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O95013

- O4F21_HUMAN

UniProt

O95013 - O4F21_HUMAN

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Protein

Olfactory receptor 4F21

Gene
OR4F21, OR4F21P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4F21
Gene namesi
Name:OR4F21
Synonyms:OR4F21P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:19583. OR4F21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4924Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7922Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini80 – 10021Extracellular Reviewed predictionAdd
BLAST
Transmembranei101 – 12020Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 15819Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini159 – 19537Extracellular Reviewed predictionAdd
BLAST
Transmembranei196 – 21924Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini220 – 23516Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei236 – 25823Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 26911Extracellular Reviewed predictionAdd
BLAST
Transmembranei270 – 28920Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini290 – 31223Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 4F21PRO_0000150545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95013.
PRIDEiO95013.

PTM databases

PhosphoSiteiO95013.

Expressioni

Gene expression databases

CleanExiHS_OR4F21.
GenevestigatoriO95013.

Organism-specific databases

HPAiHPA047705.

Structurei

3D structure databases

ProteinModelPortaliO95013.
SMRiO95013. Positions 17-295.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG116959.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO95013.
KOiK04257.
OMAiWPHPKSQ.
OrthoDBiEOG75XGMH.
PhylomeDBiO95013.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95013-1 [UniParc]FASTAAdd to Basket

« Hide

MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNIFIVFSVT    50
TDPHLHSPMY FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ 100
IFFIHVIGGV EMVLLIAMAF DRYVALCKPL HYLTIMSPRM CLSFLAVAWT 150
LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD LPRLLRLACT DTYRLQFMVT 200
VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL SAHSTVVLLF 250
FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR 300
VCKQLVIYKK IS 312
Length:312
Mass (Da):35,094
Last modified:November 13, 2007 - v2
Checksum:iAC23E27AA9A69586
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441F → L in AAD05195. 1 Publication
Sequence conflicti310 – 3101K → R in AAD05195. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC131281 Genomic DNA. No translation available.
AC004908 Genomic DNA. Translation: AAD05195.1.
CCDSiCCDS34792.1.
RefSeqiNP_001005504.1. NM_001005504.1.
UniGeneiHs.690459.

Genome annotation databases

EnsembliENST00000320901; ENSP00000318878; ENSG00000176269.
GeneIDi441308.
KEGGihsa:441308.
UCSCiuc011kwf.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC131281 Genomic DNA. No translation available.
AC004908 Genomic DNA. Translation: AAD05195.1 .
CCDSi CCDS34792.1.
RefSeqi NP_001005504.1. NM_001005504.1.
UniGenei Hs.690459.

3D structure databases

ProteinModelPortali O95013.
SMRi O95013. Positions 17-295.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O95013.

Proteomic databases

PaxDbi O95013.
PRIDEi O95013.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320901 ; ENSP00000318878 ; ENSG00000176269 .
GeneIDi 441308.
KEGGi hsa:441308.
UCSCi uc011kwf.2. human.

Organism-specific databases

CTDi 441308.
GeneCardsi GC08M000116.
HGNCi HGNC:19583. OR4F21.
HPAi HPA047705.
neXtProti NX_O95013.
PharmGKBi PA134918173.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG116959.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi O95013.
KOi K04257.
OMAi WPHPKSQ.
OrthoDBi EOG75XGMH.
PhylomeDBi O95013.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii 441308.
NextBioi 110016.
PROi O95013.

Gene expression databases

CleanExi HS_OR4F21.
Genevestigatori O95013.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiO4F21_HUMAN
AccessioniPrimary (citable) accession number: O95013
Secondary accession number(s): A6NIU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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