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O94991

- SLIK5_HUMAN

UniProt

O94991 - SLIK5_HUMAN

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Protein
SLIT and NTRK-like protein 5
Gene
SLITRK5, KIAA0918, LRRC11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Suppresses neurite outgrowth By similarity.

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. axonogenesis Source: Ensembl
  3. cardiovascular system development Source: Ensembl
  4. dendrite morphogenesis Source: Ensembl
  5. grooming behavior Source: Ensembl
  6. response to xenobiotic stimulus Source: Ensembl
  7. skin development Source: Ensembl
  8. striatum development Source: Ensembl
  9. synaptic transmission Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT and NTRK-like protein 5
Alternative name(s):
Leucine-rich repeat-containing protein 11
Gene namesi
Name:SLITRK5
Synonyms:KIAA0918, LRRC11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:20295. SLITRK5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini41 – 664624Extracellular Reviewed prediction
Add
BLAST
Transmembranei665 – 68521Helical; Reviewed prediction
Add
BLAST
Topological domaini686 – 958273Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4040 Reviewed prediction
Add
BLAST
Chaini41 – 958918SLIT and NTRK-like protein 5
PRO_0000032681Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi644 – 6441N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO94991.
PRIDEiO94991.

PTM databases

PhosphoSiteiO94991.

Expressioni

Tissue specificityi

Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla.1 Publication

Gene expression databases

ArrayExpressiO94991.
BgeeiO94991.
CleanExiHS_SLITRK5.
GenevestigatoriO94991.

Organism-specific databases

HPAiHPA013843.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366283.

Structurei

3D structure databases

ProteinModelPortaliO94991.
SMRiO94991. Positions 48-283, 372-615.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati82 – 10322LRR 1
Add
BLAST
Repeati106 – 12722LRR 2
Add
BLAST
Repeati130 – 15122LRR 3
Add
BLAST
Repeati154 – 17522LRR 4
Add
BLAST
Repeati178 – 19922LRR 5
Add
BLAST
Repeati201 – 22222LRR 6
Add
BLAST
Domaini235 – 28652LRRCT 1
Add
BLAST
Domaini365 – 40743LRRNT
Add
BLAST
Repeati410 – 43122LRR 7
Add
BLAST
Repeati434 – 45522LRR 8
Add
BLAST
Repeati458 – 47922LRR 9
Add
BLAST
Repeati482 – 50322LRR 10
Add
BLAST
Repeati506 – 52722LRR 11
Add
BLAST
Repeati529 – 55022LRR 12
Add
BLAST
Domaini563 – 61452LRRCT 2
Add
BLAST

Sequence similaritiesi

Belongs to the SLITRK family.
Contains 2 LRRCT domains.
Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147171.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiO94991.
OMAiVICKAPK.
OrthoDBiEOG7W9RT2.
PhylomeDBiO94991.
TreeFamiTF326378.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94991-1 [UniParc]FASTAAdd to Basket

« Hide

MHTCCPPVTL EQDLHRKMHS WMLQTLAFAV TSLVLSCAET IDYYGEICDN    50
ACPCEEKDGI LTVSCENRGI ISLSEISPPR FPIYHLLLSG NLLNRLYPNE 100
FVNYTGASIL HLGSNVIQDI ETGAFHGLRG LRRLHLNNNK LELLRDDTFL 150
GLENLEYLQV DYNYISVIEP NAFGKLHLLQ VLILNDNLLS SLPNNLFRFV 200
PLTHLDLRGN RLKLLPYVGL LQHMDKVVEL QLEENPWNCS CELISLKDWL 250
DSISYSALVG DVVCETPFRL HGRDLDEVSK QELCPRRLIS DYEMRPQTPL 300
STTGYLHTTP ASVNSVATSS SAVYKPPLKP PKGTRQPNKP RVRPTSRQPS 350
KDLGYSNYGP SIAYQTKSPV PLECPTACSC NLQISDLGLN VNCQERKIES 400
IAELQPKPYN PKKMYLTENY IAVVRRTDFL EATGLDLLHL GNNRISMIQD 450
RAFGDLTNLR RLYLNGNRIE RLSPELFYGL QSLQYLFLQY NLIREIQSGT 500
FDPVPNLQLL FLNNNLLQAM PSGVFSGLTL LRLNLRSNHF TSLPVSGVLD 550
QLKSLIQIDL HDNPWDCTCD IVGMKLWVEQ LKVGVLVDEV ICKAPKKFAE 600
TDMRSIKSEL LCPDYSDVVV STPTPSSIQV PARTSAVTPA VRLNSTGAPA 650
SLGAGGGASS VPLSVLILSL LLVFIMSVFV AAGLFVLVMK RRKKNQSDHT 700
STNNSDVSSF NMQYSVYGGG GGTGGHPHAH VHHRGPALPK VKTPAGHVYE 750
YIPHPLGHMC KNPIYRSREG NSVEDYKDLH ELKVTYSSNH HLQQQQQPPP 800
PPQQPQQQPP PQLQLQPGEE ERRESHHLRS PAYSVSTIEP REDLLSPVQD 850
ADRFYRGILE PDKHCSTTPA GNSLPEYPKF PCSPAAYTFS PNYDLRRPHQ 900
YLHPGAGDSR LREPVLYSPP SAVFVEPNRN EYLELKAKLN VEPDYLEVLE 950
KQTTFSQF 958
Length:958
Mass (Da):107,486
Last modified:April 13, 2004 - v2
Checksum:i69E71DC1EE3C568B
GO

