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Protein

Olfactory receptor 2A4

Gene

OR2A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of cytokinesis Source: UniProtKB
  • regulation of actin cytoskeleton organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A4
Alternative name(s):
Olfactory receptor 2A10
Olfactory receptor OR6-37
Gene namesi
Name:OR2A4
Synonyms:OR2A10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14729. OR2A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7822Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cleavage furrow Source: UniProtKB
  • Flemming body Source: UniProtKB
  • integral component of membrane Source: GO_Central
  • mitotic spindle midzone Source: UniProtKB
  • mitotic spindle pole Source: UniProtKB
  • plasma membrane Source: Reactome
  • recycling endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32117.

Polymorphism and mutation databases

BioMutaiOR2A4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 2A4PRO_0000150454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO95047.
PRIDEiO95047.

PTM databases

iPTMnetiO95047.
PhosphoSiteiO95047.

Expressioni

Gene expression databases

BgeeiENSG00000180658.
CleanExiHS_OR2A4.
GenevisibleiO95047. HS.

Organism-specific databases

HPAiHPA058272.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319546.

Structurei

3D structure databases

ProteinModelPortaliO95047.
SMRiO95047. Positions 108-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIT7. Eukaryota.
ENOG41118P9. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO95047.
KOiK04257.
OMAiHINEIAV.
OrthoDBiEOG091G0CU6.
PhylomeDBiO95047.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDNITSIRE FLLLGFPVGP RIQMLLFGLF SLFYVFTLLG NGTILGLISL
60 70 80 90 100
DSRLHAPMYF FLSHLAVVDI AYACNTVPRM LVNLLHPAKP ISFAGRMMQT
110 120 130 140 150
FLFSTFAVTE CLLLVVMSYD LYVAICHPLR YLAIMTWRVC ITLAVTSWTT
160 170 180 190 200
GVLLSLIHLV LLLPLPFCRP QKIYHFFCEI LAVLKLACAD THINENMVLA
210 220 230 240 250
GAISGLVGPL STIVVSYMCI LCAILQIQSR EVQRKAFRTC FSHLCVIGLV
260 270 280 290 300
YGTAIIMYVG PRYGNPKEQK KYLLLFHSLF NPMLNPLICS LRNSEVKNTL
310
KRVLGVERAL
Length:310
Mass (Da):34,802
Last modified:May 1, 1999 - v1
Checksum:i8C4F26BB855C8D7A
GO

Sequence cautioni

The sequence CAB99212 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005587 Genomic DNA. Translation: AAD05193.1.
AL135904 Genomic DNA. Translation: CAB99212.1. Different initiation.
BC120953 mRNA. Translation: AAI20954.1.
BC120954 mRNA. Translation: AAI20955.1.
BK004444 Genomic DNA. Translation: DAA04842.1.
CCDSiCCDS5149.1.
RefSeqiNP_112170.1. NM_030908.2.
UniGeneiHs.486488.
Hs.658609.
Hs.734368.

Genome annotation databases

EnsembliENST00000315453; ENSP00000319546; ENSG00000180658.
GeneIDi79541.
KEGGihsa:79541.
UCSCiuc011ecd.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005587 Genomic DNA. Translation: AAD05193.1.
AL135904 Genomic DNA. Translation: CAB99212.1. Different initiation.
BC120953 mRNA. Translation: AAI20954.1.
BC120954 mRNA. Translation: AAI20955.1.
BK004444 Genomic DNA. Translation: DAA04842.1.
CCDSiCCDS5149.1.
RefSeqiNP_112170.1. NM_030908.2.
UniGeneiHs.486488.
Hs.658609.
Hs.734368.

3D structure databases

ProteinModelPortaliO95047.
SMRiO95047. Positions 108-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319546.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95047.
PhosphoSiteiO95047.

Polymorphism and mutation databases

BioMutaiOR2A4.

Proteomic databases

PaxDbiO95047.
PRIDEiO95047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315453; ENSP00000319546; ENSG00000180658.
GeneIDi79541.
KEGGihsa:79541.
UCSCiuc011ecd.2. human.

Organism-specific databases

CTDi79541.
GeneCardsiOR2A4.
HGNCiHGNC:14729. OR2A4.
HPAiHPA058272.
neXtProtiNX_O95047.
PharmGKBiPA32117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIT7. Eukaryota.
ENOG41118P9. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO95047.
KOiK04257.
OMAiHINEIAV.
OrthoDBiEOG091G0CU6.
PhylomeDBiO95047.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2A4.
GenomeRNAii79541.
PROiO95047.

Gene expression databases

BgeeiENSG00000180658.
CleanExiHS_OR2A4.
GenevisibleiO95047. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2A4_HUMAN
AccessioniPrimary (citable) accession number: O95047
Secondary accession number(s): Q0VAR3, Q6IF18, Q9NQN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.