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O95013 (O4F21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4F21
Gene names
Name:OR4F21
Synonyms:OR4F21P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 4F21
PRO_0000150545

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23516Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 26911Extracellular Potential
Transmembrane270 – 28920Helical; Name=7; Potential
Topological domain290 – 31223Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Experimental info

Sequence conflict441F → L in AAD05195. Ref.1
Sequence conflict3101K → R in AAD05195. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O95013 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: AC23E27AA9A69586

FASTA31235,094
        10         20         30         40         50         60 
MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNIFIVFSVT TDPHLHSPMY 

        70         80         90        100        110        120 
FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ IFFIHVIGGV EMVLLIAMAF 

       130        140        150        160        170        180 
DRYVALCKPL HYLTIMSPRM CLSFLAVAWT LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD 

       190        200        210        220        230        240 
LPRLLRLACT DTYRLQFMVT VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL 

       250        260        270        280        290        300 
SAHSTVVLLF FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR 

       310 
VCKQLVIYKK IS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC131281 Genomic DNA. No translation available.
AC004908 Genomic DNA. Translation: AAD05195.1.
RefSeqNP_001005504.1. NM_001005504.1.
UniGeneHs.690459.

3D structure databases

ProteinModelPortalO95013.
SMRO95013. Positions 17-303.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO95013.

Proteomic databases

PaxDbO95013.
PRIDEO95013.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320901; ENSP00000318878; ENSG00000176269.
GeneID441308.
KEGGhsa:441308.
UCSCuc011kwf.2. human.

Organism-specific databases

CTD441308.
GeneCardsGC08M000116.
HGNCHGNC:19583. OR4F21.
HPAHPA047705.
neXtProtNX_O95013.
PharmGKBPA134918173.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG116959.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidO95013.
KOK04257.
OMAWPHPKSQ.
OrthoDBEOG75XGMH.
PhylomeDBO95013.
TreeFamTF336512.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4F21.
GenevestigatorO95013.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi441308.
NextBio110016.
PROO95013.

Entry information

Entry nameO4F21_HUMAN
AccessionPrimary (citable) accession number: O95013
Secondary accession number(s): A6NIU1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries