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UniProtKB - O94979 (SC31A_HUMAN)

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Protein

Protein transport protein Sec31A

Gene

SEC31A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-381038. XBP1(S) activates chaperone genes.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
SignaLinkiO94979.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec31A
Alternative name(s):
ABP125
ABP130
SEC31-like protein 1
SEC31-related protein A
Web1-like protein
Gene namesi
Name:SEC31A
Synonyms:KIAA0905, SEC31L1
ORF Names:HSPC275, HSPC334
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:17052. SEC31A.

Subcellular locationi

GO - Cellular componenti

  • COPII vesicle coat Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: HPA
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum exit site Source: UniProtKB
  • endoplasmic reticulum membrane Source: Reactome
  • ER to Golgi transport vesicle Source: UniProtKB
  • ER to Golgi transport vesicle membrane Source: Reactome
  • Golgi membrane Source: GOC
  • intracellular membrane-bounded organelle Source: HPA
  • perinuclear region of cytoplasm Source: UniProtKB
  • vesicle coat Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi647K → R: Does not abolish monoubiquitination by the BCR(KLHL12) E3 ubiquitin ligase complex, revealing flexibility of ubiquitination sites; when associated with R-1217. 1 Publication1
Mutagenesisi1217K → R: Does not abolish monoubiquitination by the BCR(KLHL12) E3 ubiquitin ligase complex, revealing flexibility of ubiquitination sites; when associated with R-647. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi22872.
OpenTargetsiENSG00000138674.
PharmGKBiPA162402737.

Polymorphism and mutation databases

BioMutaiSEC31A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951471 – 1220Protein transport protein Sec31AAdd BLAST1220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei527PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei799PhosphoserineCombined sources1
Modified residuei1161PhosphothreonineCombined sources1
Modified residuei1163PhosphoserineCombined sources1
Cross-linki1217Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO94979.
MaxQBiO94979.
PaxDbiO94979.
PeptideAtlasiO94979.
PRIDEiO94979.

PTM databases

iPTMnetiO94979.
PhosphoSitePlusiO94979.
SwissPalmiO94979.

Expressioni

Tissue specificityi

Abundantly and ubiquitously expressed.2 Publications

Gene expression databases

BgeeiENSG00000138674.
ExpressionAtlasiO94979. baseline and differential.
GenevisibleiO94979. HS.

Organism-specific databases

HPAiHPA005457.

Interactioni

Subunit structurei

COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with PDCD6; interaction takes place in response to cytosolic calcium increase and leads to bridge together the BCR(KLHL12) complex and SEC31A, leading to monoubiquitination (PubMed:27716508) (PubMed:16957052, PubMed:17196169, PubMed:27716508, PubMed:25667979). Interacts with KLHL12.By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
Complete GO annotation...

Protein-protein interaction databases

BioGridi116539. 52 interactors.
DIPiDIP-40438N.
IntActiO94979. 35 interactors.
MINTiMINT-3002555.
STRINGi9606.ENSP00000347329.

Structurei

Secondary structure

11220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi841 – 843Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXAX-ray2.36C/D837-848[»]
ProteinModelPortaliO94979.
SMRiO94979.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 47WD 1Add BLAST44
Repeati68 – 111WD 2Add BLAST44
Repeati120 – 160WD 3Add BLAST41
Repeati166 – 206WD 4Add BLAST41
Repeati209 – 254WD 5Add BLAST46
Repeati258 – 298WD 6Add BLAST41
Repeati301 – 342WD 7Add BLAST42
Repeati397 – 430WD 8; interaction with SEC13PROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 471Interaction with SEC131 PublicationAdd BLAST311
Regioni800 – 1113Interaction with PDCD61 PublicationAdd BLAST314

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi842 – 848ALG-2-binding site motif-2 (ABS-2),7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi800 – 1091Pro-richAdd BLAST292

Domaini

The ALG-2-binding site motif-2 (ABS-2) contains a PXPGF sequence that binds hydrophobic pocket 3 of PDCD6.1 Publication

Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0307. Eukaryota.
ENOG410XQ1D. LUCA.
GeneTreeiENSGT00390000003175.
HOGENOMiHOG000230582.
HOVERGENiHBG055626.
InParanoidiO94979.
KOiK14005.
PhylomeDBiO94979.
TreeFamiTF313842.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR024298. ACE1_Sec16_Sec31.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF12931. Sec16_C. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 6 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94979-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL 
        60         70         80         90        100
SDPSLDMKSC ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL 
       110        120        130        140        150
YDPSKIIAGD KEVVIAQNDK HTGPVRALDV NIFQTNLVAS GANESEIYIW 
       160        170        180        190        200
DLNNFATPMT PGAKTQPPED ISCIAWNRQV QHILASASPS GRATVWDLRK 
       210        220        230        240        250
NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV IQMWDLRFAS 
       260        270        280        290        300
SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 
       310        320        330        340        350
TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS 
       360        370        380        390        400
SSFGNLDPFG TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF 
       410        420        430        440        450
GGKLVTFENV RMPSHQGAEQ QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ 
       460        470        480        490        500
SQGFINYCQK KIDASQTEFE KNVWSFLKVN FEDDSRGKYL ELLGYRKEDL 
       510        520        530        540        550
GKKIALALNK VDGANVALKD SDQVAQSDGE ESPAAEEQLL GEHIKEEKEE 
       560        570        580        590        600
SEFLPSSGGT FNISVSGDID GLITQALLTG NFESAVDLCL HDNRMADAII 
       610        620        630        640        650
LAIAGGQELL ARTQKKYFAK SQSKITRLIT AVVMKNWKEI VESCDLKNWR 
       660        670        680        690        700
EALAAVLTYA KPDEFSALCD LLGTRLENEG DSLLQTQACL CYICAGNVEK 
       710        720        730        740        750
LVACWTKAQD GSHPLSLQDL IEKVVILRKA VQLTQAMDTS TVGVLLAAKM 
       760        770        780        790        800
SQYANLLAAQ GSIAAALAFL PDNTNQPNIM QLRDRLCRAQ GEPVAGHESP 
       810        820        830        840        850
KIPYEKQQLP KGRPGPVAGH HQMPRVQTQQ YYPHGENPPP PGFIMHGNVN 
       860        870        880        890        900
PNAAGQLPTS PGHMHTQVPP YPQPQPYQPA QPYPFGTGGS AMYRPQQPVA 
       910        920        930        940        950
PPTSNAYPNT PYISSASSYT GQSQLYAAQH QASSPTSSPA TSFPPPPSSG 
       960        970        980        990       1000
ASFQHGGPGA PPSSSAYALP PGTTGTLPAA SELPASQRTG PQNGWNDPPA 
      1010       1020       1030       1040       1050
LNRVPKKKKM PENFMPPVPI TSPIMNPLGD PQSQMLQQQP SAPVPLSSQS 
      1060       1070       1080       1090       1100
SFPQPHLPGG QPFHGVQQPL GQTGMPPSFS KPNIEGAPGA PIGNTFQHVQ 
      1110       1120       1130       1140       1150
SLPTKKITKK PIPDEHLILK TTFEDLIQRC LSSATDPQTK RKLDDASKRL 
      1160       1170       1180       1190       1200
EFLYDKLREQ TLSPTITSGL HNIARSIETR NYSEGLTMHT HIVSTSNFSE 
      1210       1220
TSAFMPVLKV VLTQANKLGV
Length:1,220
Mass (Da):133,015
Last modified:July 10, 2007 - v3
Checksum:i2A633B4436DB7482
GO
Isoform 2 (identifier: O94979-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     974-988: Missing.

Show »
Length:1,205
Mass (Da):131,534
Checksum:i245E11A9AD589F74
GO
Isoform 3 (identifier: O94979-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-876: P → R
     877-990: Missing.

Show »
Length:1,106
Mass (Da):121,651
Checksum:iD21AB6B647E1291B
GO
Isoform 4 (identifier: O94979-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-542: Missing.

Show »
Length:1,181
Mass (Da):129,036
Checksum:i6FCDB50DE1A19BF0
GO
Isoform 5 (identifier: O94979-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-509: IALALN → VNFWES
     510-1220: Missing.

Note: No experimental confirmation available.
Show »
Length:509
Mass (Da):56,731
Checksum:i883FD8815650FA25
GO
Isoform 6 (identifier: O94979-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-542: Missing.
     876-876: P → R
     877-990: Missing.

Show »
Length:1,067
Mass (Da):117,673
Checksum:iF2D05279DCE51522
GO
Isoform 7 (identifier: O94979-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-228: Missing.
     229-260: MVLASEDDRLPVIQMWDLRFASSPLRVLENHA → MVKLVLLSIVLLKVTVPKLSNYLLQLDFMPIH
     504-542: Missing.
     834-834: H → HVRIAPTVTTWSNKTPTALPSHPPAASPSDTQ
     974-988: Missing.

Note: No experimental confirmation available.
Show »
Length:969
Mass (Da):105,753
Checksum:iC968C7ACE341CCAB
GO
Isoform 8 (identifier: O94979-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-989: T → TENQSIQDQAPMLE

Show »
Length:1,233
Mass (Da):134,499
Checksum:i1D63F1DEA3EC45F4
GO
Isoform 9 (identifier: O94979-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MKLKEVDRTAMQAWSPAQNHPIYLAT → MLGESDERCTNAGSGCRRSSP
     974-988: Missing.

Note: No experimental confirmation available.
Show »
Length:1,200
Mass (Da):130,747
Checksum:iF2E4A99D905A6389
GO
Isoform 10 (identifier: O94979-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-542: Missing.
     974-988: Missing.

Note: No experimental confirmation available.
Show »
Length:1,166
Mass (Da):127,556
Checksum:iC780B386B096906E
GO

Sequence cautioni

The sequence AAF28953 differs from that shown. Reason: Frameshift at positions 857 and 1079.Curated
The sequence AAF29012 differs from that shown. Reason: Frameshift at positions 922, 946, 1029 and 1080.Curated
The sequence CAI45995 differs from that shown. Reason: Erroneous termination at position 221. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200K → E in BAA84923 (Ref. 2) Curated1
Sequence conflicti284K → R in BAC86336 (PubMed:14702039).Curated1
Sequence conflicti854A → S in BAA84923 (Ref. 2) Curated1
Sequence conflicti854A → S in BAA84924 (Ref. 2) Curated1
Sequence conflicti1007K → R in BAG58628 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033225263I → V. Corresponds to variant dbSNP:rs34554214Ensembl.1
Natural variantiVAR_053414456N → K. Corresponds to variant dbSNP:rs3797036Ensembl.1
Natural variantiVAR_033226841P → L. Corresponds to variant dbSNP:rs35579207Ensembl.1
Natural variantiVAR_0332271055P → T. Corresponds to variant dbSNP:rs35739017Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0267421 – 228Missing in isoform 7. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_0446021 – 26MKLKE…IYLAT → MLGESDERCTNAGSGCRRSS P in isoform 9. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_026743229 – 260MVLAS…LENHA → MVKLVLLSIVLLKVTVPKLS NYLLQLDFMPIH in isoform 7. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_026744504 – 542Missing in isoform 4, isoform 6, isoform 7 and isoform 10. 4 PublicationsAdd BLAST39
Alternative sequenceiVSP_026745504 – 509IALALN → VNFWES in isoform 5. 1 Publication6
Alternative sequenceiVSP_026746510 – 1220Missing in isoform 5. 1 PublicationAdd BLAST711
Alternative sequenceiVSP_026747834H → HVRIAPTVTTWSNKTPTALP SHPPAASPSDTQ in isoform 7. 1 Publication1
Alternative sequenceiVSP_026748876P → R in isoform 3 and isoform 6. 2 Publications1
Alternative sequenceiVSP_026749877 – 990Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST114
Alternative sequenceiVSP_026750974 – 988Missing in isoform 2, isoform 7, isoform 9 and isoform 10. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_026751989T → TENQSIQDQAPMLE in isoform 8. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139184 mRNA. Translation: AAF67836.1.
AB018358 mRNA. Translation: BAA84923.1.
AB018359 mRNA. Translation: BAA84924.1.
AB020712 mRNA. Translation: BAA74928.2.
AK125897 mRNA. Translation: BAC86336.1.
AK295810 mRNA. Translation: BAG58628.1.
AL049463 mRNA. Translation: CAH56418.1.
CR933696 mRNA. Translation: CAI45995.1. Sequence problems.
AC021105 Genomic DNA. No translation available.
AC108469 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05908.1.
BC047883 mRNA. Translation: AAH47883.1.
BC084583 mRNA. Translation: AAH84583.1.
BC117221 mRNA. Translation: AAI17222.1.
BC143489 mRNA. Translation: AAI43490.1.
BC143491 mRNA. Translation: AAI43492.1.
BC143492 mRNA. Translation: AAI43493.1.
AY137583 mRNA. Translation: AAN15221.1.
AF161393 mRNA. Translation: AAF28953.1. Frameshift.
AF161452 mRNA. Translation: AAF29012.1. Frameshift.
CCDSiCCDS3596.1. [O94979-1]
CCDS3597.1. [O94979-4]
CCDS43244.1. [O94979-3]
CCDS47088.1. [O94979-2]
CCDS54773.1. [O94979-9]
CCDS75155.1. [O94979-6]
CCDS75156.1. [O94979-10]
RefSeqiNP_001070674.1. NM_001077206.3. [O94979-3]
NP_001070675.1. NM_001077207.3. [O94979-1]
NP_001070676.1. NM_001077208.3. [O94979-2]
NP_001177978.1. NM_001191049.2. [O94979-9]
NP_001287673.1. NM_001300744.2. [O94979-6]
NP_001287674.1. NM_001300745.2. [O94979-10]
NP_001305048.1. NM_001318119.1. [O94979-2]
NP_001305049.1. NM_001318120.1. [O94979-1]
NP_057295.2. NM_016211.4. [O94979-4]
UniGeneiHs.370024.
Hs.617723.
Hs.728916.

