O94979 (SC31A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein transport protein Sec31A

Alternative name(s):
ABP125
ABP130
SEC31-like protein 1
SEC31-related protein A
Web1-like protein

Gene names

Name:	SEC31A
Synonyms:	KIAA0905, SEC31L1
ORF Names:	HSPC275, HSPC334

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1220 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules By similarity. Ref.1
Subunit structure	COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 By similarity. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12. Ref.14 Ref.16 Ref.22
Subcellular location	Cytoplasm By similarity. Cytoplasmic vesicle › COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Note: Associates with membranes in a GTP-dependent manner By similarity. Ref.1 Ref.14 Ref.22
Tissue specificity	Abundantly and ubiquitously expressed. Ref.1 Ref.12
Post-translational modification	Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.
Involvement in disease	A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.
Sequence similarities	Belongs to the WD repeat SEC31 family. Contains 8 WD repeats.
Sequence caution	The sequence AAF28953.1 differs from that shown. Reason: Frameshift at positions 857 and 1079. The sequence AAF29012.1 differs from that shown. Reason: Frameshift at positions 922, 946, 1029 and 1080. The sequence CAI45995.1 differs from that shown. Reason: Erroneous termination at position 221. Translated as Trp.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Cytoplasm Cytoplasmic vesicle Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Domain	Repeat WD repeat
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	COPII vesicle coating Traceable author statement. Source: Reactome ER to Golgi vesicle-mediated transport Non-traceable author statement Ref.1. Source: UniProtKB activation of signaling protein activity involved in unfolded protein response Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class II Traceable author statement. Source: Reactome antigen processing and presentation of peptide antigen via MHC class I Traceable author statement. Source: Reactome cellular protein metabolic process Traceable author statement. Source: Reactome endoplasmic reticulum unfolded protein response Traceable author statement. Source: Reactome membrane organization Traceable author statement. Source: Reactome post-translational protein modification Traceable author statement. Source: Reactome protein N-linked glycosylation via asparagine Traceable author statement. Source: Reactome protein transport Inferred from electronic annotation. Source: UniProtKB-KW response to calcium ion Inferred from direct assay Ref.16. Source: UniProtKB
Cellular_component	COPII vesicle coat Non-traceable author statement Ref.1. Source: UniProtKB ER to Golgi transport vesicle Inferred from direct assay Ref.22. Source: UniProtKB ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: GOC cytoplasm Inferred from direct assay Ref.16. Source: UniProtKB cytosol Traceable author statement. Source: Reactome endoplasmic reticulum Inferred from direct assay Ref.16. Source: UniProtKB endoplasmic reticulum membrane Traceable author statement. Source: Reactome intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA perinuclear region of cytoplasm Inferred from direct assay Ref.16. Source: UniProtKB vesicle coat Inferred from direct assay PubMed 22792322. Source: MGI
Molecular_function	calcium-dependent protein binding Inferred from physical interaction Ref.14Ref.16. Source: UniProtKB protein binding Inferred from physical interaction Ref.16PubMed 17214967PubMed 18256029. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PDCD6	O75340	6	EBI-1767898,EBI-352915

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94979-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94979-2)

The sequence of this isoform differs from the canonical sequence as follows:
     974-988: Missing.

Isoform 3 (identifier: O94979-3)

The sequence of this isoform differs from the canonical sequence as follows:
     876-876: P → R
     877-990: Missing.

Isoform 4 (identifier: O94979-4)

The sequence of this isoform differs from the canonical sequence as follows:
     504-542: Missing.

Isoform 5 (identifier: O94979-5)

The sequence of this isoform differs from the canonical sequence as follows:
     504-509: IALALN → VNFWES
     510-1220: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: O94979-6)

The sequence of this isoform differs from the canonical sequence as follows:
     504-542: Missing.
     876-876: P → R
     877-990: Missing.

Isoform 7 (identifier: O94979-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.
     229-260: MVLASEDDRLPVIQMWDLRFASSPLRVLENHA → MVKLVLLSIVLLKVTVPKLSNYLLQLDFMPIH
     504-542: Missing.
     834-834: H → HVRIAPTVTTWSNKTPTALPSHPPAASPSDTQ
     974-988: Missing.

Note: No experimental confirmation available.

Isoform 8 (identifier: O94979-8)

The sequence of this isoform differs from the canonical sequence as follows:
     989-989: T → TENQSIQDQAPMLE

Isoform 9 (identifier: O94979-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MKLKEVDRTAMQAWSPAQNHPIYLAT → MLGESDERCTNAGSGCRRSSP
     974-988: Missing.

Note: No experimental confirmation available.

