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O95049

- ZO3_HUMAN

UniProt

O95049 - ZO3_HUMAN

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Protein
Tight junction protein ZO-3
Gene
TJP3, ZO3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. regulation of G1/S transition of mitotic cell cycle Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tight junction protein ZO-3
Alternative name(s):
Tight junction protein 3
Zona occludens protein 3
Zonula occludens protein 3
Gene namesi
Name:TJP3
Synonyms:ZO3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11829. TJP3.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. nucleus Source: UniProtKB
  3. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36534.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Tight junction protein ZO-3
PRO_0000094546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei164 – 1641Phosphoserine4 Publications
Modified residuei169 – 1691Phosphoserine By similarity
Modified residuei905 – 9051Phosphoserine2 Publications
Modified residuei906 – 9061Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO95049.
PaxDbiO95049.
PRIDEiO95049.

PTM databases

PhosphoSiteiO95049.

Expressioni

Gene expression databases

ArrayExpressiO95049.
BgeeiO95049.
CleanExiHS_TJP3.
GenevestigatoriO95049.

Organism-specific databases

HPAiCAB013244.

Interactioni

Subunit structurei

Interacts with occludin, claudins and ZO-1. Interacts with INADL By similarity. Interacts with UBN1. Interacts with FASLG.2 Publications

Protein-protein interaction databases

BioGridi118025. 5 interactions.
IntActiO95049. 2 interactions.
MINTiMINT-210473.
STRINGi9606.ENSP00000262968.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi478 – 4825
Beta strandi490 – 4934
Beta strandi501 – 5066
Beta strandi522 – 5276
Beta strandi533 – 5397
Helixi542 – 55514
Helixi596 – 6027
Beta strandi606 – 6149
Beta strandi621 – 6255
Helixi628 – 63811
Turni640 – 6423
Beta strandi643 – 6453
Helixi661 – 6699
Beta strandi673 – 6764
Helixi680 – 6889
Beta strandi694 – 7018
Helixi703 – 71311
Helixi721 – 73515
Helixi736 – 7383
Beta strandi740 – 7456
Beta strandi747 – 7493
Helixi751 – 76313
Beta strandi766 – 7716

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KFVX-ray2.80A475-775[»]
ProteinModelPortaliO95049.
SMRiO95049. Positions 6-93, 196-271, 379-772.

Miscellaneous databases

EvolutionaryTraceiO95049.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9383PDZ 1
Add
BLAST
Domaini195 – 27278PDZ 2
Add
BLAST
Domaini380 – 44667PDZ 3
Add
BLAST
Domaini475 – 54975SH3
Add
BLAST
Domaini580 – 761182Guanylate kinase-like
Add
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG239704.
HOGENOMiHOG000230923.
HOVERGENiHBG017627.
InParanoidiO95049.
KOiK06097.
OMAiQILKTCT.
TreeFamiTF315606.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZonOcculdens.
IPR005420. ZonOcculS3.
[Graphical view]
PANTHERiPTHR13865:SF11. PTHR13865:SF11. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01597. ZONOCCLUDNS.
PR01600. ZONOCCLUDNS3.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 5 (identifier: O95049-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEELTIWEQH TATLSKDPRR GFGIAISGGR DRPGGSMVVS DVVPGGPAEG    50
RLQTGDHIVM VNGVSMENAT SAFAIQILKT CTKMANITVK RPRRIHLPAT 100
KASPSSPGRQ DSDEDDGPQR VEEVDQGRGY DGDSSSGSGR SWDERSRRPR 150
PGRRGRAGSH GRRSPGGGSE ANGLALVSGF KRLPRQDVQM KPVKSVLVKR 200
RDSEEFGVKL GSQIFIKHIT DSGLAARHRG LQEGDLILQI NGVSSQNLSL 250
NDTRRLIEKS EGKLSLLVLR DRGQFLVNIP PAVSDSDSSP LEDISDLASE 300
LSQAPPSHIP PPPRHAQRSP EASQTDSPVE SPRLRRESSV DSRTISEPDE 350
QRSELPRESS YDIYRVPSSQ SMEDRGYSPD TRVVRFLKGK SIGLRLAGGN 400
DVGIFVSGVQ AGSPADGQGI QEGDQILQVN DVPFQNLTRE EAVQFLLGLP 450
PGEEMELVTQ RKQDIFWKMV QSRVGDSFYI RTHFELEPSP PSGLGFTRGD 500
VFHVLDTLHP GPGQSHARGG HWLAVRMGRD LREQERGIIP NQSRAEQLAS 550
LEAAQRAVGV GPGSSAGSNA RAEFWRLRGL RRGAKKTTQR SREDLSALTR 600
QGRYPPYERV VLREASFKRP VVILGPVADI AMQKLTAEMP DQFEIAETVS 650
RTDSPSKIIK LDTVRVIAEK DKHALLDVTP SAIERLNYVQ YYPIVVFFIP 700
ESRPALKALR QWLAPASRRS TRRLYAQAQK LRKHSSHLFT ATIPLNGTSD 750
TWYQELKAII REQQTRPIWT AEDQLDGSLE DNLDLPHHGL ADSSADLSCD 800
SRVNSDYETD GEGGAYTDGE GYTDGEGGPY TDVDDEPPAP ALARSSEPVQ 850
ADESQSPRDR GRISAHQGAQ VDSRHPQGQW RQDSMRTYER EALKKKFMRV 900
HDAESSDEDG YDWGPATDL 919
Length:919
Mass (Da):101,397
Last modified:March 19, 2014 - v3
Checksum:iD36EB684E7E4A6C8
GO
Isoform 3 (identifier: O95049-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNLCGLMPIFPAPLDQVADM

Note: No experimental confirmation available.

Show »
Length:938
Mass (Da):103,424
Checksum:i603411581EB7FA85
GO
Isoform 4 (identifier: O95049-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAVRFQVADM

Show »
Length:928
Mass (Da):102,415
Checksum:iB418537346F205CF
GO
Isoform 6 (identifier: O95049-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:883
Mass (Da):97,488
Checksum:i511564BFC624B3A8
GO

Sequence cautioni

The sequence AAC72274.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAW69293.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti898 – 8981M → T.1 Publication
Corresponds to variant rs1046268 [ dbSNP | Ensembl ].
VAR_056114

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 6.
VSP_053844Add
BLAST
Alternative sequencei1 – 11M → MNLCGLMPIFPAPLDQVADM in isoform 3.
VSP_040238
Alternative sequencei1 – 11M → MAVRFQVADM in isoform 4.
VSP_047022

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191R → H in AAI08907. 1 Publication
Sequence conflicti96 – 961H → L in BAG52285. 1 Publication
Sequence conflicti449 – 4491L → P in BAG54652. 1 Publication
Sequence conflicti802 – 8021R → H in BAG52285. 1 Publication
Sequence conflicti901 – 9011H → R in BAG52285. 1 Publication
Sequence conflicti917 – 9171T → M in BAG65278. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091118 mRNA. Translation: BAG52285.1.
AK128237 mRNA. Translation: BAG54652.1.
AK304462 mRNA. Translation: BAG65278.1.
AC005954 Genomic DNA. Translation: AAC72274.1. Sequence problems.
AC006125 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69293.1. Sequence problems.
BC108906 mRNA. Translation: AAI08907.1.
CCDSiCCDS32873.2. [O95049-1]
CCDS59332.1. [O95049-4]
RefSeqiNP_001254489.1. NM_001267560.1. [O95049-1]
NP_001254490.1. NM_001267561.1. [O95049-4]
XP_005259596.1. XM_005259539.2. [O95049-3]
XP_006722787.1. XM_006722724.1. [O95049-1]
UniGeneiHs.25527.

