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O94973

- AP2A2_HUMAN

UniProt

O94973 - AP2A2_HUMAN

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Protein

AP-2 complex subunit alpha-2

Gene

AP2A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Phosphatidylinositol lipid headgroupBy similarity
Binding sitei53 – 531Phosphatidylinositol lipid headgroupBy similarity
Binding sitei57 – 571Phosphatidylinositol lipid headgroupBy similarity
Binding sitei58 – 581Phosphatidylinositol lipid headgroupBy similarity
Binding sitei61 – 611Phosphatidylinositol lipid headgroupBy similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. protein kinase binding Source: ParkinsonsUK-UCL
  3. protein transporter activity Source: InterPro

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. axon guidance Source: Reactome
  3. endocytosis Source: UniProtKB-KW
  4. epidermal growth factor receptor signaling pathway Source: Reactome
  5. intracellular protein transport Source: InterPro
  6. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  7. neurotrophin TRK receptor signaling pathway Source: Reactome
  8. regulation of defense response to virus by virus Source: Reactome
  9. synaptic transmission Source: Reactome
  10. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_11166. Nef Mediated CD4 Down-regulation.
REACT_11200. Nef Mediated CD8 Down-regulation.
REACT_121399. MHC class II antigen presentation.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12484. EGFR downregulation.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_18422. Trafficking of GluR2-containing AMPA receptors.
REACT_22365. Recycling pathway of L1.
REACT_228189. EPH-ephrin mediated repulsion of cells.
SignaLinkiO94973.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit alpha-2
Alternative name(s):
100 kDa coated vesicle protein C
Adaptor protein complex AP-2 subunit alpha-2
Adaptor-related protein complex 2 subunit alpha-2
Alpha-adaptin C
Alpha2-adaptin
Clathrin assembly protein complex 2 alpha-C large chain
Huntingtin yeast partner J
Huntingtin-interacting protein 9
Short name:
HIP-9
Huntingtin-interacting protein J
Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
Gene namesi
Name:AP2A2
Synonyms:ADTAB, CLAPA2, HIP9, HYPJ, KIAA0899
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:562. AP2A2.

Subcellular locationi

Cell membrane By similarity. Membranecoated pit By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.By similarity

GO - Cellular componenti

  1. clathrin adaptor complex Source: InterPro
  2. clathrin-coated endocytic vesicle membrane Source: Reactome
  3. coated pit Source: UniProtKB-KW
  4. cytosol Source: Reactome
  5. endocytic vesicle membrane Source: Reactome
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 939938AP-2 complex subunit alpha-2PRO_0000193732Add
BLAST

Proteomic databases

MaxQBiO94973.
PaxDbiO94973.
PRIDEiO94973.

PTM databases

PhosphoSiteiO94973.

Miscellaneous databases

PMAP-CutDBO94973.

Expressioni

Gene expression databases

BgeeiO94973.
CleanExiHS_AP2A2.
ExpressionAtlasiO94973. baseline and differential.
GenevestigatoriO94973.

Organism-specific databases

HPAiCAB017514.

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Binds EPN1, EPS15, AMPH, SNAP91 and BIN1. Interacts with HIP1. Interacts with DGKD isoform 2 (By similarity). Interacts with DENND1A, DENND1B and DENND1C (By similarity). Interacts with FCHO1 and DAB2. Interacts with ATAT1; this interaction is required for efficient alpha-tubulin acetylation by ATAT1.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dab2P980782EBI-1642835,EBI-1391846From a different organism.
Kcnj11Q617432EBI-1642835,EBI-8603527From a different organism.

Protein-protein interaction databases

BioGridi106670. 33 interactions.
IntActiO94973. 20 interactions.
MINTiMINT-1198502.
STRINGi9606.ENSP00000413234.

