ID   CMTA2_HUMAN             Reviewed;        1202 AA.
AC   O94983; B9EGL0; D3DTL5; E7EWU5; Q7Z6M8; Q8N3V0; Q8NDG4; Q96G17;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 3.
DT   27-MAR-2024, entry version 188.
DE   RecName: Full=Calmodulin-binding transcription activator 2;
GN   Name=CAMTA2; Synonyms=KIAA0909;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS PRO-267
RP   AND PRO-903.
RC   TISSUE=Brain;
RX   PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA   Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XII. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 5:355-364(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), AND VARIANTS
RP   PRO-267 AND PRO-903.
RC   TISSUE=Amygdala, and Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PRO-267.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6), AND
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 485-1202 (ISOFORM 2).
RC   TISSUE=Eye, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   FUNCTION, TISSUE SPECIFICITY, SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=11925432; DOI=10.1074/jbc.m200268200;
RA   Bouche N., Scharlat A., Snedden W., Bouchez D., Fromm H.;
RT   "A novel family of calmodulin-binding transcription activators in
RT   multicellular organisms.";
RL   J. Biol. Chem. 277:21851-21861(2002).
RN   [7]
RP   ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
RX   PubMed=15138581;
RA   Nakatani K., Nishioka J., Itakura T., Nakanishi Y., Horinouchi J., Abe Y.,
RA   Wada H., Nobori T.;
RT   "Cell cycle-dependent transcriptional regulation of calmodulin-binding
RT   transcription activator 1 in neuroblastoma cells.";
RL   Int. J. Oncol. 24:1407-1412(2004).
CC   -!- FUNCTION: Transcription activator. May act as tumor suppressor.
CC       {ECO:0000269|PubMed:11925432}.
CC   -!- SUBUNIT: May interact with calmodulin. {ECO:0000305}.
CC   -!- INTERACTION:
CC       O94983; P42582: Nkx2-5; Xeno; NbExp=2; IntAct=EBI-936534, EBI-297021;
CC       O94983-5; B4DJ51: CALM1; NbExp=5; IntAct=EBI-10176008, EBI-10171450;
CC       O94983-5; P27797: CALR; NbExp=3; IntAct=EBI-10176008, EBI-1049597;
CC       O94983-5; P12830: CDH1; NbExp=3; IntAct=EBI-10176008, EBI-727477;
CC       O94983-5; Q15078: CDK5R1; NbExp=3; IntAct=EBI-10176008, EBI-746189;
CC       O94983-5; P36957: DLST; NbExp=3; IntAct=EBI-10176008, EBI-351007;
CC       O94983-5; P43360: MAGEA6; NbExp=3; IntAct=EBI-10176008, EBI-1045155;
CC       O94983-5; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-10176008, EBI-1104564;
CC       O94983-5; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-10176008, EBI-1055945;
CC       O94983-5; Q6P088: ZNF483; NbExp=3; IntAct=EBI-10176008, EBI-10196963;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:11925432}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=6;
CC       Name=1;
CC         IsoId=O94983-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O94983-2; Sequence=VSP_018493;
CC       Name=3;
CC         IsoId=O94983-3; Sequence=VSP_018490, VSP_018493;
CC       Name=4;
CC         IsoId=O94983-4; Sequence=VSP_018491, VSP_018492;
CC       Name=5;
CC         IsoId=O94983-5; Sequence=VSP_018489;
CC       Name=6;
CC         IsoId=O94983-6; Sequence=VSP_018491, VSP_046059;
CC   -!- TISSUE SPECIFICITY: Detected in brain. Expressed at constant levels
CC       throughout the cell cycle in neuroblastoma cell lines.
CC       {ECO:0000269|PubMed:11925432, ECO:0000269|PubMed:15138581}.
CC   -!- SIMILARITY: Belongs to the CAMTA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH16163.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAA74932.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB020716; BAA74932.1; ALT_INIT; mRNA.
DR   EMBL; AL833974; CAD38818.2; -; mRNA.
DR   EMBL; AL831849; CAD38553.1; -; mRNA.
DR   EMBL; AC004771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471108; EAW90372.1; -; Genomic_DNA.
DR   EMBL; CH471108; EAW90373.1; -; Genomic_DNA.
DR   EMBL; BC010050; AAH10050.2; -; mRNA.
