O94983 (CMTA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calmodulin-binding transcription activator 2

Gene names

Name:	CAMTA2
Synonyms:	KIAA0909

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1202 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription activator. May act as tumor suppressor. Ref.6
Subunit structure	May interact with calmodulin Potential. Ref.6
Subcellular location	Nucleus Probable Ref.6.
Tissue specificity	Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines. Ref.6 Ref.7
Sequence similarities	Belongs to the CAMTA family. Contains 3 ANK repeats. Contains 1 CG-1 DNA-binding domain. Contains 1 IPT/TIG domain. Contains 2 IQ domains.
Sequence caution	The sequence AAH16163.1 differs from that shown. Reason: Frameshift at position 865. The sequence BAA74932.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac muscle hypertrophy in response to stress Inferred from direct assay PubMed 16678093. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 16678093. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 16678093. Source: MGI
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro chromatin binding Inferred from direct assay PubMed 16678093. Source: MGI histone deacetylase binding Inferred from direct assay PubMed 16678093. Source: MGI transcription factor binding Inferred from genetic interaction PubMed 16678093. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Nkx2-5	P42582	2	EBI-936534,EBI-297021	From a different organism.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94983-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94983-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1094: Missing.

Isoform 3 (identifier: O94983-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MNTKDTTEVA → MAAAAVTRGTPG
     1088-1094: Missing.

Isoform 4 (identifier: O94983-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     114-137: Missing.

Isoform 5 (identifier: O94983-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-873: Missing.

