B gene.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3