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Protein

Calsyntenin-1

Gene

CLSTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).By similarity1 Publication

GO - Molecular functioni

  • beta-amyloid binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • kinesin binding Source: UniProtKB
  • X11-like protein binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Calsyntenin-1
Alternative name(s):
Alcadein-alpha
Short name:
Alc-alpha
Alzheimer-related cadherin-like protein
Non-classical cadherin XB31alpha
Cleaved into the following 2 chains:
Soluble Alc-alpha
Short name:
SAlc-alpha
Alternative name(s):
C-terminal fragment 1-alpha
Gene namesi
Name:CLSTN1
Synonyms:CS1, KIAA0911
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17447. CLSTN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 859831ExtracellularSequence analysisAdd
BLAST
Transmembranei860 – 88021HelicalSequence analysisAdd
BLAST
Topological domaini881 – 981101CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi913 – 9142NP → AA: Abolishes interaction with APBA2. 1 Publication
Mutagenesisi918 – 9181Y → A: No effect on APBA2-binding. 1 Publication

Organism-specific databases

PharmGKBiPA38238.

Polymorphism and mutation databases

BioMutaiCLSTN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 981953Calsyntenin-1PRO_0000004021Add
BLAST
Chaini29 – 825797Soluble Alc-alphaPRO_0000323597Add
BLAST
Chaini826 – 981156CTF1-alphaPRO_0000323598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence analysis
Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei824 – 8252CleavageBy similarity
Sitei853 – 8542CleavageBy similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO94985.
MaxQBiO94985.
PaxDbiO94985.
PeptideAtlasiO94985.
PRIDEiO94985.

PTM databases

iPTMnetiO94985.
PhosphoSiteiO94985.

Miscellaneous databases

PMAP-CutDBO94985.

Expressioni

Tissue specificityi

Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level).2 Publications

Gene expression databases

BgeeiO94985.
CleanExiHS_CLSTN1.
ExpressionAtlasiO94985. baseline and differential.
GenevisibleiO94985. HS.

Organism-specific databases

HPAiHPA012412.

Interactioni

Subunit structurei

Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. The CTF1 chain interacts with PSEN1. The intracellular fragment AlcICD interacts with APBB1; this interaction stabilizes AlcICD metabolism. Interacts with KLC1 and APBB1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Klc1Q8CD767EBI-522075,EBI-6271950From a different organism.

GO - Molecular functioni

  • kinesin binding Source: UniProtKB
  • X11-like protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116550. 27 interactions.
DIPiDIP-31694N.
IntActiO94985. 13 interactions.
MINTiMINT-4544144.
STRINGi9606.ENSP00000366513.

Structurei

3D structure databases

ProteinModelPortaliO94985.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 164127Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini165 – 265101Cadherin 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi916 – 95944Glu-rich (highly acidic)Add
BLAST

Domaini

The cytoplasmic domain is involved in interaction with APBA2, as well as the binding of synaptic Ca2+.By similarity

Sequence similaritiesi

Contains 2 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1834. Eukaryota.
ENOG410XT2J. LUCA.
GeneTreeiENSGT00390000010858.
HOGENOMiHOG000037537.
HOVERGENiHBG051146.
InParanoidiO94985.
OMAiITSTVKC.
OrthoDBiEOG7SFHVX.
PhylomeDBiO94985.
TreeFamiTF315946.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 2 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR026914. Calsyntenin.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR14139. PTHR14139. 2 hits.
PfamiPF00028. Cadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50268. CADHERIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94985-1) [UniParc]FASTAAdd to basket

Also known as: Alcalpha2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRRPAPALA PAARLLLAGL LCGGGVWAAR VNKHKPWLEP TYHGIVTEND
60 70 80 90 100
NTVLLDPPLI ALDKDAPLRF AESFEVTVTK EGEICGFKIH GQNVPFDAVV
110 120 130 140 150
VDKSTGEGVI RSKEKLDCEL QKDYSFTIQA YDCGKGPDGT NVKKSHKATV
160 170 180 190 200
HIQVNDVNEY APVFKEKSYK ATVIEGKQYD SILRVEAVDA DCSPQFSQIC
210 220 230 240 250
SYEIITPDVP FTVDKDGYIK NTEKLNYGKE HQYKLTVTAY DCGKKRATED
260 270 280 290 300
VLVKISIKPT CTPGWQGWNN RIEYEPGTGA LAVFPNIHLE TCDEPVASVQ
310 320 330 340 350
ATVELETSHI GKGCDRDTYS EKSLHRLCGA AAGTAELLPS PSGSLNWTMG
360 370 380 390 400
LPTDNGHDSD QVFEFNGTQA VRIPDGVVSV SPKEPFTISV WMRHGPFGRK
410 420 430 440 450
KETILCSSDK TDMNRHHYSL YVHGCRLIFL FRQDPSEEKK YRPAEFHWKL
460 470 480 490 500
NQVCDEEWHH YVLNVEFPSV TLYVDGTSHE PFSVTEDYPL HPSKIETQLV
510 520 530 540 550
VGACWQEFSG VENDNETEPV TVASAGGDLH MTQFFRGNLA GLTLRSGKLA
560 570 580 590 600
DKKVIDCLYT CKEGLDLQVL EDSGRGVQIQ AHPSQLVLTL EGEDLGELDK
610 620 630 640 650
AMQHISYLNS RQFPTPGIRR LKITSTIKCF NEATCISVPP VDGYVMVLQP
660 670 680 690 700
EEPKISLSGV HHFARAASEF ESSEGVFLFP ELRIISTITR EVEPEGDGAE
710 720 730 740 750
DPTVQESLVS EEIVHDLDTC EVTVEGEELN HEQESLEVDM ARLQQKGIEV
760 770 780 790 800
SSSELGMTFT GVDTMASYEE VLHLLRYRNW HARSLLDRKF KLICSELNGR
810 820 830 840 850
YISNEFKVEV NVIHTANPME HANHMAAQPQ FVHPEHRSFV DLSGHNLANP
860 870 880 890 900
HPFAVVPSTA TVVIVVCVSF LVFMIILGVF RIRAAHRRTM RDQDTGKENE
910 920 930 940 950
MDWDDSALTI TVNPMETYED QHSSEEEEEE EEEEESEDGE EEDDITSAES
960 970 980
ESSEEEEGEQ GDPQNATRQQ QLEWDDSTLS Y
Length:981
Mass (Da):109,793
Last modified:May 1, 1999 - v1
Checksum:i01856284DEC3FC73
GO
Isoform 2 (identifier: O94985-2) [UniParc]FASTAAdd to basket

Also known as: Alcalpha1

The sequence of this isoform differs from the canonical sequence as follows:
     72-81: Missing.

Show »
Length:971
Mass (Da):108,643
Checksum:iE772045354046E4F
GO

Sequence cautioni

The sequence BAA74934.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021D → G in BAF82487 (PubMed:14702039).Curated
Sequence conflicti553 – 5531K → R in BAF82487 (PubMed:14702039).Curated
Sequence conflicti886 – 8872HR → ST in AAQ04552 (PubMed:12972431).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321A → T.
Corresponds to variant rs7550295 [ dbSNP | Ensembl ].
VAR_048582
Natural varianti474 – 4741V → A.1 Publication
Corresponds to variant rs17853245 [ dbSNP | Ensembl ].
VAR_039552
Natural varianti524 – 5241S → C.1 Publication
Corresponds to variant rs17853244 [ dbSNP | Ensembl ].
VAR_039553
Natural varianti583 – 5831P → R.1 Publication
Corresponds to variant rs17853243 [ dbSNP | Ensembl ].
VAR_039554
Natural varianti857 – 8571P → H.1 Publication
Corresponds to variant rs17855572 [ dbSNP | Ensembl ].
VAR_039555
Natural varianti870 – 8701F → S.1 Publication
Corresponds to variant rs17855573 [ dbSNP | Ensembl ].
VAR_039556

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei72 – 8110Missing in isoform 2. 3 PublicationsVSP_032035

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF438482 mRNA. Translation: AAQ04552.1.
AY753301 mRNA. Translation: AAV30551.1.
AB020718 mRNA. Translation: BAA74934.2. Different initiation.
AK289798 mRNA. Translation: BAF82487.1.
AL691449, AL357140 Genomic DNA. Translation: CAI15699.1.
AL691449, AL357140 Genomic DNA. Translation: CAI15700.1.
AL357140, AL691449 Genomic DNA. Translation: CAI16884.1.
AL357140, AL691449 Genomic DNA. Translation: CAI16885.1.
BC033902 mRNA. Translation: AAH33902.1.
CCDSiCCDS105.1. [O94985-2]
CCDS30580.1. [O94985-1]
RefSeqiNP_001009566.1. NM_001009566.2. [O94985-1]
NP_001289812.1. NM_001302883.1.
NP_055759.3. NM_014944.4. [O94985-2]
UniGeneiHs.29665.

