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Protein

E3 ubiquitin-protein ligase UBR5

Gene

UBR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.By similarity3 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2768Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1177 – 1245UBR-typePROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • RNA binding Source: InterPro
  • ubiquitin-protein transferase activity Source: ProtInc
  • ubiquitin-ubiquitin ligase activity Source: BHF-UCL
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cell proliferation Source: ProtInc
  • cellular response to DNA damage stimulus Source: UniProtKB
  • DNA repair Source: UniProtKB-KW
  • negative regulation of double-strand break repair Source: UniProtKB
  • negative regulation of histone H2A K63-linked ubiquitination Source: UniProtKB
  • positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • positive regulation of catenin import into nucleus Source: BHF-UCL
  • positive regulation of protein import into nucleus, translocation Source: BHF-UCL
  • progesterone receptor signaling pathway Source: HGNC
  • protein polyubiquitination Source: BHF-UCL
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104517-MONOMER.
BRENDAi6.3.2.19. 2681.
SignaLinkiO95071.
SIGNORiO95071.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR5 (EC:2.3.2.26)
Alternative name(s):
E3 ubiquitin-protein ligase, HECT domain-containing 1
HECT-type E3 ubiquitin transferase UBR5
Hyperplastic discs protein homolog
Short name:
hHYD
Progestin-induced protein
Gene namesi
Name:UBR5
Synonyms:EDD, EDD1, HYD, KIAA0896
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:16806. UBR5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2768C → A: Loss of ubiquitin binding. 1 Publication1

Organism-specific databases

DisGeNETi51366.
OpenTargetsiENSG00000104517.
PharmGKBiPA162408175.

Polymorphism and mutation databases

BioMutaiUBR5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000869312 – 2799E3 ubiquitin-protein ligase UBR5Add BLAST2798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei110PhosphoserineCombined sources1 Publication1
Modified residuei327PhosphoserineCombined sources1 Publication1
Modified residuei352Phosphoserine1 Publication1
Modified residuei578PhosphoserineCombined sources1 Publication1
Modified residuei612PhosphoserineCombined sources1 Publication1
Modified residuei637Phosphothreonine1 Publication1
Modified residuei808PhosphoserineCombined sources1 Publication1
Modified residuei928Phosphoserine1 Publication1
Modified residuei1018Phosphoserine1 Publication1
Modified residuei1115Phosphothreonine1 Publication1
Modified residuei1135Phosphothreonine1 Publication1
Modified residuei1227Phosphoserine1 Publication1
Modified residuei1308PhosphoserineCombined sources1 Publication1
Modified residuei1355Phosphoserine1 Publication1
Modified residuei1375Phosphoserine1 Publication1
Modified residuei1481Phosphoserine1 Publication1
Modified residuei1549PhosphoserineCombined sources1
Modified residuei1736Phosphothreonine1 Publication1
Modified residuei1741Phosphoserine1 Publication1
Modified residuei1746PhosphotyrosineCombined sources1
Modified residuei1780Phosphoserine1 Publication1
Modified residuei1969PhosphothreonineCombined sources1 Publication1
Modified residuei1990PhosphoserineCombined sources1
Modified residuei2026Phosphoserine1 Publication1
Modified residuei2028Phosphoserine1 Publication1
Modified residuei2030Phosphothreonine1 Publication1
Modified residuei2076Phosphoserine1 Publication1
Modified residuei2213Phosphothreonine1 Publication1
Modified residuei2241PhosphoserineCombined sources1
Modified residuei2289Phosphoserine1 Publication1
Modified residuei2469PhosphoserineCombined sources1
Modified residuei2484Phosphoserine1 Publication1
Modified residuei2486PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95071.
MaxQBiO95071.
PaxDbiO95071.
PeptideAtlasiO95071.
PRIDEiO95071.

PTM databases

iPTMnetiO95071.
PhosphoSitePlusiO95071.

Expressioni

Tissue specificityi

Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.

Gene expression databases

BgeeiENSG00000104517.
CleanExiHS_UBR5.
ExpressionAtlasiO95071. baseline and differential.
GenevisibleiO95071. HS.

Organism-specific databases

HPAiHPA024728.
HPA053688.

