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O95049

- ZO3_HUMAN

UniProt

O95049 - ZO3_HUMAN

Protein

Tight junction protein ZO-3

Gene

TJP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (19 Mar 2014)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. regulation of G1/S transition of mitotic cell cycle Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tight junction protein ZO-3
    Alternative name(s):
    Tight junction protein 3
    Zona occludens protein 3
    Zonula occludens protein 3
    Gene namesi
    Name:TJP3
    Synonyms:ZO3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11829. TJP3.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cell junctiontight junction By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. nucleus Source: UniProtKB
    3. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36534.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 919919Tight junction protein ZO-3PRO_0000094546Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei164 – 1641Phosphoserine4 Publications
    Modified residuei169 – 1691PhosphoserineBy similarity
    Modified residuei905 – 9051Phosphoserine2 Publications
    Modified residuei906 – 9061Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO95049.
    PaxDbiO95049.
    PRIDEiO95049.

    PTM databases

    PhosphoSiteiO95049.

    Expressioni

    Gene expression databases

    ArrayExpressiO95049.
    BgeeiO95049.
    CleanExiHS_TJP3.
    GenevestigatoriO95049.

    Organism-specific databases

    HPAiCAB013244.

    Interactioni

    Subunit structurei

    Interacts with occludin, claudins and ZO-1. Interacts with INADL By similarity. Interacts with UBN1. Interacts with FASLG.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi118025. 5 interactions.
    IntActiO95049. 2 interactions.
    MINTiMINT-210473.
    STRINGi9606.ENSP00000262968.

    Structurei

    Secondary structure

    1
    919
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi478 – 4825
    Beta strandi490 – 4934
    Beta strandi501 – 5066
    Beta strandi522 – 5276
    Beta strandi533 – 5397
    Helixi542 – 55514
    Helixi596 – 6027
    Beta strandi606 – 6149
    Beta strandi621 – 6255
    Helixi628 – 63811
    Turni640 – 6423
    Beta strandi643 – 6453
    Helixi661 – 6699
    Beta strandi673 – 6764
    Helixi680 – 6889
    Beta strandi694 – 7018
    Helixi703 – 71311
    Helixi721 – 73515
    Helixi736 – 7383
    Beta strandi740 – 7456
    Beta strandi747 – 7493
    Helixi751 – 76313
    Beta strandi766 – 7716

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KFVX-ray2.80A475-775[»]
    ProteinModelPortaliO95049.
    SMRiO95049. Positions 6-93, 196-271, 379-772.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95049.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 9383PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 27278PDZ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini380 – 44667PDZ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini475 – 54975SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini580 – 761182Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MAGUK family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG239704.
    HOGENOMiHOG000230923.
    HOVERGENiHBG017627.
    InParanoidiO95049.
    KOiK06097.
    OMAiQILKTCT.
    TreeFamiTF315606.

