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Protein

Olfactory receptor 4F21

Gene

OR4F21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176269-MONOMER.
ZFISH:ENSG00000177799-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4F21
Gene namesi
Name:OR4F21
Synonyms:OR4F21P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:19583. OR4F21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 312CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176269.
PharmGKBiPA134918173.

Polymorphism and mutation databases

BioMutaiOR4F21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505451 – 312Olfactory receptor 4F21Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95013.
PRIDEiO95013.

PTM databases

iPTMnetiO95013.
PhosphoSitePlusiO95013.

Expressioni

Gene expression databases

CleanExiHS_OR4F21.
GenevisibleiO95013. HS.

Organism-specific databases

HPAiHPA047705.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318878.

Structurei

3D structure databases

ProteinModelPortaliO95013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVRR. Eukaryota.
ENOG4111AZC. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO95013.
KOiK04257.
OMAiLFFGPPV.
OrthoDBiEOG091G0CY9.
PhylomeDBiO95013.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNIFIVFSVT
60 70 80 90 100
TDPHLHSPMY FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ
110 120 130 140 150
IFFIHVIGGV EMVLLIAMAF DRYVALCKPL HYLTIMSPRM CLSFLAVAWT
160 170 180 190 200
LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD LPRLLRLACT DTYRLQFMVT
210 220 230 240 250
VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL SAHSTVVLLF
260 270 280 290 300
FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR
310
VCKQLVIYKK IS
Length:312
Mass (Da):35,094
Last modified:November 13, 2007 - v2
Checksum:iAC23E27AA9A69586
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44F → L in AAD05195 (PubMed:16421571).Curated1
Sequence conflicti310K → R in AAD05195 (PubMed:16421571).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131281 Genomic DNA. No translation available.
AC004908 Genomic DNA. Translation: AAD05195.1.
CCDSiCCDS34792.1.
RefSeqiNP_001005504.1. NM_001005504.1.
UniGeneiHs.690459.

Genome annotation databases

EnsembliENST00000320901; ENSP00000318878; ENSG00000176269.
GeneIDi441308.
KEGGihsa:441308.
UCSCiuc011kwf.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131281 Genomic DNA. No translation available.
AC004908 Genomic DNA. Translation: AAD05195.1.
CCDSiCCDS34792.1.
RefSeqiNP_001005504.1. NM_001005504.1.
UniGeneiHs.690459.

3D structure databases

ProteinModelPortaliO95013.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318878.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95013.
PhosphoSitePlusiO95013.

Polymorphism and mutation databases

BioMutaiOR4F21.

Proteomic databases

PaxDbiO95013.
PRIDEiO95013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320901; ENSP00000318878; ENSG00000176269.
GeneIDi441308.
KEGGihsa:441308.
UCSCiuc011kwf.3. human.

Organism-specific databases

CTDi441308.
GeneCardsiOR4F21.
HGNCiHGNC:19583. OR4F21.
HPAiHPA047705.
neXtProtiNX_O95013.
OpenTargetsiENSG00000176269.
PharmGKBiPA134918173.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVRR. Eukaryota.
ENOG4111AZC. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO95013.
KOiK04257.
OMAiLFFGPPV.
OrthoDBiEOG091G0CY9.
PhylomeDBiO95013.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176269-MONOMER.
ZFISH:ENSG00000177799-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii441308.
PROiO95013.

Gene expression databases

CleanExiHS_OR4F21.
GenevisibleiO95013. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO4F21_HUMAN
AccessioniPrimary (citable) accession number: O95013
Secondary accession number(s): A6NIU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.