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O95070

- YIF1A_HUMAN

UniProt

O95070 - YIF1A_HUMAN

Protein

Protein YIF1A

Gene

YIF1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    Possible role in transport between endoplasmic reticulum and Golgi.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
    2. cellular protein metabolic process Source: Reactome
    3. endoplasmic reticulum unfolded protein response Source: Reactome
    4. protein transport Source: UniProtKB-KW
    5. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein YIF1A
    Alternative name(s):
    54TMp
    YIP1-interacting factor homolog A
    Gene namesi
    Name:YIF1A
    Synonyms:54TM, HYIF1P, YIF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:16688. YIF1A.

    Subcellular locationi

    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
    Note: Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment.

    GO - Cellular componenti

    1. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
    2. endoplasmic reticulum membrane Source: Reactome
    3. Golgi apparatus Source: HPA
    4. Golgi membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW
    6. intracellular membrane-bounded organelle Source: HPA
    7. microtubule organizing center Source: HPA

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134985105.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 293292Protein YIF1APRO_0000233275Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei12 – 121Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO95070.
    PaxDbiO95070.
    PRIDEiO95070.

    PTM databases

    PhosphoSiteiO95070.

    Expressioni

    Gene expression databases

    ArrayExpressiO95070.
    BgeeiO95070.
    CleanExiHS_YIF1A.
    GenevestigatoriO95070.

    Organism-specific databases

    HPAiHPA014840.

    Interactioni

    Subunit structurei

    Interacts with YIPF5.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATP13A2Q9NQ112EBI-2799703,EBI-6308763
    VAPBO952929EBI-2799703,EBI-1188298

    Protein-protein interaction databases

    BioGridi116103. 5 interactions.
    IntActiO95070. 10 interactions.
    STRINGi9606.ENSP00000366098.

    Structurei

    3D structure databases

    ProteinModelPortaliO95070.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 138137CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 17415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini196 – 2038CytoplasmicSequence Analysis
    Topological domaini227 – 2293ExtracellularSequence Analysis
    Topological domaini250 – 27122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini293 – 2931ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 24920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the YIF1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5197.
    HOGENOMiHOG000234333.
    HOVERGENiHBG053252.
    OMAiYPAPGAD.
    PhylomeDBiO95070.
    TreeFamiTF314528.

    Family and domain databases

    InterProiIPR005578. Hrf1.
    [Graphical view]
    PANTHERiPTHR14083. PTHR14083. 1 hit.
    PfamiPF03878. YIF1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95070-1 [UniParc]FASTAAdd to Basket

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    MAYHSGYGAH GSKHRARAAP DPPPLFDDTS GGYSSQPGGY PATGADVAFS    50
    VNHLLGDPMA NVAMAYGSSI ASHGKDMVHK ELHRFVSVSK LKYFFAVDTA 100
    YVAKKLGLLV FPYTHQNWEV QYSRDAPLPP RQDLNAPDLY IPTMAFITYV 150
    LLAGMALGIQ KRFSPEVLGL CASTALVWVV MEVLALLLGL YLATVRSDLS 200
    TFHLLAYSGY KYVGMILSVL TGLLFGSDGY YVALAWTSSA LMYFIVRSLR 250
    TAALGPDSMG GPVPRQRLQL YLTLGAAAFQ PLIIYWLTFH LVR 293
    Length:293
    Mass (Da):32,011
    Last modified:May 2, 2006 - v2
    Checksum:iAFD61379A56085EA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti144 – 1441M → K in CAG32991. 1 PublicationCurated
    Sequence conflicti144 – 1441M → K in AAH01299. 1 PublicationCurated
    Sequence conflicti144 – 1441M → K in AAH09892. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004876 mRNA. Translation: AAD01206.1.
    CR456710 mRNA. Translation: CAG32991.1.
    AP001107 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74509.1.
    BC001299 mRNA. Translation: AAH01299.1.
    BC009892 mRNA. Translation: AAH09892.2.
    CCDSiCCDS8132.1.
    RefSeqiNP_065203.2. NM_020470.2.
    UniGeneiHs.446445.

    Genome annotation databases

    EnsembliENST00000376901; ENSP00000366098; ENSG00000174851.
    GeneIDi10897.
    KEGGihsa:10897.
    UCSCiuc001ohk.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004876 mRNA. Translation: AAD01206.1 .
    CR456710 mRNA. Translation: CAG32991.1 .
    AP001107 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74509.1 .
    BC001299 mRNA. Translation: AAH01299.1 .
    BC009892 mRNA. Translation: AAH09892.2 .
    CCDSi CCDS8132.1.
    RefSeqi NP_065203.2. NM_020470.2.
    UniGenei Hs.446445.

    3D structure databases

    ProteinModelPortali O95070.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116103. 5 interactions.
    IntActi O95070. 10 interactions.
    STRINGi 9606.ENSP00000366098.

    PTM databases

    PhosphoSitei O95070.

    Proteomic databases

    MaxQBi O95070.
    PaxDbi O95070.
    PRIDEi O95070.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376901 ; ENSP00000366098 ; ENSG00000174851 .
    GeneIDi 10897.
    KEGGi hsa:10897.
    UCSCi uc001ohk.4. human.

    Organism-specific databases

    CTDi 10897.
    GeneCardsi GC11M066052.
    HGNCi HGNC:16688. YIF1A.
    HPAi HPA014840.
    MIMi 611484. gene.
    neXtProti NX_O95070.
    PharmGKBi PA134985105.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5197.
    HOGENOMi HOG000234333.
    HOVERGENi HBG053252.
    OMAi YPAPGAD.
    PhylomeDBi O95070.
    TreeFami TF314528.

    Enzyme and pathway databases

    Reactomei REACT_18273. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    GeneWikii YIF1A.
    GenomeRNAii 10897.
    NextBioi 41381.
    PROi O95070.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95070.
    Bgeei O95070.
    CleanExi HS_YIF1A.
    Genevestigatori O95070.

    Family and domain databases

    InterProi IPR005578. Hrf1.
    [Graphical view ]
    PANTHERi PTHR14083. PTHR14083. 1 hit.
    Pfami PF03878. YIF1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Wilson L.A., Field D., Cruz L., Friesen J., Siminovitch K.A.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: T-cell.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Placenta.
    6. "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46."
      Breuza L., Halbeisen R., Jenoe P., Otte S., Barlowe C., Hong W., Hauri H.-P.
      J. Biol. Chem. 279:47242-47253(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "Human Yip1A specifies the localization of Yif1 to the Golgi apparatus."
      Jin C., Zhang Y., Zhu H., Ahmed K., Fu C., Yao X.
      Biochem. Biophys. Res. Commun. 334:16-22(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH YIPF5, SUBCELLULAR LOCATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYIF1A_HUMAN
    AccessioniPrimary (citable) accession number: O95070
    Secondary accession number(s): A6NM00, Q96G83, Q9BVD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3