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O95059

- RPP14_HUMAN

UniProt

O95059 - RPP14_HUMAN

Protein

Ribonuclease P protein subunit p14

Gene

RPP14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC
    2. RNA binding Source: ProtInc

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p14 (EC:3.1.26.5)
    Gene namesi
    Name:RPP14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30327. RPP14.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134896894.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 124123Ribonuclease P protein subunit p14PRO_0000140010Add
    BLAST

    Proteomic databases

    MaxQBiO95059.
    PaxDbiO95059.
    PRIDEiO95059.

    Expressioni

    Gene expression databases

    BgeeiO95059.
    CleanExiHS_RPP14.
    GenevestigatoriO95059.

    Organism-specific databases

    HPAiHPA036194.

    Interactioni

    Subunit structurei

    RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

    Protein-protein interaction databases

    BioGridi116283. 18 interactions.
    IntActiO95059. 16 interactions.
    MINTiMINT-1368513.
    STRINGi9606.ENSP00000295959.

    Structurei

    3D structure databases

    ProteinModelPortaliO95059.
    SMRiO95059. Positions 18-115.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG77977.
    HOGENOMiHOG000006985.
    HOVERGENiHBG079505.
    InParanoidiO95059.
    KOiK14529.
    OMAiHHYMKVC.
    PhylomeDBiO95059.
    TreeFamiTF324711.

    Family and domain databases

    InterProiIPR002759. RNase_P/MRP_subunit.
    [Graphical view]
    PfamiPF01900. RNase_P_Rpp14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95059-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAPAATYER VVYKNPSEYH YMKVCLEFQD CGVGLNAAQF KQLLISAVKD    50
    LFGEVDAALP LDILTYEEKT LSAILRICSS GLVKLWSSLT LLGSYKGKKC 100
    AFRVIQVSPF LLALSGNSRE LVLD 124
    Length:124
    Mass (Da):13,693
    Last modified:January 23, 2007 - v3
    Checksum:i10AF6C947785DD90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001175 mRNA. Translation: AAD00892.1.
    CR407611 mRNA. Translation: CAG28539.1.
    AK311969 mRNA. Translation: BAG34908.1.
    BC002441 mRNA. Translation: AAH02441.1.
    BC007342 mRNA. Translation: AAH07342.1.
    BC012017 mRNA. Translation: AAH12017.1.
    CCDSiCCDS2888.1.
    RefSeqiNP_001092253.1. NM_001098783.2.
    NP_008973.1. NM_007042.4.
    UniGeneiHs.446320.
    Hs.700016.

    Genome annotation databases

    EnsembliENST00000295959; ENSP00000295959; ENSG00000163684.
    ENST00000445193; ENSP00000412894; ENSG00000163684.
    ENST00000466547; ENSP00000419909; ENSG00000163684.
    GeneIDi11102.
    KEGGihsa:11102.
    UCSCiuc003dju.5. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001175 mRNA. Translation: AAD00892.1 .
    CR407611 mRNA. Translation: CAG28539.1 .
    AK311969 mRNA. Translation: BAG34908.1 .
    BC002441 mRNA. Translation: AAH02441.1 .
    BC007342 mRNA. Translation: AAH07342.1 .
    BC012017 mRNA. Translation: AAH12017.1 .
    CCDSi CCDS2888.1.
    RefSeqi NP_001092253.1. NM_001098783.2.
    NP_008973.1. NM_007042.4.
    UniGenei Hs.446320.
    Hs.700016.

    3D structure databases

    ProteinModelPortali O95059.
    SMRi O95059. Positions 18-115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116283. 18 interactions.
    IntActi O95059. 16 interactions.
    MINTi MINT-1368513.
    STRINGi 9606.ENSP00000295959.

    Proteomic databases

    MaxQBi O95059.
    PaxDbi O95059.
    PRIDEi O95059.

    Protocols and materials databases

    DNASUi 11102.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295959 ; ENSP00000295959 ; ENSG00000163684 .
    ENST00000445193 ; ENSP00000412894 ; ENSG00000163684 .
    ENST00000466547 ; ENSP00000419909 ; ENSG00000163684 .
    GeneIDi 11102.
    KEGGi hsa:11102.
    UCSCi uc003dju.5. human.

    Organism-specific databases

    CTDi 11102.
    GeneCardsi GC03P058267.
    HGNCi HGNC:30327. RPP14.
    HPAi HPA036194.
    MIMi 606112. gene.
    neXtProti NX_O95059.
    PharmGKBi PA134896894.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77977.
    HOGENOMi HOG000006985.
    HOVERGENi HBG079505.
    InParanoidi O95059.
    KOi K14529.
    OMAi HHYMKVC.
    PhylomeDBi O95059.
    TreeFami TF324711.

    Miscellaneous databases

    ChiTaRSi RPP14. human.
    GeneWikii RPP14.
    GenomeRNAii 11102.
    NextBioi 42210.
    PROi O95059.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95059.
    CleanExi HS_RPP14.
    Genevestigatori O95059.

    Family and domain databases

    InterProi IPR002759. RNase_P/MRP_subunit.
    [Graphical view ]
    Pfami PF01900. RNase_P_Rpp14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rpp14 and Rpp29, two protein subunits of human ribonuclease P."
      Jarrous N., Eder P.S., Wesolowski D., Altman S.
      RNA 5:153-157(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-14.
      Tissue: Liver and Spleen.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland and Skin.
    5. "An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing."
      Autio K.J., Kastaniotis A.J., Pospiech H., Miinalainen I.J., Schonauer M.S., Dieckmann C.L., Hiltunen J.K.
      FASEB J. 22:569-578(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF BICISTRONIC GENE.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRPP14_HUMAN
    AccessioniPrimary (citable) accession number: O95059
    Secondary accession number(s): Q53X97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3