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O95013

- O4F21_HUMAN

UniProt

O95013 - O4F21_HUMAN

Protein

Olfactory receptor 4F21

Gene

OR4F21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4F21
    Gene namesi
    Name:OR4F21
    Synonyms:OR4F21P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:19583. OR4F21.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134918173.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 4F21PRO_0000150545Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95013.
    PRIDEiO95013.

    PTM databases

    PhosphoSiteiO95013.

    Expressioni

    Gene expression databases

    CleanExiHS_OR4F21.
    GenevestigatoriO95013.

    Organism-specific databases

    HPAiHPA047705.

    Structurei

    3D structure databases

    ProteinModelPortaliO95013.
    SMRiO95013. Positions 17-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23516CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 26911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31223CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG116959.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiO95013.
    KOiK04257.
    OMAiWPHPKSQ.
    OrthoDBiEOG75XGMH.
    PhylomeDBiO95013.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95013-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNIFIVFSVT    50
    TDPHLHSPMY FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ 100
    IFFIHVIGGV EMVLLIAMAF DRYVALCKPL HYLTIMSPRM CLSFLAVAWT 150
    LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD LPRLLRLACT DTYRLQFMVT 200
    VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL SAHSTVVLLF 250
    FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR 300
    VCKQLVIYKK IS 312
    Length:312
    Mass (Da):35,094
    Last modified:November 13, 2007 - v2
    Checksum:iAC23E27AA9A69586
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441F → L in AAD05195. (PubMed:16421571)Curated
    Sequence conflicti310 – 3101K → R in AAD05195. (PubMed:16421571)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC131281 Genomic DNA. No translation available.
    AC004908 Genomic DNA. Translation: AAD05195.1.
    CCDSiCCDS34792.1.
    RefSeqiNP_001005504.1. NM_001005504.1.
    UniGeneiHs.690459.

    Genome annotation databases

    EnsembliENST00000320901; ENSP00000318878; ENSG00000176269.
    GeneIDi441308.
    KEGGihsa:441308.
    UCSCiuc011kwf.2. human.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC131281 Genomic DNA. No translation available.
    AC004908 Genomic DNA. Translation: AAD05195.1 .
    CCDSi CCDS34792.1.
    RefSeqi NP_001005504.1. NM_001005504.1.
    UniGenei Hs.690459.

    3D structure databases

    ProteinModelPortali O95013.
    SMRi O95013. Positions 17-295.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O95013.

    Proteomic databases

    PaxDbi O95013.
    PRIDEi O95013.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320901 ; ENSP00000318878 ; ENSG00000176269 .
    GeneIDi 441308.
    KEGGi hsa:441308.
    UCSCi uc011kwf.2. human.

    Organism-specific databases

    CTDi 441308.
    GeneCardsi GC08M000116.
    HGNCi HGNC:19583. OR4F21.
    HPAi HPA047705.
    neXtProti NX_O95013.
    PharmGKBi PA134918173.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG116959.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi O95013.
    KOi K04257.
    OMAi WPHPKSQ.
    OrthoDBi EOG75XGMH.
    PhylomeDBi O95013.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GenomeRNAii 441308.
    NextBioi 110016.
    PROi O95013.

    Gene expression databases

    CleanExi HS_OR4F21.
    Genevestigatori O95013.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiO4F21_HUMAN
    AccessioniPrimary (citable) accession number: O95013
    Secondary accession number(s): A6NIU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3