Isoform 10 (identifier: O94979-10)

The sequence of this isoform differs from the canonical sequence as follows:
     504-542: Missing.
     974-988: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1220	1220	Protein transport protein Sec31A		PRO_0000295147
Regions
	Repeat	4 – 47	44	WD 1
	Repeat	68 – 111	44	WD 2
	Repeat	120 – 160	41	WD 3
	Repeat	166 – 206	41	WD 4
	Repeat	209 – 254	46	WD 5
	Repeat	258 – 298	41	WD 6
	Repeat	301 – 342	42	WD 7
	Repeat	397 – 430	34	WD 8; interaction with SEC13 By similarity
	Region	161 – 471	311	Interaction with SEC13
	Region	800 – 1113	314	Interaction with PDCD6
	Compositional bias	800 – 1091	292	Pro-rich
Amino acid modifications
	Modified residue	527	1	Phosphoserine Ref.13 Ref.21
	Modified residue	532	1	Phosphoserine Ref.13
	Modified residue	799	1	Phosphoserine Ref.17 Ref.19 Ref.21
	Modified residue	1161	1	Phosphothreonine Ref.19
	Modified residue	1163	1	Phosphoserine Ref.17
	Cross-link	647		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.22
	Cross-link	1217		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.22
Natural variations
	Alternative sequence	1 – 228	228	Missing in isoform 7.		VSP_026742
	Alternative sequence	1 – 26	26	MKLKE…IYLAT → MLGESDERCTNAGSGCRRSS P in isoform 9.		VSP_044602
	Alternative sequence	229 – 260	32	MVLAS…LENHA → MVKLVLLSIVLLKVTVPKLS NYLLQLDFMPIH in isoform 7.		VSP_026743
	Alternative sequence	504 – 542	39	Missing in isoform 4, isoform 6, isoform 7 and isoform 10.		VSP_026744
	Alternative sequence	504 – 509	6	IALALN → VNFWES in isoform 5.		VSP_026745
	Alternative sequence	510 – 1220	711	Missing in isoform 5.		VSP_026746
	Alternative sequence	834	1	H → HVRIAPTVTTWSNKTPTALP SHPPAASPSDTQ in isoform 7.		VSP_026747
	Alternative sequence	876	1	P → R in isoform 3 and isoform 6.		VSP_026748
	Alternative sequence	877 – 990	114	Missing in isoform 3 and isoform 6.		VSP_026749
	Alternative sequence	974 – 988	15	Missing in isoform 2, isoform 7, isoform 9 and isoform 10.		VSP_026750
	Alternative sequence	989	1	T → TENQSIQDQAPMLE in isoform 8.		VSP_026751
	Natural variant	263	1	I → V. Corresponds to variant rs34554214 [ dbSNP | Ensembl ].		VAR_033225
	Natural variant	456	1	N → K. Corresponds to variant rs3797036 [ dbSNP | Ensembl ].		VAR_053414
	Natural variant	841	1	P → L. Corresponds to variant rs35579207 [ dbSNP | Ensembl ].		VAR_033226
	Natural variant	1055	1	P → T. Corresponds to variant rs35739017 [ dbSNP | Ensembl ].		VAR_033227
Experimental info
	Mutagenesis	647	1	K → R: Does not abolish monoubiquitination by the BCR(KLHL12) E3 ubiquitin ligase complex, revealing flexibility of ubiquitination sites; when associated with R-1217. Ref.22
	Mutagenesis	1217	1	K → R: Does not abolish monoubiquitination by the BCR(KLHL12) E3 ubiquitin ligase complex, revealing flexibility of ubiquitination sites; when associated with R-647. Ref.22
	Sequence conflict	200	1	K → E in BAA84923. Ref.2
	Sequence conflict	284	1	K → R in BAC86336. Ref.5
	Sequence conflict	854	1	A → S in BAA84923. Ref.2
	Sequence conflict	854	1	A → S in BAA84924. Ref.2
	Sequence conflict	1007	1	K → R in BAG58628. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 10, 2007. Version 3. Checksum: 2A633B4436DB7482	FASTA	1,220	133,015
