O95070 (YIF1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein YIF1A

Alternative name(s):
54TMp
YIP1-interacting factor homolog A

Gene names

Name:	YIF1A
Synonyms:	54TM, HYIF1P, YIF1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possible role in transport between endoplasmic reticulum and Golgi. Ref.7
Subunit structure	Interacts with YIPF5. Ref.7
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note: Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment. Ref.6 Ref.7
Sequence similarities	Belongs to the YIF1 family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of signaling protein activity involved in unfolded protein response Traceable author statement. Source: Reactome protein transport Inferred from electronic annotation. Source: UniProtKB-KW vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell centrosome Inferred from direct assay. Source: HPA endoplasmic reticulum membrane Traceable author statement. Source: Reactome endoplasmic reticulum-Golgi intermediate compartment Inferred from direct assay Ref.6. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATP13A2	Q9NQ11	2	EBI-2799703,EBI-6308763

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.9
	Chain	2 – 293	292	Protein YIF1A		PRO_0000233275
Regions
	Topological domain	2 – 138	137	Cytoplasmic Potential
	Transmembrane	139 – 159	21	Helical; Potential
	Topological domain	160 – 174	15	Extracellular Potential
	Transmembrane	175 – 195	21	Helical; Potential
	Topological domain	196 – 203	8	Cytoplasmic Potential
	Transmembrane	204 – 226	23	Helical; Potential
	Topological domain	227 – 229	3	Extracellular Potential
	Transmembrane	230 – 249	20	Helical; Potential
	Topological domain	250 – 271	22	Cytoplasmic Potential
	Transmembrane	272 – 292	21	Helical; Potential
	Topological domain	293	1	Extracellular Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.9
	Modified residue	12	1	Phosphoserine Ref.9
Experimental info
	Sequence conflict	144	1	M → K in CAG32991. Ref.2
	Sequence conflict	144	1	M → K in AAH01299. Ref.4
	Sequence conflict	144	1	M → K in AAH09892. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O95070 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: AFD61379A56085EA	FASTA	293	32,011
	10 20 30 40 50 60 MAYHSGYGAH GSKHRARAAP DPPPLFDDTS GGYSSQPGGY PATGADVAFS VNHLLGDPMA 70 80 90 100 110 120 NVAMAYGSSI ASHGKDMVHK ELHRFVSVSK LKYFFAVDTA YVAKKLGLLV FPYTHQNWEV 130 140 150 160 170 180 QYSRDAPLPP RQDLNAPDLY IPTMAFITYV LLAGMALGIQ KRFSPEVLGL CASTALVWVV 190 200 210 220 230 240 MEVLALLLGL YLATVRSDLS TFHLLAYSGY KYVGMILSVL TGLLFGSDGY YVALAWTSSA 250 260 270 280 290 LMYFIVRSLR TAALGPDSMG GPVPRQRLQL YLTLGAAAFQ PLIIYWLTFH LVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wilson L.A., Field D., Cruz L., Friesen J., Siminovitch K.A. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Placenta.
[6]	"Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46." Breuza L., Halbeisen R., Jenoe P., Otte S., Barlowe C., Hong W., Hauri H.-P. J. Biol. Chem. 279:47242-47253(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[7]	"Human Yip1A specifies the localization of Yif1 to the Golgi apparatus." Jin C., Zhang Y., Zhu H., Ahmed K., Fu C., Yao X. Biochem. Biophys. Res. Commun. 334:16-22(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH YIPF5, SUBCELLULAR LOCATION.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF004876 mRNA. Translation: AAD01206.1. CR456710 mRNA. Translation: CAG32991.1. AP001107 Genomic DNA. No translation available. CH471076 Genomic DNA. Translation: EAW74509.1. BC001299 mRNA. Translation: AAH01299.1. BC009892 mRNA. Translation: AAH09892.2.
IPI	IPI00007607.
RefSeq	NP_065203.2. NM_020470.2.
UniGene	Hs.446445.
3D structure databases
ProteinModelPortal	O95070.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95070. 2 interactions.
STRING	9606.ENSP00000366098.
PTM databases
PhosphoSite	O95070.
Proteomic databases
PaxDb	O95070.
PRIDE	O95070.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376901; ENSP00000366098; ENSG00000174851.
GeneID	10897.
KEGG	hsa:10897.
UCSC	uc001ohk.4. human.
Organism-specific databases
CTD	10897.
GeneCards	GC11M066052.
HGNC	HGNC:16688. YIF1A.
HPA	HPA014840.
MIM	611484. gene.
neXtProt	NX_O95070.
PharmGKB	PA134985105.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5197.
HOGENOM	HOG000234333.
HOVERGEN	HBG053252.
OrthoDB	EOG4JM7QF.
PhylomeDB	O95070.
Enzyme and pathway databases
Reactome	REACT_116125. Disease.
Gene expression databases
ArrayExpress	O95070.
Bgee	O95070.
CleanEx	HS_YIF1A.
Genevestigator	O95070.
GermOnline	ENSG00000174851. Homo sapiens.
Family and domain databases
InterPro	IPR005578. Hrf1. [Graphical view]
PANTHER	PTHR14083. PTHR14083. 1 hit.
Pfam	PF03878. YIF1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10897.
NextBio	41381.
SOURCE	Search...

Entry information

Entry name

YIF1A_HUMAN

Accession

Primary (citable) accession number: O95070
Secondary accession number(s): A6NM00, Q96G83, Q9BVD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	April 3, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.