O94991 (SLIK5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SLIT and NTRK-like protein 5

Alternative name(s):
Leucine-rich repeat-containing protein 11

Gene names

Name:	SLITRK5
Synonyms:	KIAA0918, LRRC11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	958 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Suppresses neurite outgrowth By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Probable.
Tissue specificity	Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. Ref.6
Sequence similarities	Belongs to the SLITRK family. Contains 12 LRR (leucine-rich) repeats. Contains 2 LRRCT domains. Contains 1 LRRNT domain.
Sequence caution	The sequence BAA74941.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 40	40	Potential
	Chain	41 – 958	918	SLIT and NTRK-like protein 5		PRO_0000032681
Regions
	Topological domain	41 – 664	624	Extracellular Potential
	Transmembrane	665 – 685	21	Helical; Potential
	Topological domain	686 – 958	273	Cytoplasmic Potential
	Repeat	82 – 103	22	LRR 1
	Repeat	106 – 127	22	LRR 2
	Repeat	130 – 151	22	LRR 3
	Repeat	154 – 175	22	LRR 4
	Repeat	178 – 199	22	LRR 5
	Repeat	201 – 222	22	LRR 6
	Domain	235 – 286	52	LRRCT 1
	Domain	365 – 407	43	LRRNT
	Repeat	410 – 431	22	LRR 7
	Repeat	434 – 455	22	LRR 8
	Repeat	458 – 479	22	LRR 9
	Repeat	482 – 503	22	LRR 10
	Repeat	506 – 527	22	LRR 11
	Repeat	529 – 550	22	LRR 12
	Domain	563 – 614	52	LRRCT 2
Amino acid modifications
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	644	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O94991 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: 69E71DC1EE3C568B	FASTA	958	107,486
	10 20 30 40 50 60 MHTCCPPVTL EQDLHRKMHS WMLQTLAFAV TSLVLSCAET IDYYGEICDN ACPCEEKDGI 70 80 90 100 110 120 LTVSCENRGI ISLSEISPPR FPIYHLLLSG NLLNRLYPNE FVNYTGASIL HLGSNVIQDI 130 140 150 160 170 180 ETGAFHGLRG LRRLHLNNNK LELLRDDTFL GLENLEYLQV DYNYISVIEP NAFGKLHLLQ 190 200 210 220 230 240 VLILNDNLLS SLPNNLFRFV PLTHLDLRGN RLKLLPYVGL LQHMDKVVEL QLEENPWNCS 250 260 270 280 290 300 CELISLKDWL DSISYSALVG DVVCETPFRL HGRDLDEVSK QELCPRRLIS DYEMRPQTPL 310 320 330 340 350 360 STTGYLHTTP ASVNSVATSS SAVYKPPLKP PKGTRQPNKP RVRPTSRQPS KDLGYSNYGP 370 380 390 400 410 420 SIAYQTKSPV PLECPTACSC NLQISDLGLN VNCQERKIES IAELQPKPYN PKKMYLTENY 430 440 450 460 470 480 IAVVRRTDFL EATGLDLLHL GNNRISMIQD RAFGDLTNLR RLYLNGNRIE RLSPELFYGL 490 500 510 520 530 540 QSLQYLFLQY NLIREIQSGT FDPVPNLQLL FLNNNLLQAM PSGVFSGLTL LRLNLRSNHF 550 560 570 580 590 600 TSLPVSGVLD QLKSLIQIDL HDNPWDCTCD IVGMKLWVEQ LKVGVLVDEV ICKAPKKFAE 610 620 630 640 650 660 TDMRSIKSEL LCPDYSDVVV STPTPSSIQV PARTSAVTPA VRLNSTGAPA SLGAGGGASS 670 680 690 700 710 720 VPLSVLILSL LLVFIMSVFV AAGLFVLVMK RRKKNQSDHT STNNSDVSSF NMQYSVYGGG 730 740 750 760 770 780 GGTGGHPHAH VHHRGPALPK VKTPAGHVYE YIPHPLGHMC KNPIYRSREG NSVEDYKDLH 790 800 810 820 830 840 ELKVTYSSNH HLQQQQQPPP PPQQPQQQPP PQLQLQPGEE ERRESHHLRS PAYSVSTIEP 850 860 870 880 890 900 REDLLSPVQD ADRFYRGILE PDKHCSTTPA GNSLPEYPKF PCSPAAYTFS PNYDLRRPHQ 910 920 930 940 950 YLHPGAGDSR LREPVLYSPP SAVFVEPNRN EYLELKAKLN VEPDYLEVLE KQTTFSQF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue." Aruga J., Yokota N., Mikoshiba K. Gene 315:87-94(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY. Tissue: Brain and Brain tumor.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB020725 mRNA. Translation: BAA74941.1. Different initiation. AK024251 mRNA. Translation: BAG51280.1. AL603883 Genomic DNA. Translation: CAH73026.1. CH471085 Genomic DNA. Translation: EAX08917.1. BC098106 mRNA. Translation: AAH98106.1. BC103509 mRNA. Translation: AAI03510.1.
IPI	IPI00016679.
RefSeq	NP_056382.1. NM_015567.1.
UniGene	Hs.591208.
3D structure databases
ProteinModelPortal	O94991.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366283.
PTM databases
PhosphoSite	O94991.
Proteomic databases
PaxDb	O94991.
PRIDE	O94991.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325089; ENSP00000366283; ENSG00000165300.
GeneID	26050.
KEGG	hsa:26050.
UCSC	uc001vln.3. human.
Organism-specific databases
CTD	26050.
GeneCards	GC13P088324.
HGNC	HGNC:20295. SLITRK5.
HPA	HPA013843.
MIM	609680. gene.
neXtProt	NX_O94991.
PharmGKB	PA134885524.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147171.
HOGENOM	HOG000290667.
HOVERGEN	HBG056407.
InParanoid	O94991.
OMA	HHRGPAL.
OrthoDB	EOG4X97GH.
PhylomeDB	O94991.
Gene expression databases
ArrayExpress	O94991.
Bgee	O94991.
CleanEx	HS_SLITRK5.
Genevestigator	O94991.
GermOnline	ENSG00000165300. Homo sapiens.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF00560. LRR_1. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 4 hits. SM00082. LRRCT. 2 hits. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 11 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26050.
NextBio	47908.
SOURCE	Search...

Entry information

Entry name

SLIK5_HUMAN

Accession

Primary (citable) accession number: O94991
Secondary accession number(s): B3KNB8, Q5VT81

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	April 13, 2004
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.