	10 20 30 40 50 60 MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 70 80 90 100 110 120 ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQNDK 130 140 150 160 170 180 HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 190 200 210 220 230 240 QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 250 260 270 280 290 300 IQMWDLRFAS SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 310 320 330 340 350 360 TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS SSFGNLDPFG 370 380 390 400 410 420 TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFENV RMPSHQGAEQ 430 440 450 460 470 480 QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ SQGFINYCQK KIDASQTEFE KNVWSFLKVN 490 500 510 520 530 540 FEDDSRGKYL ELLGYRKEDL GKKIALALNK VDGANVALKD SDQVAQSDGE ESPAAEEQLL 550 560 570 580 590 600 GEHIKEEKEE SEFLPSSGGT FNISVSGDID GLITQALLTG NFESAVDLCL HDNRMADAII 610 620 630 640 650 660 LAIAGGQELL ARTQKKYFAK SQSKITRLIT AVVMKNWKEI VESCDLKNWR EALAAVLTYA 670 680 690 700 710 720 KPDEFSALCD LLGTRLENEG DSLLQTQACL CYICAGNVEK LVACWTKAQD GSHPLSLQDL 730 740 750 760 770 780 IEKVVILRKA VQLTQAMDTS TVGVLLAAKM SQYANLLAAQ GSIAAALAFL PDNTNQPNIM 790 800 810 820 830 840 QLRDRLCRAQ GEPVAGHESP KIPYEKQQLP KGRPGPVAGH HQMPRVQTQQ YYPHGENPPP 850 860 870 880 890 900 PGFIMHGNVN PNAAGQLPTS PGHMHTQVPP YPQPQPYQPA QPYPFGTGGS AMYRPQQPVA 910 920 930 940 950 960 PPTSNAYPNT PYISSASSYT GQSQLYAAQH QASSPTSSPA TSFPPPPSSG ASFQHGGPGA 970 980 990 1000 1010 1020 PPSSSAYALP PGTTGTLPAA SELPASQRTG PQNGWNDPPA LNRVPKKKKM PENFMPPVPI 1030 1040 1050 1060 1070 1080 TSPIMNPLGD PQSQMLQQQP SAPVPLSSQS SFPQPHLPGG QPFHGVQQPL GQTGMPPSFS 1090 1100 1110 1120 1130 1140 KPNIEGAPGA PIGNTFQHVQ SLPTKKITKK PIPDEHLILK TTFEDLIQRC LSSATDPQTK 1150 1160 1170 1180 1190 1200 RKLDDASKRL EFLYDKLREQ TLSPTITSGL HNIARSIETR NYSEGLTMHT HIVSTSNFSE 1210 1220 TSAFMPVLKV VLTQANKLGV
	Isoform 2 [UniParc]. Checksum: 245E11A9AD589F74	FASTA	1,205	131,534
	10 20 30 40 50 60 MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 70 80 90 100 110 120 ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQNDK 130 140 150 160 170 180 HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 190 200 210 220 230 240 QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 250 260 270 280 290 300 IQMWDLRFAS SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 310 320 330 340 350 360 TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS SSFGNLDPFG 370 380 390 400 410 420 TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFENV RMPSHQGAEQ 430 440 450 460 470 480 QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ SQGFINYCQK KIDASQTEFE KNVWSFLKVN 490 500 510 520 530 540 FEDDSRGKYL ELLGYRKEDL GKKIALALNK VDGANVALKD SDQVAQSDGE ESPAAEEQLL 550 560 570 580 590 600 GEHIKEEKEE SEFLPSSGGT FNISVSGDID GLITQALLTG NFESAVDLCL HDNRMADAII 610 620 630 640 650 660 LAIAGGQELL ARTQKKYFAK SQSKITRLIT AVVMKNWKEI VESCDLKNWR EALAAVLTYA 670 680 690 700 710 720 KPDEFSALCD LLGTRLENEG DSLLQTQACL CYICAGNVEK LVACWTKAQD GSHPLSLQDL 730 740 750 760 770 780 IEKVVILRKA VQLTQAMDTS TVGVLLAAKM SQYANLLAAQ GSIAAALAFL PDNTNQPNIM 790 800 810 820 830 840 QLRDRLCRAQ GEPVAGHESP KIPYEKQQLP KGRPGPVAGH HQMPRVQTQQ YYPHGENPPP 850 860 870 880 890 900 PGFIMHGNVN PNAAGQLPTS PGHMHTQVPP YPQPQPYQPA QPYPFGTGGS AMYRPQQPVA 910 920 930 940 950 960 PPTSNAYPNT PYISSASSYT GQSQLYAAQH QASSPTSSPA TSFPPPPSSG ASFQHGGPGA 970 980 990 1000 1010 1020 PPSSSAYALP PGTTGPQNGW NDPPALNRVP KKKKMPENFM PPVPITSPIM NPLGDPQSQM 1030 1040 1050 1060 1070 1080 LQQQPSAPVP LSSQSSFPQP HLPGGQPFHG VQQPLGQTGM PPSFSKPNIE GAPGAPIGNT 1090 1100 1110 1120 1130 1140 FQHVQSLPTK KITKKPIPDE HLILKTTFED LIQRCLSSAT DPQTKRKLDD ASKRLEFLYD 1150 1160 1170 1180 1190 1200 KLREQTLSPT ITSGLHNIAR SIETRNYSEG LTMHTHIVST SNFSETSAFM PVLKVVLTQA NKLGV