DR   EMBL; BC016163; AAH16163.1; ALT_FRAME; mRNA.
DR   EMBL; BC136534; AAI36535.1; -; mRNA.
DR   EMBL; BC142606; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS11063.1; -. [O94983-1]
DR   CCDS; CCDS54071.1; -. [O94983-4]
DR   CCDS; CCDS54072.1; -. [O94983-6]
DR   CCDS; CCDS54073.1; -. [O94983-3]
DR   RefSeq; NP_001164637.1; NM_001171166.1. [O94983-3]
DR   RefSeq; NP_001164638.1; NM_001171167.1. [O94983-6]
DR   RefSeq; NP_001164639.1; NM_001171168.1. [O94983-4]
DR   RefSeq; NP_055914.2; NM_015099.3. [O94983-1]
DR   AlphaFoldDB; O94983; -.
DR   SMR; O94983; -.
DR   BioGRID; 116744; 18.
DR   IntAct; O94983; 18.
DR   MINT; O94983; -.
DR   STRING; 9606.ENSP00000412886; -.
DR   iPTMnet; O94983; -.
DR   PhosphoSitePlus; O94983; -.
DR   BioMuta; CAMTA2; -.
DR   jPOST; O94983; -.
DR   MassIVE; O94983; -.
DR   PaxDb; 9606-ENSP00000412886; -.
DR   PeptideAtlas; O94983; -.
DR   ProteomicsDB; 18913; -.
DR   ProteomicsDB; 50603; -. [O94983-1]
DR   ProteomicsDB; 50604; -. [O94983-2]
DR   ProteomicsDB; 50605; -. [O94983-3]
DR   ProteomicsDB; 50606; -. [O94983-4]
DR   ProteomicsDB; 50607; -. [O94983-5]
DR   Antibodypedia; 53152; 30 antibodies from 19 providers.
DR   DNASU; 23125; -.
DR   Ensembl; ENST00000348066.8; ENSP00000321813.7; ENSG00000108509.21. [O94983-1]
DR   Ensembl; ENST00000361571.9; ENSP00000354828.5; ENSG00000108509.21. [O94983-4]
DR   Ensembl; ENST00000381311.9; ENSP00000370712.5; ENSG00000108509.21. [O94983-3]
DR   Ensembl; ENST00000414043.7; ENSP00000412886.3; ENSG00000108509.21. [O94983-6]
DR   GeneID; 23125; -.
DR   KEGG; hsa:23125; -.
DR   MANE-Select; ENST00000348066.8; ENSP00000321813.7; NM_015099.4; NP_055914.2.
DR   UCSC; uc002gag.3; human. [O94983-1]
DR   AGR; HGNC:18807; -.
DR   CTD; 23125; -.
DR   DisGeNET; 23125; -.
DR   GeneCards; CAMTA2; -.
DR   HGNC; HGNC:18807; CAMTA2.
DR   HPA; ENSG00000108509; Tissue enhanced (brain).
DR   MIM; 611508; gene.
DR   neXtProt; NX_O94983; -.
DR   OpenTargets; ENSG00000108509; -.
DR   PharmGKB; PA38689; -.
DR   VEuPathDB; HostDB:ENSG00000108509; -.
DR   eggNOG; KOG0520; Eukaryota.
DR   GeneTree; ENSGT00940000160105; -.
DR   HOGENOM; CLU_003170_2_0_1; -.
DR   InParanoid; O94983; -.
DR   OMA; VQLYSNP; -.
DR   OrthoDB; 470813at2759; -.
DR   PhylomeDB; O94983; -.
DR   TreeFam; TF323452; -.
DR   PathwayCommons; O94983; -.
DR   SignaLink; O94983; -.
DR   BioGRID-ORCS; 23125; 13 hits in 1180 CRISPR screens.
DR   ChiTaRS; CAMTA2; human.
DR   GenomeRNAi; 23125; -.
DR   Pharos; O94983; Tbio.
DR   PRO; PR:O94983; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; O94983; Protein.
DR   Bgee; ENSG00000108509; Expressed in right hemisphere of cerebellum and 158 other cell types or tissues.
