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Protein

Olfactory receptor 2A4

Gene

OR2A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of cytokinesis Source: UniProtKB
  • regulation of actin cytoskeleton organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180658-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A4
Alternative name(s):
Olfactory receptor 2A10
Olfactory receptor OR6-37
Gene namesi
Name:OR2A4
Synonyms:OR2A10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14729. OR2A4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 194ExtracellularSequence analysisAdd BLAST37
Transmembranei195 – 218Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • cleavage furrow Source: UniProtKB
  • Flemming body Source: UniProtKB
  • integral component of membrane Source: GO_Central
  • mitotic spindle midzone Source: UniProtKB
  • mitotic spindle pole Source: UniProtKB
  • plasma membrane Source: Reactome
  • recycling endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180658.
PharmGKBiPA32117.

Polymorphism and mutation databases

BioMutaiOR2A4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504541 – 310Olfactory receptor 2A4Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO95047.
PRIDEiO95047.

PTM databases

iPTMnetiO95047.
PhosphoSitePlusiO95047.

Expressioni

Gene expression databases

BgeeiENSG00000180658.
CleanExiHS_OR2A4.
ExpressionAtlasiO95047. differential.
GenevisibleiO95047. HS.

Organism-specific databases

HPAiHPA058272.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319546.

Structurei

3D structure databases

ProteinModelPortaliO95047.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIT7. Eukaryota.
ENOG41118P9. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO95047.
KOiK04257.
OMAiHINEIAV.
OrthoDBiEOG091G0CU6.
PhylomeDBiO95047.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDNITSIRE FLLLGFPVGP RIQMLLFGLF SLFYVFTLLG NGTILGLISL
60 70 80 90 100
DSRLHAPMYF FLSHLAVVDI AYACNTVPRM LVNLLHPAKP ISFAGRMMQT
110 120 130 140 150
FLFSTFAVTE CLLLVVMSYD LYVAICHPLR YLAIMTWRVC ITLAVTSWTT
160 170 180 190 200
GVLLSLIHLV LLLPLPFCRP QKIYHFFCEI LAVLKLACAD THINENMVLA
210 220 230 240 250
GAISGLVGPL STIVVSYMCI LCAILQIQSR EVQRKAFRTC FSHLCVIGLV
260 270 280 290 300
YGTAIIMYVG PRYGNPKEQK KYLLLFHSLF NPMLNPLICS LRNSEVKNTL
310
KRVLGVERAL
Length:310
Mass (Da):34,802
Last modified:May 1, 1999 - v1
Checksum:i8C4F26BB855C8D7A
GO

Sequence cautioni

The sequence CAB99212 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005587 Genomic DNA. Translation: AAD05193.1.
AL135904 Genomic DNA. Translation: CAB99212.1. Different initiation.
BC120953 mRNA. Translation: AAI20954.1.
BC120954 mRNA. Translation: AAI20955.1.
BK004444 Genomic DNA. Translation: DAA04842.1.
CCDSiCCDS5149.1.
RefSeqiNP_112170.1. NM_030908.2.
UniGeneiHs.486488.
Hs.658609.
Hs.734368.

Genome annotation databases

EnsembliENST00000315453; ENSP00000319546; ENSG00000180658.
GeneIDi79541.
KEGGihsa:79541.
UCSCiuc011ecd.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005587 Genomic DNA. Translation: AAD05193.1.
AL135904 Genomic DNA. Translation: CAB99212.1. Different initiation.
BC120953 mRNA. Translation: AAI20954.1.
BC120954 mRNA. Translation: AAI20955.1.
BK004444 Genomic DNA. Translation: DAA04842.1.
CCDSiCCDS5149.1.
RefSeqiNP_112170.1. NM_030908.2.
UniGeneiHs.486488.
Hs.658609.
Hs.734368.

3D structure databases

ProteinModelPortaliO95047.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319546.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95047.
PhosphoSitePlusiO95047.

Polymorphism and mutation databases

BioMutaiOR2A4.

Proteomic databases

PaxDbiO95047.
PRIDEiO95047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315453; ENSP00000319546; ENSG00000180658.
GeneIDi79541.
KEGGihsa:79541.
UCSCiuc011ecd.2. human.

Organism-specific databases

CTDi79541.
GeneCardsiOR2A4.
HGNCiHGNC:14729. OR2A4.
HPAiHPA058272.
neXtProtiNX_O95047.
OpenTargetsiENSG00000180658.
PharmGKBiPA32117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIT7. Eukaryota.
ENOG41118P9. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO95047.
KOiK04257.
OMAiHINEIAV.
OrthoDBiEOG091G0CU6.
PhylomeDBiO95047.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180658-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2A4.
GenomeRNAii79541.
PROiO95047.

Gene expression databases

BgeeiENSG00000180658.
CleanExiHS_OR2A4.
ExpressionAtlasiO95047. differential.
GenevisibleiO95047. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2A4_HUMAN
AccessioniPrimary (citable) accession number: O95047
Secondary accession number(s): Q0VAR3, Q6IF18, Q9NQN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.