	Isoform 3 [UniParc]. Checksum: D21AB6B647E1291B	FASTA	1,106	121,651
	10 20 30 40 50 60 MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 70 80 90 100 110 120 ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQNDK 130 140 150 160 170 180 HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 190 200 210 220 230 240 QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 250 260 270 280 290 300 IQMWDLRFAS SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 310 320 330 340 350 360 TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS SSFGNLDPFG 370 380 390 400 410 420 TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFENV RMPSHQGAEQ 430 440 450 460 470 480 QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ SQGFINYCQK KIDASQTEFE KNVWSFLKVN 490 500 510 520 530 540 FEDDSRGKYL ELLGYRKEDL GKKIALALNK VDGANVALKD SDQVAQSDGE ESPAAEEQLL 550 560 570 580 590 600 GEHIKEEKEE SEFLPSSGGT FNISVSGDID GLITQALLTG NFESAVDLCL HDNRMADAII 610 620 630 640 650 660 LAIAGGQELL ARTQKKYFAK SQSKITRLIT AVVMKNWKEI VESCDLKNWR EALAAVLTYA 670 680 690 700 710 720 KPDEFSALCD LLGTRLENEG DSLLQTQACL CYICAGNVEK LVACWTKAQD GSHPLSLQDL 730 740 750 760 770 780 IEKVVILRKA VQLTQAMDTS TVGVLLAAKM SQYANLLAAQ GSIAAALAFL PDNTNQPNIM 790 800 810 820 830 840 QLRDRLCRAQ GEPVAGHESP KIPYEKQQLP KGRPGPVAGH HQMPRVQTQQ YYPHGENPPP 850 860 870 880 890 900 PGFIMHGNVN PNAAGQLPTS PGHMHTQVPP YPQPQRPQNG WNDPPALNRV PKKKKMPENF 910 920 930 940 950 960 MPPVPITSPI MNPLGDPQSQ MLQQQPSAPV PLSSQSSFPQ PHLPGGQPFH GVQQPLGQTG 970 980 990 1000 1010 1020 MPPSFSKPNI EGAPGAPIGN TFQHVQSLPT KKITKKPIPD EHLILKTTFE DLIQRCLSSA 1030 1040 1050 1060 1070 1080 TDPQTKRKLD DASKRLEFLY DKLREQTLSP TITSGLHNIA RSIETRNYSE GLTMHTHIVS 1090 1100 TSNFSETSAF MPVLKVVLTQ ANKLGV
	Isoform 4 [UniParc]. Checksum: 6FCDB50DE1A19BF0	FASTA	1,181	129,036
	10 20 30 40 50 60 MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 70 80 90 100 110 120 ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQNDK 130 140 150 160 170 180 HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 190 200 210 220 230 240 QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 250 260 270 280 290 300 IQMWDLRFAS SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 310 320 330 340 350 360 TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS SSFGNLDPFG 370 380 390 400 410 420 TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFENV RMPSHQGAEQ 430 440 450 460 470 480 QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ SQGFINYCQK KIDASQTEFE KNVWSFLKVN 490 500 510 520 530 540 FEDDSRGKYL ELLGYRKEDL GKKHIKEEKE ESEFLPSSGG TFNISVSGDI DGLITQALLT 550 560 570 580 590 600 GNFESAVDLC LHDNRMADAI ILAIAGGQEL LARTQKKYFA KSQSKITRLI TAVVMKNWKE 610 620 630 640 650 660 IVESCDLKNW REALAAVLTY AKPDEFSALC DLLGTRLENE GDSLLQTQAC LCYICAGNVE 670 680 690 700 710 720 KLVACWTKAQ DGSHPLSLQD LIEKVVILRK AVQLTQAMDT STVGVLLAAK MSQYANLLAA 730 740 750 760 770 780 QGSIAAALAF LPDNTNQPNI MQLRDRLCRA QGEPVAGHES PKIPYEKQQL PKGRPGPVAG 790 800 810 820 830 840 HHQMPRVQTQ QYYPHGENPP PPGFIMHGNV NPNAAGQLPT SPGHMHTQVP PYPQPQPYQP 850 860 870 880 890 900 AQPYPFGTGG SAMYRPQQPV APPTSNAYPN TPYISSASSY TGQSQLYAAQ HQASSPTSSP 910 920 930 940 950 960 ATSFPPPPSS GASFQHGGPG APPSSSAYAL PPGTTGTLPA ASELPASQRT GPQNGWNDPP 970 980 990 1000 1010 1020 ALNRVPKKKK MPENFMPPVP ITSPIMNPLG DPQSQMLQQQ PSAPVPLSSQ SSFPQPHLPG 1030 1040 1050 1060 1070 1080 GQPFHGVQQP LGQTGMPPSF SKPNIEGAPG APIGNTFQHV QSLPTKKITK KPIPDEHLIL 1090 1100 1110 1120 1130 1140 KTTFEDLIQR CLSSATDPQT KRKLDDASKR LEFLYDKLRE QTLSPTITSG LHNIARSIET 1150 1160 1170 1180 RNYSEGLTMH THIVSTSNFS ETSAFMPVLK VVLTQANKLG V