Genome annotation databases

EnsembliENST00000382008; ENSP00000371438; ENSG00000105289. [O95049-1]
ENST00000539908; ENSP00000439991; ENSG00000105289.
ENST00000541714; ENSP00000439278; ENSG00000105289.
ENST00000587686; ENSP00000467864; ENSG00000105289. [O95049-3]
ENST00000589378; ENSP00000465419; ENSG00000105289. [O95049-4]
GeneIDi27134.
KEGGihsa:27134.
UCSCiuc010xhu.3. human. [O95049-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK091118 mRNA. Translation: BAG52285.1 .
AK128237 mRNA. Translation: BAG54652.1 .
AK304462 mRNA. Translation: BAG65278.1 .
AC005954 Genomic DNA. Translation: AAC72274.1 . Sequence problems.
AC006125 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69293.1 . Sequence problems.
BC108906 mRNA. Translation: AAI08907.1 .
CCDSi CCDS32873.2. [O95049-1 ]
CCDS59332.1. [O95049-4 ]
RefSeqi NP_001254489.1. NM_001267560.1. [O95049-1 ]
NP_001254490.1. NM_001267561.1. [O95049-4 ]
XP_005259596.1. XM_005259539.2. [O95049-3 ]
XP_006722787.1. XM_006722724.1. [O95049-1 ]
UniGenei Hs.25527.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KFV X-ray 2.80 A 475-775 [» ]
ProteinModelPortali O95049.
SMRi O95049. Positions 6-93, 196-271, 379-772.
ModBasei Search...

Protein-protein interaction databases

BioGridi 118025. 5 interactions.
IntActi O95049. 2 interactions.
MINTi MINT-210473.
STRINGi 9606.ENSP00000262968.

PTM databases

PhosphoSitei O95049.

Proteomic databases

MaxQBi O95049.
PaxDbi O95049.
PRIDEi O95049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382008 ; ENSP00000371438 ; ENSG00000105289 . [O95049-1 ]
ENST00000539908 ; ENSP00000439991 ; ENSG00000105289 .
ENST00000541714 ; ENSP00000439278 ; ENSG00000105289 .
ENST00000587686 ; ENSP00000467864 ; ENSG00000105289 . [O95049-3 ]
ENST00000589378 ; ENSP00000465419 ; ENSG00000105289 . [O95049-4 ]
GeneIDi 27134.
KEGGi hsa:27134.
UCSCi uc010xhu.3. human. [O95049-3 ]

Organism-specific databases

CTDi 27134.
GeneCardsi GC19P003708.
H-InvDB HIX0014645.
HGNCi HGNC:11829. TJP3.
HPAi CAB013244.
MIMi 612689. gene.
neXtProti NX_O95049.
PharmGKBi PA36534.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239704.
HOGENOMi HOG000230923.
HOVERGENi HBG017627.
InParanoidi O95049.
KOi K06097.
OMAi QILKTCT.
TreeFami TF315606.

Miscellaneous databases

EvolutionaryTracei O95049.
GeneWikii TJP3.
GenomeRNAii 27134.
NextBioi 13603241.
PROi O95049.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95049.
Bgeei O95049.
CleanExi HS_TJP3.
Genevestigatori O95049.

Family and domain databases

Gene3Di 2.30.42.10. 3 hits.
3.40.50.300. 1 hit.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR005417. ZonOcculdens.
IPR005420. ZonOcculS3.
[Graphical view ]
PANTHERi PTHR13865:SF11. PTHR13865:SF11. 1 hit.
Pfami PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 3 hits.
PF07653. SH3_2. 1 hit.
[Graphical view ]
PRINTSi PR01597. ZONOCCLUDNS.
PR01600. ZONOCCLUDNS3.
SMARTi SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
    Tissue: Stomach, Testis and Tongue.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT THR-898.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-905 AND SER-906, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.
  7. "Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)."
    Aho S., Lupo J., Coly P.-A., Sabine A., Castellazzi M., Morand P., Sergeant A., Manet E., Boyer V., Gruffat H.
    Biol. Cell 101:319-334(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBN1.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-905 AND SER-906, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form."
    Structural genomics consortium (SGC)
    Submitted (NOV-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 475-775.

Entry informationi

Entry nameiZO3_HUMAN
AccessioniPrimary (citable) accession number: O95049
Secondary accession number(s): A6NFP3
, B3KR73, B3KXZ0, B4E2W6, F5H2X0, F5H4S9, K7EK22, Q32N01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 19, 2014
Last modified: September 3, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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