Structurei

3D structure databases

ProteinModelPortaliO94973.
SMRiO94973. Positions 9-607, 702-939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni5 – 8076Lipid-bindingAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5096.
GeneTreeiENSGT00550000074757.
HOGENOMiHOG000170596.
HOVERGENiHBG050518.
InParanoidiO94973.
KOiK11824.
OMAiQDVFRQH.
OrthoDBiEOG7GQXV2.
PhylomeDBiO94973.
TreeFamiTF300308.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1030. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013038. Clathrin_a-adaptin_app_Ig-like.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O94973-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL
60 70 80 90 100
DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNRYTE KQIGYLFISV
110 120 130 140 150
LVNSNSELIR LINNAIKNDL ASRNPTFMGL ALHCIASVGS REMAEAFAGE
160 170 180 190 200
IPKVLVAGDT MDSVKQSAAL CLLRLYRTSP DLVPMGDWTS RVVHLLNDQH
210 220 230 240 250
LGVVTAATSL ITTLAQKNPE EFKTSVSLAV SRLSRIVTSA STDLQDYTYY
260 270 280 290 300
FVPAPWLSVK LLRLLQCYPP PDPAVRGRLT ECLETILNKA QEPPKSKKVQ
310 320 330 340 350
HSNAKNAVLF EAISLIIHHD SEPNLLVRAC NQLGQFLQHR ETNLRYLALE
360 370 380 390 400
SMCTLASSEF SHEAVKTHIE TVINALKTER DVSVRQRAVD LLYAMCDRSN
410 420 430 440 450
APQIVAEMLS YLETADYSIR EEIVLKVAIL AEKYAVDYTW YVDTILNLIR
460 470 480 490 500
IAGDYVSEEV WYRVIQIVIN RDDVQGYAAK TVFEALQAPA CHENLVKVGG
510 520 530 540 550
YILGEFGNLI AGDPRSSPLI QFHLLHSKFH LCSVPTRALL LSTYIKFVNL
560 570 580 590 600
FPEVKPTIQD VLRSDSQLRN ADVELQQRAV EYLRLSTVAS TDILATVLEE
610 620 630 640 650
MPPFPERESS ILAKLKKKKG PSTVTDLEDT KRDRSVDVNG GPEPAPASTS
660 670 680 690 700
AVSTPSPSAD LLGLGAAPPA PAGPPPSSGG SGLLVDVFSD SASVVAPLAP
710 720 730 740 750
GSEDNFARFV CKNNGVLFEN QLLQIGLKSE FRQNLGRMFI FYGNKTSTQF
760 770 780 790 800
LNFTPTLICS DDLQPNLNLQ TKPVDPTVEG GAQVQQVVNI ECVSDFTEAP
810 820 830 840 850
VLNIQFRYGG TFQNVSVQLP ITLNKFFQPT EMASQDFFQR WKQLSNPQQE
860 870 880 890 900
VQNIFKAKHP MDTEVTKAKI IGFGSALLEE VDPNPANFVG AGIIHTKTTQ
910 920 930
IGCLLRLEPN LQAQMYRLTL RTSKEAVSQR LCELLSAQF
Length:939
Mass (Da):103,960
Last modified:January 24, 2001 - v2
Checksum:iA8D3CC1B15B8C6BF
GO
Isoform 2 (identifier: O94973-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-271: P → PE

Note: No experimental confirmation available.

Show »
Length:940
Mass (Da):104,090
Checksum:i98F8345F9BBB149C
GO
Isoform 3 (identifier: O94973-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-271: P → PE
     653-655: STP → VCL
     656-939: Missing.

Note: No experimental confirmation available.

Show »
Length:656
Mass (Da):73,128
Checksum:i98E2FE160BFAC0AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201I → T in BAB55435. (PubMed:14702039)Curated
Sequence conflicti450 – 4501R → Q in AAC27505. (PubMed:9700202)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei271 – 2711P → PE in isoform 2 and isoform 3. 2 PublicationsVSP_035762
Alternative sequencei653 – 6553STP → VCL in isoform 3. 1 PublicationVSP_035763
Alternative sequencei656 – 939284Missing in isoform 3. 1 PublicationVSP_035764Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020706 mRNA. Translation: BAA74922.2.
AK223558 mRNA. Translation: BAD97278.1.
AK027891 mRNA. Translation: BAB55435.1.
BC006155 mRNA. Translation: AAH06155.1.
AF049527 mRNA. Translation: AAC27505.1.
CCDSiCCDS44512.1. [O94973-1]
CCDS73234.1. [O94973-2]
RefSeqiNP_001229766.1. NM_001242837.1. [O94973-2]
NP_036437.1. NM_012305.3. [O94973-1]
UniGeneiHs.19121.

Genome annotation databases

EnsembliENST00000332231; ENSP00000327694; ENSG00000183020. [O94973-2]
ENST00000448903; ENSP00000413234; ENSG00000183020. [O94973-1]
ENST00000528815; ENSP00000431630; ENSG00000183020. [O94973-3]
GeneIDi161.
KEGGihsa:161.
UCSCiuc001lss.3. human. [O94973-1]
uc001lst.2. human. [O94973-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020706 mRNA. Translation: BAA74922.2 .
AK223558 mRNA. Translation: BAD97278.1 .
AK027891 mRNA. Translation: BAB55435.1 .
BC006155 mRNA. Translation: AAH06155.1 .
AF049527 mRNA. Translation: AAC27505.1 .
CCDSi CCDS44512.1. [O94973-1 ]
CCDS73234.1. [O94973-2 ]
RefSeqi NP_001229766.1. NM_001242837.1. [O94973-2 ]
NP_036437.1. NM_012305.3. [O94973-1 ]
UniGenei Hs.19121.