	Isoform 5 [UniParc]. Checksum: 883FD8815650FA25	FASTA	509	56,731
	10 20 30 40 50 60 MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 70 80 90 100 110 120 ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQNDK 130 140 150 160 170 180 HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 190 200 210 220 230 240 QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 250 260 270 280 290 300 IQMWDLRFAS SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 310 320 330 340 350 360 TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS SSFGNLDPFG 370 380 390 400 410 420 TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFENV RMPSHQGAEQ 430 440 450 460 470 480 QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ SQGFINYCQK KIDASQTEFE KNVWSFLKVN 490 500 FEDDSRGKYL ELLGYRKEDL GKKVNFWES
	Isoform 6 [UniParc]. Checksum: F2D05279DCE51522	FASTA	1,067	117,673
	10 20 30 40 50 60 MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 70 80 90 100 110 120 ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQNDK 130 140 150 160 170 180 HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 190 200 210 220 230 240 QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 250 260 270 280 290 300 IQMWDLRFAS SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 310 320 330 340 350 360 TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS SSFGNLDPFG 370 380 390 400 410 420 TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFENV RMPSHQGAEQ 430 440 450 460 470 480 QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ SQGFINYCQK KIDASQTEFE KNVWSFLKVN 490 500 510 520 530 540 FEDDSRGKYL ELLGYRKEDL GKKHIKEEKE ESEFLPSSGG TFNISVSGDI DGLITQALLT 550 560 570 580 590 600 GNFESAVDLC LHDNRMADAI ILAIAGGQEL LARTQKKYFA KSQSKITRLI TAVVMKNWKE 610 620 630 640 650 660 IVESCDLKNW REALAAVLTY AKPDEFSALC DLLGTRLENE GDSLLQTQAC LCYICAGNVE 670 680 690 700 710 720 KLVACWTKAQ DGSHPLSLQD LIEKVVILRK AVQLTQAMDT STVGVLLAAK MSQYANLLAA 730 740 750 760 770 780 QGSIAAALAF LPDNTNQPNI MQLRDRLCRA QGEPVAGHES PKIPYEKQQL PKGRPGPVAG 790 800 810 820 830 840 HHQMPRVQTQ QYYPHGENPP PPGFIMHGNV NPNAAGQLPT SPGHMHTQVP PYPQPQRPQN 850 860 870 880 890 900 GWNDPPALNR VPKKKKMPEN FMPPVPITSP IMNPLGDPQS QMLQQQPSAP VPLSSQSSFP 910 920 930 940 950 960 QPHLPGGQPF HGVQQPLGQT GMPPSFSKPN IEGAPGAPIG NTFQHVQSLP TKKITKKPIP 970 980 990 1000 1010 1020 DEHLILKTTF EDLIQRCLSS ATDPQTKRKL DDASKRLEFL YDKLREQTLS PTITSGLHNI 1030 1040 1050 1060 ARSIETRNYS EGLTMHTHIV STSNFSETSA FMPVLKVVLT QANKLGV
	Isoform 7 [UniParc]. Checksum: C968C7ACE341CCAB	FASTA	969	105,753