Interactioni

Subunit structurei

Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts directly with DYRK2. Interacts with PIH1D1 (PubMed:24656813).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352226EBI-358329,EBI-491549
GSK3BP498418EBI-358329,EBI-373586
PAIP2Q9BPZ35EBI-358329,EBI-2957445

Protein-protein interaction databases

BioGridi119501. 136 interactors.
DIPiDIP-32930N.
IntActiO95071. 57 interactors.
MINTiMINT-196086.
STRINGi9606.ENSP00000429084.

Structurei

Secondary structure

12799
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi182 – 184Combined sources3
Helixi187 – 196Combined sources10
Helixi202 – 211Combined sources10
Turni212 – 214Combined sources3
Helixi216 – 224Combined sources9
Helixi2394 – 2408Combined sources15
Helixi2410 – 2412Combined sources3
Helixi2413 – 2420Combined sources8
Helixi2425 – 2433Combined sources9
Helixi2435 – 2452Combined sources18
Helixi2687 – 2692Combined sources6
Beta strandi2695 – 2698Combined sources4
Helixi2704 – 2720Combined sources17
Helixi2723 – 2734Combined sources12
Beta strandi2751 – 2756Combined sources6
Beta strandi2764 – 2766Combined sources3
Turni2767 – 2770Combined sources4
Beta strandi2771 – 2775Combined sources5
Helixi2780 – 2791Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I2TX-ray1.04A2393-2453[»]
2QHOX-ray1.85B/D/F/H180-230[»]
3PT3X-ray1.97A/B2687-2799[»]
ProteinModelPortaliO95071.
SMRiO95071.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95071.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2377 – 2454PABCPROSITE-ProRule annotationAdd BLAST78
Domaini2462 – 2799HECTPROSITE-ProRule annotationAdd BLAST338

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi940 – 945Poly-Glu6
Compositional biasi980 – 985Poly-Ser6
Compositional biasi1528 – 1537Poly-Ser10
Compositional biasi1671 – 1681Poly-SerAdd BLAST11
Compositional biasi1762 – 1768Poly-Ala7
Compositional biasi1986 – 1997Asp/Glu-rich (acidic)Add BLAST12
Compositional biasi2036 – 2059Pro-richAdd BLAST24
Compositional biasi2329 – 2348Arg/Glu-rich (mixed charge)Add BLAST20
Compositional biasi2357 – 2366Arg/Asp-rich (mixed charge)10
Compositional biasi2489 – 2500Asp/Glu-rich (acidic)Add BLAST12
Compositional biasi2737 – 2757Pro-richAdd BLAST21

Sequence similaritiesi

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation
Contains 1 PABC domain.PROSITE-ProRule annotation
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1177 – 1245UBR-typePROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0943. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00850000132302.
HOGENOMiHOG000046848.
HOVERGENiHBG096012.
InParanoidiO95071.
KOiK10593.
OMAiENSLYWW.
OrthoDBiEOG091G005O.
PhylomeDBiO95071.
TreeFamiTF314406.