Sequence cautioni

The sequence BAA74941.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020725 mRNA. Translation: BAA74941.1. Different initiation.
AK024251 mRNA. Translation: BAG51280.1.
AL603883 Genomic DNA. Translation: CAH73026.1.
CH471085 Genomic DNA. Translation: EAX08917.1.
BC098106 mRNA. Translation: AAH98106.1.
BC103509 mRNA. Translation: AAI03510.1.
CCDSiCCDS9465.1.
RefSeqiNP_056382.1. NM_015567.1.
XP_005254095.1. XM_005254038.2.
XP_005254096.1. XM_005254039.1.
UniGeneiHs.591208.

Genome annotation databases

EnsembliENST00000325089; ENSP00000366283; ENSG00000165300.
GeneIDi26050.
KEGGihsa:26050.
UCSCiuc001vln.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020725 mRNA. Translation: BAA74941.1 . Different initiation.
AK024251 mRNA. Translation: BAG51280.1 .
AL603883 Genomic DNA. Translation: CAH73026.1 .
CH471085 Genomic DNA. Translation: EAX08917.1 .
BC098106 mRNA. Translation: AAH98106.1 .
BC103509 mRNA. Translation: AAI03510.1 .
CCDSi CCDS9465.1.
RefSeqi NP_056382.1. NM_015567.1.
XP_005254095.1. XM_005254038.2.
XP_005254096.1. XM_005254039.1.
UniGenei Hs.591208.

3D structure databases

ProteinModelPortali O94991.
SMRi O94991. Positions 48-283, 372-615.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000366283.

PTM databases

PhosphoSitei O94991.

Proteomic databases

PaxDbi O94991.
PRIDEi O94991.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325089 ; ENSP00000366283 ; ENSG00000165300 .
GeneIDi 26050.
KEGGi hsa:26050.
UCSCi uc001vln.3. human.

Organism-specific databases

CTDi 26050.
GeneCardsi GC13P088324.
HGNCi HGNC:20295. SLITRK5.
HPAi HPA013843.
MIMi 609680. gene.
neXtProti NX_O94991.
PharmGKBi PA134885524.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147171.
HOGENOMi HOG000290667.
HOVERGENi HBG056407.
InParanoidi O94991.
OMAi VICKAPK.
OrthoDBi EOG7W9RT2.
PhylomeDBi O94991.
TreeFami TF326378.

Miscellaneous databases

GeneWikii SLITRK5.
GenomeRNAii 26050.
NextBioi 47908.
PROi O94991.
SOURCEi Search...

Gene expression databases

ArrayExpressi O94991.
Bgeei O94991.
CleanExi HS_SLITRK5.
Genevestigatori O94991.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 2 hits.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue."
    Aruga J., Yokota N., Mikoshiba K.
    Gene 315:87-94(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    Tissue: Brain and Brain tumor.

Entry informationi

Entry nameiSLIK5_HUMAN
AccessioniPrimary (citable) accession number: O94991
Secondary accession number(s): B3KNB8, Q5VT81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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