Isoform 6 (identifier: O94983-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGTDSPSPRPLRPGVTLPPGALTM
     1158-1202: GSFLTKKQDQ...EGLPQPGLAT → LLSHQEAGPG...SPPWGRLVQS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1202	1202	Calmodulin-binding transcription activator 2		PRO_0000235821
Regions
	Domain	535 – 617	83	IPT/TIG
	Repeat	712 – 745	34	ANK 1
	Repeat	757 – 787	31	ANK 2
	Repeat	791 – 821	31	ANK 3
	Domain	1049 – 1078	30	IQ 1
	Domain	1102 – 1131	30	IQ 2
	DNA binding	30 – 155	126	CG-1
	Motif	79 – 86	8	Nuclear localization signal Potential
	Compositional bias	289 – 300	12	Ser-rich
Natural variations
	Alternative sequence	1 – 873	873	Missing in isoform 5.		VSP_018489
	Alternative sequence	1 – 10	10	MNTKDTTEVA → MAAAAVTRGTPG in isoform 3.		VSP_018490
	Alternative sequence	1	1	M → MGTDSPSPRPLRPGVTLPPG ALTM in isoform 4 and isoform 6.		VSP_018491
	Alternative sequence	114 – 137	24	Missing in isoform 4.		VSP_018492
	Alternative sequence	1088 – 1094	7	Missing in isoform 2 and isoform 3.		VSP_018493
	Alternative sequence	1158 – 1202	45	GSFLT…PGLAT → LLSHQEAGPGSPEDHEIPAA LPTQDEGTEAEPGAGRASPA GTGHMTWPPPFSPPWGRLVQ S in isoform 6.		VSP_046059
	Natural variant	267	1	A → P. Ref.1 Ref.2 Ref.4 Corresponds to variant rs238234 [ dbSNP | Ensembl ].		VAR_026417
	Natural variant	903	1	S → P. Ref.1 Ref.2 Corresponds to variant rs16942615 [ dbSNP | Ensembl ].		VAR_026418
Experimental info
	Sequence conflict	140	1	D → G in CAD38818. Ref.2
	Sequence conflict	682	1	A → V in CAD38818. Ref.2
	Sequence conflict	688	1	V → L in CAD38818. Ref.2
	Sequence conflict	788	1	S → P in CAD38818. Ref.2
	Sequence conflict	1175	1	F → S in CAD38818. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2007. Version 3. Checksum: 09E17E4E240F4A58	FASTA	1,202	131,530
	10 20 30 40 50 60 MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY LITFEKHDEW 70 80 90 100 110 120 LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT REDHMKLKVQ GMECLYGCYV 130 140 150 160 170 180 HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP ALEDCGKGCS PIFCSISSDR REWLKWSREE 190 200 210 220 230 240 LLGQLKPMFH GIKWSCGNGT EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH 250 260 270 280 290 300 KCSSTKHRII SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG 310 320 330 340 350 360 FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP RPSMSLAVVV 370 380 390 400 410 420 GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF PEAEAAHTPC SALEPAAALE 430 440 450 460 470 480 PQAAARGPPP QSVAGGRRGN CFFIQDDDSG EELKGHGAAP PIPSPPPSPP PSPAPLEPSS 490 500 510 520 530 540 RVGRGEALFG GPVGASELEP FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP 550 560 570 580 590 600 EWSYPEGGVK VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA 610 620 630 640 650 660 GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK RMAEIAAAGQ 670 680 690 700 710 720 VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP ERLAHGSPFR GMSLLHLAAA 730 740 750 760 770 780 QGYARLIETL SQWRSVETGS LDLEQEVDPL NVDHFSCTPL MWACALGHLE AAVLLFRWNR 790 800 810 820 830 840 QALSIPDSLG RLPLSVAHSR GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS 850 860 870 880 890 900 