    Family and domain databases

    Gene3Di2.30.42.10. 3 hits.
    3.40.50.300. 1 hit.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    IPR005417. ZonOcculdens.
    IPR005420. ZonOcculS3.
    [Graphical view]
    PANTHERiPTHR13865:SF11. PTHR13865:SF11. 1 hit.
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF00595. PDZ. 3 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR01597. ZONOCCLUDNS.
    PR01600. ZONOCCLUDNS3.
    SMARTiSM00072. GuKc. 1 hit.
    SM00228. PDZ. 3 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 3 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 3 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 5 (identifier: O95049-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEELTIWEQH TATLSKDPRR GFGIAISGGR DRPGGSMVVS DVVPGGPAEG    50
    RLQTGDHIVM VNGVSMENAT SAFAIQILKT CTKMANITVK RPRRIHLPAT 100
    KASPSSPGRQ DSDEDDGPQR VEEVDQGRGY DGDSSSGSGR SWDERSRRPR 150
    PGRRGRAGSH GRRSPGGGSE ANGLALVSGF KRLPRQDVQM KPVKSVLVKR 200
    RDSEEFGVKL GSQIFIKHIT DSGLAARHRG LQEGDLILQI NGVSSQNLSL 250
    NDTRRLIEKS EGKLSLLVLR DRGQFLVNIP PAVSDSDSSP LEDISDLASE 300
    LSQAPPSHIP PPPRHAQRSP EASQTDSPVE SPRLRRESSV DSRTISEPDE 350
    QRSELPRESS YDIYRVPSSQ SMEDRGYSPD TRVVRFLKGK SIGLRLAGGN 400
    DVGIFVSGVQ AGSPADGQGI QEGDQILQVN DVPFQNLTRE EAVQFLLGLP 450
    PGEEMELVTQ RKQDIFWKMV QSRVGDSFYI RTHFELEPSP PSGLGFTRGD 500
    VFHVLDTLHP GPGQSHARGG HWLAVRMGRD LREQERGIIP NQSRAEQLAS 550
    LEAAQRAVGV GPGSSAGSNA RAEFWRLRGL RRGAKKTTQR SREDLSALTR 600
    QGRYPPYERV VLREASFKRP VVILGPVADI AMQKLTAEMP DQFEIAETVS 650
    RTDSPSKIIK LDTVRVIAEK DKHALLDVTP SAIERLNYVQ YYPIVVFFIP 700
    ESRPALKALR QWLAPASRRS TRRLYAQAQK LRKHSSHLFT ATIPLNGTSD 750
    TWYQELKAII REQQTRPIWT AEDQLDGSLE DNLDLPHHGL ADSSADLSCD 800
    SRVNSDYETD GEGGAYTDGE GYTDGEGGPY TDVDDEPPAP ALARSSEPVQ 850
    ADESQSPRDR GRISAHQGAQ VDSRHPQGQW RQDSMRTYER EALKKKFMRV 900
    HDAESSDEDG YDWGPATDL 919
    Length:919
    Mass (Da):101,397
    Last modified:March 19, 2014 - v3
    Checksum:iD36EB684E7E4A6C8
    GO
    Isoform 3 (identifier: O95049-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MNLCGLMPIFPAPLDQVADM

    Note: No experimental confirmation available.

    Show »
    Length:938
    Mass (Da):103,424
    Checksum:i603411581EB7FA85
    GO
    Isoform 4 (identifier: O95049-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MAVRFQVADM

    Show »
    Length:928
    Mass (Da):102,415
    Checksum:iB418537346F205CF
    GO
    Isoform 6 (identifier: O95049-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: Missing.

    Show »
    Length:883
    Mass (Da):97,488
    Checksum:i511564BFC624B3A8
    GO

    Sequence cautioni

    The sequence AAC72274.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAW69293.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191R → H in AAI08907. (PubMed:15489334)Curated
    Sequence conflicti96 – 961H → L in BAG52285. (PubMed:14702039)Curated
    Sequence conflicti449 – 4491L → P in BAG54652. (PubMed:14702039)Curated
    Sequence conflicti802 – 8021R → H in BAG52285. (PubMed:14702039)Curated
    Sequence conflicti901 – 9011H → R in BAG52285. (PubMed:14702039)Curated
    Sequence conflicti917 – 9171T → M in BAG65278. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti898 – 8981M → T.1 Publication
    Corresponds to variant rs1046268 [ dbSNP | Ensembl ].
    VAR_056114

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3636Missing in isoform 6. 1 PublicationVSP_053844Add
    BLAST
    Alternative sequencei1 – 11M → MNLCGLMPIFPAPLDQVADM in isoform 3. 1 PublicationVSP_040238
    Alternative sequencei1 – 11M → MAVRFQVADM in isoform 4. 1 PublicationVSP_047022

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091118 mRNA. Translation: BAG52285.1.
    AK128237 mRNA. Translation: BAG54652.1.
    AK304462 mRNA. Translation: BAG65278.1.
    AC005954 Genomic DNA. Translation: AAC72274.1. Sequence problems.
    AC006125 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69293.1. Sequence problems.
    BC108906 mRNA. Translation: AAI08907.1.
    CCDSiCCDS32873.2. [O95049-1]
    CCDS59332.1. [O95049-4]
    RefSeqiNP_001254489.1. NM_001267560.1. [O95049-1]
    NP_001254490.1. NM_001267561.1. [O95049-4]
    XP_005259596.1. XM_005259539.2. [O95049-3]
    XP_006722787.1. XM_006722724.1. [O95049-1]
    UniGeneiHs.25527.

