O95059 (RPP14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit p14
EC=3.1.26.5

Gene names

Name:

RPP14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.
Subcellular location	Nucleus Potential.
Miscellaneous	This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Traceable author statement Ref.1. Source: ProtInc
Molecular_function	RNA binding Traceable author statement Ref.1. Source: ProtInc ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 124	123	Ribonuclease P protein subunit p14		PRO_0000140010

Sequences

	Sequence		Length	Mass (Da)
	O95059 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 10AF6C947785DD90	FASTA	124	13,693
	10 20 30 40 50 60 MPAPAATYER VVYKNPSEYH YMKVCLEFQD CGVGLNAAQF KQLLISAVKD LFGEVDAALP 70 80 90 100 110 120 LDILTYEEKT LSAILRICSS GLVKLWSSLT LLGSYKGKKC AFRVIQVSPF LLALSGNSRE LVLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rpp14 and Rpp29, two protein subunits of human ribonuclease P." Jarrous N., Eder P.S., Wesolowski D., Altman S. RNA 5:153-157(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-14. Tissue: Liver and Spleen.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland and Skin.
[5]	"An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing." Autio K.J., Kastaniotis A.J., Pospiech H., Miinalainen I.J., Schonauer M.S., Dieckmann C.L., Hiltunen J.K. FASEB J. 22:569-578(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF BICISTRONIC GENE.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF001175 mRNA. Translation: AAD00892.1. CR407611 mRNA. Translation: CAG28539.1. AK311969 mRNA. Translation: BAG34908.1. BC002441 mRNA. Translation: AAH02441.1. BC007342 mRNA. Translation: AAH07342.1. BC012017 mRNA. Translation: AAH12017.1.
IPI	IPI00215966.
RefSeq	NP_001092253.1. NM_001098783.2. NP_008973.1. NM_007042.4.
UniGene	Hs.446320. Hs.700016.
3D structure databases
ProteinModelPortal	O95059.
SMR	O95059. Positions 21-114.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95059. 6 interactions.
MINT	MINT-1368513.
STRING	9606.ENSP00000295959.
Proteomic databases
PaxDb	O95059.
PRIDE	O95059.
Protocols and materials databases
DNASU	11102.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295959; ENSP00000295959; ENSG00000163684. ENST00000445193; ENSP00000412894; ENSG00000163684. ENST00000466547; ENSP00000419909; ENSG00000163684.
GeneID	11102.
KEGG	hsa:11102.
UCSC	uc003dju.4. human.
Organism-specific databases
CTD	11102.
GeneCards	GC03P058267.
HGNC	HGNC:30327. RPP14.
HPA	HPA036194.
MIM	606112. gene.
neXtProt	NX_O95059.
PharmGKB	PA134896894.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG77977.
HOGENOM	HOG000006985.
HOVERGEN	HBG079505.
InParanoid	O95059.
KO	K14529.
OMA	YERIVYK.
OrthoDB	EOG447FVV.
PhylomeDB	O95059.
Gene expression databases
Bgee	O95059.
CleanEx	HS_RPP14.
Genevestigator	O95059.
GermOnline	ENSG00000163684. Homo sapiens.
Family and domain databases
InterPro	IPR002759. RNase_P/MRP_subunit. [Graphical view]
Pfam	PF01900. RNase_P_Rpp14. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPP14. human.
GenomeRNAi	11102.
NextBio	42210.
SOURCE	Search...

Entry information

Entry name

RPP14_HUMAN

Accession

Primary (citable) accession number: O95059
Secondary accession number(s): Q53X97

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.