SPSELSDGTF SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA 910 920 930 940 950 960 TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT PERIKREDFV 970 980 990 1000 1010 1020 GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP PSELPFERGR LAVPSAPSWA 1030 1040 1050 1060 1070 1080 EFLSASTSGK MESDFALLTL SDHEQRELYE AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR 1090 1100 1110 1120 1130 1140 CYRKYKQLTW IALKFALYKK MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR 1150 1160 1170 1180 1190 1200 RPGPPHRTSA TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL AT
	Isoform 2 [UniParc]. Checksum: E172544E3C189739	FASTA	1,195	130,704
	10 20 30 40 50 60 MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY LITFEKHDEW 70 80 90 100 110 120 LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT REDHMKLKVQ GMECLYGCYV 130 140 150 160 170 180 HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP ALEDCGKGCS PIFCSISSDR REWLKWSREE 190 200 210 220 230 240 LLGQLKPMFH GIKWSCGNGT EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH 250 260 270 280 290 300 KCSSTKHRII SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG 310 320 330 340 350 360 FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP RPSMSLAVVV 370 380 390 400 410 420 GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF PEAEAAHTPC SALEPAAALE 430 440 450 460 470 480 PQAAARGPPP QSVAGGRRGN CFFIQDDDSG EELKGHGAAP PIPSPPPSPP PSPAPLEPSS 490 500 510 520 530 540 RVGRGEALFG GPVGASELEP FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP 550 560 570 580 590 600 EWSYPEGGVK VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA 610 620 630 640 650 660 GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK RMAEIAAAGQ 670 680 690 700 710 720 VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP ERLAHGSPFR GMSLLHLAAA 730 740 750 760 770 780 QGYARLIETL SQWRSVETGS LDLEQEVDPL NVDHFSCTPL MWACALGHLE AAVLLFRWNR 790 800 810 820 830 840 QALSIPDSLG RLPLSVAHSR GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS 850 860 870 880 890 900 SPSELSDGTF SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA 910 920 930 940 950 960 TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT PERIKREDFV 970 980 990 1000 1010 1020 GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP PSELPFERGR LAVPSAPSWA 1030 1040 1050 1060 1070 1080 EFLSASTSGK MESDFALLTL SDHEQRELYE AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR 1090 1100 1110 1120 1130 1140 CYRKYKQFAL YKKMTQAAIL IQSKFRSYYE QKRFQQSRRA AVLIQQHYRS YRRRPGPPHR 1150 1160 1170 1180 1190 TSATLPARNK GSFLTKKQDQ AARKIMRFLR RCRHRMRELK QNQELEGLPQ PGLAT
	Isoform 3 [UniParc]. Checksum: A256178E19EC9555	FASTA	1,197	130,697
	10 20 30 40 50 60 MAAAAVTRGT PGENSHHLKI FLPKKLLECL PRCPLLPPER LRWNTNEEIA SYLITFEKHD 70 80 90 100 110 120 EWLSCAPKTR PQNGSIILYN RKKVKYRKDG YLWKKRKDGK TTREDHMKLK VQGMECLYGC 130 140 150 160 170 180 YVHSSIVPTF HRRCYWLLQN PDIVLVHYLN VPALEDCGKG CSPIFCSISS DRREWLKWSR 190 200 210 220 230 240 EELLGQLKPM FHGIKWSCGN GTEEFSVEHL VQQILDTHPT KPAPRTHACL CSGGLGSGSL 250 260 270 280 290 300 THKCSSTKHR IISPKVEPRA LTLTSIPHAH PPEPPPLIAP LPPELPKAHT SPSSSSSSSS 310 320 330 340 350 360 SGFAEPLEIR PSPPTSRGGS SRGGTAILLL TGLEQRAGGL TPTRHLAPQA DPRPSMSLAV 370 380 390 400 410 420 VVGTEPSAPP APPSPAFDPD RFLNSPQRGQ TYGGGQGVSP DFPEAEAAHT PCSALEPAAA 430 440 450 460 470 480 LEPQAAARGP PPQSVAGGRR GNCFFIQDDD SGEELKGHGA APPIPSPPPS PPPSPAPLEP 490 500 510 520 530 540 SSRVGRGEAL FGGPVGASEL EPFSLSSFPD LMGELISDEA PSIPAPTPQL SPALSTITDF 550 560 570 580 590 600 SPEWSYPEGG VKVLITGPWT EAAEHYSCVF DHIAVPASLV QPGVLRCYCP AHEVGLVSLQ 610 620 630 640 650 660 VAGREGPLSA SVLFEYRARR FLSLPSTQLD WLSLDDNQFR MSILERLEQM EKRMAEIAAA 670 680 690 700 710 720 GQVPCQGPDA PPVQDEGQGP GFEARVVVLV ESMIPRSTWK GPERLAHGSP FRGMSLLHLA 730 740 750 760 770 780 AAQGYARLIE TLSQWRSVET GSLDLEQEVD PLNVDHFSCT PLMWACALGH LEAAVLLFRW 790 800 810 820 830 840 NRQALSIPDS LGRLPLSVAH SRGHVRLARC LEELQRQEPS VEPPFALSPP SSSPDTGLSS 850 860 870 880 890 900 VSSPSELSDG TFSVTSAYSS APDGSPPPAP LPASEMTMED MAPGQLSSGV PEAPLLLMDY 910 920 930 940 950 960 EATNSKGPLS SLPALPPASD DGAAPEDADS PQAVDVIPVD MISLAKQIIE ATPERIKRED 970 980 990 1000 1010 1020 FVGLPEAGAS MRERTGAVGL SETMSWLASY LENVDHFPSS TPPSELPFER GRLAVPSAPS 1030 1040 1050 1060 1070 1080 WAEFLSASTS GKMESDFALL TLSDHEQREL YEAARVIQTA FRKYKGRRLK EQQEVAAAVI 1090 1100 1110 1120 1130 1140 QRCYRKYKQF ALYKKMTQAA ILIQSKFRSY YEQKRFQQSR RAAVLIQQHY RSYRRRPGPP 1150 1160 1170 1180 1190 HRTSATLPAR NKGSFLTKKQ DQAARKIMRF LRRCRHRMRE LKQNQELEGL PQPGLAT
	Isoform 4 [UniParc]. Checksum: C3CB80558CE61B4E	FASTA	1,201	130,902
	10 20 30 40 50 60 MGTDSPSPRP LRPGVTLPPG ALTMNTKDTT EVAENSHHLK IFLPKKLLEC LPRCPLLPPE 70 80 90 100 110 120 RLRWNTNEEI ASYLITFEKH DEWLSCAPKT RPQNGSIILY NRKKVKYRKD GYLWKKRKDG 130 140 150 160 170 180 KTTREDHMKL KVQGMENPDI VLVHYLNVPA LEDCGKGCSP IFCSISSDRR EWLKWSREEL 190 200 210 220 230 240 LGQLKPMFHG IKWSCGNGTE EFSVEHLVQQ ILDTHPTKPA PRTHACLCSG GLGSGSLTHK 250 260 270 280 290 300 CSSTKHRIIS PKVEPRALTL TSIPHAHPPE PPPLIAPLPP ELPKAHTSPS SSSSSSSSGF 310 320 330 340 350 360 AEPLEIRPSP PTSRGGSSRG GTAILLLTGL EQRAGGLTPT RHLAPQADPR PSMSLAVVVG 370 380 390 400 410 420 TEPSAPPAPP SPAFDPDRFL NSPQRGQTYG GGQGVSPDFP EAEAAHTPCS ALEPAAALEP 430 440 450 460 470 480 QAAARGPPPQ SVAGGRRGNC FFIQDDDSGE ELKGHGAAPP IPSPPPSPPP SPAPLEPSSR 490 500 510 520 530 540 VGRGEALFGG PVGASELEPF SLSSFPDLMG ELISDEAPSI PAPTPQLSPA LSTITDFSPE 550 560 570 580 590 600 WSYPEGGVKV LITGPWTEAA EHYSCVFDHI AVPASLVQPG VLRCYCPAHE VGLVSLQVAG 610 620 630 640 650 660 REGPLSASVL FEYRARRFLS LPSTQLDWLS LDDNQFRMSI LERLEQMEKR MAEIAAAGQV 670 680 690 700 710 720 PCQGPDAPPV QDEGQGPGFE ARVVVLVESM IPRSTWKGPE RLAHGSPFRG MSLLHLAAAQ 730 740 750 760 770 780 GYARLIETLS QWRSVETGSL DLEQEVDPLN VDHFSCTPLM WACALGHLEA AVLLFRWNRQ 790 800 810 820 830 840 ALSIPDSLGR LPLSVAHSRG HVRLARCLEE LQRQEPSVEP PFALSPPSSS PDTGLSSVSS 850 860 870 880 890 900 PSELSDGTFS VTSAYSSAPD GSPPPAPLPA SEMTMEDMAP GQLSSGVPEA PLLLMDYEAT 910 920 930 940 950 960 NSKGPLSSLP ALPPASDDGA APEDADSPQA VDVIPVDMIS LAKQIIEATP ERIKREDFVG 970 980 990 1000 1010 1020 LPEAGASMRE RTGAVGLSET MSWLASYLEN VDHFPSSTPP SELPFERGRL AVPSAPSWAE 1030 1040 1050 1060 1070 1080 FLSASTSGKM ESDFALLTLS DHEQRELYEA ARVIQTAFRK YKGRRLKEQQ EVAAAVIQRC 1090 1100 1110 1120 1130 1140 YRKYKQLTWI ALKFALYKKM TQAAILIQSK FRSYYEQKRF QQSRRAAVLI QQHYRSYRRR 1150 1160 1170 1180 1190 1200 PGPPHRTSAT LPARNKGSFL TKKQDQAARK IMRFLRRCRH RMRELKQNQE LEGLPQPGLA T
	Isoform 5 [UniParc]. Checksum: 69FDCB63AF1DD38F	FASTA	329	37,129
	10 20 30 40 50 60 MTMEDMAPGQ LSSGVPEAPL LLMDYEATNS KGPLSSLPAL PPASDDGAAP EDADSPQAVD 70 80 90 100 110 120 VIPVDMISLA KQIIEATPER IKREDFVGLP EAGASMRERT GAVGLSETMS WLASYLENVD 130 140 150 160 170 180 HFPSSTPPSE LPFERGRLAV PSAPSWAEFL SASTSGKMES DFALLTLSDH EQRELYEAAR 190 200 210 220 230 240 VIQTAFRKYK GRRLKEQQEV AAAVIQRCYR KYKQLTWIAL KFALYKKMTQ AAILIQSKFR 250 260 270 280 290 300 SYYEQKRFQQ SRRAAVLIQQ HYRSYRRRPG PPHRTSATLP ARNKGSFLTK KQDQAARKIM 310 320 RFLRRCRHRM RELKQNQELE GLPQPGLAT
	Isoform 6 [UniParc]. Checksum: 0E19A0F98947BB34	FASTA	1,241	134,800
	10 20 30 40 50 60 MGTDSPSPRP LRPGVTLPPG ALTMNTKDTT EVAENSHHLK IFLPKKLLEC LPRCPLLPPE 70 80 90 100 110 120 RLRWNTNEEI ASYLITFEKH DEWLSCAPKT RPQNGSIILY NRKKVKYRKD GYLWKKRKDG 130 140 150 160 170 180 KTTREDHMKL KVQGMECLYG CYVHSSIVPT FHRRCYWLLQ NPDIVLVHYL NVPALEDCGK 190 200 210 220 230 240 GCSPIFCSIS SDRREWLKWS REELLGQLKP MFHGIKWSCG NGTEEFSVEH LVQQILDTHP 250 260 270 280 290 300 TKPAPRTHAC LCSGGLGSGS LTHKCSSTKH RIISPKVEPR ALTLTSIPHA HPPEPPPLIA 310 320 330 340 350 360 PLPPELPKAH TSPSSSSSSS SSGFAEPLEI RPSPPTSRGG SSRGGTAILL LTGLEQRAGG 370 380 390 400 410 420 LTPTRHLAPQ ADPRPSMSLA VVVGTEPSAP PAPPSPAFDP DRFLNSPQRG QTYGGGQGVS 430 440 450 460 470 480 PDFPEAEAAH TPCSALEPAA ALEPQAAARG PPPQSVAGGR RGNCFFIQDD DSGEELKGHG 490 500 510 520 530 540 AAPPIPSPPP SPPPSPAPLE PSSRVGRGEA LFGGPVGASE LEPFSLSSFP DLMGELISDE 550 560 570 580 590 600 APSIPAPTPQ LSPALSTITD FSPEWSYPEG GVKVLITGPW TEAAEHYSCV FDHIAVPASL 610 620 630 640 650 660 VQPGVLRCYC PAHEVGLVSL QVAGREGPLS ASVLFEYRAR RFLSLPSTQL DWLSLDDNQF 670 680 690 700 710 720 RMSILERLEQ MEKRMAEIAA AGQVPCQGPD APPVQDEGQG PGFEARVVVL VESMIPRSTW 730 740 750 760 770 780 KGPERLAHGS PFRGMSLLHL AAAQGYARLI ETLSQWRSVE TGSLDLEQEV DPLNVDHFSC 790 800 810 820 830 840 TPLMWACALG HLEAAVLLFR WNRQALSIPD SLGRLPLSVA HSRGHVRLAR CLEELQRQEP 850 860 870 880 890 900 SVEPPFALSP PSSSPDTGLS SVSSPSELSD GTFSVTSAYS SAPDGSPPPA PLPASEMTME 910 920 930 940 950 960 DMAPGQLSSG VPEAPLLLMD YEATNSKGPL SSLPALPPAS DDGAAPEDAD SPQAVDVIPV 970 980 990 1000 1010 1020 DMISLAKQII EATPERIKRE DFVGLPEAGA SMRERTGAVG LSETMSWLAS YLENVDHFPS 1030 1040 1050 1060 1070 1080 STPPSELPFE RGRLAVPSAP SWAEFLSAST SGKMESDFAL LTLSDHEQRE LYEAARVIQT 1090 1100 1110 1120 1130 1140 AFRKYKGRRL KEQQEVAAAV IQRCYRKYKQ LTWIALKFAL YKKMTQAAIL IQSKFRSYYE 1150 1160 1170 1180 1190 1200 QKRFQQSRRA AVLIQQHYRS YRRRPGPPHR TSATLPARNK LLSHQEAGPG SPEDHEIPAA 1210 1220 1230 1240 LPTQDEGTEA EPGAGRASPA GTGHMTWPPP FSPPWGRLVQ S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PRO-267 AND PRO-903. Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANTS PRO-267 AND PRO-903. Tissue: Amygdala and Brain.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-267.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 485-1202 (ISOFORM 2). Tissue: Eye and Placenta.
[6]	"A novel family of calmodulin-binding transcription activators in multicellular organisms." Bouche N., Scharlat A., Snedden W., Bouchez D., Fromm H. J. Biol. Chem. 277:21851-21861(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, SUBUNIT, SUBCELLULAR LOCATION.
