Reviewed, UniProtKB/Swiss-Prot O95059 (RPP14_HUMAN)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein subunit p14
    EC=3.1.26.5

Gene names

Name:

RPP14

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Ref.1 Traceable author statement. Source: ProtInc
Molecular function	RNA binding Ref.1 Traceable author statement. Source: ProtInc identical protein binding Inferred from physical interaction. Source: IntAct ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-366542,EBI-366542
POP4	O95707	1	EBI-366542,EBI-366477
POP5	Q969H6	1	EBI-366542,EBI-366525
RPP25	Q9BUL9	1	EBI-366542,EBI-366570
RPP30	P78346	1	EBI-366542,EBI-366553
RPP40	O75818	1	EBI-366542,EBI-366505

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 124	123	Ribonuclease P protein subunit p14		PRO_0000140010

Sequences

	Sequence		Length	Mass (Da)
	O95059-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 10AF6C947785DD90	FASTA	124	13,693
	10 20 30 40 50 60 MPAPAATYER VVYKNPSEYH YMKVCLEFQD CGVGLNAAQF KQLLISAVKD LFGEVDAALP 70 80 90 100 110 120 LDILTYEEKT LSAILRICSS GLVKLWSSLT LLGSYKGKKC AFRVIQVSPF LLALSGNSRE LVLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rpp14 and Rpp29, two protein subunits of human ribonuclease P." Jarrous N., Eder P.S., Wesolowski D., Altman S. RNA 5:153-157(1999) [PubMed: 10024167] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-14. Tissue: Liver and Spleen.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF001175 mRNA. Translation: AAD00892.1. CR407611 mRNA. Translation: CAG28539.1. AK311969 mRNA. Translation: BAG34908.1. BC002441 mRNA. Translation: AAH02441.1. BC007342 mRNA. Translation: AAH07342.1. BC012017 mRNA. Translation: AAH12017.1.
IPI	IPI00215966.
RefSeq	NP_001092253.1. NP_008973.1.
UniGene	Hs.446320 Hs.700016
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O95059. 7 interactions.
STRING	O95059.
Proteomic databases
PRIDE	O95059.
Genome annotation databases
Ensembl	ENST00000295959; ENSP00000295959; ENSG00000163684; Homo sapiens. [Genome view] ENST00000445193; ENSP00000412894; ENSG00000163684; Homo sapiens. [Genome view] ENST00000466547; ENSP00000419909; ENSG00000163684; Homo sapiens. [Genome view]
GeneID	11102.
KEGG	hsa:11102.
UCSC	uc003dju.2. human.
Organism-specific databases
CTD	11102.
GeneCards	GC03P058267.
H-InvDB	HIX0003400.
HGNC	HGNC:30327. RPP14.
MIM	606112. gene.
PharmGKB	PA134896894.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O95059.
HOVERGEN	O95059.
OMA	AQFKQLI
OrthoDB	EOG9ZW7WS
Enzyme and pathway databases
BRENDA	3.1.26.5. 247.
Gene expression databases
ArrayExpress	O95059.
Bgee	O95059.
CleanEx	HS_RPP14.
Genevestigator	O95059.
GermOnline	ENSG00000163684. Homo sapiens.
Family and domain databases
InterPro	IPR002759. RNase_P_related. [Graphical view]
Pfam	PF01900. RNase_P_Rpp14. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	42210.
SOURCE	Search...

Entry information

Entry name

RPP14_HUMAN

Accession

Primary (citable) accession number: O95059
Secondary accession number(s): Q53X97

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	November 24, 2009
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.