	10 20 30 40 50 60 MVKLVLLSIV LLKVTVPKLS NYLLQLDFMP IHRGILAIAW SMADPELLLS CGKDAKILCS 70 80 90 100 110 120 NPNTGEVLYE LPTNTQWCFD IQWCPRNPAV LSAASFDGRI SVYSIMGGST DGLRQKQVDK 130 140 150 160 170 180 LSSSFGNLDP FGTGQPLPPL QIPQQTAQHS IVLPLKKPPK WIRRPVGASF SFGGKLVTFE 190 200 210 220 230 240 NVRMPSHQGA EQQQQQHHVF ISQVVTEKEF LSRSDQLQQA VQSQGFINYC QKKIDASQTE 250 260 270 280 290 300 FEKNVWSFLK VNFEDDSRGK YLELLGYRKE DLGKKHIKEE KEESEFLPSS GGTFNISVSG 310 320 330 340 350 360 DIDGLITQAL LTGNFESAVD LCLHDNRMAD AIILAIAGGQ ELLARTQKKY FAKSQSKITR 370 380 390 400 410 420 LITAVVMKNW KEIVESCDLK NWREALAAVL TYAKPDEFSA LCDLLGTRLE NEGDSLLQTQ 430 440 450 460 470 480 ACLCYICAGN VEKLVACWTK AQDGSHPLSL QDLIEKVVIL RKAVQLTQAM DTSTVGVLLA 490 500 510 520 530 540 AKMSQYANLL AAQGSIAAAL AFLPDNTNQP NIMQLRDRLC RAQGEPVAGH ESPKIPYEKQ 550 560 570 580 590 600 QLPKGRPGPV AGHHQMPRVQ TQQYYPHVRI APTVTTWSNK TPTALPSHPP AASPSDTQGE 610 620 630 640 650 660 NPPPPGFIMH GNVNPNAAGQ LPTSPGHMHT QVPPYPQPQP YQPAQPYPFG TGGSAMYRPQ 670 680 690 700 710 720 QPVAPPTSNA YPNTPYISSA SSYTGQSQLY AAQHQASSPT SSPATSFPPP PSSGASFQHG 730 740 750 760 770 780 GPGAPPSSSA YALPPGTTGP QNGWNDPPAL NRVPKKKKMP ENFMPPVPIT SPIMNPLGDP 790 800 810 820 830 840 QSQMLQQQPS APVPLSSQSS FPQPHLPGGQ PFHGVQQPLG QTGMPPSFSK PNIEGAPGAP 850 860 870 880 890 900 IGNTFQHVQS LPTKKITKKP IPDEHLILKT TFEDLIQRCL SSATDPQTKR KLDDASKRLE 910 920 930 940 950 960 FLYDKLREQT LSPTITSGLH NIARSIETRN YSEGLTMHTH IVSTSNFSET SAFMPVLKVV LTQANKLGV
	Isoform 8 [UniParc]. Checksum: 1D63F1DEA3EC45F4	FASTA	1,233	134,499
	10 20 30 40 50 60 MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 70 80 90 100 110 120 ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQNDK 130 140 150 160 170 180 HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 190 200 210 220 230 240 QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 250 260 270 280 290 300 IQMWDLRFAS SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 310 320 330 340 350 360 TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS SSFGNLDPFG 370 380 390 400 410 420 TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFENV RMPSHQGAEQ 430 440 450 460 470 480 QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ SQGFINYCQK KIDASQTEFE KNVWSFLKVN 490 500 510 520 530 540 FEDDSRGKYL ELLGYRKEDL GKKIALALNK VDGANVALKD SDQVAQSDGE ESPAAEEQLL 550 560 570 580 590 600 GEHIKEEKEE SEFLPSSGGT FNISVSGDID GLITQALLTG NFESAVDLCL HDNRMADAII 610 620 630 640 650 660 LAIAGGQELL ARTQKKYFAK SQSKITRLIT AVVMKNWKEI VESCDLKNWR EALAAVLTYA 670 680 690 700 710 720 KPDEFSALCD LLGTRLENEG DSLLQTQACL CYICAGNVEK LVACWTKAQD GSHPLSLQDL 730 740 750 760 770 780 IEKVVILRKA VQLTQAMDTS TVGVLLAAKM SQYANLLAAQ GSIAAALAFL PDNTNQPNIM 790 800 810 820 830 840 QLRDRLCRAQ GEPVAGHESP KIPYEKQQLP KGRPGPVAGH HQMPRVQTQQ YYPHGENPPP 850 860 870 880 890 900 PGFIMHGNVN PNAAGQLPTS PGHMHTQVPP YPQPQPYQPA QPYPFGTGGS AMYRPQQPVA 910 920 930 940 950 960 PPTSNAYPNT PYISSASSYT GQSQLYAAQH QASSPTSSPA TSFPPPPSSG ASFQHGGPGA 970 980 990 1000 1010 1020 PPSSSAYALP PGTTGTLPAA SELPASQRTE NQSIQDQAPM LEGPQNGWND PPALNRVPKK 1030 1040 1050 1060 1070 1080 KKMPENFMPP VPITSPIMNP LGDPQSQMLQ QQPSAPVPLS SQSSFPQPHL PGGQPFHGVQ 1090 1100 1110 1120 1130 1140 QPLGQTGMPP SFSKPNIEGA PGAPIGNTFQ HVQSLPTKKI TKKPIPDEHL ILKTTFEDLI 1150 1160 1170 1180 1190 1200 QRCLSSATDP QTKRKLDDAS KRLEFLYDKL REQTLSPTIT SGLHNIARSI ETRNYSEGLT 1210 1220 1230 MHTHIVSTSN FSETSAFMPV LKVVLTQANK LGV
	Isoform 9 [UniParc]. Checksum: F2E4A99D905A6389	FASTA	1,200	130,747
	10 20 30 40 50 60 MLGESDERCT NAGSGCRRSS PGTSAQQLDA TFSTNASLEI FELDLSDPSL DMKSCATFSS 70 80 90 100 110 120 SHRYHKLIWG PYKMDSKGDV SGVLIAGGEN GNIILYDPSK IIAGDKEVVI AQNDKHTGPV 130 140 150 160 170 180 RALDVNIFQT NLVASGANES EIYIWDLNNF ATPMTPGAKT QPPEDISCIA WNRQVQHILA 190 200 210 220 230 240 SASPSGRATV WDLRKNEPII KVSDHSNRMH CSGLAWHPDV ATQMVLASED DRLPVIQMWD 250 260 270 280 290 300 LRFASSPLRV LENHARGILA IAWSMADPEL LLSCGKDAKI LCSNPNTGEV LYELPTNTQW 310 320 330 340 350 360 CFDIQWCPRN PAVLSAASFD GRISVYSIMG GSTDGLRQKQ VDKLSSSFGN LDPFGTGQPL 370 380 390 400 410 420 PPLQIPQQTA QHSIVLPLKK PPKWIRRPVG ASFSFGGKLV TFENVRMPSH QGAEQQQQQH 430 440 450 460 470 480 HVFISQVVTE KEFLSRSDQL QQAVQSQGFI NYCQKKIDAS QTEFEKNVWS FLKVNFEDDS 490 500 510 520 530 540 RGKYLELLGY RKEDLGKKIA LALNKVDGAN VALKDSDQVA QSDGEESPAA EEQLLGEHIK 550 560 570 580 590 600 EEKEESEFLP SSGGTFNISV SGDIDGLITQ ALLTGNFESA VDLCLHDNRM ADAIILAIAG 610 620 630 640 650 660 GQELLARTQK KYFAKSQSKI TRLITAVVMK NWKEIVESCD LKNWREALAA VLTYAKPDEF 670 680 690 700 710 720 SALCDLLGTR LENEGDSLLQ TQACLCYICA GNVEKLVACW TKAQDGSHPL SLQDLIEKVV 730 740 750 760 770 780 ILRKAVQLTQ AMDTSTVGVL LAAKMSQYAN LLAAQGSIAA ALAFLPDNTN QPNIMQLRDR 790 800 810 820 830 840 LCRAQGEPVA GHESPKIPYE KQQLPKGRPG PVAGHHQMPR VQTQQYYPHG ENPPPPGFIM 850 860 870 880 890 900 HGNVNPNAAG QLPTSPGHMH TQVPPYPQPQ PYQPAQPYPF GTGGSAMYRP QQPVAPPTSN 910 920 930 940 950 960 AYPNTPYISS ASSYTGQSQL YAAQHQASSP TSSPATSFPP PPSSGASFQH GGPGAPPSSS 970 980 990 1000 1010 1020 AYALPPGTTG PQNGWNDPPA LNRVPKKKKM PENFMPPVPI TSPIMNPLGD PQSQMLQQQP 1030 1040 1050 1060 1070 1080 SAPVPLSSQS SFPQPHLPGG QPFHGVQQPL GQTGMPPSFS KPNIEGAPGA PIGNTFQHVQ 1090 1100 1110 1120 1130 1140 SLPTKKITKK PIPDEHLILK TTFEDLIQRC LSSATDPQTK RKLDDASKRL EFLYDKLREQ 1150 1160 1170 1180 1190 1200 TLSPTITSGL HNIARSIETR NYSEGLTMHT HIVSTSNFSE TSAFMPVLKV VLTQANKLGV
	Isoform 10 [UniParc]. Checksum: C780B386B096906E	FASTA	1,166	127,556
	10 20 30 40 50 60 MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 70 80 90 100 110 120 ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQNDK 130 140 150 160 170 180 HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 190 200 210 220 230 240 QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 250 260 270 280 290 300 IQMWDLRFAS SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 310 320 330 340 350 360 TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS SSFGNLDPFG 370 380 390 400 410 420 TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFENV RMPSHQGAEQ 430 440 450 460 470 480 QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ SQGFINYCQK KIDASQTEFE KNVWSFLKVN 490 500 510 520 530 540 FEDDSRGKYL ELLGYRKEDL GKKHIKEEKE ESEFLPSSGG TFNISVSGDI DGLITQALLT 550 560 570 580 590 600 GNFESAVDLC LHDNRMADAI ILAIAGGQEL LARTQKKYFA KSQSKITRLI TAVVMKNWKE 610 620 630 640 650 660 IVESCDLKNW REALAAVLTY AKPDEFSALC DLLGTRLENE GDSLLQTQAC LCYICAGNVE 670 680 690 700 710 720 KLVACWTKAQ DGSHPLSLQD LIEKVVILRK AVQLTQAMDT STVGVLLAAK MSQYANLLAA 730 740 750 760 770 780 QGSIAAALAF LPDNTNQPNI MQLRDRLCRA QGEPVAGHES PKIPYEKQQL PKGRPGPVAG 790 800 810 820 830 840 HHQMPRVQTQ QYYPHGENPP PPGFIMHGNV NPNAAGQLPT SPGHMHTQVP PYPQPQPYQP 850 860 870 880 890 900 AQPYPFGTGG SAMYRPQQPV APPTSNAYPN TPYISSASSY TGQSQLYAAQ HQASSPTSSP 910 920 930 940 950 960 ATSFPPPPSS GASFQHGGPG APPSSSAYAL PPGTTGPQNG WNDPPALNRV PKKKKMPENF 970 980 990 1000 1010 1020 MPPVPITSPI MNPLGDPQSQ MLQQQPSAPV PLSSQSSFPQ PHLPGGQPFH GVQQPLGQTG 1030 1040 1050 1060 1070 1080 MPPSFSKPNI EGAPGAPIGN TFQHVQSLPT KKITKKPIPD EHLILKTTFE DLIQRCLSSA 1090 1100 1110 1120 1130 1140 TDPQTKRKLD DASKRLEFLY DKLREQTLSP TITSGLHNIA RSIETRNYSE GLTMHTHIVS 1150 1160 TSNFSETSAF MPVLKVVLTQ ANKLGV