Family and domain databases

CDDicd14423. CUE_UBR5. 1 hit.
Gene3Di1.10.1900.10. 1 hit.
2.130.10.30. 3 hits.
InterProiIPR024725. E3_UbLigase_EDD_UBA.
IPR000569. HECT_dom.
IPR002004. PABP_HYD.
IPR009091. RCC1/BLIP-II.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF11547. E3_UbLigase_EDD. 1 hit.
PF00632. HECT. 1 hit.
PF00658. PABP. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00517. PolyA. 1 hit.
SM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF56204. SSF56204. 2 hits.
SSF63570. SSF63570. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS51309. PABC. 1 hit.
PS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ
60 70 80 90 100
CVVGPNHAAF LLEDGRVCRI GFSVQPDRLE LGKPDNNDGS KLNSNSGAGR
110 120 130 140 150
TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG
160 170 180 190 200
ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI PASVIPEELI SQAQVVLQGK
210 220 230 240 250
SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE SYLPGEDLMS
260 270 280 290 300
LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRVLLLP
310 320 330 340 350
LERDSELLRE RESVLRLRER RWLDGASFDN ERGSTSKEGE PNLDKKNTPV
360 370 380 390 400
QSPVSLGEDL QWWPDKDGTK FICIGALYSE LLAVSSKGEL YQWKWSESEP
410 420 430 440 450
YRNAQNPSLH HPRATFLGLT NEKIVLLSAN SIRATVATEN NKVATWVDET
460 470 480 490 500
LSSVASKLEH TAQTYSELQG ERIVSLHCCA LYTCAQLENS LYWWGVVPFS
510 520 530 540 550
QRKKMLEKAR AKNKKPKSSA GISSMPNITV GTQVCLRNNP LYHAGAVAFS
560 570 580 590 600
ISAGIPKVGV LMESVWNMND SCRFQLRSPE SLKNMEKASK TTEAKPESKQ
610 620 630 640 650
EPVKTEMGPP PSPASTCSDA SSIASSASMP YKRRRSTPAP KEEEKVNEEQ
660 670 680 690 700
WSLREVVFVE DVKNVPVGKV LKVDGAYVAV KFPGTSSNTN CQNSSGPDAD
710 720 730 740 750
PSSLLQDCRL LRIDELQVVK TGGTPKVPDC FQRTPKKLCI PEKTEILAVN
760 770 780 790 800
VDSKGVHAVL KTGNWVRYCI FDLATGKAEQ ENNFPTSSIA FLGQNERNVA
810 820 830 840 850
IFTAGQESPI ILRDGNGTIY PMAKDCMGGI RDPDWLDLPP ISSLGMGVHS
860 870 880 890 900
LINLPANSTI KKKAAVIIMA VEKQTLMQHI LRCDYEACRQ YLMNLEQAVV
910 920 930 940 950
LEQNLQMLQT FISHRCDGNR NILHACVSVC FPTSNKETKE EEEAERSERN
960 970 980 990 1000
TFAERLSAVE AIANAISVVS SNGPGNRAGS SSSRSLRLRE MMRRSLRAAG
1010 1020 1030 1040 1050
LGRHEAGASS SDHQDPVSPP IAPPSWVPDP PAMDPDGDID FILAPAVGSL
1060 1070 1080 1090 1100
TTAATGTGQG PSTSTIPGPS TEPSVVESKD RKANAHFILK LLCDSVVLQP
1110 1120 1130 1140 1150
YLRELLSAKD ARGMTPFMSA VSGRAYPAAI TILETAQKIA KAEISSSEKE
1160 1170 1180 1190 1200
EDVFMGMVCP SGTNPDDSPL YVLCCNDTCS FTWTGAEHIN QDIFECRTCG
1210 1220 1230 1240 1250
LLESLCCCTE CARVCHKGHD CKLKRTSPTA YCDCWEKCKC KTLIAGQKSA
1260 1270 1280 1290 1300
RLDLLYRLLT ATNLVTLPNS RGEHLLLFLV QTVARQTVEH CQYRPPRIRE
1310 1320 1330 1340 1350
DRNRKTASPE DSDMPDHDLE PPRFAQLALE RVLQDWNALK SMIMFGSQEN
1360 1370 1380 1390 1400
KDPLSASSRI GHLLPEEQVY LNQQSGTIRL DCFTHCLIVK CTADILLLDT
1410 1420 1430 1440 1450
LLGTLVKELQ NKYTPGRREE AIAVTMRFLR SVARVFVILS VEMASSKKKN
1460 1470 1480 1490 1500
NFIPQPIGKC KRVFQALLPY AVEELCNVAE SLIVPVRMGI ARPTAPFTLA
1510 1520 1530 1540 1550
STSIDAMQGS EELFSVEPLP PRPSSDQSSS SSQSQSSYII RNPQQRRISQ
1560 1570 1580 1590 1600
SQPVRGRDEE QDDIVSADVE EVEVVEGVAG EEDHHDEQEE HGEENAEAEG
1610 1620 1630 1640 1650
QHDEHDEDGS DMELDLLAAA ETESDSESNH SNQDNASGRR SVVTAATAGS
1660 1670 1680 1690 1700
EAGASSVPAF FSEDDSQSND SSDSDSSSSQ SDDIEQETFM LDEPLERTTN
1710 1720 1730 1740 1750
SSHANGAAQA PRSMQWAVRN TQHQRAASTA PSSTSTPAAS SAGLIYIDPS
1760 1770 1780 1790 1800
NLRRSGTIST SAAAAAAALE ASNASSYLTS ASSLARAYSI VIRQISDLMG
1810 1820 1830 1840 1850
LIPKYNHLVY SQIPAAVKLT YQDAVNLQNY VEEKLIPTWN WMVSIMDSTE
1860 1870 1880 1890 1900
AQLRYGSALA SAGDPGHPNH PLHASQNSAR RERMTAREEA SLRTLEGRRR
1910 1920 1930 1940 1950
ATLLSARQGM MSARGDFLNY ALSLMRSHND EHSDVLPVLD VCSLKHVAYV
1960 1970 1980 1990 2000
FQALIYWIKA MNQQTTLDTP QLERKRTREL LELGIDNEDS EHENDDDTNQ
2010 2020 2030 2040 2050
SATLNDKDDD SLPAETGQNH PFFRRSDSMT FLGCIPPNPF EVPLAEAIPL
2060 2070 2080 2090 2100
ADQPHLLQPN ARKEDLFGRP SQGLYSSSAS SGKCLMEVTV DRNCLEVLPT
2110 2120 2130 2140 2150
KMSYAANLKN VMNMQNRQKK EGEEQPVLPE ETESSKPGPS AHDLAAQLKS
2160 2170 2180 2190 2200
SLLAEIGLTE SEGPPLTSFR PQCSFMGMVI SHDMLLGRWR LSLELFGRVF
2210 2220 2230 2240 2250
MEDVGAEPGS ILTELGGFEV KESKFRREME KLRNQQSRDL SLEVDRDRDL
2260 2270 2280 2290 2300
LIQQTMRQLN NHFGRRCATT PMAVHRVKVT FKDEPGEGSG VARSFYTAIA
2310 2320 2330 2340 2350
QAFLSNEKLP NLECIQNANK GTHTSLMQRL RNRGERDRER EREREMRRSS
2360 2370 2380 2390 2400
GLRAGSRRDR DRDFRRQLSI DTRPFRPASE GNPSDDPEPL PAHRQALGER
2410 2420 2430 2440 2450
LYPRVQAMQP AFASKITGML LELSPAQLLL LLASEDSLRA RVDEAMELII
2460 2470 2480 2490 2500
AHGRENGADS ILDLGLVDSS EKVQQENRKR HGSSRSVVDM DLDDTDDGDD
2510 2520 2530 2540 2550
NAPLFYQPGK RGFYTPRPGK NTEARLNCFR NIGRILGLCL LQNELCPITL
2560 2570 2580 2590 2600
NRHVIKVLLG RKVNWHDFAF FDPVMYESLR QLILASQSSD ADAVFSAMDL
2610 2620 2630 2640 2650
AFAIDLCKEE GGGQVELIPN GVNIPVTPQN VYEYVRKYAE HRMLVVAEQP
2660 2670 2680 2690 2700
LHAMRKGLLD VLPKNSLEDL TAEDFRLLVN GCGEVNVQML ISFTSFNDES
2710 2720 2730 2740 2750
GENAEKLLQF KRWFWSIVEK MSMTERQDLV YFWTSSPSLP ASEEGFQPMP
2760 2770 2780 2790
SITIRPPDDQ HLPTANTCIS RLYVPLYSSK QILKQKLLLA IKTKNFGFV
Length:2,799
Mass (Da):309,352
Last modified:October 1, 2001 - v2
Checksum:i871300DB404FF561
GO
Isoform 2 (identifier: O95071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2474-2474: Missing.

Note: No experimental confirmation available.
Show »
Length:2,798
Mass (Da):309,224
Checksum:iD0743129ECF82394
GO

Sequence cautioni

The sequence BAA74919 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134S → P in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti229E → K in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti258S → Y in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti374 – 375IG → M in AAF88143 (PubMed:11714696).Curated2
Sequence conflicti772D → H in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti780Q → R in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti884D → G in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti1811S → P in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti2144L → H in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti2282K → R in AAF88143 (PubMed:11714696).Curated1
Sequence conflicti2489D → N in AAF88143 (PubMed:11714696).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0514662150S → R.Corresponds to variant rs1062822dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0543992474Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006010 mRNA. Translation: AAD01259.2.
U95000 mRNA. Translation: AAF88143.1.
AB020703 mRNA. Translation: BAA74919.3. Different initiation.
AP002907 Genomic DNA. No translation available.
AP002981 Genomic DNA. No translation available.
BC137234 mRNA. Translation: AAI37235.1.
CCDSiCCDS34933.1. [O95071-1]
CCDS64946.1. [O95071-2]
RefSeqiNP_001269802.1. NM_001282873.1. [O95071-2]
NP_056986.2. NM_015902.5. [O95071-1]
UniGeneiHs.492445.

Genome annotation databases

EnsembliENST00000220959; ENSP00000220959; ENSG00000104517. [O95071-2]
ENST00000520539; ENSP00000429084; ENSG00000104517. [O95071-1]
GeneIDi51366.
KEGGihsa:51366.
UCSCiuc003ykr.3. human. [O95071-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006010 mRNA. Translation: AAD01259.2.
U95000 mRNA. Translation: AAF88143.1.
AB020703 mRNA. Translation: BAA74919.3. Different initiation.
AP002907 Genomic DNA. No translation available.
AP002981 Genomic DNA. No translation available.
BC137234 mRNA. Translation: AAI37235.1.
CCDSiCCDS34933.1. [O95071-1]
CCDS64946.1. [O95071-2]
RefSeqiNP_001269802.1. NM_001282873.1. [O95071-2]
NP_056986.2. NM_015902.5. [O95071-1]
UniGeneiHs.492445.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I2TX-ray1.04A2393-2453[»]
2QHOX-ray1.85B/D/F/H180-230[»]
3PT3X-ray1.97A/B2687-2799[»]
ProteinModelPortaliO95071.
SMRiO95071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119501. 136 interactors.
DIPiDIP-32930N.
IntActiO95071. 57 interactors.
MINTiMINT-196086.
STRINGi9606.ENSP00000429084.

PTM databases

iPTMnetiO95071.
PhosphoSitePlusiO95071.

Polymorphism and mutation databases

BioMutaiUBR5.

Proteomic databases

EPDiO95071.
MaxQBiO95071.
PaxDbiO95071.
PeptideAtlasiO95071.
PRIDEiO95071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220959; ENSP00000220959; ENSG00000104517. [O95071-2]
ENST00000520539; ENSP00000429084; ENSG00000104517. [O95071-1]
GeneIDi51366.
KEGGihsa:51366.
UCSCiuc003ykr.3. human. [O95071-1]

Organism-specific databases

CTDi51366.
DisGeNETi51366.
GeneCardsiUBR5.
H-InvDBHIX0025542.
HGNCiHGNC:16806. UBR5.
HPAiHPA024728.
HPA053688.
MIMi608413. gene.
neXtProtiNX_O95071.
OpenTargetsiENSG00000104517.
PharmGKBiPA162408175.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0943. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00850000132302.
HOGENOMiHOG000046848.
HOVERGENiHBG096012.
InParanoidiO95071.
KOiK10593.
OMAiENSLYWW.
OrthoDBiEOG091G005O.
PhylomeDBiO95071.
TreeFamiTF314406.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000104517-MONOMER.
BRENDAi6.3.2.19. 2681.
SignaLinkiO95071.
SIGNORiO95071.

Miscellaneous databases

ChiTaRSiUBR5. human.
EvolutionaryTraceiO95071.
GeneWikiiUBR5.
GenomeRNAii51366.
PROiO95071.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104517.
CleanExiHS_UBR5.
ExpressionAtlasiO95071. baseline and differential.
GenevisibleiO95071. HS.

Family and domain databases

CDDicd14423. CUE_UBR5. 1 hit.
Gene3Di1.10.1900.10. 1 hit.
2.130.10.30. 3 hits.
InterProiIPR024725. E3_UbLigase_EDD_UBA.
IPR000569. HECT_dom.
IPR002004. PABP_HYD.
IPR009091. RCC1/BLIP-II.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF11547. E3_UbLigase_EDD. 1 hit.
PF00632. HECT. 1 hit.
PF00658. PABP. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00517. PolyA. 1 hit.
SM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 1 hit.
SSF56204. SSF56204. 2 hits.
SSF63570. SSF63570. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS51309. PABC. 1 hit.
PS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBR5_HUMAN
AccessioniPrimary (citable) accession number: O95071
Secondary accession number(s): B2RP24
, J3KMW7, O94970, Q9NPL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A cysteine residue is required for ubiquitin-thioester formation.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.