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Protein

GTP-binding protein Di-Ras1

Gene

DIRAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Displays low GTPase activity and exists predominantly in the GTP-bound form.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151GTP; via amide nitrogenCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 22GTPCombined sources1 Publication6
Nucleotide bindingi33 – 39GTPBy similarity7
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi121 – 125GTPCombined sources1 Publication5
Nucleotide bindingi151 – 152GTPBy similarity2

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176490-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Di-Ras1
Alternative name(s):
Distinct subgroup of the Ras family member 1
Ras-related inhibitor of cell growth
Short name:
Rig
Small GTP-binding tumor suppressor 1
Gene namesi
Name:DIRAS1
Synonyms:GBTS1, RIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19127. DIRAS1.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi148252.
OpenTargetsiENSG00000176490.
PharmGKBiPA134951835.

Polymorphism and mutation databases

BioMutaiDIRAS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916481 – 195GTP-binding protein Di-Ras1Add BLAST195
PropeptideiPRO_0000370775196 – 198Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei195Cysteine methyl esterSequence analysis1
Lipidationi195S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO95057.
MaxQBiO95057.
PaxDbiO95057.
PeptideAtlasiO95057.
PRIDEiO95057.

PTM databases

iPTMnetiO95057.
PhosphoSitePlusiO95057.

Expressioni

Tissue specificityi

Highly expressed in heart and brain.2 Publications

Gene expression databases

BgeeiENSG00000176490.
CleanExiHS_DIRAS1.
ExpressionAtlasiO95057. baseline and differential.
GenevisibleiO95057. HS.

Interactioni

Protein-protein interaction databases

BioGridi127135. 9 interactors.
IntActiO95057. 2 interactors.
STRINGi9606.ENSP00000325836.

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 14Combined sources7
Helixi20 – 29Combined sources10
Beta strandi42 – 50Combined sources9
Beta strandi53 – 61Combined sources9
Helixi64 – 66Combined sources3
Helixi69 – 78Combined sources10
Beta strandi80 – 87Combined sources8
Helixi91 – 95Combined sources5
Helixi98 – 108Combined sources11
Helixi111 – 113Combined sources3
Beta strandi116 – 121Combined sources6
Helixi132 – 142Combined sources11
Beta strandi145 – 148Combined sources4
Turni151 – 154Combined sources4
Helixi157 – 167Combined sources11
Beta strandi169 – 171Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GF0X-ray1.90A/B/C/D1-198[»]
ProteinModelPortaliO95057.
SMRiO95057.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95057.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Di-Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO95057.
KOiK07840.
OMAiLGPIYQL.
OrthoDBiEOG091G0SBH.
PhylomeDBiO95057.
TreeFamiTF313014.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC
60 70 80 90 100
DKSVCTLQIT DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLEELGPI
110 120 130 140 150
YKLIVQIKGS VEDIPVMLVG NKCDETQREV DTREAQAVAQ EWKCAFMETS
160 170 180 190
AKMNYNVKEL FQELLTLETR RNMSLNIDGK RSGKQKRTDR VKGKCTLM
Length:198
Mass (Da):22,329
Last modified:May 1, 1999 - v1
Checksum:i32E979AF80BB9A7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076888 mRNA. Translation: BAC01115.1.
AY056037 mRNA. Translation: AAL23715.1.
AY059641 mRNA. Translation: AAL17968.1.
AY180973 mRNA. Translation: AAO22153.1.
AC006538 Genomic DNA. Translation: AAD13119.1.
BC030660 mRNA. Translation: AAH30660.1.
CCDSiCCDS12092.1.
RefSeqiNP_660156.1. NM_145173.3.
UniGeneiHs.172753.

Genome annotation databases

EnsembliENST00000323469; ENSP00000325836; ENSG00000176490.
ENST00000585334; ENSP00000468417; ENSG00000176490.
GeneIDi148252.
KEGGihsa:148252.
UCSCiuc002lwf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076888 mRNA. Translation: BAC01115.1.
AY056037 mRNA. Translation: AAL23715.1.
AY059641 mRNA. Translation: AAL17968.1.
AY180973 mRNA. Translation: AAO22153.1.
AC006538 Genomic DNA. Translation: AAD13119.1.
BC030660 mRNA. Translation: AAH30660.1.
CCDSiCCDS12092.1.
RefSeqiNP_660156.1. NM_145173.3.
UniGeneiHs.172753.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GF0X-ray1.90A/B/C/D1-198[»]
ProteinModelPortaliO95057.
SMRiO95057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127135. 9 interactors.
IntActiO95057. 2 interactors.
STRINGi9606.ENSP00000325836.

PTM databases

iPTMnetiO95057.
PhosphoSitePlusiO95057.

Polymorphism and mutation databases

BioMutaiDIRAS1.

Proteomic databases

EPDiO95057.
MaxQBiO95057.
PaxDbiO95057.
PeptideAtlasiO95057.
PRIDEiO95057.

Protocols and materials databases

DNASUi148252.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323469; ENSP00000325836; ENSG00000176490.
ENST00000585334; ENSP00000468417; ENSG00000176490.
GeneIDi148252.
KEGGihsa:148252.
UCSCiuc002lwf.4. human.

Organism-specific databases

CTDi148252.
DisGeNETi148252.
GeneCardsiDIRAS1.
HGNCiHGNC:19127. DIRAS1.
MIMi607862. gene.
neXtProtiNX_O95057.
OpenTargetsiENSG00000176490.
PharmGKBiPA134951835.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO95057.
KOiK07840.
OMAiLGPIYQL.
OrthoDBiEOG091G0SBH.
PhylomeDBiO95057.
TreeFamiTF313014.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176490-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO95057.
GenomeRNAii148252.
PROiO95057.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176490.
CleanExiHS_DIRAS1.
ExpressionAtlasiO95057. baseline and differential.
GenevisibleiO95057. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDIRA1_HUMAN
AccessioniPrimary (citable) accession number: O95057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.