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O94983

- CMTA2_HUMAN

UniProt

O94983 - CMTA2_HUMAN

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Protein
Calmodulin-binding transcription activator 2
Gene
CAMTA2, KIAA0909
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription activator. May act as tumor suppressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi30 – 155126CG-1
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. chromatin binding Source: MGI
  3. histone deacetylase binding Source: MGI
  4. protein binding Source: IntAct
  5. transcription factor binding Source: MGI

GO - Biological processi

  1. cardiac muscle hypertrophy in response to stress Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. regulation of transcription from RNA polymerase II promoter Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 2
Gene namesi
Name:CAMTA2
Synonyms:KIAA0909
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18807. CAMTA2.

Subcellular locationi

Nucleus Inferred 1 Publication

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12021202Calmodulin-binding transcription activator 2
PRO_0000235821Add
BLAST

Proteomic databases

PaxDbiO94983.
PRIDEiO94983.

PTM databases

PhosphoSiteiO94983.

Expressioni

Tissue specificityi

Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines.2 Publications

Gene expression databases

ArrayExpressiO94983.
BgeeiO94983.
CleanExiHS_CAMTA2.
GenevestigatoriO94983.

Organism-specific databases

HPAiHPA051147.

Interactioni

Subunit structurei

May interact with calmodulin Reviewed prediction.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nkx2-5P425822EBI-936534,EBI-297021From a different organism.

Protein-protein interaction databases

BioGridi116744. 2 interactions.
IntActiO94983. 3 interactions.
STRINGi9606.ENSP00000321813.

Structurei

3D structure databases

ProteinModelPortaliO94983.
SMRiO94983. Positions 535-616, 709-810, 1111-1141.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini535 – 61783IPT/TIG
Add
BLAST
Repeati712 – 74534ANK 1
Add
BLAST
Repeati757 – 78731ANK 2
Add
BLAST
Repeati791 – 82131ANK 3
Add
BLAST
Domaini1049 – 107830IQ 1
Add
BLAST
Domaini1102 – 113130IQ 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi79 – 868Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi289 – 30012Ser-rich
Add
BLAST

Sequence similaritiesi

Belongs to the CAMTA family.
Contains 3 ANK repeats.
Contains 1 IPT/TIG domain.
Contains 2 IQ domains.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG294285.
HOVERGENiHBG058078.
InParanoidiO94983.
OMAiVAENSHH.
OrthoDBiEOG74R1PX.
PhylomeDBiO94983.
TreeFamiTF323452.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF00612. IQ. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM01076. CG-1. 1 hit.
SM00015. IQ. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O94983-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY     50
LITFEKHDEW LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT 100
REDHMKLKVQ GMECLYGCYV HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP 150
ALEDCGKGCS PIFCSISSDR REWLKWSREE LLGQLKPMFH GIKWSCGNGT 200
EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH KCSSTKHRII 250
SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG 300
FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP 350
RPSMSLAVVV GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF 400
PEAEAAHTPC SALEPAAALE PQAAARGPPP QSVAGGRRGN CFFIQDDDSG 450
EELKGHGAAP PIPSPPPSPP PSPAPLEPSS RVGRGEALFG GPVGASELEP 500
FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP EWSYPEGGVK 550
VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA 600
GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK 650
RMAEIAAAGQ VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP 700
ERLAHGSPFR GMSLLHLAAA QGYARLIETL SQWRSVETGS LDLEQEVDPL 750
NVDHFSCTPL MWACALGHLE AAVLLFRWNR QALSIPDSLG RLPLSVAHSR 800
GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS SPSELSDGTF 850
SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA 900
TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT 950
PERIKREDFV GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP 1000
PSELPFERGR LAVPSAPSWA EFLSASTSGK MESDFALLTL SDHEQRELYE 1050
AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR CYRKYKQLTW IALKFALYKK 1100
MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR RPGPPHRTSA 1150
TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL 1200
AT 1202
Length:1,202
Mass (Da):131,530
Last modified:February 6, 2007 - v3
Checksum:i09E17E4E240F4A58
GO
Isoform 2 (identifier: O94983-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1094: Missing.