3D structure databases

ProteinModelPortali O94973.
SMRi O94973. Positions 9-607, 702-939.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106670. 33 interactions.
IntActi O94973. 20 interactions.
MINTi MINT-1198502.
STRINGi 9606.ENSP00000413234.

PTM databases

PhosphoSitei O94973.

Proteomic databases

MaxQBi O94973.
PaxDbi O94973.
PRIDEi O94973.

Protocols and materials databases

DNASUi 161.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332231 ; ENSP00000327694 ; ENSG00000183020 . [O94973-2 ]
ENST00000448903 ; ENSP00000413234 ; ENSG00000183020 . [O94973-1 ]
ENST00000528815 ; ENSP00000431630 ; ENSG00000183020 . [O94973-3 ]
GeneIDi 161.
KEGGi hsa:161.
UCSCi uc001lss.3. human. [O94973-1 ]
uc001lst.2. human. [O94973-2 ]

Organism-specific databases

CTDi 161.
GeneCardsi GC11P000915.
HGNCi HGNC:562. AP2A2.
HPAi CAB017514.
MIMi 607242. gene.
neXtProti NX_O94973.
PharmGKBi PA24853.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5096.
GeneTreei ENSGT00550000074757.
HOGENOMi HOG000170596.
HOVERGENi HBG050518.
InParanoidi O94973.
KOi K11824.
OMAi QDVFRQH.
OrthoDBi EOG7GQXV2.
PhylomeDBi O94973.
TreeFami TF300308.

Enzyme and pathway databases

Reactomei REACT_11166. Nef Mediated CD4 Down-regulation.
REACT_11200. Nef Mediated CD8 Down-regulation.
REACT_121399. MHC class II antigen presentation.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12484. EGFR downregulation.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_18422. Trafficking of GluR2-containing AMPA receptors.
REACT_22365. Recycling pathway of L1.
REACT_228189. EPH-ephrin mediated repulsion of cells.
SignaLinki O94973.

Miscellaneous databases

ChiTaRSi AP2A2. human.
GeneWikii AP2A2.
GenomeRNAii 161.
NextBioi 643.
PMAP-CutDB O94973.
PROi O94973.
SOURCEi Search...

Gene expression databases

Bgeei O94973.
CleanExi HS_AP2A2.
ExpressionAtlasi O94973. baseline and differential.
Genevestigatori O94973.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
2.60.40.1030. 1 hit.
3.30.310.30. 1 hit.
InterProi IPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013038. Clathrin_a-adaptin_app_Ig-like.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view ]
PIRSFi PIRSF037091. AP2_complex_alpha. 1 hit.
SMARTi SM00809. Alpha_adaptinC2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-476.
    Tissue: Testis.
  7. "The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis."
    Waelter S., Scherzinger E., Hasenbank R., Nordhoff E., Lurz R., Goehler H., Gauss C., Sathasivam K., Bates G.P., Lehrach H., Wanker E.E.
    Hum. Mol. Genet. 10:1807-1817(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIP1.
  8. "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network."
    Nakatsu F., Ohno H.
    Cell Struct. Funct. 28:419-429(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  9. "Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells."
    Hinrichsen L., Harborth J., Andrees L., Weber K., Ungewickell E.J.
    J. Biol. Chem. 278:45160-45170(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  10. "Adaptors for clathrin coats: structure and function."
    Owen D.J., Collins B.M., Evans P.R.
    Annu. Rev. Cell Dev. Biol. 20:153-191(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  11. "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway."
    Lau A.W., Chou M.M.
    J. Cell Sci. 121:4008-4017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE AP-2 COMPLEX IN NON-CLATHRIN-DEPENDENT ENDOCYTOSIS.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."
    Umasankar P.K., Sanker S., Thieman J.R., Chakraborty S., Wendland B., Tsang M., Traub L.M.
    Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FCHO1.
  14. Cited for: INTERACTION WITH ATAT1.

Entry informationi

Entry nameiAP2A2_HUMAN
AccessioniPrimary (citable) accession number: O94973
Secondary accession number(s): O75403, Q53ET1, Q96SI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: November 26, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3