Genome annotation databases

EnsembliENST00000311785; ENSP00000309070; ENSG00000138674. [O94979-3]
ENST00000348405; ENSP00000337602; ENSG00000138674. [O94979-4]
ENST00000355196; ENSP00000347329; ENSG00000138674. [O94979-1]
ENST00000395310; ENSP00000378721; ENSG00000138674. [O94979-1]
ENST00000443462; ENSP00000408027; ENSG00000138674. [O94979-9]
ENST00000448323; ENSP00000400926; ENSG00000138674. [O94979-1]
ENST00000500777; ENSP00000421464; ENSG00000138674. [O94979-6]
ENST00000505984; ENSP00000424451; ENSG00000138674. [O94979-10]
ENST00000508502; ENSP00000424635; ENSG00000138674. [O94979-2]
ENST00000509142; ENSP00000426569; ENSG00000138674. [O94979-3]
ENST00000513858; ENSP00000426886; ENSG00000138674. [O94979-6]
GeneIDi22872.
KEGGihsa:22872.
UCSCiuc003hnf.3. human. [O94979-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139184 mRNA. Translation: AAF67836.1.
AB018358 mRNA. Translation: BAA84923.1.
AB018359 mRNA. Translation: BAA84924.1.
AB020712 mRNA. Translation: BAA74928.2.
AK125897 mRNA. Translation: BAC86336.1.
AK295810 mRNA. Translation: BAG58628.1.
AL049463 mRNA. Translation: CAH56418.1.
CR933696 mRNA. Translation: CAI45995.1. Sequence problems.
AC021105 Genomic DNA. No translation available.
AC108469 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05908.1.
BC047883 mRNA. Translation: AAH47883.1.
BC084583 mRNA. Translation: AAH84583.1.
BC117221 mRNA. Translation: AAI17222.1.
BC143489 mRNA. Translation: AAI43490.1.
BC143491 mRNA. Translation: AAI43492.1.
BC143492 mRNA. Translation: AAI43493.1.
AY137583 mRNA. Translation: AAN15221.1.
AF161393 mRNA. Translation: AAF28953.1. Frameshift.
AF161452 mRNA. Translation: AAF29012.1. Frameshift.
CCDSiCCDS3596.1. [O94979-1]
CCDS3597.1. [O94979-4]
CCDS43244.1. [O94979-3]
CCDS47088.1. [O94979-2]
CCDS54773.1. [O94979-9]
CCDS75155.1. [O94979-6]
CCDS75156.1. [O94979-10]
RefSeqiNP_001070674.1. NM_001077206.3. [O94979-3]
NP_001070675.1. NM_001077207.3. [O94979-1]
NP_001070676.1. NM_001077208.3. [O94979-2]
NP_001177978.1. NM_001191049.2. [O94979-9]
NP_001287673.1. NM_001300744.2. [O94979-6]
NP_001287674.1. NM_001300745.2. [O94979-10]
NP_001305048.1. NM_001318119.1. [O94979-2]
NP_001305049.1. NM_001318120.1. [O94979-1]
NP_057295.2. NM_016211.4. [O94979-4]
UniGeneiHs.370024.
Hs.617723.
Hs.728916.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXAX-ray2.36C/D837-848[»]
ProteinModelPortaliO94979.
SMRiO94979.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116539. 52 interactors.
DIPiDIP-40438N.
IntActiO94979. 35 interactors.
MINTiMINT-3002555.
STRINGi9606.ENSP00000347329.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