References

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[1]	"Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport." Tang B.L., Zhang T., Low D.Y.H., Wong E.T., Horstmann H., Hong W. J. Biol. Chem. 275:13597-13604(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Pancreas.
[2]	"The yeast web1-like human protein that has WD repeat domain." Noguchi J., Shibata M. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4). Tissue: Spleen.
[3]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	Ohara O., Suyama M., Kikuno R., Nagase T., Ishikawa K. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 9). Tissue: Hippocampus and Testis.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Uterine endothelium and Uterus.
[7]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 5 AND 10). Tissue: Brain and PNS.
[10]	"SEC31 splicing variant." Yang Y., Trejo J. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 599-1220 (ISOFORMS 3/6). Tissue: Placenta.
[11]	"Human partial CDS from CD34+ stem cells." Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 852-1220 (ISOFORM 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 899-1220 (ISOFORM 1). Tissue: Blood.
[12]	"Identification of the putative mammalian orthologue of Sec31P, a component of the COPII coat." Shugrue C.A., Kolen E.R., Peters H., Czernik A., Kaiser C., Matovcik L., Hubbard A.L., Gorelick F. J. Cell Sci. 112:4547-4556(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[13]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-527 AND SER-532, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A." Yamasaki A., Tani K., Yamamoto A., Kitamura N., Komada M. Mol. Biol. Cell 17:4876-4887(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH PDCD6 AND SEC13, SUBCELLULAR LOCATION.
[15]	"Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor." Panagopoulos I., Nilsson T., Domanski H.A., Isaksson M., Lindblom P., Mertens F., Mandahl N. Int. J. Cancer 118:1181-1186(2006) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH ALK.
[16]	"ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner." Shibata H., Suzuki H., Yoshida H., Maki M. Biochem. Biophys. Res. Commun. 353:756-763(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PDCD6.
[17]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-799 AND SER-1163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[18]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[19]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-799 AND THR-1161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[20]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[21]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-527 AND SER-799, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[22]	"Ubiquitin-dependent regulation of COPII coat size and function." Jin L., Pahuja K.B., Wickliffe K.E., Gorur A., Baumgartel C., Schekman R., Rape M. Nature 482:495-500(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, UBIQUITINATION AT LYS-647 AND LYS-1217, MUTAGENESIS OF LYS-647 AND LYS-1217, INTERACTION WITH KLHL12.
[23]	"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R. Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF139184 mRNA. Translation: AAF67836.1. AB018358 mRNA. Translation: BAA84923.1. AB018359 mRNA. Translation: BAA84924.1. AB020712 mRNA. Translation: BAA74928.2. AK125897 mRNA. Translation: BAC86336.1. AK295810 mRNA. Translation: BAG58628.1. AL049463 mRNA. Translation: CAH56418.1. CR933696 mRNA. Translation: CAI45995.1. Sequence problems. AC021105 Genomic DNA. No translation available. AC108469 Genomic DNA. No translation available. CH471057 Genomic DNA. Translation: EAX05908.1. BC047883 mRNA. Translation: AAH47883.1. BC084583 mRNA. Translation: AAH84583.1. BC117221 mRNA. Translation: AAI17222.1. BC143489 mRNA. Translation: AAI43490.1. BC143491 mRNA. Translation: AAI43492.1. BC143492 mRNA. Translation: AAI43493.1. AY137583 mRNA. Translation: AAN15221.1. AF161393 mRNA. Translation: AAF28953.1. Frameshift. AF161452 mRNA. Translation: AAF29012.1. Frameshift.
CCDS	CCDS3596.1. [O94979-1] CCDS3597.1. [O94979-4] CCDS43244.1. [O94979-3] CCDS47088.1. [O94979-2] CCDS54773.1. [O94979-9]
RefSeq	NP_001070674.1. NM_001077206.2. [O94979-3] NP_001070675.1. NM_001077207.2. [O94979-1] NP_001070676.1. NM_001077208.2. [O94979-2] NP_001177978.1. NM_001191049.1. [O94979-9] NP_055748.2. NM_014933.3. [O94979-1] NP_057295.2. NM_016211.3. [O94979-4] XP_005262904.1. XM_005262847.1. [O94979-8] XP_005262907.1. XM_005262850.1. [O94979-2] XP_005262909.1. XM_005262852.1. [O94979-10] XP_005262911.1. XM_005262854.1. [O94979-6] XP_006714204.1. XM_006714141.1. [O94979-8] XP_006714205.1. XM_006714142.1. [O94979-8] XP_006714206.1. XM_006714143.1. [O94979-8]
UniGene	Hs.370024.
3D structure databases
ProteinModelPortal	O94979.
SMR	O94979. Positions 4-770.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	116539. 13 interactions.
DIP	DIP-40438N.
IntAct	O94979. 32 interactions.
MINT	MINT-3002555.
PTM databases
PhosphoSite	O94979.
Proteomic databases
MaxQB	O94979.
PaxDb	O94979.
PRIDE	O94979.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311785; ENSP00000309070; ENSG00000138674. [O94979-3] ENST00000326950; ENSP00000325087; ENSG00000138674. [O94979-4] ENST00000348405; ENSP00000337602; ENSG00000138674. [O94979-4] ENST00000355196; ENSP00000347329; ENSG00000138674. [O94979-1] ENST00000395310; ENSP00000378721; ENSG00000138674. [O94979-1] ENST00000432794; ENSP00000407944; ENSG00000138674. [O94979-8] ENST00000443462; ENSP00000408027; ENSG00000138674. [O94979-9] ENST00000448323; ENSP00000400926; ENSG00000138674. [O94979-1] ENST00000500777; ENSP00000421464; ENSG00000138674. [O94979-6] ENST00000505984; ENSP00000424451; ENSG00000138674. ENST00000508502; ENSP00000424635; ENSG00000138674. [O94979-2] ENST00000509142; ENSP00000426569; ENSG00000138674. [O94979-3] ENST00000513858; ENSP00000426886; ENSG00000138674. [O94979-6]
GeneID	22872.
KEGG	hsa:22872.
UCSC	uc003hnf.3. human. [O94979-1] uc003hng.3. human. [O94979-2] uc003hni.3. human. [O94979-3] uc003hnk.3. human. [O94979-4] uc003hnl.3. human. [O94979-6] uc003hno.3. human. [O94979-5]
Organism-specific databases
CTD	22872.
GeneCards	GC04M083739.
HGNC	HGNC:17052. SEC31A.
HPA	HPA005457.
MIM	610257. gene.
neXtProt	NX_O94979.
PharmGKB	PA162402737.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG248389.
HOVERGEN	HBG055626.
InParanoid	O94979.
KO	K14005.
OrthoDB	EOG7B31M1.
PhylomeDB	O94979.
TreeFam	TF313842.
Enzyme and pathway databases
Reactome	REACT_11123. Membrane Trafficking. REACT_17015. Metabolism of proteins. REACT_6900. Immune System.
SignaLink	O94979.
Gene expression databases
ArrayExpress	O94979.
Bgee	O94979.
Genevestigator	O94979.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. SSF50978. 1 hit.
PROSITE	PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SEC31A. human.
GeneWiki	SEC31A.
GenomeRNAi	22872.
NextBio	35481219.
PRO	O94979.
SOURCE	Search...

Entry information

Entry name

SC31A_HUMAN

Accession

Primary (citable) accession number: O94979
Secondary accession number(s): B4DIW6 , B7ZKZ7, B7ZL00, H7C2W3, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	July 9, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.