O94985 (CSTN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calsyntenin-1

Alternative name(s):
Alcadein-alpha
Short name=Alc-alpha
Alzheimer-related cadherin-like protein
Non-classical cadherin XB31alpha

Cleaved into the following 2 chains:

1. Soluble Alc-alpha
   Short name=SAlc-alpha
2. CTF1-alpha
   Alternative name(s):
   C-terminal fragment 1-alpha

Gene names

Name:	CLSTN1
Synonyms:	CS1, KIAA0911

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	981 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals By similarity. Ref.1
Subunit structure	Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. The CTF1 chain interacts with PSEN1. The intracellular fragment AlcICD interacts with APBB1; this interaction stabilizes AlcICD metabolism. Interacts with KLC1 and APBB1 By similarity. Ref.1 Ref.8
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane. Cell projection. Cell junction › synapse › postsynaptic cell membrane; Single-pass type I membrane protein By similarity. Nucleus. Note: Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses By similarity. The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. Ref.8
Tissue specificity	Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). Ref.1 Ref.7
Domain	The cytoplasmic domain is involved in interaction with APBA2, as well as the binding of synaptic Ca2+ By similarity.
Post-translational modification	Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1.
Sequence similarities	Contains 2 cadherin domains.
Sequence caution	The sequence BAA74934.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Cell projection Endoplasmic reticulum Golgi apparatus Membrane Nucleus Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cell junction Inferred from electronic annotation. Source: UniProtKB-KW cell projection Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94985-1)

Also known as: Alcalpha2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94985-2)

Also known as: Alcalpha1;

