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O94986

- CE152_HUMAN

UniProt

O94986 - CE152_HUMAN

Protein

Centrosomal protein of 152 kDa

Gene

CEP152

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 4 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. cell projection organization Source: UniProtKB-KW
    2. centriole replication Source: UniProtKB
    3. centrosome duplication Source: UniProtKB
    4. de novo centriole assembly Source: UniProtKB
    5. G2/M transition of mitotic cell cycle Source: Reactome
    6. mitotic cell cycle Source: Reactome

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Enzyme and pathway databases

    ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centrosomal protein of 152 kDa
    Short name:
    Cep152
    Gene namesi
    Name:CEP152
    Synonyms:KIAA0912
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:29298. CEP152.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 4 Publications
    Note: Colocalizes with CEP63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. Localizes to the deuterosome.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytosol Source: Reactome
    3. deuterosome Source: UniProtKB
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Involvement in diseasei

    Microcephaly 9, primary, autosomal recessive (MCPH9) [MIM:614852]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti265 – 2651Q → P in MCPH9. 1 Publication
    VAR_063813
    Seckel syndrome 5 (SCKL5) [MIM:613823]: A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti667 – 6671K → R in SCKL5. 1 Publication
    Corresponds to variant rs200879436 [ dbSNP | Ensembl ].
    VAR_065258

    Keywords - Diseasei

    Disease mutation, Dwarfism, Mental retardation, Primary microcephaly

    Organism-specific databases

    MIMi613823. phenotype.
    614852. phenotype.
    Orphaneti2512. Autosomal recessive primary microcephaly.
    808. Seckel syndrome.
    PharmGKBiPA142672126.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17101710Centrosomal protein of 152 kDaPRO_0000089462Add
    BLAST

    Proteomic databases

    MaxQBiO94986.
    PaxDbiO94986.
    PRIDEiO94986.

    PTM databases

    PhosphoSiteiO94986.

    Expressioni

    Gene expression databases

    ArrayExpressiO94986.
    BgeeiO94986.
    CleanExiHS_CEP152.
    GenevestigatoriO94986.

    Organism-specific databases

    HPAiHPA039408.

    Interactioni

    Subunit structurei

    Interacts (via N-terminus) with PLK4. Interacts (via C-terminus) with CENPJ (via-N-terminus). Interacts with CINP. Interacts with CEP63; this interaction recruits CEP152 to centrosomes.4 Publications

    Protein-protein interaction databases

    BioGridi116642. 8 interactions.
    DIPiDIP-31701N.
    IntActiO94986. 7 interactions.
    MINTiMINT-7034544.
    STRINGi9606.ENSP00000382271.

    Structurei

    3D structure databases

    ProteinModelPortaliO94986.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili234 – 490257Sequence AnalysisAdd
    BLAST
    Coiled coili615 – 66450Sequence AnalysisAdd
    BLAST
    Coiled coili700 – 77273Sequence AnalysisAdd
    BLAST
    Coiled coili902 – 99392Sequence AnalysisAdd
    BLAST
    Coiled coili1170 – 124172Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CEP152 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG140168.
    HOGENOMiHOG000111522.
    HOVERGENiHBG096403.
    KOiK16728.
    OMAiDDHRNKI.
    OrthoDBiEOG7B8S36.
    TreeFamiTF332017.

    Family and domain databases

    InterProiIPR029598. Cep152.
    [Graphical view]
    PANTHERiPTHR10337:SF6. PTHR10337:SF6. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 4 (identifier: O94986-4) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLDFGSVAL PVQNEDEEYD EEDYEREKEL QQLLTDLPHD MLDDDLSSPE     50
    LQYSDCSEDG TDGQPHHPEQ LEMSWNEQML PKSQSVNGYN EIQSLYAGEK 100
    CGNVWEENRS KTEDRHPVYH PEEGGDEGGS GYSPPSKCEQ TDLYHLPENF 150
    RPYTNGQKQE FNNQATNVIK FSDPQWNHFQ GPSCQGLEPY NKVTYKPYQS 200
    SAQNNGSPAQ EITGSDTFEG LQQQFLGANE NSAENMQIIQ LQVLNKAKER 250
    QLENLIEKLN ESERQIRYLN HQLVIIKDEK DGLTLSLRES QKLFQNGKER 300
    EIQLEAQIKA LETQIQALKV NEEQMIKKSR TTEMALESLK QQLVDLHHSE 350
    SLQRAREQHE SIVMGLTKKY EEQVLSLQKN LDATVTALKE QEDICSRLKD 400
    HVKQLERNQE AIKLEKTEII NKLTRSLEES QKQCAHLLQS GSVQEVAQLQ 450
    FQLQQAQKAH AMSANMNKAL QEELTELKDE ISLYESAAKL GIHPSDSEGE 500
    LNIELTESYV DLGIKKVNWK KSKVTSIVQE EDPNEELSKD EFILKLKAEV 550
    QRLLGSNSMK RHLVSQLQND LKDCHKKIED LHQVKKDEKS IEVETKTDTS 600
    EKPKNQLWPE SSTSDVVRDD ILLLKNEIQV LQQQNQELKE TEGKLRNTNQ 650
    DLCNQMRQMV QDFDHDKQEA VDRCERTYQQ HHEAMKTQIR ESLLAKHALE 700
    KQQLFEAYER THLQLRSELD KLNKEVTAVQ ECYLEVCREK DNLELTLRKT 750
    TEKEQQTQEK IKEKLIQQLE KEWQSKLDQT IKAMKKKTLD CGSQTDQVTT 800
    SDVISKKEMA IMIEEQKCTI QQNLEQEKDI AIKGAMKKLE IELELKHCEN 850
    ITKQVEIAVQ NAHQRWLGEL PELAEYQALV KAEQKKWEEQ HEVSVNKRIS 900
    FAVSEAKEKW KSELENMRKN ILPGKELEEK IHSLQKELEL KNEEVPVVIR 950
    AELAKARSEW NKEKQEEIHR IQEQNEQDYR QFLDDHRNKI NEVLAAAKED 1000
    FMKQKTELLL QKETELQTCL DQSRREWTMQ EAKRIQLEIY QYEEDILTVL 1050
    GVLLSDTQKE HISDSEDKQL LEIMSTCSSK WMSVQYFEKL KGCIQKAFQD 1100
    TLPLLVENAD PEWKKRNMAE LSKDSASQGT GQGDPGPAAG HHAQPLALQA 1150
    TEAEADKKKV LEIKDLCCGH CFQELEKAKQ ECQDLKGKLE KCCRHLQHLE 1200
    RKHKAVVEKI GEENNKVVEE LIEENNDMKN KLEELQTLCK TPPRSLSAGA 1250
    IENACLPCSG GALEELRGQY IKAVKKIKCD MLRYIQESKE RAAEMVKAEV 1300
    LRERQETARK MRKYYLICLQ QILQDDGKEG AEKKIMNAAS KLATMAKLLE 1350
    TPISSKSQSK TTQSALPLTS EMLIAVKKSK RNDVNQKIPC CIESKSNSVN 1400
    TITRTLCEQA PKRRAACNLQ RLLENSEHQS IKHVGSKETH LEFQFGDGSC 1450
    KHLNSLPRNV SPEFVPCEGE GGFGLHKKKD LLSDNGSESL PHSAAYPFLG 1500
    TLGNKPSPRC TPGPSESGCM HITFRDSNER LGLKVYKCNP LMESENAASE 1550
    KSQGLDVQEP PVKDGGDLSD CLGWPSSSAT LSFDSREASF VHGRPQGTLE 1600
    IPSESVKSKQ FSPSGYLSDT EESNMICQTM KCQRYQTPYL SEETTYLEPG 1650
    KISVNCGHPS RHKADRLKSD FKKLSSTLPS SVCQQPSRKL IVPLSSQQDS 1700
    GFDSPFVNLD 1710

    Note: Gene prediction based on EST data.

    Length:1,710
    Mass (Da):195,626
    Last modified:June 26, 2013 - v4
    Checksum:i1727BDA921E1F6BD
    GO
    Isoform 1 (identifier: O94986-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         89-181: Missing.
         1365-1368: ALPL → GMSK
         1369-1710: Missing.

    Show »
    Length:1,275
    Mass (Da):147,345
    Checksum:iD1E91CED05D5E054
    GO
    Isoform 2 (identifier: O94986-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1365-1368: ALPL → GMSK
         1369-1710: Missing.

    Show »
    Length:1,368
    Mass (Da):158,079
    Checksum:i03F71584CB87AB49
    GO
    Isoform 3 (identifier: O94986-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1156-1211: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,654
    Mass (Da):189,071
    Checksum:iC517B4CFBDAB87E9
    GO

    Sequence cautioni

    The sequence AAH69186.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAA74935.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti558 – 5581S → P in AAH69186. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541S → L.
    Corresponds to variant rs2289181 [ dbSNP | Ensembl ].
    VAR_047932
    Natural varianti265 – 2651Q → P in MCPH9. 1 Publication
    VAR_063813
    Natural varianti667 – 6671K → R in SCKL5. 1 Publication
    Corresponds to variant rs200879436 [ dbSNP | Ensembl ].
    VAR_065258
    Natural varianti793 – 7931S → I.1 Publication
    Corresponds to variant rs2289178 [ dbSNP | Ensembl ].
    VAR_050779
    Natural varianti914 – 9141L → V.
    Corresponds to variant rs16961560 [ dbSNP | Ensembl ].
    VAR_050780
    Natural varianti1106 – 11061V → A.
    Corresponds to variant rs16961557 [ dbSNP | Ensembl ].
    VAR_050781

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei89 – 18193Missing in isoform 1. 1 PublicationVSP_035981Add
    BLAST
    Alternative sequencei1156 – 121156Missing in isoform 3. 1 PublicationVSP_047002Add
    BLAST
    Alternative sequencei1365 – 13684ALPL → GMSK in isoform 1 and isoform 2. 1 PublicationVSP_035983
    Alternative sequencei1369 – 1710342Missing in isoform 1 and isoform 2. 1 PublicationVSP_035984Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020719 mRNA. Translation: BAA74935.1. Different initiation.
    AC012379 Genomic DNA. No translation available.
    AC022084 Genomic DNA. No translation available.
    AC084757 Genomic DNA. No translation available.
    BC069186 mRNA. Translation: AAH69186.1. Sequence problems.
    BC117182 mRNA. Translation: AAI17183.1.
    CCDSiCCDS42033.1. [O94986-3]
    CCDS58361.1. [O94986-4]
    RefSeqiNP_001181927.1. NM_001194998.1. [O94986-4]
    NP_055800.2. NM_014985.3. [O94986-3]
    XP_006720500.1. XM_006720437.1. [O94986-4]
    UniGeneiHs.443005.
    Hs.597323.

    Genome annotation databases

    EnsembliENST00000325747; ENSP00000321000; ENSG00000103995. [O94986-1]
    ENST00000380950; ENSP00000370337; ENSG00000103995. [O94986-4]
    ENST00000399334; ENSP00000382271; ENSG00000103995. [O94986-3]
    GeneIDi22995.
    KEGGihsa:22995.
    UCSCiuc001zwy.3. human. [O94986-4]
    uc001zxa.2. human. [O94986-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020719 mRNA. Translation: BAA74935.1 . Different initiation.
    AC012379 Genomic DNA. No translation available.
    AC022084 Genomic DNA. No translation available.
    AC084757 Genomic DNA. No translation available.
    BC069186 mRNA. Translation: AAH69186.1 . Sequence problems.
    BC117182 mRNA. Translation: AAI17183.1 .
    CCDSi CCDS42033.1. [O94986-3 ]
    CCDS58361.1. [O94986-4 ]
    RefSeqi NP_001181927.1. NM_001194998.1. [O94986-4 ]
    NP_055800.2. NM_014985.3. [O94986-3 ]
    XP_006720500.1. XM_006720437.1. [O94986-4 ]
    UniGenei Hs.443005.
    Hs.597323.

    3D structure databases

    ProteinModelPortali O94986.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116642. 8 interactions.
    DIPi DIP-31701N.
    IntActi O94986. 7 interactions.
    MINTi MINT-7034544.
    STRINGi 9606.ENSP00000382271.

    PTM databases

    PhosphoSitei O94986.

    Proteomic databases

    MaxQBi O94986.
    PaxDbi O94986.
    PRIDEi O94986.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325747 ; ENSP00000321000 ; ENSG00000103995 . [O94986-1 ]
    ENST00000380950 ; ENSP00000370337 ; ENSG00000103995 . [O94986-4 ]
    ENST00000399334 ; ENSP00000382271 ; ENSG00000103995 . [O94986-3 ]
    GeneIDi 22995.
    KEGGi hsa:22995.
    UCSCi uc001zwy.3. human. [O94986-4 ]
    uc001zxa.2. human. [O94986-1 ]

    Organism-specific databases

    CTDi 22995.
    GeneCardsi GC15M049005.
    GeneReviewsi CEP152.
    HGNCi HGNC:29298. CEP152.
    HPAi HPA039408.
    MIMi 613529. gene.
    613823. phenotype.
    614852. phenotype.
    neXtProti NX_O94986.
    Orphaneti 2512. Autosomal recessive primary microcephaly.
    808. Seckel syndrome.
    PharmGKBi PA142672126.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG140168.
    HOGENOMi HOG000111522.
    HOVERGENi HBG096403.
    KOi K16728.
    OMAi DDHRNKI.
    OrthoDBi EOG7B8S36.
    TreeFami TF332017.

    Enzyme and pathway databases

    Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Miscellaneous databases

    ChiTaRSi CEP152. human.
    GeneWikii CEP152.
    GenomeRNAii 22995.
    NextBioi 43860.
    PROi O94986.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94986.
    Bgeei O94986.
    CleanExi HS_CEP152.
    Genevestigatori O94986.

    Family and domain databases

    InterProi IPR029598. Cep152.
    [Graphical view ]
    PANTHERi PTHR10337:SF6. PTHR10337:SF6. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Heart, Lung and Testis.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome."
      Cizmecioglu O., Arnold M., Bahtz R., Settele F., Ehret L., Haselmann-Weiss U., Antony C., Hoffmann I.
      J. Cell Biol. 191:731-739(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PLK4.
    6. Cited for: FUNCTION, INTERACTION WITH PLK4 AND CENPJ.
    7. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CINP, VARIANT SCKL5 ARG-667.
    8. "A primary microcephaly protein complex forms a ring around parental centrioles."
      Sir J.H., Barr A.R., Nicholas A.K., Carvalho O.P., Khurshid M., Sossick A., Reichelt S., D'Santos C., Woods C.G., Gergely F.
      Nat. Genet. 43:1147-1153(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CEP63, SUBCELLULAR LOCATION.
    9. Cited for: VARIANT MCPH9 PRO-265, SUBCELLULAR LOCATION.
    10. Cited for: VARIANT ILE-793.

    Entry informationi

    Entry nameiCE152_HUMAN
    AccessioniPrimary (citable) accession number: O94986
    Secondary accession number(s): E7ER66, Q17RV1, Q6NTA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 108 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3