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O94973

- AP2A2_HUMAN

UniProt

O94973 - AP2A2_HUMAN

Protein

AP-2 complex subunit alpha-2

Gene

AP2A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (24 Jan 2001)
      Previous versions | rss
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    Functioni

    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431Phosphatidylinositol lipid headgroupBy similarity
    Binding sitei53 – 531Phosphatidylinositol lipid headgroupBy similarity
    Binding sitei57 – 571Phosphatidylinositol lipid headgroupBy similarity
    Binding sitei58 – 581Phosphatidylinositol lipid headgroupBy similarity
    Binding sitei61 – 611Phosphatidylinositol lipid headgroupBy similarity

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein kinase binding Source: ParkinsonsUK-UCL
    4. protein transporter activity Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. axon guidance Source: Reactome
    3. endocytosis Source: UniProtKB-KW
    4. epidermal growth factor receptor signaling pathway Source: Reactome
    5. intracellular protein transport Source: InterPro
    6. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
    7. neurotrophin TRK receptor signaling pathway Source: Reactome
    8. regulation of defense response to virus by virus Source: Reactome
    9. synaptic transmission Source: Reactome
    10. viral process Source: Reactome

    Keywords - Biological processi

    Endocytosis, Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    ReactomeiREACT_11166. Nef Mediated CD4 Down-regulation.
    REACT_11200. Nef Mediated CD8 Down-regulation.
    REACT_121399. MHC class II antigen presentation.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_12484. EGFR downregulation.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_18422. Trafficking of GluR2-containing AMPA receptors.
    REACT_22365. Recycling pathway of L1.
    SignaLinkiO94973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-2 complex subunit alpha-2
    Alternative name(s):
    100 kDa coated vesicle protein C
    Adaptor protein complex AP-2 subunit alpha-2
    Adaptor-related protein complex 2 subunit alpha-2
    Alpha-adaptin C
    Alpha2-adaptin
    Clathrin assembly protein complex 2 alpha-C large chain
    Huntingtin yeast partner J
    Huntingtin-interacting protein 9
    Short name:
    HIP-9
    Huntingtin-interacting protein J
    Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
    Gene namesi
    Name:AP2A2
    Synonyms:ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:562. AP2A2.

    Subcellular locationi

    Cell membrane By similarity. Membranecoated pit By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.By similarity

    GO - Cellular componenti

    1. clathrin adaptor complex Source: InterPro
    2. clathrin-coated endocytic vesicle membrane Source: Reactome
    3. coated pit Source: UniProtKB-SubCell
    4. cytosol Source: Reactome
    5. endocytic vesicle membrane Source: Reactome
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Coated pit, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24853.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 939938AP-2 complex subunit alpha-2PRO_0000193732Add
    BLAST

    Proteomic databases

    MaxQBiO94973.
    PaxDbiO94973.
    PRIDEiO94973.

    PTM databases

    PhosphoSiteiO94973.

    Miscellaneous databases

    PMAP-CutDBO94973.

    Expressioni

    Gene expression databases

    ArrayExpressiO94973.
    BgeeiO94973.
    CleanExiHS_AP2A2.
    GenevestigatoriO94973.

    Organism-specific databases

    HPAiCAB017514.

    Interactioni

    Subunit structurei

    Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Binds EPN1, EPS15, AMPH, SNAP91 and BIN1. Interacts with HIP1. Interacts with DGKD isoform 2 By similarity. Interacts with DENND1A, DENND1B and DENND1C By similarity. Interacts with FCHO1 and DAB2. Interacts with ATAT1; this interaction is required for efficient alpha-tubulin acetylation by ATAT1.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dab2P980782EBI-1642835,EBI-1391846From a different organism.
    Kcnj11Q617432EBI-1642835,EBI-8603527From a different organism.

    Protein-protein interaction databases

    BioGridi106670. 28 interactions.
    IntActiO94973. 18 interactions.
    MINTiMINT-1198502.
    STRINGi9606.ENSP00000413234.