The sequence of this isoform differs from the canonical sequence as follows:
     72-81: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Ref.6
	Chain	29 – 981	953	Calsyntenin-1		PRO_0000004021
	Chain	29 – 825	797	Soluble Alc-alpha		PRO_0000323597
	Chain	826 – 981	156	CTF1-alpha		PRO_0000323598
Regions
	Topological domain	29 – 859	831	Extracellular Potential
	Transmembrane	860 – 880	21	Helical; Potential
	Topological domain	881 – 981	101	Cytoplasmic Potential
	Domain	38 – 164	127	Cadherin 1
	Domain	165 – 265	101	Cadherin 2
	Compositional bias	916 – 959	44	Glu-rich (highly acidic)
Amino acid modifications
	Glycosylation	346	1	N-linked (GlcNAc...) Potential
	Glycosylation	366	1	N-linked (GlcNAc...) Potential
	Glycosylation	515	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	72 – 81	10	Missing in isoform 2.		VSP_032035
	Natural variant	332	1	A → T. Corresponds to variant rs7550295 [ dbSNP | Ensembl ].		VAR_048582
	Natural variant	474	1	V → A. Ref.5 Corresponds to variant rs17853245 [ dbSNP | Ensembl ].		VAR_039552
	Natural variant	524	1	S → C. Ref.5 Corresponds to variant rs17853244 [ dbSNP | Ensembl ].		VAR_039553
	Natural variant	583	1	P → R. Ref.5 Corresponds to variant rs17853243 [ dbSNP | Ensembl ].		VAR_039554
	Natural variant	857	1	P → H. Ref.5 Corresponds to variant rs17855572 [ dbSNP | Ensembl ].		VAR_039555
	Natural variant	870	1	F → S. Ref.5 Corresponds to variant rs17855573 [ dbSNP | Ensembl ].		VAR_039556
Experimental info
	Mutagenesis	913 – 914	2	NP → AA: Abolishes interaction with APBA2.
	Mutagenesis	918	1	Y → A: No effect on APBA2-binding. Ref.1
	Sequence conflict	102	1	D → G in BAF82487. Ref.3
	Sequence conflict	553	1	K → R in BAF82487. Ref.3
	Sequence conflict	886 – 887	2	HR → ST in AAQ04552. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alcalpha2) [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 01856284DEC3FC73	FASTA	981	109,793
	10 20 30 40 50 60 MLRRPAPALA PAARLLLAGL LCGGGVWAAR VNKHKPWLEP TYHGIVTEND NTVLLDPPLI 70 80 90 100 110 120 ALDKDAPLRF AESFEVTVTK EGEICGFKIH GQNVPFDAVV VDKSTGEGVI RSKEKLDCEL 130 140 150 160 170 180 QKDYSFTIQA YDCGKGPDGT NVKKSHKATV HIQVNDVNEY APVFKEKSYK ATVIEGKQYD 190 200 210 220 230 240 SILRVEAVDA DCSPQFSQIC SYEIITPDVP FTVDKDGYIK NTEKLNYGKE HQYKLTVTAY 250 260 270 280 290 300 DCGKKRATED VLVKISIKPT CTPGWQGWNN RIEYEPGTGA LAVFPNIHLE TCDEPVASVQ 310 320 330 340 350 360 ATVELETSHI GKGCDRDTYS EKSLHRLCGA AAGTAELLPS PSGSLNWTMG LPTDNGHDSD 370 380 390 400 410 420 QVFEFNGTQA VRIPDGVVSV SPKEPFTISV WMRHGPFGRK KETILCSSDK TDMNRHHYSL 430 440 450 460 470 480 YVHGCRLIFL FRQDPSEEKK YRPAEFHWKL NQVCDEEWHH YVLNVEFPSV TLYVDGTSHE 490 500 510 520 530 540 PFSVTEDYPL HPSKIETQLV VGACWQEFSG VENDNETEPV TVASAGGDLH MTQFFRGNLA 550 560 570 580 590 600 GLTLRSGKLA DKKVIDCLYT CKEGLDLQVL EDSGRGVQIQ AHPSQLVLTL EGEDLGELDK 610 620 630 640 650 660 AMQHISYLNS RQFPTPGIRR LKITSTIKCF NEATCISVPP VDGYVMVLQP EEPKISLSGV 670 680 690 700 710 720 HHFARAASEF ESSEGVFLFP ELRIISTITR EVEPEGDGAE DPTVQESLVS EEIVHDLDTC 730 740 750 760 770 780 EVTVEGEELN HEQESLEVDM ARLQQKGIEV SSSELGMTFT GVDTMASYEE VLHLLRYRNW 790 800 810 820 830 840 HARSLLDRKF KLICSELNGR YISNEFKVEV NVIHTANPME HANHMAAQPQ FVHPEHRSFV 850 860 870 880 890 900 DLSGHNLANP HPFAVVPSTA TVVIVVCVSF LVFMIILGVF RIRAAHRRTM RDQDTGKENE 910 920 930 940 950 960 MDWDDSALTI TVNPMETYED QHSSEEEEEE EEEEESEDGE EEDDITSAES ESSEEEEGEQ 970 980 GDPQNATRQQ QLEWDDSTLS Y
	Isoform 2 (Alcalpha1) [UniParc]. Checksum: E772045354046E4F	FASTA	971	108,643
	10 20 30 40 50 60 MLRRPAPALA PAARLLLAGL LCGGGVWAAR VNKHKPWLEP TYHGIVTEND NTVLLDPPLI 70 80 90 100 110 120 ALDKDAPLRF AGEICGFKIH GQNVPFDAVV VDKSTGEGVI RSKEKLDCEL QKDYSFTIQA 130 140 150 160 170 180 YDCGKGPDGT NVKKSHKATV HIQVNDVNEY APVFKEKSYK ATVIEGKQYD SILRVEAVDA 190 200 210 220 230 240 DCSPQFSQIC SYEIITPDVP FTVDKDGYIK NTEKLNYGKE HQYKLTVTAY DCGKKRATED 250 260 270 280 290 300 VLVKISIKPT CTPGWQGWNN RIEYEPGTGA LAVFPNIHLE TCDEPVASVQ ATVELETSHI 310 320 330 340 350 360 GKGCDRDTYS EKSLHRLCGA AAGTAELLPS PSGSLNWTMG LPTDNGHDSD QVFEFNGTQA 370 380 390 400 410 420 VRIPDGVVSV SPKEPFTISV WMRHGPFGRK KETILCSSDK TDMNRHHYSL YVHGCRLIFL 430 440 450 460 470 480 FRQDPSEEKK YRPAEFHWKL NQVCDEEWHH YVLNVEFPSV TLYVDGTSHE PFSVTEDYPL 490 500 510 520 530 540 HPSKIETQLV VGACWQEFSG VENDNETEPV TVASAGGDLH MTQFFRGNLA GLTLRSGKLA 550 560 570 580 590 600 DKKVIDCLYT CKEGLDLQVL EDSGRGVQIQ AHPSQLVLTL EGEDLGELDK AMQHISYLNS 610 620 630 640 650 660 RQFPTPGIRR LKITSTIKCF NEATCISVPP VDGYVMVLQP EEPKISLSGV HHFARAASEF 670 680 690 700 710 720 ESSEGVFLFP ELRIISTITR EVEPEGDGAE DPTVQESLVS EEIVHDLDTC EVTVEGEELN 730 740 750 760 770 780 HEQESLEVDM ARLQQKGIEV SSSELGMTFT GVDTMASYEE VLHLLRYRNW HARSLLDRKF 790 800 810 820 830 840 KLICSELNGR YISNEFKVEV NVIHTANPME HANHMAAQPQ FVHPEHRSFV DLSGHNLANP 850 860 870 880 890 900 HPFAVVPSTA TVVIVVCVSF LVFMIILGVF RIRAAHRRTM RDQDTGKENE MDWDDSALTI 910 920 930 940 950 960 TVNPMETYED QHSSEEEEEE EEEEESEDGE EEDDITSAES ESSEEEEGEQ GDPQNATRQQ 970 QLEWDDSTLS Y

