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O95070 (YIF1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein YIF1A
Alternative name(s):
54TMp
YIP1-interacting factor homolog A
Gene names
Name:YIF1A
Synonyms:54TM, HYIF1P, YIF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possible role in transport between endoplasmic reticulum and Golgi. Ref.7

Subunit structure

Interacts with YIPF5. Ref.7

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note: Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment. Ref.6 Ref.7

Sequence similarities

Belongs to the YIF1 family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.9
Chain2 – 293292Protein YIF1A
PRO_0000233275

Regions

Topological domain2 – 138137Cytoplasmic Potential
Transmembrane139 – 15921Helical; Potential
Topological domain160 – 17415Extracellular Potential
Transmembrane175 – 19521Helical; Potential
Topological domain196 – 2038Cytoplasmic Potential
Transmembrane204 – 22623Helical; Potential
Topological domain227 – 2293Extracellular Potential
Transmembrane230 – 24920Helical; Potential
Topological domain250 – 27122Cytoplasmic Potential
Transmembrane272 – 29221Helical; Potential
Topological domain2931Extracellular Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.9
Modified residue121Phosphoserine Ref.9

Experimental info

Sequence conflict1441M → K in CAG32991. Ref.2
Sequence conflict1441M → K in AAH01299. Ref.4
Sequence conflict1441M → K in AAH09892. Ref.4

Sequences

Sequence LengthMass (Da)Tools
O95070 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: AFD61379A56085EA

FASTA29332,011
        10         20         30         40         50         60 
MAYHSGYGAH GSKHRARAAP DPPPLFDDTS GGYSSQPGGY PATGADVAFS VNHLLGDPMA 

        70         80         90        100        110        120 
NVAMAYGSSI ASHGKDMVHK ELHRFVSVSK LKYFFAVDTA YVAKKLGLLV FPYTHQNWEV 

       130        140        150        160        170        180 
QYSRDAPLPP RQDLNAPDLY IPTMAFITYV LLAGMALGIQ KRFSPEVLGL CASTALVWVV 

       190        200        210        220        230        240 
MEVLALLLGL YLATVRSDLS TFHLLAYSGY KYVGMILSVL TGLLFGSDGY YVALAWTSSA 

       250        260        270        280        290 
LMYFIVRSLR TAALGPDSMG GPVPRQRLQL YLTLGAAAFQ PLIIYWLTFH LVR 

« Hide

References

« Hide 'large scale' references
[1]Wilson L.A., Field D., Cruz L., Friesen J., Siminovitch K.A.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Placenta.
[6]"Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46."
Breuza L., Halbeisen R., Jenoe P., Otte S., Barlowe C., Hong W., Hauri H.-P.
J. Biol. Chem. 279:47242-47253(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Human Yip1A specifies the localization of Yif1 to the Golgi apparatus."
Jin C., Zhang Y., Zhu H., Ahmed K., Fu C., Yao X.
Biochem. Biophys. Res. Commun. 334:16-22(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH YIPF5, SUBCELLULAR LOCATION.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF004876 mRNA. Translation: AAD01206.1.
CR456710 mRNA. Translation: CAG32991.1.
AP001107 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74509.1.
BC001299 mRNA. Translation: AAH01299.1.
BC009892 mRNA. Translation: AAH09892.2.
RefSeqNP_065203.2. NM_020470.2.
UniGeneHs.446445.

3D structure databases

ProteinModelPortalO95070.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116103. 5 interactions.
IntActO95070. 9 interactions.
STRING9606.ENSP00000366098.

PTM databases

PhosphoSiteO95070.

Proteomic databases

PaxDbO95070.
PRIDEO95070.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376901; ENSP00000366098; ENSG00000174851.
GeneID10897.
KEGGhsa:10897.
UCSCuc001ohk.4. human.

Organism-specific databases

CTD10897.
GeneCardsGC11M066052.
HGNCHGNC:16688. YIF1A.
HPAHPA014840.
MIM611484. gene.
neXtProtNX_O95070.
PharmGKBPA134985105.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5197.
HOGENOMHOG000234333.
HOVERGENHBG053252.
PhylomeDBO95070.
TreeFamTF314528.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressO95070.
BgeeO95070.
CleanExHS_YIF1A.
GenevestigatorO95070.

Family and domain databases

InterProIPR005578. Hrf1.
[Graphical view]
PANTHERPTHR14083. PTHR14083. 1 hit.
PfamPF03878. YIF1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiYIF1A.
GenomeRNAi10897.
NextBio41381.
PROO95070.
SOURCESearch...

Entry information

Entry nameYIF1A_HUMAN
AccessionPrimary (citable) accession number: O95070
Secondary accession number(s): A6NM00, Q96G83, Q9BVD0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: March 19, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM