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Protein

G2/mitotic-specific cyclin-B2

Gene

CCNB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-156711. Polo-like kinase mediated events.
R-HSA-157881. Cyclin B2 mediated events.
R-HSA-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-2514853. Condensation of Prometaphase Chromosomes.
R-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-69273. Cyclin A/B1 associated events during G2/M transition.
R-HSA-69478. G2/M DNA replication checkpoint.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
SignaLinkiO95067.
SIGNORiO95067.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B2
Gene namesi
Name:CCNB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:1580. CCNB2.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • centrosome Source: UniProtKB
  • cytosol Source: Reactome
  • membrane Source: Ensembl
  • microtubule cytoskeleton Source: LIFEdb
  • nucleoplasm Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9133.
OpenTargetsiENSG00000157456.
PharmGKBiPA26148.

Chemistry databases

ChEMBLiCHEMBL2094127.

Polymorphism and mutation databases

BioMutaiCCNB2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803611 – 398G2/mitotic-specific cyclin-B2Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphothreonineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei94PhosphothreonineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO95067.
MaxQBiO95067.
PaxDbiO95067.
PeptideAtlasiO95067.
PRIDEiO95067.

PTM databases

iPTMnetiO95067.
PhosphoSitePlusiO95067.

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Gene expression databases

BgeeiENSG00000157456.
CleanExiHS_CCNB2.
ExpressionAtlasiO95067. baseline and differential.
GenevisibleiO95067. HS.

Organism-specific databases

HPAiCAB009575.
HPA008873.

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK2P249412EBI-375024,EBI-375096
FLNAP213338EBI-375024,EBI-350432

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi114581. 35 interactors.
DIPiDIP-31730N.
IntActiO95067. 28 interactors.
MINTiMINT-1201520.
STRINGi9606.ENSP00000288207.

Chemistry databases

BindingDBiO95067.

Structurei

3D structure databases

ProteinModelPortaliO95067.
SMRiO95067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiO95067.
KOiK05868.
OMAiHYHPSEI.
OrthoDBiEOG091G0E9B.
PhylomeDBiO95067.
TreeFamiTF101001.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLRRPTVS SDLENIDTGV NSKVKSHVTI RRTVLEEIGN RVTTRAAQVA
60 70 80 90 100
KKAQNTKVPV QPTKTTNVNK QLKPTASVKP VQMEKLAPKG PSPTPEDVSM
110 120 130 140 150
KEENLCQAFS DALLCKIEDI DNEDWENPQL CSDYVKDIYQ YLRQLEVLQS
160 170 180 190 200
INPHFLDGRD INGRMRAILV DWLVQVHSKF RLLQETLYMC VGIMDRFLQV
210 220 230 240 250
QPVSRKKLQL VGITALLLAS KYEEMFSPNI EDFVYITDNA YTSSQIREME
260 270 280 290 300
TLILKELKFE LGRPLPLHFL RRASKAGEVD VEQHTLAKYL MELTLIDYDM
310 320 330 340 350
VHYHPSKVAA AASCLSQKVL GQGKWNLKQQ YYTGYTENEV LEVMQHMAKN
360 370 380 390
VVKVNENLTK FIAIKNKYAS SKLLKISMIP QLNSKAVKDL ASPLIGRS
Length:398
Mass (Da):45,282
Last modified:May 1, 1999 - v1
Checksum:i874466E1DD68A4C4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022221100M → T.1 PublicationCorresponds to variant rs16941036dbSNPEnsembl.1
Natural variantiVAR_053052135V → I.Corresponds to variant rs2306785dbSNPEnsembl.1
Natural variantiVAR_022222395I → T.1 PublicationCorresponds to variant rs28383563dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002822 mRNA. Translation: AAD09309.1.
AB020981 mRNA. Translation: BAA78387.1.
AL080146 mRNA. Translation: CAB45739.1.
CR533527 mRNA. Translation: CAG38558.1.
AY864066 Genomic DNA. Translation: AAW34361.1.
AK001404 mRNA. Translation: BAG50905.1.
CH471082 Genomic DNA. Translation: EAW77563.1.
BC105086 mRNA. Translation: AAI05087.1.
BC105112 mRNA. Translation: AAI05113.1.
CCDSiCCDS10170.1.
PIRiT12530.
RefSeqiNP_004692.1. NM_004701.3.
UniGeneiHs.194698.

Genome annotation databases

EnsembliENST00000288207; ENSP00000288207; ENSG00000157456.
GeneIDi9133.
KEGGihsa:9133.
UCSCiuc002afz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002822 mRNA. Translation: AAD09309.1.
AB020981 mRNA. Translation: BAA78387.1.
AL080146 mRNA. Translation: CAB45739.1.
CR533527 mRNA. Translation: CAG38558.1.
AY864066 Genomic DNA. Translation: AAW34361.1.
AK001404 mRNA. Translation: BAG50905.1.
CH471082 Genomic DNA. Translation: EAW77563.1.
BC105086 mRNA. Translation: AAI05087.1.
BC105112 mRNA. Translation: AAI05113.1.
CCDSiCCDS10170.1.
PIRiT12530.
RefSeqiNP_004692.1. NM_004701.3.
UniGeneiHs.194698.

3D structure databases

ProteinModelPortaliO95067.
SMRiO95067.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114581. 35 interactors.
DIPiDIP-31730N.
IntActiO95067. 28 interactors.
MINTiMINT-1201520.
STRINGi9606.ENSP00000288207.

Chemistry databases

BindingDBiO95067.
ChEMBLiCHEMBL2094127.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiO95067.
PhosphoSitePlusiO95067.

Polymorphism and mutation databases

BioMutaiCCNB2.

Proteomic databases

EPDiO95067.
MaxQBiO95067.
PaxDbiO95067.
PeptideAtlasiO95067.
PRIDEiO95067.

Protocols and materials databases

DNASUi9133.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288207; ENSP00000288207; ENSG00000157456.
GeneIDi9133.
KEGGihsa:9133.
UCSCiuc002afz.4. human.

Organism-specific databases

CTDi9133.
DisGeNETi9133.
GeneCardsiCCNB2.
HGNCiHGNC:1580. CCNB2.
HPAiCAB009575.
HPA008873.
MIMi602755. gene.
neXtProtiNX_O95067.
OpenTargetsiENSG00000157456.
PharmGKBiPA26148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
HOVERGENiHBG061650.
InParanoidiO95067.
KOiK05868.
OMAiHYHPSEI.
OrthoDBiEOG091G0E9B.
PhylomeDBiO95067.
TreeFamiTF101001.

Enzyme and pathway databases

ReactomeiR-HSA-156711. Polo-like kinase mediated events.
R-HSA-157881. Cyclin B2 mediated events.
R-HSA-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-2514853. Condensation of Prometaphase Chromosomes.
R-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-2980767. Activation of NIMA Kinases NEK9, NEK6, NEK7.
R-HSA-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-HSA-69273. Cyclin A/B1 associated events during G2/M transition.
R-HSA-69478. G2/M DNA replication checkpoint.
R-HSA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
SignaLinkiO95067.
SIGNORiO95067.

Miscellaneous databases

GeneWikiiCyclin_B2.
GenomeRNAii9133.
PROiO95067.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157456.
CleanExiHS_CCNB2.
ExpressionAtlasiO95067. baseline and differential.
GenevisibleiO95067. HS.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCNB2_HUMAN
AccessioniPrimary (citable) accession number: O95067
Secondary accession number(s): B3KM93, Q6FI99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.