Genome annotation databases

EnsembliENST00000361311; ENSP00000354997; ENSG00000171603. [O94985-2]
ENST00000377298; ENSP00000366513; ENSG00000171603. [O94985-1]
GeneIDi22883.
KEGGihsa:22883.
UCSCiuc001aqh.4. human. [O94985-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF438482 mRNA. Translation: AAQ04552.1.
AY753301 mRNA. Translation: AAV30551.1.
AB020718 mRNA. Translation: BAA74934.2. Different initiation.
AK289798 mRNA. Translation: BAF82487.1.
AL691449, AL357140 Genomic DNA. Translation: CAI15699.1.
AL691449, AL357140 Genomic DNA. Translation: CAI15700.1.
AL357140, AL691449 Genomic DNA. Translation: CAI16884.1.
AL357140, AL691449 Genomic DNA. Translation: CAI16885.1.
BC033902 mRNA. Translation: AAH33902.1.
CCDSiCCDS105.1. [O94985-2]
CCDS30580.1. [O94985-1]
RefSeqiNP_001009566.1. NM_001009566.2. [O94985-1]
NP_001289812.1. NM_001302883.1.
NP_055759.3. NM_014944.4. [O94985-2]
UniGeneiHs.29665.

3D structure databases

ProteinModelPortaliO94985.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116550. 27 interactions.
DIPiDIP-31694N.
IntActiO94985. 13 interactions.
MINTiMINT-4544144.
STRINGi9606.ENSP00000366513.

PTM databases

iPTMnetiO94985.
PhosphoSiteiO94985.

Polymorphism and mutation databases

BioMutaiCLSTN1.

Proteomic databases

EPDiO94985.
MaxQBiO94985.
PaxDbiO94985.
PeptideAtlasiO94985.
PRIDEiO94985.

Protocols and materials databases

DNASUi22883.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361311; ENSP00000354997; ENSG00000171603. [O94985-2]
ENST00000377298; ENSP00000366513; ENSG00000171603. [O94985-1]
GeneIDi22883.
KEGGihsa:22883.
UCSCiuc001aqh.4. human. [O94985-1]

Organism-specific databases

CTDi22883.
GeneCardsiCLSTN1.
HGNCiHGNC:17447. CLSTN1.
HPAiHPA012412.
MIMi611321. gene.
neXtProtiNX_O94985.
PharmGKBiPA38238.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1834. Eukaryota.
ENOG410XT2J. LUCA.
GeneTreeiENSGT00390000010858.
HOGENOMiHOG000037537.
HOVERGENiHBG051146.
InParanoidiO94985.
OMAiITSTVKC.
OrthoDBiEOG7SFHVX.
PhylomeDBiO94985.
TreeFamiTF315946.

Miscellaneous databases

ChiTaRSiCLSTN1. human.
GeneWikiiCLSTN1.
GenomeRNAii22883.
PMAP-CutDBO94985.
PROiO94985.
SOURCEiSearch...

Gene expression databases

BgeeiO94985.
CleanExiHS_CLSTN1.
ExpressionAtlasiO94985. baseline and differential.
GenevisibleiO94985. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 2 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR026914. Calsyntenin.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR14139. PTHR14139. 2 hits.
PfamiPF00028. Cadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50268. CADHERIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism."
    Araki Y., Tomita S., Yamaguchi H., Miyagi N., Sumioka A., Kirino Y., Suzuki T.
    J. Biol. Chem. 278:49448-49458(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH APBA2, MUTAGENESIS OF 913-ASN-PRO-914 AND TYR-918.
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ALA-474; CYS-524; ARG-583; HIS-857 AND SER-870.
    Tissue: Hippocampus.
  6. "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation."
    Araki Y., Miyagi N., Kato N., Yoshida T., Wada S., Nishimura M., Komano H., Yamamoto T., De Strooper B., Yamamoto K., Suzuki T.
    J. Biol. Chem. 279:24343-24354(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-33 AND 826-833, PROTEOLYTIC CLEAVAGE.
  7. "The calsyntenins - a family of postsynaptic membrane proteins with distinct neuronal expression patterns."
    Hintsch G., Zurlinden A., Meskenaite V., Steuble M., Fink-Widmer K., Kinter J., Sonderegger P.
    Mol. Cell. Neurosci. 21:393-409(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport."
    Araki Y., Kawano T., Taru H., Saito Y., Wada S., Miyamoto K., Kobayashi H., Ishikawa H.O., Ohsugi Y., Yamamoto T., Matsuno K., Kinjo M., Suzuki T.
    EMBO J. 26:1475-1486(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KLC1, SUBCELLULAR LOCATION, GLYCOSYLATION.

Entry informationi

Entry nameiCSTN1_HUMAN
AccessioniPrimary (citable) accession number: O94985
Secondary accession number(s): A8K183
, Q5SR52, Q5UE58, Q71MN0, Q8N4K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.