DR   ExpressionAtlas; O94983; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IDA:ARUK-UCL.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0042826; F:histone deacetylase binding; IDA:MGI.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IDA:ARUK-UCL.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0014898; P:cardiac muscle hypertrophy in response to stress; IDA:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR   Gene3D; 1.20.5.190; -; 2.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005559; CG-1_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR23335:SF9; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 2; 1.
DR   PANTHER; PTHR23335; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA; 1.
DR   Pfam; PF03859; CG-1; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SMART; SM01076; CG-1; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS51437; CG_1; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   Genevisible; O94983; HS.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; ANK repeat; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..1202
FT                   /note="Calmodulin-binding transcription activator 2"
FT                   /id="PRO_0000235821"
FT   DOMAIN          537..615
FT                   /note="IPT/TIG"
FT   REPEAT          712..745
FT                   /note="ANK 1"
FT   REPEAT          757..787
FT                   /note="ANK 2"
FT   REPEAT          791..821
FT                   /note="ANK 3"
FT   DOMAIN          1049..1078
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1102..1131
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DNA_BIND        30..155
FT                   /note="CG-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00767"
FT   REGION          263..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          421..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          817..874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          906..929
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           79..86
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00767"
FT   COMPBIAS        266..285
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..303
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..477
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        829..860
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..873
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_018489"
FT   VAR_SEQ         1..10
FT                   /note="MNTKDTTEVA -> MAAAAVTRGTPG (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_018490"
FT   VAR_SEQ         1
FT                   /note="M -> MGTDSPSPRPLRPGVTLPPGALTM (in isoform 4 and
FT                   isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_018491"
FT   VAR_SEQ         114..137
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_018492"
FT   VAR_SEQ         1088..1094
FT                   /note="Missing (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:17974005"
FT                   /id="VSP_018493"
FT   VAR_SEQ         1158..1202
FT                   /note="GSFLTKKQDQAARKIMRFLRRCRHRMRELKQNQELEGLPQPGLAT -> LLS
FT                   HQEAGPGSPEDHEIPAALPTQDEGTEAEPGAGRASPAGTGHMTWPPPFSPPWGRLVQS
FT                   (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_046059"
FT   VARIANT         267
FT                   /note="A -> P (in dbSNP:rs238234)"
FT                   /evidence="ECO:0000269|PubMed:10048485,
FT                   ECO:0000269|PubMed:17974005, ECO:0000269|Ref.4"
FT                   /id="VAR_026417"
FT   VARIANT         903
FT                   /note="S -> P (in dbSNP:rs16942615)"
FT                   /evidence="ECO:0000269|PubMed:10048485,
FT                   ECO:0000269|PubMed:17974005"
FT                   /id="VAR_026418"
FT   CONFLICT        140
FT                   /note="D -> G (in Ref. 2; CAD38818)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        682
FT                   /note="A -> V (in Ref. 2; CAD38818)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        688
FT                   /note="V -> L (in Ref. 2; CAD38818)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        788
FT                   /note="S -> P (in Ref. 2; CAD38818)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1175
FT                   /note="F -> S (in Ref. 2; CAD38818)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1202 AA;  131530 MW;  09E17E4E240F4A58 CRC64;
     MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY LITFEKHDEW
     LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT REDHMKLKVQ GMECLYGCYV
     HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP ALEDCGKGCS PIFCSISSDR REWLKWSREE
     LLGQLKPMFH GIKWSCGNGT EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH
     KCSSTKHRII SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG
     FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP RPSMSLAVVV
     GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF PEAEAAHTPC SALEPAAALE
     PQAAARGPPP QSVAGGRRGN CFFIQDDDSG EELKGHGAAP PIPSPPPSPP PSPAPLEPSS
     RVGRGEALFG GPVGASELEP FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP
     EWSYPEGGVK VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA
     GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK RMAEIAAAGQ
     VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP ERLAHGSPFR GMSLLHLAAA
     QGYARLIETL SQWRSVETGS LDLEQEVDPL NVDHFSCTPL MWACALGHLE AAVLLFRWNR
     QALSIPDSLG RLPLSVAHSR GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS
     SPSELSDGTF SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA
     TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT PERIKREDFV
     GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP PSELPFERGR LAVPSAPSWA
     EFLSASTSGK MESDFALLTL SDHEQRELYE AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR
     CYRKYKQLTW IALKFALYKK MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR
     RPGPPHRTSA TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL
     AT
//