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Protein

Protein YIF1A

Gene

YIF1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.1 Publication

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
  2. cellular protein metabolic process Source: Reactome
  3. endoplasmic reticulum unfolded protein response Source: Reactome
  4. protein transport Source: UniProtKB-KW
  5. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIF1A
Alternative name(s):
54TMp
YIP1-interacting factor homolog A
Gene namesi
Name:YIF1A
Synonyms:54TM, HYIF1P, YIF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:16688. YIF1A.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Note: Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 138137CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Topological domaini160 – 17415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Topological domaini196 – 2038CytoplasmicSequence Analysis
Transmembranei204 – 22623HelicalSequence AnalysisAdd
BLAST
Topological domaini227 – 2293ExtracellularSequence Analysis
Transmembranei230 – 24920HelicalSequence AnalysisAdd
BLAST
Topological domaini250 – 27122CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence AnalysisAdd
BLAST
Topological domaini293 – 2931ExtracellularSequence Analysis

GO - Cellular componenti

  1. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
  2. endoplasmic reticulum membrane Source: Reactome
  3. Golgi apparatus Source: HPA
  4. Golgi membrane Source: UniProtKB-SubCell
  5. integral component of membrane Source: UniProtKB-KW
  6. intracellular membrane-bounded organelle Source: HPA
  7. microtubule organizing center Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 293292Protein YIF1APRO_0000233275Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei12 – 121Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95070.
PaxDbiO95070.
PRIDEiO95070.

PTM databases

PhosphoSiteiO95070.

Expressioni

Gene expression databases

BgeeiO95070.
CleanExiHS_YIF1A.
ExpressionAtlasiO95070. baseline and differential.
GenevestigatoriO95070.

Organism-specific databases

HPAiHPA014840.

Interactioni

Subunit structurei

Interacts with YIPF5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATP13A2Q9NQ112EBI-2799703,EBI-6308763
VAPBO952929EBI-2799703,EBI-1188298

Protein-protein interaction databases

BioGridi116103. 9 interactions.
IntActiO95070. 10 interactions.
STRINGi9606.ENSP00000366098.

Structurei

3D structure databases

ProteinModelPortaliO95070.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIF1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5197.
GeneTreeiENSGT00390000009423.
HOGENOMiHOG000234333.
HOVERGENiHBG053252.
InParanoidiO95070.
OMAiPYTHQCH.
PhylomeDBiO95070.
TreeFamiTF314528.

Family and domain databases

InterProiIPR005578. Hrf1.
[Graphical view]
PANTHERiPTHR14083. PTHR14083. 1 hit.
PfamiPF03878. YIF1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95070-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYHSGYGAH GSKHRARAAP DPPPLFDDTS GGYSSQPGGY PATGADVAFS
60 70 80 90 100
VNHLLGDPMA NVAMAYGSSI ASHGKDMVHK ELHRFVSVSK LKYFFAVDTA
110 120 130 140 150
YVAKKLGLLV FPYTHQNWEV QYSRDAPLPP RQDLNAPDLY IPTMAFITYV
160 170 180 190 200
LLAGMALGIQ KRFSPEVLGL CASTALVWVV MEVLALLLGL YLATVRSDLS
210 220 230 240 250
TFHLLAYSGY KYVGMILSVL TGLLFGSDGY YVALAWTSSA LMYFIVRSLR
260 270 280 290
TAALGPDSMG GPVPRQRLQL YLTLGAAAFQ PLIIYWLTFH LVR
Length:293
Mass (Da):32,011
Last modified:May 2, 2006 - v2
Checksum:iAFD61379A56085EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441M → K in CAG32991. 1 PublicationCurated
Sequence conflicti144 – 1441M → K in AAH01299. 1 PublicationCurated
Sequence conflicti144 – 1441M → K in AAH09892. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004876 mRNA. Translation: AAD01206.1.
CR456710 mRNA. Translation: CAG32991.1.
AP001107 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74509.1.
BC001299 mRNA. Translation: AAH01299.1.
BC009892 mRNA. Translation: AAH09892.2.
CCDSiCCDS8132.1.
RefSeqiNP_065203.2. NM_020470.2.
UniGeneiHs.446445.

Genome annotation databases

EnsembliENST00000376901; ENSP00000366098; ENSG00000174851.
GeneIDi10897.
KEGGihsa:10897.
UCSCiuc001ohk.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004876 mRNA. Translation: AAD01206.1.
CR456710 mRNA. Translation: CAG32991.1.
AP001107 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74509.1.
BC001299 mRNA. Translation: AAH01299.1.
BC009892 mRNA. Translation: AAH09892.2.
CCDSiCCDS8132.1.
RefSeqiNP_065203.2. NM_020470.2.
UniGeneiHs.446445.

3D structure databases

ProteinModelPortaliO95070.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116103. 9 interactions.
IntActiO95070. 10 interactions.
STRINGi9606.ENSP00000366098.

PTM databases

PhosphoSiteiO95070.

Proteomic databases

MaxQBiO95070.
PaxDbiO95070.
PRIDEiO95070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376901; ENSP00000366098; ENSG00000174851.
GeneIDi10897.
KEGGihsa:10897.
UCSCiuc001ohk.4. human.

Organism-specific databases

CTDi10897.
GeneCardsiGC11M066052.
HGNCiHGNC:16688. YIF1A.
HPAiHPA014840.
MIMi611484. gene.
neXtProtiNX_O95070.
PharmGKBiPA134985105.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5197.
GeneTreeiENSGT00390000009423.
HOGENOMiHOG000234333.
HOVERGENiHBG053252.
InParanoidiO95070.
OMAiPYTHQCH.
PhylomeDBiO95070.
TreeFamiTF314528.

Enzyme and pathway databases

ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

Miscellaneous databases

GeneWikiiYIF1A.
GenomeRNAii10897.
NextBioi41381.
PROiO95070.
SOURCEiSearch...

Gene expression databases

BgeeiO95070.
CleanExiHS_YIF1A.
ExpressionAtlasiO95070. baseline and differential.
GenevestigatoriO95070.

Family and domain databases

InterProiIPR005578. Hrf1.
[Graphical view]
PANTHERiPTHR14083. PTHR14083. 1 hit.
PfamiPF03878. YIF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Wilson L.A., Field D., Cruz L., Friesen J., Siminovitch K.A.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  6. "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46."
    Breuza L., Halbeisen R., Jenoe P., Otte S., Barlowe C., Hong W., Hauri H.-P.
    J. Biol. Chem. 279:47242-47253(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Human Yip1A specifies the localization of Yif1 to the Golgi apparatus."
    Jin C., Zhang Y., Zhu H., Ahmed K., Fu C., Yao X.
    Biochem. Biophys. Res. Commun. 334:16-22(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH YIPF5, SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYIF1A_HUMAN
AccessioniPrimary (citable) accession number: O95070
Secondary accession number(s): A6NM00, Q96G83, Q9BVD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: January 7, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.