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism." Araki Y., Tomita S., Yamaguchi H., Miyagi N., Sumioka A., Kirino Y., Suzuki T. J. Biol. Chem. 278:49448-49458(2003) [PubMed: 12972431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH APBA2, MUTAGENESIS OF 913-ASN-PRO-914 AND TYR-918. Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed: 10048485] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ALA-474; CYS-524; ARG-583; HIS-857 AND SER-870. Tissue: Hippocampus.
[6]	"Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation." Araki Y., Miyagi N., Kato N., Yoshida T., Wada S., Nishimura M., Komano H., Yamamoto T., De Strooper B., Yamamoto K., Suzuki T. J. Biol. Chem. 279:24343-24354(2004) [PubMed: 15037614] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-33 AND 826-833, PROTEOLYTIC CLEAVAGE.
[7]	"The calsyntenins - a family of postsynaptic membrane proteins with distinct neuronal expression patterns." Hintsch G., Zurlinden A., Meskenaite V., Steuble M., Fink-Widmer K., Kinter J., Sonderegger P. Mol. Cell. Neurosci. 21:393-409(2002) [PubMed: 12498782] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport." Araki Y., Kawano T., Taru H., Saito Y., Wada S., Miyamoto K., Kobayashi H., Ishikawa H.O., Ohsugi Y., Yamamoto T., Matsuno K., Kinjo M., Suzuki T. EMBO J. 26:1475-1486(2007) [PubMed: 17332754] [Abstract] Cited for: INTERACTION WITH KLC1, SUBCELLULAR LOCATION, GLYCOSYLATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF438482 mRNA. Translation: AAQ04552.1. AY753301 mRNA. Translation: AAV30551.1. AB020718 mRNA. Translation: BAA74934.2. Different initiation. AK289798 mRNA. Translation: BAF82487.1. AL691449, AL357140 Genomic DNA. Translation: CAI15699.1. AL691449, AL357140 Genomic DNA. Translation: CAI15700.1. AL357140, AL691449 Genomic DNA. Translation: CAI16884.1. AL357140, AL691449 Genomic DNA. Translation: CAI16885.1. BC033902 mRNA. Translation: AAH33902.1.
IPI	IPI00007257. IPI00413959.
RefSeq	NP_001009566.1. NM_001009566.1. NP_055759.3. NM_014944.3.
UniGene	Hs.29665.
3D structure databases
ProteinModelPortal	O94985.
SMR	O94985. Positions 25-265.
ModBase	Search...
Protein-protein interaction databases
IntAct	O94985. 10 interactions.
MINT	MINT-4544144.
STRING	O94985.
Proteomic databases
PRIDE	O94985.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377298; ENSP00000366513; ENSG00000171603.
GeneID	22883.
KEGG	hsa:22883.
UCSC	uc001aqh.1. human. uc001aqi.1. human.
Organism-specific databases
CTD	22883.
GeneCards	GC01M009789.
H-InvDB	HIX0000108.
HGNC	HGNC:17447. CLSTN1.
HPA	HPA012412.
MIM	611321. gene.
neXtProt	NX_O94985.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15763.
GeneTree	ENSGT00390000010858.
HOGENOM	HBG444353.
HOVERGEN	HBG051146.
InParanoid	O94985.
OMA	DTCEVTV.
OrthoDB	EOG4DFPMS.
PhylomeDB	O94985.
Gene expression databases
ArrayExpress	O94985.
Bgee	O94985.
CleanEx	HS_CLSTN1.
Genevestigator	O94985.
GermOnline	ENSG00000171603. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR008985. ConA-like_lec_gl. IPR013320. ConA-like_subgrp. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 2 hits. G3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.
Pfam	PF00028. Cadherin. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 2 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 2 hits. SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00232. CADHERIN_1. False negative. PS50268. CADHERIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	43465.
PMAP-CutDB	O94985.
SOURCE	Search...

Entry information

Entry name

CSTN1_HUMAN

Accession

Primary (citable) accession number: O94985
Secondary accession number(s): A8K183 , Q5SR52, Q5UE58, Q71MN0, Q8N4K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.