Show »
Length:1,195
Mass (Da):130,704
Checksum:iE172544E3C189739
GO
Isoform 3 (identifier: O94983-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MNTKDTTEVA → MAAAAVTRGTPG
     1088-1094: Missing.

Show »
Length:1,197
Mass (Da):130,697
Checksum:iA256178E19EC9555
GO
Isoform 4 (identifier: O94983-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     114-137: Missing.

Show »
Length:1,201
Mass (Da):130,902
Checksum:iC3CB80558CE61B4E
GO
Isoform 5 (identifier: O94983-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-873: Missing.

Show »
Length:329
Mass (Da):37,129
Checksum:i69FDCB63AF1DD38F
GO
Isoform 6 (identifier: O94983-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     1158-1202: GSFLTKKQDQ...EGLPQPGLAT → LLSHQEAGPG...SPPWGRLVQS

Note: No experimental confirmation available.

Show »
Length:1,241
Mass (Da):134,800
Checksum:i0E19A0F98947BB34
GO

Sequence cautioni

The sequence AAH16163.1 differs from that shown. Reason: Frameshift at position 865.
The sequence BAA74932.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti267 – 2671A → P.3 Publications
Corresponds to variant rs238234 [ dbSNP | Ensembl ].
VAR_026417
Natural varianti903 – 9031S → P.2 Publications
Corresponds to variant rs16942615 [ dbSNP | Ensembl ].
VAR_026418

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 873873Missing in isoform 5.
VSP_018489Add
BLAST
Alternative sequencei1 – 1010MNTKDTTEVA → MAAAAVTRGTPG in isoform 3.
VSP_018490
Alternative sequencei1 – 11M → MGTDSPSPRPLRPGVTLPPG ALTM in isoform 4 and isoform 6.
VSP_018491
Alternative sequencei114 – 13724Missing in isoform 4.
VSP_018492Add
BLAST
Alternative sequencei1088 – 10947Missing in isoform 2 and isoform 3.
VSP_018493
Alternative sequencei1158 – 120245GSFLT…PGLAT → LLSHQEAGPGSPEDHEIPAA LPTQDEGTEAEPGAGRASPA GTGHMTWPPPFSPPWGRLVQ S in isoform 6.
VSP_046059Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1401D → G in CAD38818. 1 Publication
Sequence conflicti682 – 6821A → V in CAD38818. 1 Publication
Sequence conflicti688 – 6881V → L in CAD38818. 1 Publication
Sequence conflicti788 – 7881S → P in CAD38818. 1 Publication
Sequence conflicti1175 – 11751F → S in CAD38818. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020716 mRNA. Translation: BAA74932.1. Different initiation.
AL833974 mRNA. Translation: CAD38818.2.
AL831849 mRNA. Translation: CAD38553.1.
AC004771 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90372.1.
CH471108 Genomic DNA. Translation: EAW90373.1.
BC010050 mRNA. Translation: AAH10050.2.
BC016163 mRNA. Translation: AAH16163.1. Frameshift.
BC136534 mRNA. Translation: AAI36535.1.
BC142606 mRNA. No translation available.
CCDSiCCDS11063.1. [O94983-1]
CCDS54071.1. [O94983-4]
CCDS54072.1. [O94983-6]
CCDS54073.1. [O94983-3]
RefSeqiNP_001164637.1. NM_001171166.1. [O94983-3]
NP_001164638.1. NM_001171167.1. [O94983-6]
NP_001164639.1. NM_001171168.1. [O94983-4]
NP_055914.2. NM_015099.3. [O94983-1]
XP_006721543.1. XM_006721480.1. [O94983-2]
UniGeneiHs.632242.

Genome annotation databases

EnsembliENST00000348066; ENSP00000321813; ENSG00000108509. [O94983-1]
ENST00000358183; ENSP00000350910; ENSG00000108509. [O94983-2]
ENST00000361571; ENSP00000354828; ENSG00000108509. [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509. [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509. [O94983-6]
GeneIDi23125.
KEGGihsa:23125.
UCSCiuc002gag.2. human. [O94983-4]
uc002gah.2. human. [O94983-1]
uc002gai.2. human. [O94983-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020716 mRNA. Translation: BAA74932.1 . Different initiation.
AL833974 mRNA. Translation: CAD38818.2 .
AL831849 mRNA. Translation: CAD38553.1 .
AC004771 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90372.1 .
CH471108 Genomic DNA. Translation: EAW90373.1 .
BC010050 mRNA. Translation: AAH10050.2 .
BC016163 mRNA. Translation: AAH16163.1 . Frameshift.
BC136534 mRNA. Translation: AAI36535.1 .
BC142606 mRNA. No translation available.
CCDSi CCDS11063.1. [O94983-1 ]
CCDS54071.1. [O94983-4 ]
CCDS54072.1. [O94983-6 ]
CCDS54073.1. [O94983-3 ]
RefSeqi NP_001164637.1. NM_001171166.1. [O94983-3 ]
NP_001164638.1. NM_001171167.1. [O94983-6 ]
NP_001164639.1. NM_001171168.1. [O94983-4 ]
NP_055914.2. NM_015099.3. [O94983-1 ]
XP_006721543.1. XM_006721480.1. [O94983-2 ]
UniGenei Hs.632242.

3D structure databases

ProteinModelPortali O94983.
SMRi O94983. Positions 535-616, 709-810, 1111-1141.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116744. 2 interactions.
IntActi O94983. 3 interactions.
STRINGi 9606.ENSP00000321813.

PTM databases

PhosphoSitei O94983.

Proteomic databases

PaxDbi O94983.
PRIDEi O94983.

Protocols and materials databases

DNASUi 23125.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000348066 ; ENSP00000321813 ; ENSG00000108509 . [O94983-1 ]
ENST00000358183 ; ENSP00000350910 ; ENSG00000108509 . [O94983-2 ]
ENST00000361571 ; ENSP00000354828 ; ENSG00000108509 . [O94983-4 ]
ENST00000381311 ; ENSP00000370712 ; ENSG00000108509 . [O94983-3 ]
ENST00000414043 ; ENSP00000412886 ; ENSG00000108509 . [O94983-6 ]
GeneIDi 23125.
KEGGi hsa:23125.
UCSCi uc002gag.2. human. [O94983-4 ]
uc002gah.2. human. [O94983-1 ]
uc002gai.2. human. [O94983-3 ]

Organism-specific databases

CTDi 23125.
GeneCardsi GC17M004871.
HGNCi HGNC:18807. CAMTA2.
HPAi HPA051147.
MIMi 611508. gene.
neXtProti NX_O94983.
PharmGKBi PA38689.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294285.
HOVERGENi HBG058078.
InParanoidi O94983.
OMAi VAENSHH.
OrthoDBi EOG74R1PX.
PhylomeDBi O94983.
TreeFami TF323452.

Miscellaneous databases

ChiTaRSi CAMTA2. human.
GenomeRNAii 23125.
NextBioi 44355.
PROi O94983.
SOURCEi Search...

Gene expression databases

ArrayExpressi O94983.
Bgeei O94983.
CleanExi HS_CAMTA2.
Genevestigatori O94983.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view ]
Pfami PF03859. CG-1. 1 hit.
PF00612. IQ. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view ]
SMARTi SM01076. CG-1. 1 hit.
SM00015. IQ. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PRO-267 AND PRO-903.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANTS PRO-267 AND PRO-903.
    Tissue: Amygdala and Brain.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-267.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 485-1202 (ISOFORM 2).
    Tissue: Eye and Placenta.
  6. "A novel family of calmodulin-binding transcription activators in multicellular organisms."
    Bouche N., Scharlat A., Snedden W., Bouchez D., Fromm H.
    J. Biol. Chem. 277:21851-21861(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBUNIT, SUBCELLULAR LOCATION.
  7. "Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells."
    Nakatani K., Nishioka J., Itakura T., Nakanishi Y., Horinouchi J., Abe Y., Wada H., Nobori T.
    Int. J. Oncol. 24:1407-1412(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCMTA2_HUMAN
AccessioniPrimary (citable) accession number: O94983
Secondary accession number(s): B9EGL0
, D3DTL5, E7EWU5, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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