O95013 (O4F21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 4F21

Gene names

Name:	OR4F21
Synonyms:	OR4F21P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Olfactory receptor 4F21		PRO_0000150545
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 219	24	Helical; Name=5; Potential
	Topological domain	220 – 235	16	Cytoplasmic Potential
	Transmembrane	236 – 258	23	Helical; Name=6; Potential
	Topological domain	259 – 269	11	Extracellular Potential
	Transmembrane	270 – 289	20	Helical; Name=7; Potential
	Topological domain	290 – 312	23	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Experimental info
	Sequence conflict	44	1	F → L in AAD05195. Ref.1
	Sequence conflict	310	1	K → R in AAD05195. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O95013 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: AC23E27AA9A69586	FASTA	312	35,094
	10 20 30 40 50 60 MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNIFIVFSVT TDPHLHSPMY 70 80 90 100 110 120 FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ IFFIHVIGGV EMVLLIAMAF 130 140 150 160 170 180 DRYVALCKPL HYLTIMSPRM CLSFLAVAWT LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD 190 200 210 220 230 240 LPRLLRLACT DTYRLQFMVT VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL 250 260 270 280 290 300 SAHSTVVLLF FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR 310 VCKQLVIYKK IS

References

[1]

"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC131281 Genomic DNA. No translation available. AC004908 Genomic DNA. Translation: AAD05195.1.
IPI	IPI00419364.
RefSeq	NP_001005504.1. NM_001005504.1.
UniGene	Hs.690459.
3D structure databases
ProteinModelPortal	O95013.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O95013.
Proteomic databases
PaxDb	O95013.
PRIDE	O95013.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320901; ENSP00000318878; ENSG00000176269.
GeneID	441308.
KEGG	hsa:441308.
UCSC	uc011kwf.2. human.
Organism-specific databases
CTD	441308.
GeneCards	GC08M000116.
HGNC	HGNC:19583. OR4F21.
HPA	HPA047705.
neXtProt	NX_O95013.
PharmGKB	PA134918173.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG116959.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	O95013.
KO	K04257.
OMA	VIYKKIS.
OrthoDB	EOG4894N3.
PhylomeDB	O95013.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR4F21.
Genevestigator	O95013.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	441308.
NextBio	110016.

Entry information

Entry name

O4F21_HUMAN

Accession

Primary (citable) accession number: O95013
Secondary accession number(s): A6NIU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.