    Structurei

    3D structure databases

    ProteinModelPortaliO94973.
    SMRiO94973. Positions 9-607, 702-939.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni5 – 8076Lipid-bindingAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5096.
    HOGENOMiHOG000170596.
    HOVERGENiHBG050518.
    InParanoidiO94973.
    KOiK11824.
    OMAiQDVFRQH.
    OrthoDBiEOG7GQXV2.
    PhylomeDBiO94973.
    TreeFamiTF300308.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1030. 1 hit.
    3.30.310.30. 1 hit.
    InterProiIPR017104. AP2_complex_asu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR013038. Clathrin_a-adaptin_app_Ig-like.
    IPR003164. Clathrin_a-adaptin_app_sub_C.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF02296. Alpha_adaptin_C. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
    SMARTiSM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94973-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL    50
    DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNRYTE KQIGYLFISV 100
    LVNSNSELIR LINNAIKNDL ASRNPTFMGL ALHCIASVGS REMAEAFAGE 150
    IPKVLVAGDT MDSVKQSAAL CLLRLYRTSP DLVPMGDWTS RVVHLLNDQH 200
    LGVVTAATSL ITTLAQKNPE EFKTSVSLAV SRLSRIVTSA STDLQDYTYY 250
    FVPAPWLSVK LLRLLQCYPP PDPAVRGRLT ECLETILNKA QEPPKSKKVQ 300
    HSNAKNAVLF EAISLIIHHD SEPNLLVRAC NQLGQFLQHR ETNLRYLALE 350
    SMCTLASSEF SHEAVKTHIE TVINALKTER DVSVRQRAVD LLYAMCDRSN 400
    APQIVAEMLS YLETADYSIR EEIVLKVAIL AEKYAVDYTW YVDTILNLIR 450
    IAGDYVSEEV WYRVIQIVIN RDDVQGYAAK TVFEALQAPA CHENLVKVGG 500
    YILGEFGNLI AGDPRSSPLI QFHLLHSKFH LCSVPTRALL LSTYIKFVNL 550
    FPEVKPTIQD VLRSDSQLRN ADVELQQRAV EYLRLSTVAS TDILATVLEE 600
    MPPFPERESS ILAKLKKKKG PSTVTDLEDT KRDRSVDVNG GPEPAPASTS 650
    AVSTPSPSAD LLGLGAAPPA PAGPPPSSGG SGLLVDVFSD SASVVAPLAP 700
    GSEDNFARFV CKNNGVLFEN QLLQIGLKSE FRQNLGRMFI FYGNKTSTQF 750
    LNFTPTLICS DDLQPNLNLQ TKPVDPTVEG GAQVQQVVNI ECVSDFTEAP 800
    VLNIQFRYGG TFQNVSVQLP ITLNKFFQPT EMASQDFFQR WKQLSNPQQE 850
    VQNIFKAKHP MDTEVTKAKI IGFGSALLEE VDPNPANFVG AGIIHTKTTQ 900
    IGCLLRLEPN LQAQMYRLTL RTSKEAVSQR LCELLSAQF 939
    Length:939
    Mass (Da):103,960
    Last modified:January 24, 2001 - v2
    Checksum:iA8D3CC1B15B8C6BF
    GO
    Isoform 2 (identifier: O94973-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         271-271: P → PE

    Note: No experimental confirmation available.

    Show »
    Length:940
    Mass (Da):104,090
    Checksum:i98F8345F9BBB149C
    GO
    Isoform 3 (identifier: O94973-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         271-271: P → PE
         653-655: STP → VCL
         656-939: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:656
    Mass (Da):73,128
    Checksum:i98E2FE160BFAC0AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201I → T in BAB55435. (PubMed:14702039)Curated
    Sequence conflicti450 – 4501R → Q in AAC27505. (PubMed:9700202)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei271 – 2711P → PE in isoform 2 and isoform 3. 2 PublicationsVSP_035762
    Alternative sequencei653 – 6553STP → VCL in isoform 3. 1 PublicationVSP_035763
    Alternative sequencei656 – 939284Missing in isoform 3. 1 PublicationVSP_035764Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020706 mRNA. Translation: BAA74922.2.
    AK223558 mRNA. Translation: BAD97278.1.
    AK027891 mRNA. Translation: BAB55435.1.
    BC006155 mRNA. Translation: AAH06155.1.
    AF049527 mRNA. Translation: AAC27505.1.
    CCDSiCCDS44512.1. [O94973-1]
    RefSeqiNP_001229766.1. NM_001242837.1. [O94973-2]
    NP_036437.1. NM_012305.3. [O94973-1]
    UniGeneiHs.19121.

    Genome annotation databases

    EnsembliENST00000332231; ENSP00000327694; ENSG00000183020. [O94973-2]
    ENST00000448903; ENSP00000413234; ENSG00000183020. [O94973-1]
    ENST00000528815; ENSP00000431630; ENSG00000183020. [O94973-3]
    GeneIDi161.
    KEGGihsa:161.
    UCSCiuc001lss.3. human. [O94973-1]
    uc001lst.2. human. [O94973-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020706 mRNA. Translation: BAA74922.2 .
    AK223558 mRNA. Translation: BAD97278.1 .
    AK027891 mRNA. Translation: BAB55435.1 .
    BC006155 mRNA. Translation: AAH06155.1 .
    AF049527 mRNA. Translation: AAC27505.1 .
    CCDSi CCDS44512.1. [O94973-1 ]
    RefSeqi NP_001229766.1. NM_001242837.1. [O94973-2 ]
    NP_036437.1. NM_012305.3. [O94973-1 ]
    UniGenei Hs.19121.

    3D structure databases

    ProteinModelPortali O94973.
    SMRi O94973. Positions 9-607, 702-939.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106670. 28 interactions.
    IntActi O94973. 18 interactions.
    MINTi MINT-1198502.
    STRINGi 9606.ENSP00000413234.

    PTM databases

    PhosphoSitei O94973.

    Proteomic databases

    MaxQBi O94973.
    PaxDbi O94973.
    PRIDEi O94973.

    Protocols and materials databases

    DNASUi 161.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332231 ; ENSP00000327694 ; ENSG00000183020 . [O94973-2 ]
    ENST00000448903 ; ENSP00000413234 ; ENSG00000183020 . [O94973-1 ]
    ENST00000528815 ; ENSP00000431630 ; ENSG00000183020 . [O94973-3 ]
    GeneIDi 161.
    KEGGi hsa:161.
    UCSCi uc001lss.3. human. [O94973-1 ]
    uc001lst.2. human. [O94973-2 ]

    Organism-specific databases

    CTDi 161.
    GeneCardsi GC11P000915.
    HGNCi HGNC:562. AP2A2.
    HPAi CAB017514.
    MIMi 607242. gene.
    neXtProti NX_O94973.
    PharmGKBi PA24853.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5096.
    HOGENOMi HOG000170596.
    HOVERGENi HBG050518.
    InParanoidi O94973.
    KOi K11824.
    OMAi QDVFRQH.
    OrthoDBi EOG7GQXV2.
    PhylomeDBi O94973.
    TreeFami TF300308.

    Enzyme and pathway databases

    Reactomei REACT_11166. Nef Mediated CD4 Down-regulation.
    REACT_11200. Nef Mediated CD8 Down-regulation.
    REACT_121399. MHC class II antigen presentation.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_12484. EGFR downregulation.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_18422. Trafficking of GluR2-containing AMPA receptors.
    REACT_22365. Recycling pathway of L1.
    SignaLinki O94973.

    Miscellaneous databases

    ChiTaRSi AP2A2. human.
    GeneWikii AP2A2.
    GenomeRNAii 161.
    NextBioi 643.
    PMAP-CutDB O94973.
    PROi O94973.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94973.
    Bgeei O94973.
    CleanExi HS_AP2A2.
    Genevestigatori O94973.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1030. 1 hit.
    3.30.310.30. 1 hit.
    InterProi IPR017104. AP2_complex_asu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR013038. Clathrin_a-adaptin_app_Ig-like.
    IPR003164. Clathrin_a-adaptin_app_sub_C.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF02296. Alpha_adaptin_C. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037091. AP2_complex_alpha. 1 hit.
    SMARTi SM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-476.
      Tissue: Testis.
    7. "The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis."
      Waelter S., Scherzinger E., Hasenbank R., Nordhoff E., Lurz R., Goehler H., Gauss C., Sathasivam K., Bates G.P., Lehrach H., Wanker E.E.
      Hum. Mol. Genet. 10:1807-1817(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HIP1.
    8. "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network."
      Nakatsu F., Ohno H.
      Cell Struct. Funct. 28:419-429(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
    9. "Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells."
      Hinrichsen L., Harborth J., Andrees L., Weber K., Ungewickell E.J.
      J. Biol. Chem. 278:45160-45170(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CLATHRIN-MEDIATED ENDOCYTOSIS.
    10. "Adaptors for clathrin coats: structure and function."
      Owen D.J., Collins B.M., Evans P.R.
      Annu. Rev. Cell Dev. Biol. 20:153-191(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
    11. "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway."
      Lau A.W., Chou M.M.
      J. Cell Sci. 121:4008-4017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE AP-2 COMPLEX IN NON-CLATHRIN-DEPENDENT ENDOCYTOSIS.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."
      Umasankar P.K., Sanker S., Thieman J.R., Chakraborty S., Wendland B., Tsang M., Traub L.M.
      Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FCHO1.
    14. Cited for: INTERACTION WITH ATAT1.

    Entry informationi

    Entry nameiAP2A2_HUMAN
    AccessioniPrimary (citable) accession number: O94973
    Secondary accession number(s): O75403, Q53ET1, Q96SI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: January 24, 2001
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3