PTM databases

iPTMnetiO94979.
PhosphoSitePlusiO94979.
SwissPalmiO94979.

Polymorphism and mutation databases

BioMutaiSEC31A.

Proteomic databases

EPDiO94979.
MaxQBiO94979.
PaxDbiO94979.
PeptideAtlasiO94979.
PRIDEiO94979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311785; ENSP00000309070; ENSG00000138674. [O94979-3]
ENST00000348405; ENSP00000337602; ENSG00000138674. [O94979-4]
ENST00000355196; ENSP00000347329; ENSG00000138674. [O94979-1]
ENST00000395310; ENSP00000378721; ENSG00000138674. [O94979-1]
ENST00000443462; ENSP00000408027; ENSG00000138674. [O94979-9]
ENST00000448323; ENSP00000400926; ENSG00000138674. [O94979-1]
ENST00000500777; ENSP00000421464; ENSG00000138674. [O94979-6]
ENST00000505984; ENSP00000424451; ENSG00000138674. [O94979-10]
ENST00000508502; ENSP00000424635; ENSG00000138674. [O94979-2]
ENST00000509142; ENSP00000426569; ENSG00000138674. [O94979-3]
ENST00000513858; ENSP00000426886; ENSG00000138674. [O94979-6]
GeneIDi22872.
KEGGihsa:22872.
UCSCiuc003hnf.3. human. [O94979-1]

Organism-specific databases

CTDi22872.
DisGeNETi22872.
GeneCardsiSEC31A.
HGNCiHGNC:17052. SEC31A.
HPAiHPA005457.
MIMi610257. gene.
neXtProtiNX_O94979.
OpenTargetsiENSG00000138674.
PharmGKBiPA162402737.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0307. Eukaryota.
ENOG410XQ1D. LUCA.
GeneTreeiENSGT00390000003175.
HOGENOMiHOG000230582.
HOVERGENiHBG055626.
InParanoidiO94979.
KOiK14005.
PhylomeDBiO94979.
TreeFamiTF313842.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-381038. XBP1(S) activates chaperone genes.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
SignaLinkiO94979.

Miscellaneous databases

ChiTaRSiSEC31A. human.
GeneWikiiSEC31A.
GenomeRNAii22872.
PROiPR:O94979.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138674.
ExpressionAtlasiO94979. baseline and differential.
GenevisibleiO94979. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR024298. ACE1_Sec16_Sec31.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF12931. Sec16_C. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 6 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSC31A_HUMAN
AccessioniPrimary (citable) accession number: O94979
Secondary accession number(s): B4DIW6
, B7ZKZ7, B7ZL00, H7C2W3, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: June 7, 2017
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.