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Protein

Calmodulin-binding transcription activator 2

Gene

CAMTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator. May act as tumor suppressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 155CG-1PROSITE-ProRule annotationAdd BLAST126

GO - Molecular functioni

  • chromatin binding Source: MGI
  • histone deacetylase binding Source: MGI
  • sequence-specific DNA binding Source: GO_Central
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: GO_Central
  • transcription factor binding Source: MGI

GO - Biological processi

  • cardiac muscle hypertrophy in response to stress Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108509-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 2
Gene namesi
Name:CAMTA2
Synonyms:KIAA0909
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18807. CAMTA2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23125.
OpenTargetsiENSG00000108509.
PharmGKBiPA38689.

Polymorphism and mutation databases

BioMutaiCAMTA2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358211 – 1202Calmodulin-binding transcription activator 2Add BLAST1202

Proteomic databases

PaxDbiO94983.
PeptideAtlasiO94983.
PRIDEiO94983.

PTM databases

iPTMnetiO94983.
PhosphoSitePlusiO94983.

Expressioni

Tissue specificityi

Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines.2 Publications

Gene expression databases

BgeeiENSG00000108509.
CleanExiHS_CAMTA2.
ExpressionAtlasiO94983. baseline and differential.
GenevisibleiO94983. HS.

Organism-specific databases

HPAiHPA051147.

Interactioni

Subunit structurei

May interact with calmodulin.Curated

Binary interactionsi

WithEntry#Exp.IntActNotes
HEL-S-72B4DJ515EBI-10176008,EBI-10171450
Nkx2-5P425822EBI-936534,EBI-297021From a different organism.

GO - Molecular functioni

  • histone deacetylase binding Source: MGI
  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi116744. 6 interactors.
IntActiO94983. 10 interactors.
STRINGi9606.ENSP00000412886.

Structurei

3D structure databases

ProteinModelPortaliO94983.
SMRiO94983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini535 – 617IPT/TIGAdd BLAST83
Repeati712 – 745ANK 1Add BLAST34
Repeati757 – 787ANK 2Add BLAST31
Repeati791 – 821ANK 3Add BLAST31
Domaini1049 – 1078IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1102 – 1131IQ 2PROSITE-ProRule annotationAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi79 – 86Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi289 – 300Ser-richAdd BLAST12

Sequence similaritiesi

Belongs to the CAMTA family.Curated
Contains 3 ANK repeats.Curated
Contains 1 CG-1 DNA-binding domain.PROSITE-ProRule annotation
Contains 1 IPT/TIG domain.Curated
Contains 2 IQ domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0520. Eukaryota.
ENOG410XS5M. LUCA.
GeneTreeiENSGT00390000001446.
HOVERGENiHBG058078.
InParanoidiO94983.
OMAiSHQEAGP.
OrthoDBiEOG091G01MB.
PhylomeDBiO94983.
TreeFamiTF323452.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM01076. CG-1. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94983-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY
60 70 80 90 100
LITFEKHDEW LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT
110 120 130 140 150
REDHMKLKVQ GMECLYGCYV HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP
160 170 180 190 200
ALEDCGKGCS PIFCSISSDR REWLKWSREE LLGQLKPMFH GIKWSCGNGT
210 220 230 240 250
EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH KCSSTKHRII
260 270 280 290 300
SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG
310 320 330 340 350
FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP
360 370 380 390 400
RPSMSLAVVV GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF
410 420 430 440 450
PEAEAAHTPC SALEPAAALE PQAAARGPPP QSVAGGRRGN CFFIQDDDSG
460 470 480 490 500
EELKGHGAAP PIPSPPPSPP PSPAPLEPSS RVGRGEALFG GPVGASELEP
510 520 530 540 550
FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP EWSYPEGGVK
560 570 580 590 600
VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA
610 620 630 640 650
GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK
660 670 680 690 700
RMAEIAAAGQ VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP
710 720 730 740 750
ERLAHGSPFR GMSLLHLAAA QGYARLIETL SQWRSVETGS LDLEQEVDPL
760 770 780 790 800
NVDHFSCTPL MWACALGHLE AAVLLFRWNR QALSIPDSLG RLPLSVAHSR
810 820 830 840 850
GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS SPSELSDGTF
860 870 880 890 900
SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA
910 920 930 940 950
TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT
960 970 980 990 1000
PERIKREDFV GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP
1010 1020 1030 1040 1050
PSELPFERGR LAVPSAPSWA EFLSASTSGK MESDFALLTL SDHEQRELYE
1060 1070 1080 1090 1100
AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR CYRKYKQLTW IALKFALYKK
1110 1120 1130 1140 1150
MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR RPGPPHRTSA
1160 1170 1180 1190 1200
TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL

AT
Length:1,202
Mass (Da):131,530
Last modified:February 6, 2007 - v3
Checksum:i09E17E4E240F4A58
GO
Isoform 2 (identifier: O94983-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1094: Missing.

Show »
Length:1,195
Mass (Da):130,704
Checksum:iE172544E3C189739
GO
Isoform 3 (identifier: O94983-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MNTKDTTEVA → MAAAAVTRGTPG
     1088-1094: Missing.

Show »
Length:1,197
Mass (Da):130,697
Checksum:iA256178E19EC9555
GO
Isoform 4 (identifier: O94983-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     114-137: Missing.

Show »
Length:1,201
Mass (Da):130,902
Checksum:iC3CB80558CE61B4E
GO
Isoform 5 (identifier: O94983-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-873: Missing.