    Genome annotation databases

    EnsembliENST00000539908; ENSP00000439991; ENSG00000105289. [O95049-5]
    ENST00000541714; ENSP00000439278; ENSG00000105289. [O95049-1]
    ENST00000587686; ENSP00000467864; ENSG00000105289. [O95049-3]
    ENST00000589378; ENSP00000465419; ENSG00000105289. [O95049-4]
    GeneIDi27134.
    KEGGihsa:27134.
    UCSCiuc010xhu.3. human. [O95049-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091118 mRNA. Translation: BAG52285.1 .
    AK128237 mRNA. Translation: BAG54652.1 .
    AK304462 mRNA. Translation: BAG65278.1 .
    AC005954 Genomic DNA. Translation: AAC72274.1 . Sequence problems.
    AC006125 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69293.1 . Sequence problems.
    BC108906 mRNA. Translation: AAI08907.1 .
    CCDSi CCDS32873.2. [O95049-1 ]
    CCDS59332.1. [O95049-4 ]
    RefSeqi NP_001254489.1. NM_001267560.1. [O95049-1 ]
    NP_001254490.1. NM_001267561.1. [O95049-4 ]
    XP_005259596.1. XM_005259539.2. [O95049-3 ]
    XP_006722787.1. XM_006722724.1. [O95049-1 ]
    UniGenei Hs.25527.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KFV X-ray 2.80 A 475-775 [» ]
    ProteinModelPortali O95049.
    SMRi O95049. Positions 6-93, 196-271, 379-772.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118025. 5 interactions.
    IntActi O95049. 2 interactions.
    MINTi MINT-210473.
    STRINGi 9606.ENSP00000262968.

    PTM databases

    PhosphoSitei O95049.

    Proteomic databases

    MaxQBi O95049.
    PaxDbi O95049.
    PRIDEi O95049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000539908 ; ENSP00000439991 ; ENSG00000105289 . [O95049-5 ]
    ENST00000541714 ; ENSP00000439278 ; ENSG00000105289 . [O95049-1 ]
    ENST00000587686 ; ENSP00000467864 ; ENSG00000105289 . [O95049-3 ]
    ENST00000589378 ; ENSP00000465419 ; ENSG00000105289 . [O95049-4 ]
    GeneIDi 27134.
    KEGGi hsa:27134.
    UCSCi uc010xhu.3. human. [O95049-3 ]

    Organism-specific databases

    CTDi 27134.
    GeneCardsi GC19P003708.
    H-InvDB HIX0014645.
    HGNCi HGNC:11829. TJP3.
    HPAi CAB013244.
    MIMi 612689. gene.
    neXtProti NX_O95049.
    PharmGKBi PA36534.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239704.
    HOGENOMi HOG000230923.
    HOVERGENi HBG017627.
    InParanoidi O95049.
    KOi K06097.
    OMAi QILKTCT.
    TreeFami TF315606.

    Miscellaneous databases

    EvolutionaryTracei O95049.
    GeneWikii TJP3.
    GenomeRNAii 27134.
    NextBioi 13603241.
    PROi O95049.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95049.
    Bgeei O95049.
    CleanExi HS_TJP3.
    Genevestigatori O95049.

    Family and domain databases

    Gene3Di 2.30.42.10. 3 hits.
    3.40.50.300. 1 hit.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    IPR005417. ZonOcculdens.
    IPR005420. ZonOcculS3.
    [Graphical view ]
    PANTHERi PTHR13865:SF11. PTHR13865:SF11. 1 hit.
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF00595. PDZ. 3 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01597. ZONOCCLUDNS.
    PR01600. ZONOCCLUDNS3.
    SMARTi SM00072. GuKc. 1 hit.
    SM00228. PDZ. 3 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 3 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 3 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
      Tissue: Stomach, Testis and Tongue.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT THR-898.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-905 AND SER-906, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M., Lettau M., Janssen O.
      BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FASLG.
    7. "Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)."
      Aho S., Lupo J., Coly P.-A., Sabine A., Castellazzi M., Morand P., Sergeant A., Manet E., Boyer V., Gruffat H.
      Biol. Cell 101:319-334(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBN1.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; SER-905 AND SER-906, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form."
      Structural genomics consortium (SGC)
      Submitted (NOV-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 475-775.

    Entry informationi

    Entry nameiZO3_HUMAN
    AccessioniPrimary (citable) accession number: O95049
    Secondary accession number(s): A6NFP3
    , B3KR73, B3KXZ0, B4E2W6, F5H2X0, F5H4S9, K7EK22, Q32N01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: March 19, 2014
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3