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O95049

- ZO3_HUMAN

UniProt

O95049 - ZO3_HUMAN

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Protein

Tight junction protein ZO-3

Gene

TJP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. regulation of G1/S transition of mitotic cell cycle Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tight junction protein ZO-3
Alternative name(s):
Tight junction protein 3
Zona occludens protein 3
Zonula occludens protein 3
Gene namesi
Name:TJP3
Synonyms:ZO3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11829. TJP3.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctiontight junction By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. nucleus Source: UniProtKB
  3. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36534.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Tight junction protein ZO-3PRO_0000094546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei164 – 1641Phosphoserine4 Publications
Modified residuei169 – 1691PhosphoserineBy similarity
Modified residuei905 – 9051Phosphoserine2 Publications
Modified residuei906 – 9061Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95049.
PaxDbiO95049.
PRIDEiO95049.

PTM databases

PhosphoSiteiO95049.

Expressioni

Gene expression databases

BgeeiO95049.
CleanExiHS_TJP3.
ExpressionAtlasiO95049. baseline and differential.
GenevestigatoriO95049.

Organism-specific databases

HPAiCAB013244.

Interactioni

Subunit structurei

Interacts with occludin, claudins and ZO-1. Interacts with INADL (By similarity). Interacts with UBN1. Interacts with FASLG.By similarity2 Publications

Protein-protein interaction databases

BioGridi118025. 5 interactions.
IntActiO95049. 2 interactions.
MINTiMINT-210473.
STRINGi9606.ENSP00000262968.

Structurei

Secondary structure

1
919
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi478 – 4825
Beta strandi490 – 4934
Beta strandi501 – 5066
Beta strandi522 – 5276
Beta strandi533 – 5397
Helixi542 – 55514
Helixi596 – 6027
Beta strandi606 – 6149
Beta strandi621 – 6255
Helixi628 – 63811
Turni640 – 6423
Beta strandi643 – 6453
Helixi661 – 6699
Beta strandi673 – 6764
Helixi680 – 6889
Beta strandi694 – 7018
Helixi703 – 71311
Helixi721 – 73515
Helixi736 – 7383
Beta strandi740 – 7456
Beta strandi747 – 7493
Helixi751 – 76313
Beta strandi766 – 7716

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KFVX-ray2.80A475-775[»]
ProteinModelPortaliO95049.
SMRiO95049. Positions 6-93, 196-271, 379-772.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95049.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9383PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini195 – 27278PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini380 – 44667PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini475 – 54975SH3PROSITE-ProRule annotationAdd
BLAST
Domaini580 – 761182Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG239704.
GeneTreeiENSGT00640000091263.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
InParanoidiO95049.
KOiK06097.
OMAiQILKTCT.
TreeFamiTF315606.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZonOcculdens.
IPR005420. ZonOcculS3.
[Graphical view]
PANTHERiPTHR13865:SF11. PTHR13865:SF11. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01600. ZONOCCLUDNS3.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 5 (identifier: O95049-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEELTIWEQH TATLSKDPRR GFGIAISGGR DRPGGSMVVS DVVPGGPAEG
60 70 80 90 100
RLQTGDHIVM VNGVSMENAT SAFAIQILKT CTKMANITVK RPRRIHLPAT
110 120 130 140 150
KASPSSPGRQ DSDEDDGPQR VEEVDQGRGY DGDSSSGSGR SWDERSRRPR
160 170 180 190 200
PGRRGRAGSH GRRSPGGGSE ANGLALVSGF KRLPRQDVQM KPVKSVLVKR
210 220 230 240 250
RDSEEFGVKL GSQIFIKHIT DSGLAARHRG LQEGDLILQI NGVSSQNLSL
260 270 280 290 300
NDTRRLIEKS EGKLSLLVLR DRGQFLVNIP PAVSDSDSSP LEDISDLASE
310 320 330 340 350
LSQAPPSHIP PPPRHAQRSP EASQTDSPVE SPRLRRESSV DSRTISEPDE
360 370 380 390 400
QRSELPRESS YDIYRVPSSQ SMEDRGYSPD TRVVRFLKGK SIGLRLAGGN
410 420 430 440 450
DVGIFVSGVQ AGSPADGQGI QEGDQILQVN DVPFQNLTRE EAVQFLLGLP
460 470 480 490 500
PGEEMELVTQ RKQDIFWKMV QSRVGDSFYI RTHFELEPSP PSGLGFTRGD
510 520 530 540 550
VFHVLDTLHP GPGQSHARGG HWLAVRMGRD LREQERGIIP NQSRAEQLAS
560 570 580 590 600
LEAAQRAVGV GPGSSAGSNA RAEFWRLRGL RRGAKKTTQR SREDLSALTR
610 620 630 640 650
QGRYPPYERV VLREASFKRP VVILGPVADI AMQKLTAEMP DQFEIAETVS
660 670 680 690 700
RTDSPSKIIK LDTVRVIAEK DKHALLDVTP SAIERLNYVQ YYPIVVFFIP
710 720 730 740 750
ESRPALKALR QWLAPASRRS TRRLYAQAQK LRKHSSHLFT ATIPLNGTSD
760 770 780 790 800
TWYQELKAII REQQTRPIWT AEDQLDGSLE DNLDLPHHGL ADSSADLSCD
810 820 830 840 850
SRVNSDYETD GEGGAYTDGE GYTDGEGGPY TDVDDEPPAP ALARSSEPVQ
860 870 880 890 900
ADESQSPRDR GRISAHQGAQ VDSRHPQGQW RQDSMRTYER EALKKKFMRV
910
HDAESSDEDG YDWGPATDL
Length:919
Mass (Da):101,397
Last modified:March 19, 2014 - v3
Checksum:iD36EB684E7E4A6C8
GO
Isoform 3 (identifier: O95049-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNLCGLMPIFPAPLDQVADM

Note: No experimental confirmation available.

Show »
Length:938
Mass (Da):103,424
Checksum:i603411581EB7FA85
GO
Isoform 4 (identifier: O95049-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAVRFQVADM

Show »
Length:928
Mass (Da):102,415
Checksum:iB418537346F205CF
GO
Isoform 6 (identifier: O95049-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:883
Mass (Da):97,488
Checksum:i511564BFC624B3A8
GO

Sequence cautioni

The sequence AAC72274.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAW69293.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191R → H in AAI08907. (PubMed:15489334)Curated
Sequence conflicti96 – 961H → L in BAG52285. (PubMed:14702039)Curated
Sequence conflicti449 – 4491L → P in BAG54652. (PubMed:14702039)Curated
Sequence conflicti802 – 8021R → H in BAG52285. (PubMed:14702039)Curated
Sequence conflicti901 – 9011H → R in BAG52285. (PubMed:14702039)Curated
Sequence conflicti917 – 9171T → M in BAG65278. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti898 – 8981M → T.1 Publication
Corresponds to variant rs1046268 [ dbSNP | Ensembl ].
VAR_056114

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 6. 1 PublicationVSP_053844Add
BLAST
Alternative sequencei1 – 11M → MNLCGLMPIFPAPLDQVADM in isoform 3. 1 PublicationVSP_040238
Alternative sequencei1 – 11M → MAVRFQVADM in isoform 4. 1 PublicationVSP_047022

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091118 mRNA. Translation: BAG52285.1.
AK128237 mRNA. Translation: BAG54652.1.
AK304462 mRNA. Translation: BAG65278.1.
AC005954 Genomic DNA. Translation: AAC72274.1. Sequence problems.
AC006125 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69293.1. Sequence problems.
BC108906 mRNA. Translation: AAI08907.1.
CCDSiCCDS32873.2. [O95049-1]
CCDS59332.1. [O95049-4]
RefSeqiNP_001254489.1. NM_001267560.1. [O95049-1]
NP_001254490.1. NM_001267561.1. [O95049-4]
XP_005259596.1. XM_005259539.2. [O95049-3]
XP_006722787.1. XM_006722724.1. [O95049-1]
UniGeneiHs.25527.

Genome annotation databases

EnsembliENST00000539908; ENSP00000439991; ENSG00000105289. [O95049-5]
ENST00000541714; ENSP00000439278; ENSG00000105289. [O95049-1]
ENST00000587686; ENSP00000467864; ENSG00000105289. [O95049-3]
ENST00000589378; ENSP00000465419; ENSG00000105289. [O95049-4]
GeneIDi27134.
KEGGihsa:27134.
UCSCiuc010xhu.3. human. [O95049-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091118 mRNA. Translation: BAG52285.1 .
AK128237 mRNA. Translation: BAG54652.1 .
AK304462 mRNA. Translation: BAG65278.1 .
AC005954 Genomic DNA. Translation: AAC72274.1 . Sequence problems.
AC006125 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69293.1 . Sequence problems.
BC108906 mRNA. Translation: AAI08907.1 .
CCDSi CCDS32873.2. [O95049-1 ]
CCDS59332.1. [O95049-4 ]
RefSeqi NP_001254489.1. NM_001267560.1. [O95049-1 ]
NP_001254490.1. NM_001267561.1. [O95049-4 ]
XP_005259596.1. XM_005259539.2. [O95049-3 ]
XP_006722787.1. XM_006722724.1. [O95049-1 ]
UniGenei Hs.25527.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KFV X-ray 2.80 A 475-775 [» ]
ProteinModelPortali O95049.
SMRi O95049. Positions 6-93, 196-271, 379-772.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118025. 5 interactions.
IntActi O95049. 2 interactions.
MINTi MINT-210473.
STRINGi 9606.ENSP00000262968.

PTM databases

PhosphoSitei O95049.

Proteomic databases

MaxQBi O95049.
PaxDbi O95049.
PRIDEi O95049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000539908 ; ENSP00000439991 ; ENSG00000105289 . [O95049-5 ]
ENST00000541714 ; ENSP00000439278 ; ENSG00000105289 . [O95049-1 ]
ENST00000587686 ; ENSP00000467864 ; ENSG00000105289 . [O95049-3 ]
ENST00000589378 ; ENSP00000465419 ; ENSG00000105289 . [O95049-4 ]
GeneIDi 27134.
KEGGi hsa:27134.
UCSCi uc010xhu.3. human. [O95049-3 ]

Organism-specific databases

CTDi 27134.
GeneCardsi GC19P003708.
H-InvDB HIX0014645.
HGNCi HGNC:11829. TJP3.
HPAi CAB013244.
MIMi 612689. gene.
neXtProti NX_O95049.
PharmGKBi PA36534.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239704.
GeneTreei ENSGT00640000091263.
HOGENOMi HOG000230923.
HOVERGENi HBG017627.
InParanoidi O95049.
KOi K06097.
OMAi QILKTCT.
TreeFami TF315606.

Miscellaneous databases

EvolutionaryTracei O95049.
GeneWikii TJP3.
GenomeRNAii 27134.
NextBioi 13603241.
PROi O95049.
SOURCEi Search...

Gene expression databases

Bgeei O95049.
CleanExi HS_TJP3.
ExpressionAtlasi O95049. baseline and differential.
Genevestigatori O95049.

Family and domain databases

Gene3Di 2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZonOcculdens.
IPR005420. ZonOcculS3.
[Graphical view ]
PANTHERi PTHR13865:SF11. PTHR13865:SF11. 1 hit.
Pfami PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view ]
PRINTSi PR01597. ZONOCCLUDNS.
PR01600. ZONOCCLUDNS3.
SMARTi SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
    Tissue: Stomach, Testis and Tongue.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT THR-898.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-905 AND SER-906, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.
  7. "Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)."
    Aho S., Lupo J., Coly P.-A., Sabine A., Castellazzi M., Morand P., Sergeant A., Manet E., Boyer V., Gruffat H.
    Biol. Cell 101:319-334(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBN1.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-905 AND SER-906, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form."
    Structural genomics consortium (SGC)
    Submitted (NOV-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 475-775.

Entry informationi

Entry nameiZO3_HUMAN
AccessioniPrimary (citable) accession number: O95049
Secondary accession number(s): A6NFP3
, B3KR73, B3KXZ0, B4E2W6, F5H2X0, F5H4S9, K7EK22, Q32N01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 19, 2014
Last modified: October 29, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3