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Protein

Ribonuclease P protein subunit p14

Gene

RPP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC
  2. RNA binding Source: ProtInc

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p14 (EC:3.1.26.5)
Gene namesi
Name:RPP14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30327. RPP14.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 124123Ribonuclease P protein subunit p14PRO_0000140010Add
BLAST

Proteomic databases

MaxQBiO95059.
PaxDbiO95059.
PRIDEiO95059.

Expressioni

Gene expression databases

BgeeiO95059.
CleanExiHS_RPP14.
GenevestigatoriO95059.

Organism-specific databases

HPAiHPA036194.

Interactioni

Subunit structurei

RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40.

Protein-protein interaction databases

BioGridi116283. 19 interactions.
IntActiO95059. 16 interactions.
MINTiMINT-1368513.
STRINGi9606.ENSP00000295959.

Structurei

3D structure databases

ProteinModelPortaliO95059.
SMRiO95059. Positions 18-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG77977.
GeneTreeiENSGT00510000048121.
HOGENOMiHOG000006985.
HOVERGENiHBG079505.
KOiK14529.
OMAiHHYMKVC.
PhylomeDBiO95059.
TreeFamiTF324711.

Family and domain databases

InterProiIPR002759. RNase_P/MRP_subunit.
[Graphical view]
PfamiPF01900. RNase_P_Rpp14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPAATYER VVYKNPSEYH YMKVCLEFQD CGVGLNAAQF KQLLISAVKD
60 70 80 90 100
LFGEVDAALP LDILTYEEKT LSAILRICSS GLVKLWSSLT LLGSYKGKKC
110 120
AFRVIQVSPF LLALSGNSRE LVLD
Length:124
Mass (Da):13,693
Last modified:January 23, 2007 - v3
Checksum:i10AF6C947785DD90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001175 mRNA. Translation: AAD00892.1.
CR407611 mRNA. Translation: CAG28539.1.
AK311969 mRNA. Translation: BAG34908.1.
BC002441 mRNA. Translation: AAH02441.1.
BC007342 mRNA. Translation: AAH07342.1.
BC012017 mRNA. Translation: AAH12017.1.
CCDSiCCDS2888.1.
RefSeqiNP_001092253.1. NM_001098783.2.
NP_008973.1. NM_007042.4.
UniGeneiHs.446320.
Hs.700016.

Genome annotation databases

EnsembliENST00000295959; ENSP00000295959; ENSG00000163684.
ENST00000445193; ENSP00000412894; ENSG00000163684.
ENST00000466547; ENSP00000419909; ENSG00000163684.
GeneIDi11102.
KEGGihsa:11102.
UCSCiuc003dju.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001175 mRNA. Translation: AAD00892.1.
CR407611 mRNA. Translation: CAG28539.1.
AK311969 mRNA. Translation: BAG34908.1.
BC002441 mRNA. Translation: AAH02441.1.
BC007342 mRNA. Translation: AAH07342.1.
BC012017 mRNA. Translation: AAH12017.1.
CCDSiCCDS2888.1.
RefSeqiNP_001092253.1. NM_001098783.2.
NP_008973.1. NM_007042.4.
UniGeneiHs.446320.
Hs.700016.

3D structure databases

ProteinModelPortaliO95059.
SMRiO95059. Positions 18-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116283. 19 interactions.
IntActiO95059. 16 interactions.
MINTiMINT-1368513.
STRINGi9606.ENSP00000295959.

Proteomic databases

MaxQBiO95059.
PaxDbiO95059.
PRIDEiO95059.

Protocols and materials databases

DNASUi11102.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295959; ENSP00000295959; ENSG00000163684.
ENST00000445193; ENSP00000412894; ENSG00000163684.
ENST00000466547; ENSP00000419909; ENSG00000163684.
GeneIDi11102.
KEGGihsa:11102.
UCSCiuc003dju.5. human.

Organism-specific databases

CTDi11102.
GeneCardsiGC03P058295.
HGNCiHGNC:30327. RPP14.
HPAiHPA036194.
MIMi606112. gene.
neXtProtiNX_O95059.
PharmGKBiPA134896894.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG77977.
GeneTreeiENSGT00510000048121.
HOGENOMiHOG000006985.
HOVERGENiHBG079505.
KOiK14529.
OMAiHHYMKVC.
PhylomeDBiO95059.
TreeFamiTF324711.

Miscellaneous databases

ChiTaRSiRPP14. human.
GeneWikiiRPP14.
GenomeRNAii11102.
NextBioi42210.
PROiO95059.
SOURCEiSearch...

Gene expression databases

BgeeiO95059.
CleanExiHS_RPP14.
GenevestigatoriO95059.

Family and domain databases

InterProiIPR002759. RNase_P/MRP_subunit.
[Graphical view]
PfamiPF01900. RNase_P_Rpp14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rpp14 and Rpp29, two protein subunits of human ribonuclease P."
    Jarrous N., Eder P.S., Wesolowski D., Altman S.
    RNA 5:153-157(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-14.
    Tissue: Liver and Spleen.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland and Skin.
  5. "An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing."
    Autio K.J., Kastaniotis A.J., Pospiech H., Miinalainen I.J., Schonauer M.S., Dieckmann C.L., Hiltunen J.K.
    FASEB J. 22:569-578(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF BICISTRONIC GENE.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPP14_HUMAN
AccessioniPrimary (citable) accession number: O95059
Secondary accession number(s): Q53X97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.