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O95069

- KCNK2_HUMAN

UniProt

O95069 - KCNK2_HUMAN

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Protein
Potassium channel subfamily K member 2
Gene
KCNK2, TREK, TREK1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.3 Publications
Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 By similarity.3 Publications

GO - Molecular functioni

  1. outward rectifier potassium channel activity Source: UniProtKB
  2. potassium channel inhibitor activity Source: UniProtKB
  3. potassium ion leak channel activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: Ensembl
  2. potassium ion transmembrane transport Source: UniProtKB
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75819. TWIK related potassium channel (TREK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 2
Alternative name(s):
Outward rectifying potassium channel protein TREK-1
TREK-1 K(+) channel subunit
Two pore domain potassium channel TREK-1
Two pore potassium channel TPKC1
Gene namesi
Name:KCNK2
Synonyms:TREK, TREK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6277. KCNK2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST
Intramembranei144 – 17027Pore-forming; Name=Pore-forming 1; Reviewed prediction
Add
BLAST
Transmembranei172 – 19221Helical; Reviewed prediction
Add
BLAST
Topological domaini193 – 22331Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei224 – 24421Helical; Reviewed prediction
Add
BLAST
Intramembranei253 – 28331Pore-forming; Name=Pore-forming 2; Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Reviewed prediction
Add
BLAST
Topological domaini309 – 426118Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB
  4. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi348 – 3481S → A: Mimics non-phosphorylated state and has no effect on leak channel activity. 1 Publication
Mutagenesisi348 – 3481S → D: Phosphomimetic mutant which causes switch to voltage-dependent outward rectifier channel activity. 1 Publication

Organism-specific databases

PharmGKBiPA30059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Potassium channel subfamily K member 2
PRO_0000101742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Modified residuei348 – 3481Phosphoserine; by PKA1 Publication

Post-translational modificationi

Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO95069.
PRIDEiO95069.

PTM databases

PhosphoSiteiO95069.

Expressioni

Tissue specificityi

Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.1 Publication

Gene expression databases

ArrayExpressiO95069.
BgeeiO95069.
CleanExiHS_KCNK2.
GenevestigatoriO95069.

Organism-specific databases

HPAiHPA056054.

Interactioni

Subunit structurei

Homodimer Reviewed prediction.

Protein-protein interaction databases

STRINGi9606.ENSP00000394033.

Structurei

3D structure databases

ProteinModelPortaliO95069.
SMRiO95069. Positions 58-316.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni354 – 42673Required for basal channel activity By similarity
Add
BLAST
Regioni378 – 42649Essential for chloroform and halothane sensitivity By similarity
Add
BLAST

Domaini

The C-terminal region of isoform 4 mediates its intracellular retention By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOVERGENiHBG052234.
InParanoidiO95069.
KOiK04913.
OMAiAINVMKW.
PhylomeDBiO95069.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003976. 2pore_dom_K_chnl_TREK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95069-1) [UniParc]FASTAAdd to Basket

Also known as: TREK-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLPSASRERP GYRAGVAAPD LLDPKSAAQN SKPRLSFSTK PTVLASRVES    50
DTTINVMKWK TVSTIFLVVV LYLIIGATVF KALEQPHEIS QRTTIVIQKQ 100
TFISQHSCVN STELDELIQQ IVAAINAGII PLGNTSNQIS HWDLGSSFFF 150
AGTVITTIGF GNISPRTEGG KIFCIIYALL GIPLFGFLLA GVGDQLGTIF 200
GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL PAIIFKHIEG 250
WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF 300
AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE 350
IYDKFQRATS IKRKLSAELA GNHNQELTPC RRTLSVNHLT SERDVLPPLL 400
KTESIYLNGL TPHCAGEEIA VIENIK 426
Length:426
Mass (Da):47,093
Last modified:April 17, 2007 - v2
Checksum:iDB10382B1803DA13
GO
Isoform 2 (identifier: O95069-2) [UniParc]FASTAAdd to Basket

Also known as: TREK-1a

The sequence of this isoform differs from the canonical sequence as follows:
     2-16: Missing.

Show »
Length:411
Mass (Da):45,495
Checksum:iFDE40CAB21B42A1C
GO
Isoform 3 (identifier: O95069-3) [UniParc]FASTAAdd to Basket

Also known as: TREK-1c

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MLPSASRERPGYRAGV → MMNPRAKRDFYL

Show »
Length:422
Mass (Da):46,888
Checksum:i1AD4E0B5C1B6CBE7
GO
Isoform 4 (identifier: O95069-4) [UniParc]FASTAAdd to Basket

Also known as: TREK-1e

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MLPSASRERPGYRAGV → MMNPRAKRDFYL
     213-232: KWNVSQTKIRIISTIIFILF → VDPILNIWTSISLSCGSGSL
     233-426: Missing.

Show »
Length:228
Mass (Da):24,682
Checksum:i3BEEDE6F7B5EE839
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1616MLPSA…YRAGV → MMNPRAKRDFYL in isoform 3 and isoform 4.
VSP_024428Add
BLAST
Alternative sequencei2 – 1615Missing in isoform 2.
VSP_024429Add
BLAST
Alternative sequencei213 – 23220KWNVS…IFILF → VDPILNIWTSISLSCGSGSL in isoform 4.
VSP_047567Add
BLAST
Alternative sequencei233 – 426194Missing in isoform 4.
VSP_047568Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti309 – 3113DWL → RLV in AAD01203. 1 Publication
Sequence conflicti391 – 3911S → N in AAD47569. 1 Publication
Sequence conflicti411 – 4111T → A in AAD01203. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129399 mRNA. Translation: AAD47569.1.
AF171068 mRNA. Translation: AAF89743.1.
AF004711 mRNA. Translation: AAD01203.1.
AY552980 mRNA. Translation: AAT49015.2.
AY552981 mRNA. Translation: AAT49016.1.
EF165334 mRNA. Translation: ABM47413.1.
EF165335 mRNA. Translation: ABM47414.1.
AK291483 mRNA. Translation: BAF84172.1.
AK315249 mRNA. Translation: BAG37671.1.
AC092804 Genomic DNA. No translation available.
AC099675 Genomic DNA. No translation available.
AL583830 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93347.1.
CH471100 Genomic DNA. Translation: EAW93349.1.
BC069462 mRNA. Translation: AAH69462.1.
BC101693 mRNA. Translation: AAI01694.1.
BC101695 mRNA. Translation: AAI01696.1.
BC143586 mRNA. Translation: AAI43587.1.
CCDSiCCDS31024.1. [O95069-2]
CCDS41466.1. [O95069-3]
CCDS41467.1. [O95069-1]
RefSeqiNP_001017424.1. NM_001017424.2. [O95069-3]
NP_001017425.2. NM_001017425.2. [O95069-1]
NP_055032.1. NM_014217.3. [O95069-2]
UniGeneiHs.497745.

Genome annotation databases

EnsembliENST00000391894; ENSP00000375764; ENSG00000082482. [O95069-2]
ENST00000391895; ENSP00000375765; ENSG00000082482. [O95069-3]
ENST00000444842; ENSP00000394033; ENSG00000082482. [O95069-1]
ENST00000467031; ENSP00000420203; ENSG00000082482. [O95069-4]
GeneIDi3776.
KEGGihsa:3776.
UCSCiuc001hko.3. human. [O95069-3]
uc001hkq.3. human. [O95069-1]
uc001hkr.4. human. [O95069-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129399 mRNA. Translation: AAD47569.1 .
AF171068 mRNA. Translation: AAF89743.1 .
AF004711 mRNA. Translation: AAD01203.1 .
AY552980 mRNA. Translation: AAT49015.2 .
AY552981 mRNA. Translation: AAT49016.1 .
EF165334 mRNA. Translation: ABM47413.1 .
EF165335 mRNA. Translation: ABM47414.1 .
AK291483 mRNA. Translation: BAF84172.1 .
AK315249 mRNA. Translation: BAG37671.1 .
AC092804 Genomic DNA. No translation available.
AC099675 Genomic DNA. No translation available.
AL583830 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93347.1 .
CH471100 Genomic DNA. Translation: EAW93349.1 .
BC069462 mRNA. Translation: AAH69462.1 .
BC101693 mRNA. Translation: AAI01694.1 .
BC101695 mRNA. Translation: AAI01696.1 .
BC143586 mRNA. Translation: AAI43587.1 .
CCDSi CCDS31024.1. [O95069-2 ]
CCDS41466.1. [O95069-3 ]
CCDS41467.1. [O95069-1 ]
RefSeqi NP_001017424.1. NM_001017424.2. [O95069-3 ]
NP_001017425.2. NM_001017425.2. [O95069-1 ]
NP_055032.1. NM_014217.3. [O95069-2 ]
UniGenei Hs.497745.

3D structure databases

ProteinModelPortali O95069.
SMRi O95069. Positions 58-316.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000394033.

Chemistry

ChEMBLi CHEMBL2321615.
DrugBanki DB00204. Dofetilide.
GuidetoPHARMACOLOGYi 514.

PTM databases

PhosphoSitei O95069.

Proteomic databases

PaxDbi O95069.
PRIDEi O95069.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000391894 ; ENSP00000375764 ; ENSG00000082482 . [O95069-2 ]
ENST00000391895 ; ENSP00000375765 ; ENSG00000082482 . [O95069-3 ]
ENST00000444842 ; ENSP00000394033 ; ENSG00000082482 . [O95069-1 ]
ENST00000467031 ; ENSP00000420203 ; ENSG00000082482 . [O95069-4 ]
GeneIDi 3776.
KEGGi hsa:3776.
UCSCi uc001hko.3. human. [O95069-3 ]
uc001hkq.3. human. [O95069-1 ]
uc001hkr.4. human. [O95069-2 ]

Organism-specific databases

CTDi 3776.
GeneCardsi GC01P215178.
HGNCi HGNC:6277. KCNK2.
HPAi HPA056054.
MIMi 603219. gene.
neXtProti NX_O95069.
PharmGKBi PA30059.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOVERGENi HBG052234.
InParanoidi O95069.
KOi K04913.
OMAi AINVMKW.
PhylomeDBi O95069.
TreeFami TF313947.

Enzyme and pathway databases

Reactomei REACT_75819. TWIK related potassium channel (TREK).

Miscellaneous databases

ChiTaRSi KCNK2. human.
GeneWikii KCNK2.
GenomeRNAii 3776.
NextBioi 14811.
PROi O95069.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95069.
Bgeei O95069.
CleanExi HS_KCNK2.
Genevestigatori O95069.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003976. 2pore_dom_K_chnl_TREK.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PRINTSi PR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inhalational anesthetics activate two-pore-domain background K+ channels."
    Patel A.J., Honore E., Lesage F., Fink M., Romey G., Lazdunski M.
    Nat. Neurosci. 2:422-426(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ACTIVATION.
  2. "Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel."
    Meadows H.J., Benham C.D., Cairns W., Gloger I., Jennings C., Medhurst A.D., Murdock P., Chapman C.G.
    Pflugers Arch. 439:714-722(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
    Tissue: Brain.
  3. Price L.A., Hellings S.E., Hayashi J.H., Pausch M.H.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels."
    Rinne S., Renigunta V., Schlichthorl G., Zuzarte M., Bittner S., Meuth S.G., Decher N., Daut J., Preisig-Muller R.
    Pflugers Arch. 0:0-0(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  5. Thomas D., Sullivan A.N., Goldstein S.A.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain and Heart.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  10. "KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel."
    Bockenhauer D., Zilberberg N., Goldstein S.A.
    Nat. Neurosci. 4:486-491(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT SER-348, MUTAGENESIS OF SER-348.

Entry informationi

Entry nameiKCNK2_HUMAN
AccessioniPrimary (citable) accession number: O95069
Secondary accession number(s): A1Z1V3
, A8K618, B2RCS4, B7ZL56, D3DTA5, Q5DP47, Q5DP48, Q9NRT2, Q9UNE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi