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Protein

Ribonuclease P protein subunit p14

Gene

RPP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: UniProtKB-EC
  • RNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6784531. tRNA processing in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p14 (EC:3.1.26.5)
Gene namesi
Name:RPP14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30327. RPP14.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896894.

Polymorphism and mutation databases

BioMutaiABHD6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 124123Ribonuclease P protein subunit p14PRO_0000140010Add
BLAST

Proteomic databases

EPDiO95059.
MaxQBiO95059.
PaxDbiO95059.
PeptideAtlasiO95059.
PRIDEiO95059.
TopDownProteomicsiO95059.

PTM databases

iPTMnetiO95059.
PhosphoSiteiO95059.

Expressioni

Gene expression databases

BgeeiENSG00000163684.
CleanExiHS_RPP14.
GenevisibleiO95059. HS.

Organism-specific databases

HPAiHPA036194.

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

Protein-protein interaction databases

BioGridi116283. 20 interactions.
IntActiO95059. 17 interactions.
MINTiMINT-1368513.
STRINGi9606.ENSP00000295959.

Structurei

3D structure databases

ProteinModelPortaliO95059.
SMRiO95059. Positions 18-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IXUB. Eukaryota.
ENOG4112ADM. LUCA.
GeneTreeiENSGT00510000048121.
HOGENOMiHOG000006985.
HOVERGENiHBG079505.
KOiK14529.
OMAiRNPSEHH.
OrthoDBiEOG091G10J1.
PhylomeDBiO95059.
TreeFamiTF324711.

Family and domain databases

InterProiIPR002759. RNase_P/MRP_subunit.
[Graphical view]
PfamiPF01900. RNase_P_Rpp14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPAATYER VVYKNPSEYH YMKVCLEFQD CGVGLNAAQF KQLLISAVKD
60 70 80 90 100
LFGEVDAALP LDILTYEEKT LSAILRICSS GLVKLWSSLT LLGSYKGKKC
110 120
AFRVIQVSPF LLALSGNSRE LVLD
Length:124
Mass (Da):13,693
Last modified:January 23, 2007 - v3
Checksum:i10AF6C947785DD90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001175 mRNA. Translation: AAD00892.1.
CR407611 mRNA. Translation: CAG28539.1.
AK311969 mRNA. Translation: BAG34908.1.
BC002441 mRNA. Translation: AAH02441.1.
BC007342 mRNA. Translation: AAH07342.1.
BC012017 mRNA. Translation: AAH12017.1.
CCDSiCCDS2888.1.
RefSeqiNP_001092253.1. NM_001098783.2.
NP_008973.1. NM_007042.4.
XP_011531615.1. XM_011533313.2.
UniGeneiHs.446320.
Hs.700016.

Genome annotation databases

EnsembliENST00000295959; ENSP00000295959; ENSG00000163684.
ENST00000445193; ENSP00000412894; ENSG00000163684.
ENST00000466547; ENSP00000419909; ENSG00000163684.
GeneIDi11102.
KEGGihsa:11102.
UCSCiuc003dju.6. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001175 mRNA. Translation: AAD00892.1.
CR407611 mRNA. Translation: CAG28539.1.
AK311969 mRNA. Translation: BAG34908.1.
BC002441 mRNA. Translation: AAH02441.1.
BC007342 mRNA. Translation: AAH07342.1.
BC012017 mRNA. Translation: AAH12017.1.
CCDSiCCDS2888.1.
RefSeqiNP_001092253.1. NM_001098783.2.
NP_008973.1. NM_007042.4.
XP_011531615.1. XM_011533313.2.
UniGeneiHs.446320.
Hs.700016.

3D structure databases

ProteinModelPortaliO95059.
SMRiO95059. Positions 18-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116283. 20 interactions.
IntActiO95059. 17 interactions.
MINTiMINT-1368513.
STRINGi9606.ENSP00000295959.

PTM databases

iPTMnetiO95059.
PhosphoSiteiO95059.

Polymorphism and mutation databases

BioMutaiABHD6.

Proteomic databases

EPDiO95059.
MaxQBiO95059.
PaxDbiO95059.
PeptideAtlasiO95059.
PRIDEiO95059.
TopDownProteomicsiO95059.

Protocols and materials databases

DNASUi11102.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295959; ENSP00000295959; ENSG00000163684.
ENST00000445193; ENSP00000412894; ENSG00000163684.
ENST00000466547; ENSP00000419909; ENSG00000163684.
GeneIDi11102.
KEGGihsa:11102.
UCSCiuc003dju.6. human.

Organism-specific databases

CTDi11102.
GeneCardsiRPP14.
HGNCiHGNC:30327. RPP14.
HPAiHPA036194.
MIMi606112. gene.
neXtProtiNX_O95059.
PharmGKBiPA134896894.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXUB. Eukaryota.
ENOG4112ADM. LUCA.
GeneTreeiENSGT00510000048121.
HOGENOMiHOG000006985.
HOVERGENiHBG079505.
KOiK14529.
OMAiRNPSEHH.
OrthoDBiEOG091G10J1.
PhylomeDBiO95059.
TreeFamiTF324711.

Enzyme and pathway databases

ReactomeiR-HSA-6784531. tRNA processing in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

ChiTaRSiRPP14. human.
GeneWikiiRPP14.
GenomeRNAii11102.
PROiO95059.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163684.
CleanExiHS_RPP14.
GenevisibleiO95059. HS.

Family and domain databases

InterProiIPR002759. RNase_P/MRP_subunit.
[Graphical view]
PfamiPF01900. RNase_P_Rpp14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPP14_HUMAN
AccessioniPrimary (citable) accession number: O95059
Secondary accession number(s): Q53X97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.