Show »
Length:329
Mass (Da):37,129
Checksum:i69FDCB63AF1DD38F
GO
Isoform 6 (identifier: O94983-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     1158-1202: GSFLTKKQDQ...EGLPQPGLAT → LLSHQEAGPG...SPPWGRLVQS

Note: No experimental confirmation available.
Show »
Length:1,241
Mass (Da):134,800
Checksum:i0E19A0F98947BB34
GO

Sequence cautioni

The sequence AAH16163 differs from that shown. Reason: Frameshift at position 865.Curated
The sequence BAA74932 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140D → G in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti682A → V in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti688V → L in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti788S → P in CAD38818 (PubMed:17974005).Curated1
Sequence conflicti1175F → S in CAD38818 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026417267A → P.3 PublicationsCorresponds to variant rs238234dbSNPEnsembl.1
Natural variantiVAR_026418903S → P.2 PublicationsCorresponds to variant rs16942615dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0184891 – 873Missing in isoform 5. 1 PublicationAdd BLAST873
Alternative sequenceiVSP_0184901 – 10MNTKDTTEVA → MAAAAVTRGTPG in isoform 3. 1 Publication10
Alternative sequenceiVSP_0184911M → MGTDSPSPRPLRPGVTLPPG ALTM in isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_018492114 – 137Missing in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0184931088 – 1094Missing in isoform 2 and isoform 3. 2 Publications7
Alternative sequenceiVSP_0460591158 – 1202GSFLT…PGLAT → LLSHQEAGPGSPEDHEIPAA LPTQDEGTEAEPGAGRASPA GTGHMTWPPPFSPPWGRLVQ S in isoform 6. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020716 mRNA. Translation: BAA74932.1. Different initiation.
AL833974 mRNA. Translation: CAD38818.2.
AL831849 mRNA. Translation: CAD38553.1.
AC004771 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90372.1.
CH471108 Genomic DNA. Translation: EAW90373.1.
BC010050 mRNA. Translation: AAH10050.2.
BC016163 mRNA. Translation: AAH16163.1. Frameshift.
BC136534 mRNA. Translation: AAI36535.1.
BC142606 mRNA. No translation available.
CCDSiCCDS11063.1. [O94983-1]
CCDS54071.1. [O94983-4]
CCDS54072.1. [O94983-6]
CCDS54073.1. [O94983-3]
RefSeqiNP_001164637.1. NM_001171166.1. [O94983-3]
NP_001164638.1. NM_001171167.1. [O94983-6]
NP_001164639.1. NM_001171168.1. [O94983-4]
NP_055914.2. NM_015099.3. [O94983-1]
UniGeneiHs.632242.

Genome annotation databases

EnsembliENST00000348066; ENSP00000321813; ENSG00000108509. [O94983-1]
ENST00000361571; ENSP00000354828; ENSG00000108509. [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509. [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509. [O94983-6]
GeneIDi23125.
KEGGihsa:23125.
UCSCiuc002gag.3. human. [O94983-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020716 mRNA. Translation: BAA74932.1. Different initiation.
AL833974 mRNA. Translation: CAD38818.2.
AL831849 mRNA. Translation: CAD38553.1.
AC004771 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90372.1.
CH471108 Genomic DNA. Translation: EAW90373.1.
BC010050 mRNA. Translation: AAH10050.2.
BC016163 mRNA. Translation: AAH16163.1. Frameshift.
BC136534 mRNA. Translation: AAI36535.1.
BC142606 mRNA. No translation available.
CCDSiCCDS11063.1. [O94983-1]
CCDS54071.1. [O94983-4]
CCDS54072.1. [O94983-6]
CCDS54073.1. [O94983-3]
RefSeqiNP_001164637.1. NM_001171166.1. [O94983-3]
NP_001164638.1. NM_001171167.1. [O94983-6]
NP_001164639.1. NM_001171168.1. [O94983-4]
NP_055914.2. NM_015099.3. [O94983-1]
UniGeneiHs.632242.

3D structure databases

ProteinModelPortaliO94983.
SMRiO94983.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116744. 6 interactors.
IntActiO94983. 10 interactors.
STRINGi9606.ENSP00000412886.

PTM databases

iPTMnetiO94983.
PhosphoSitePlusiO94983.

Polymorphism and mutation databases

BioMutaiCAMTA2.

Proteomic databases

PaxDbiO94983.
PeptideAtlasiO94983.
PRIDEiO94983.

Protocols and materials databases

DNASUi23125.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348066; ENSP00000321813; ENSG00000108509. [O94983-1]
ENST00000361571; ENSP00000354828; ENSG00000108509. [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509. [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509. [O94983-6]
GeneIDi23125.
KEGGihsa:23125.
UCSCiuc002gag.3. human. [O94983-1]

Organism-specific databases

CTDi23125.
DisGeNETi23125.
GeneCardsiCAMTA2.
HGNCiHGNC:18807. CAMTA2.
HPAiHPA051147.
MIMi611508. gene.
neXtProtiNX_O94983.
OpenTargetsiENSG00000108509.
PharmGKBiPA38689.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0520. Eukaryota.
ENOG410XS5M. LUCA.
GeneTreeiENSGT00390000001446.
HOVERGENiHBG058078.
InParanoidiO94983.
OMAiSHQEAGP.
OrthoDBiEOG091G01MB.
PhylomeDBiO94983.
TreeFamiTF323452.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108509-MONOMER.

Miscellaneous databases

ChiTaRSiCAMTA2. human.
GenomeRNAii23125.
PROiO94983.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108509.
CleanExiHS_CAMTA2.
ExpressionAtlasiO94983. baseline and differential.
GenevisibleiO94983. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM01076. CG-1. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMTA2_HUMAN
AccessioniPrimary (citable) accession number: O94983
Secondary accession number(s): B9EGL0
, D3DTL5, E7EWU5, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 6, 2007
Last modified: November 30, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.