[7]	"Cell cycle-dependent transcriptional regulation of calmodulin-binding transcription activator 1 in neuroblastoma cells." Nakatani K., Nishioka J., Itakura T., Nakanishi Y., Horinouchi J., Abe Y., Wada H., Nobori T. Int. J. Oncol. 24:1407-1412(2004) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB020716 mRNA. Translation: BAA74932.1. Different initiation. AL833974 mRNA. Translation: CAD38818.2. AL831849 mRNA. Translation: CAD38553.1. AC004771 Genomic DNA. No translation available. CH471108 Genomic DNA. Translation: EAW90372.1. CH471108 Genomic DNA. Translation: EAW90373.1. BC010050 mRNA. Translation: AAH10050.2. BC016163 mRNA. Translation: AAH16163.1. Frameshift. BC136534 mRNA. Translation: AAI36535.1. BC142606 mRNA. No translation available.
IPI	IPI00183704. IPI00478847. IPI00744658. IPI00744877. IPI00747254. IPI00954863.
RefSeq	NP_001164637.1. NM_001171166.1. NP_001164638.1. NM_001171167.1. NP_001164639.1. NM_001171168.1. NP_055914.2. NM_015099.3.
UniGene	Hs.632242.
3D structure databases
ProteinModelPortal	O94983.
ModBase	Search...
Protein-protein interaction databases
IntAct	O94983. 3 interactions.
STRING	9606.ENSP00000321813.
PTM databases
PhosphoSite	O94983.
Proteomic databases
PaxDb	O94983.
PRIDE	O94983.
Protocols and materials databases
DNASU	23125.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000348066; ENSP00000321813; ENSG00000108509. ENST00000358183; ENSP00000350910; ENSG00000108509. ENST00000361571; ENSP00000354828; ENSG00000108509. ENST00000381311; ENSP00000370712; ENSG00000108509. ENST00000414043; ENSP00000412886; ENSG00000108509.
GeneID	23125.
KEGG	hsa:23125.
UCSC	uc002gag.2. human. uc002gah.2. human. uc002gai.2. human. uc010cku.2. human.
Organism-specific databases
CTD	23125.
GeneCards	GC17M004871.
HGNC	HGNC:18807. CAMTA2.
MIM	611508. gene.
neXtProt	NX_O94983.
PharmGKB	PA38689.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG294285.
HOVERGEN	HBG058078.
InParanoid	O94983.
OrthoDB	EOG4J9MZ4.
Gene expression databases
ArrayExpress	O94983.
Bgee	O94983.
CleanEx	HS_CAMTA2.
Genevestigator	O94983.
GermOnline	ENSG00000108509. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR020683. Ankyrin_rpt-contain_dom. IPR005559. CG-1_dom. IPR014756. Ig_E-set. IPR002909. IPT_TIG_rcpt. IPR000048. IQ_motif_EF-hand-BS. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF03859. CG-1. 1 hit. PF00612. IQ. 1 hit. PF01833. TIG. 1 hit. [Graphical view]
SMART	SM01076. CG-1. 1 hit. SM00015. IQ. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF81296. Ig_E-set. 1 hit. SSF52540. SSF52540. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. False negative. PS51437. CG_1. 1 hit. PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CAMTA2. human.
GenomeRNAi	23125.
NextBio	44355.
SOURCE	Search...

Entry information

Entry name

CMTA2_HUMAN

Accession

Primary (citable) accession number: O94983
Secondary accession number(s): B9EGL0 , D3DTL5, E7EWU5, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	February 6, 2007
Last modified:	May 29, 2013
This is version 106 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.