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O94983 (CMTA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calmodulin-binding transcription activator 2
Gene names
Name:CAMTA2
Synonyms:KIAA0909
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1202 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription activator. May act as tumor suppressor. Ref.6

Subunit structure

May interact with calmodulin Potential. Ref.6

Subcellular location

Nucleus Probable Ref.6.

Tissue specificity

Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines. Ref.6 Ref.7

Sequence similarities

Belongs to the CAMTA family.

Contains 3 ANK repeats.

Contains 1 CG-1 DNA-binding domain.

Contains 1 IPT/TIG domain.

Contains 2 IQ domains.

Sequence caution

The sequence AAH16163.1 differs from that shown. Reason: Frameshift at position 865.

The sequence BAA74932.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Nkx2-5P425822EBI-936534,EBI-297021From a different organism.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O94983-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O94983-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1094: Missing.
Isoform 3 (identifier: O94983-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MNTKDTTEVA → MAAAAVTRGTPG
     1088-1094: Missing.
Isoform 4 (identifier: O94983-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     114-137: Missing.
Isoform 5 (identifier: O94983-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-873: Missing.
Isoform 6 (identifier: O94983-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     1158-1202: GSFLTKKQDQ...EGLPQPGLAT → LLSHQEAGPG...SPPWGRLVQS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12021202Calmodulin-binding transcription activator 2
PRO_0000235821

Regions

Domain535 – 61783IPT/TIG
Repeat712 – 74534ANK 1
Repeat757 – 78731ANK 2
Repeat791 – 82131ANK 3
Domain1049 – 107830IQ 1
Domain1102 – 113130IQ 2
DNA binding30 – 155126CG-1
Motif79 – 868Nuclear localization signal Potential
Compositional bias289 – 30012Ser-rich

Natural variations

Alternative sequence1 – 873873Missing in isoform 5.
VSP_018489
Alternative sequence1 – 1010MNTKDTTEVA → MAAAAVTRGTPG in isoform 3.
VSP_018490
Alternative sequence11M → MGTDSPSPRPLRPGVTLPPG ALTM in isoform 4 and isoform 6.
VSP_018491
Alternative sequence114 – 13724Missing in isoform 4.
VSP_018492
Alternative sequence1088 – 10947Missing in isoform 2 and isoform 3.
VSP_018493
Alternative sequence1158 – 120245GSFLT…PGLAT → LLSHQEAGPGSPEDHEIPAA LPTQDEGTEAEPGAGRASPA GTGHMTWPPPFSPPWGRLVQ S in isoform 6.
VSP_046059
Natural variant2671A → P. Ref.1 Ref.2 Ref.4
Corresponds to variant rs238234 [ dbSNP | Ensembl ].
VAR_026417
Natural variant9031S → P. Ref.1 Ref.2
Corresponds to variant rs16942615 [ dbSNP | Ensembl ].
VAR_026418

Experimental info

Sequence conflict1401D → G in CAD38818. Ref.2
Sequence conflict6821A → V in CAD38818. Ref.2
Sequence conflict6881V → L in CAD38818. Ref.2
Sequence conflict7881S → P in CAD38818. Ref.2
Sequence conflict11751F → S in CAD38818. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2007. Version 3.
Checksum: 09E17E4E240F4A58

FASTA1,202131,530
        10         20         30         40         50         60 
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY LITFEKHDEW 

        70         80         90        100        110        120 
LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT REDHMKLKVQ GMECLYGCYV 

       130        140        150        160        170        180 
HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP ALEDCGKGCS PIFCSISSDR REWLKWSREE 

       190        200        210        220        230        240 
LLGQLKPMFH GIKWSCGNGT EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH 

       250        260        270        280        290        300 
KCSSTKHRII SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG 

       310        320        330        340        350        360 
FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP RPSMSLAVVV 

       370        380        390        400        410        420 
GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF PEAEAAHTPC SALEPAAALE 

       430        440        450        460        470        480 
PQAAARGPPP QSVAGGRRGN CFFIQDDDSG EELKGHGAAP PIPSPPPSPP PSPAPLEPSS 

       490        500        510        520        530        540 
RVGRGEALFG GPVGASELEP FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP 

       550        560        570        580        590        600 
EWSYPEGGVK VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA 

       610        620        630        640        650        660 
GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK RMAEIAAAGQ 

       670        680        690        700        710        720 
VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP ERLAHGSPFR GMSLLHLAAA 

       730        740        750        760        770        780 
QGYARLIETL SQWRSVETGS LDLEQEVDPL NVDHFSCTPL MWACALGHLE AAVLLFRWNR 

       790        800        810        820        830        840 
QALSIPDSLG RLPLSVAHSR GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS 

       850        860        870        880        890        900 
SPSELSDGTF SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA 

       910        920        930        940        950        960 
TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT PERIKREDFV 

       970        980        990       1000       1010       1020 
GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP PSELPFERGR LAVPSAPSWA 

      1030       1040       1050       1060       1070       1080 
EFLSASTSGK MESDFALLTL SDHEQRELYE AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR 

      1090       1100       1110       1120       1130       1140 
CYRKYKQLTW IALKFALYKK MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR 

      1150       1160       1170       1180       1190       1200 
RPGPPHRTSA TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL 


AT 

« Hide

Isoform 2 [UniParc].

Checksum: E172544E3C189739
Show »

FASTA1,195130,704
Isoform 3 [UniParc].

Checksum: A256178E19EC9555
Show »

FASTA1,197130,697
Isoform 4 [UniParc].

Checksum: C3CB80558CE61B4E
Show »

FASTA1,201130,902
Isoform 5 [UniParc].

Checksum: 69FDCB63AF1DD38F
Show »

FASTA32937,129
Isoform 6 [UniParc].

Checksum: 0E19A0F98947BB34
Show »

FASTA1,241134,800

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PRO-267 AND PRO-903.
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANTS PRO-267 AND PRO-903.
Tissue: Amygdala and Brain.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-267.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 485-1202 (ISOFORM 2).
Tissue: Eye and Placenta.
[6]"A novel family of calmodulin-binding transcription activators in multicellular organisms."
Bouche N., Scharlat A., Snedden W., Bouchez D., Fromm H.
J. Biol. Chem. 277:21851-21861(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, SUBUNIT, SUBCELLULAR LOCATION.
[7]"Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells."
Nakatani K., Nishioka J., Itakura T., Nakanishi Y., Horinouchi J., Abe Y., Wada H., Nobori T.
Int. J. Oncol. 24:1407-1412(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB020716 mRNA. Translation: BAA74932.1. Different initiation.
AL833974 mRNA. Translation: CAD38818.2.
AL831849 mRNA. Translation: CAD38553.1.
AC004771 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90372.1.
CH471108 Genomic DNA. Translation: EAW90373.1.
BC010050 mRNA. Translation: AAH10050.2.
BC016163 mRNA. Translation: AAH16163.1. Frameshift.
BC136534 mRNA. Translation: AAI36535.1.
BC142606 mRNA. No translation available.
CCDSCCDS11063.1. [O94983-1]
CCDS54071.1. [O94983-4]
CCDS54072.1. [O94983-6]
CCDS54073.1. [O94983-3]
RefSeqNP_001164637.1. NM_001171166.1. [O94983-3]
NP_001164638.1. NM_001171167.1. [O94983-6]
NP_001164639.1. NM_001171168.1. [O94983-4]
NP_055914.2. NM_015099.3. [O94983-1]
XP_006721543.1. XM_006721480.1. [O94983-2]
UniGeneHs.632242.

3D structure databases

ProteinModelPortalO94983.
SMRO94983. Positions 535-616, 709-810, 1111-1141.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116744. 2 interactions.
IntActO94983. 3 interactions.
STRING9606.ENSP00000321813.

PTM databases

PhosphoSiteO94983.

Proteomic databases

PaxDbO94983.
PRIDEO94983.

Protocols and materials databases

DNASU23125.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000348066; ENSP00000321813; ENSG00000108509. [O94983-1]
ENST00000358183; ENSP00000350910; ENSG00000108509. [O94983-2]
ENST00000361571; ENSP00000354828; ENSG00000108509. [O94983-4]
ENST00000381311; ENSP00000370712; ENSG00000108509. [O94983-3]
ENST00000414043; ENSP00000412886; ENSG00000108509. [O94983-6]
GeneID23125.
KEGGhsa:23125.
UCSCuc002gag.2. human. [O94983-4]
uc002gah.2. human. [O94983-1]
uc002gai.2. human. [O94983-3]

Organism-specific databases

CTD23125.
GeneCardsGC17M004871.
HGNCHGNC:18807. CAMTA2.
HPAHPA051147.
MIM611508. gene.
neXtProtNX_O94983.
PharmGKBPA38689.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG294285.
HOVERGENHBG058078.
InParanoidO94983.
OMAVAENSHH.
OrthoDBEOG74R1PX.
PhylomeDBO94983.
TreeFamTF323452.

Gene expression databases

ArrayExpressO94983.
BgeeO94983.
CleanExHS_CAMTA2.
GenevestigatorO94983.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamPF03859. CG-1. 1 hit.
PF00612. IQ. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTSM01076. CG-1. 1 hit.
SM00015. IQ. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCAMTA2. human.
GenomeRNAi23125.
NextBio44355.
PROO94983.
SOURCESearch...

Entry information

Entry nameCMTA2_HUMAN
AccessionPrimary (citable) accession number: O94983
Secondary accession number(s): B9EGL0 expand/collapse secondary AC list , D3DTL5, E7EWU5, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM