O94966 (UBP19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 19
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 19
Ubiquitin thioesterase 19
Ubiquitin-specific-processing protease 19
Zinc finger MYND domain-containing protein 9

Gene names

Name:	USP19
Synonyms:	KIAA0891, ZMYND9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains. Ref.6 Ref.9 Ref.10 Ref.11
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit structure	Interacts with RNF123 By similarity. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with HIF1A (via N-terminus). Ref.9 Ref.11
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein Ref.6.
Sequence similarities	Belongs to the peptidase C19 family. Contains 2 CS domains. Contains 1 MYND-type zinc finger.
Sequence caution	The sequence AAI06030.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAI06030.1 differs from that shown. Reason: Frameshift at position 572. The sequence AAI42661.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAA74914.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Protease Thiol protease
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER-associated protein catabolic process Inferred from direct assay Ref.6. Source: UniProtKB negative regulation of skeletal muscle tissue development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell cycle process Inferred from sequence or structural similarity. Source: UniProtKB protein deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB regulation of cellular response to hypoxia Inferred from mutant phenotype Ref.11. Source: UniProtKB regulation of protein stability Inferred from sequence or structural similarity. Source: UniProtKB response to endoplasmic reticulum stress Inferred from expression pattern Ref.6. Source: UniProtKB skeletal muscle atrophy Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	endoplasmic reticulum membrane Inferred from direct assay Ref.6. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro ubiquitin-specific protease activity Inferred from direct assay Ref.6. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94966-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94966-2)

The sequence of this isoform differs from the canonical sequence as follows:
     100-114: Missing.
     202-202: L → LKKPLGTQEL...PPFVADPATQ
     573-574: IV → RL
     575-1318: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O94966-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1244-1298: ASRIWQELEA...LRYFVLGTVA → GLGPGQAPEV...PTYSNMEEVD
     1299-1318: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: O94966-4)

The sequence of this isoform differs from the canonical sequence as follows:
     100-114: Missing.
     389-389: R → RGA
     1244-1298: ASRIWQELEA...LRYFVLGTVA → GLGPGQAPEV...PTYSNMEEVD
     1299-1318: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: O94966-5)

The sequence of this isoform differs from the canonical sequence as follows:
     202-202: L → LKKPLGTQEL...PPFVADPATQ

Note: No experimental confirmation available.

Isoform 6 (identifier: O94966-6)

The sequence of this isoform differs from the canonical sequence as follows:
     202-202: L → LKKPLGTQEL...PPFVADPATQ
     389-389: R → RGA
     1244-1298: ASRIWQELEA...LRYFVLGTVA → GLGPGQAPEV...PTYSNMEEVD

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1318

1318

Ubiquitin carboxyl-terminal hydrolase 19

PRO_0000080646

Regions

Topological domain

1 – 1291

1291

Cytoplasmic Potential

Transmembrane

1292 – 1312

21

Helical; Potential

Topological domain

1313 – 1318

6

Lumenal Potential

Domain

113 – 202

90

CS 1

Domain

282 – 384

103

CS 2

Zinc finger

791 – 833

43

MYND-type

Sites

Active site

506

1

Nucleophile By similarity

Active site

1165

1

Proton acceptor By similarity

Natural variations

Alternative sequence

100 – 114

15

Missing in isoform 2 and isoform 4.

VSP_026708

Alternative sequence

202

1

L → LKKPLGTQELVPGLRCQENG QELSPIALEPGPEPHRAKQE ARNQKRAQGRGEVGAGAGPG AQAGPSAKRAVHLCRGPEGD GSRDDPGPRGDAPPFVADPA TQ in isoform 2, isoform 5 and isoform 6.

VSP_026709

Alternative sequence

389

1

R → RGA in isoform 4 and isoform 6.

VSP_045891

Alternative sequence

573 – 574

2

IV → RL in isoform 2.

VSP_026710

Alternative sequence

575 – 1318

744

Missing in isoform 2.

VSP_026711

Alternative sequence

1244 – 1298

55

ASRIW…LGTVA → GLGPGQAPEVAPTRTAPERF APPVDRPAPTYSNMEEVD in isoform 3, isoform 4 and isoform 6.

VSP_026712

Alternative sequence

1299 – 1318

20

Missing in isoform 3 and isoform 4.

VSP_026713

Natural variant

36

1

D → H.
Corresponds to variant rs11552724 [ dbSNP | Ensembl ].

VAR_051528

Experimental info

Sequence conflict

942

1

S → C in BAG57894. Ref.2

Isoform 4:

Sequence conflict

1251

1

A → T in AAH82241. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1318

Helix Strand Turn

Details...

Helix

276 – 278

3

Beta strand

279 – 283

5

Beta strand

287 – 292

6

Turn

293 – 295

3

Beta strand

296 – 302

7

Beta strand

312 – 315

4

Beta strand

317 – 324

8

Helix

329 – 334

6

Beta strand

344 – 352

9

Turn

356 – 358

3

Beta strand

360 – 363

4

Beta strand

365 – 377

13

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: EA9F318D03304AA1	FASTA	1,318	145,651
	10 20 30 40 50 60 MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLEPLASGD 70 80 90 100 110 120 PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPTPELLLDW 130 140 150 160 170 180 RQSAEEVIVK LRVGVGPLQL EDVDAAFTDT DCVVRFAGGQ QWGGVFYAEI KSSCAKVQTR 190 200 210 220 230 240 KGSLLHLTLP KKVPMLTWPS LLVEADEQLC IPPLNSQTCL LGSEENLAPL AGEKAVPPGN 250 260 270 280 290 300 DPVSPAMVRS RNPGKDDCAK EEMAVAADAA TLVDEPESMV NLAFVKNDSY EKGPDSVVVH 310 320 330 340 350 360 VYVKEICRDT SRVLFREQDF TLIFQTRDGN FLRLHPGCGP HTTFRWQVKL RNLIEPEQCT 370 380 390 400 410 420 FCFTASRIDI CLRKRQSQRW GGLEAPAARV GGAKVAVPTG PTPLDSTPPG GAPHPLTGQE 430 440 450 460 470 480 EARAVEKDKS KARSEDTGLD SVATRTPMEH VTPKPETHLA SPKPTCMVPP MPHSPVSGDS 490 500 510 520 530 540 VEEEEEEEKK VCLPGFTGLV NLGNTCFMNS VIQSLSNTRE LRDFFHDRSF EAEINYNNPL 550 560 570 580 590 600 GTGGRLAIGF AVLLRALWKG THHAFQPSKL KAIVASKASQ FTGYAQHDAQ EFMAFLLDGL 610 620 630 640 650 660 HEDLNRIQNK PYTETVDSDG RPDEVVAEEA WQRHKMRNDS FIVDLFQGQY KSKLVCPVCA 670 680 690 700 710 720 KVSITFDPFL YLPVPLPQKQ KVLPVFYFAR EPHSKPIKFL VSVSKENSTA SEVLDSLSQS 730 740 750 760 770 780 VHVKPENLRL AEVIKNRFHR VFLPSHSLDT VSPSDTLLCF ELLSSELAKE RVVVLEVQQR 790 800 810 820 830 840 PQVPSVPISK CAACQRKQQS EDEKLKRCTR CYRVGYCNQL CQKTHWPDHK GLCRPENIGY 850 860 870 880 890 900 PFLVSVPASR LTYARLAQLL EGYARYSVSV FQPPFQPGRM ALESQSPGCT TLLSTGSLEA 910 920 930 940 950 960 GDSERDPIQP PELQLVTPMA EGDTGLPRVW AAPDRGPVPS TSGISSEMLA SGPIEVGSLP 970 980 990 1000 1010 1020 AGERVSRPEA AVPGYQHPSE AMNAHTPQFF IYKIDSSNRE QRLEDKGDTP LELGDDCSLA 1030 1040 1050 1060 1070 1080 LVWRNNERLQ EFVLVASKEL ECAEDPGSAG EAARAGHFTL DQCLNLFTRP EVLAPEEAWY 1090 1100 1110 1120 1130 1140 CPQCKQHREA SKQLLLWRLP NVLIVQLKRF SFRSFIWRDK INDLVEFPVR NLDLSKFCIG 1150 1160 1170 1180 1190 1200 QKEEQLPSYD LYAVINHYGG MIGGHYTACA RLPNDRSSQR SDVGWRLFDD STVTTVDESQ 1210 1220 1230 1240 1250 1260 VVTRYAYVLF YRRRNSPVER PPRAGHSEHH PDLGPAAEAA ASQASRIWQE LEAEEEPVPE 1270 1280 1290 1300 1310 GSGPLGPWGP QDWVGPLPRG PTTPDEGCLR YFVLGTVAAL VALVLNVFYP LVSQSRWR
	Isoform 2 [UniParc]. Checksum: 3DEF7C14294E7E92	FASTA	660	71,090
	10 20 30 40 50 60 MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLEPLASGD 70 80 90 100 110 120 PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEE LLLDWRQSAE EVIVKLRVGV 130 140 150 160 170 180 GPLQLEDVDA AFTDTDCVVR FAGGQQWGGV FYAEIKSSCA KVQTRKGSLL HLTLPKKVPM 190 200 210 220 230 240 LTWPSLLKKP LGTQELVPGL RCQENGQELS PIALEPGPEP HRAKQEARNQ KRAQGRGEVG 250 260 270 280 290 300 AGAGPGAQAG PSAKRAVHLC RGPEGDGSRD DPGPRGDAPP FVADPATQVE ADEQLCIPPL 310 320 330 340 350 360 NSQTCLLGSE ENLAPLAGEK AVPPGNDPVS PAMVRSRNPG KDDCAKEEMA VAADAATLVD 370 380 390 400 410 420 EPESMVNLAF VKNDSYEKGP DSVVVHVYVK EICRDTSRVL FREQDFTLIF QTRDGNFLRL 430 440 450 460 470 480 HPGCGPHTTF RWQVKLRNLI EPEQCTFCFT ASRIDICLRK RQSQRWGGLE APAARVGGAK 490 500 510 520 530 540 VAVPTGPTPL DSTPPGGAPH PLTGQEEARA VEKDKSKARS EDTGLDSVAT RTPMEHVTPK 550 560 570 580 590 600 PETHLASPKP TCMVPPMPHS PVSGDSVEEE EEEEKKVCLP GFTGLVNLGN TCFMNSVIQS 610 620 630 640 650 660 LSNTRELRDF FHDRSFEAEI NYNNPLGTGG RLAIGFAVLL RALWKGTHHA FQPSKLKARL
	Isoform 3 [UniParc]. Checksum: 442FF7C6DE59AE94	FASTA	1,281	141,413
	10 20 30 40 50 60 MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLEPLASGD 70 80 90 100 110 120 PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPTPELLLDW 130 140 150 160 170 180 RQSAEEVIVK LRVGVGPLQL EDVDAAFTDT DCVVRFAGGQ QWGGVFYAEI KSSCAKVQTR 190 200 210 220 230 240 KGSLLHLTLP KKVPMLTWPS LLVEADEQLC IPPLNSQTCL LGSEENLAPL AGEKAVPPGN 250 260 270 280 290 300 DPVSPAMVRS RNPGKDDCAK EEMAVAADAA TLVDEPESMV NLAFVKNDSY EKGPDSVVVH 310 320 330 340 350 360 VYVKEICRDT SRVLFREQDF TLIFQTRDGN FLRLHPGCGP HTTFRWQVKL RNLIEPEQCT 370 380 390 400 410 420 FCFTASRIDI CLRKRQSQRW GGLEAPAARV GGAKVAVPTG PTPLDSTPPG GAPHPLTGQE 430 440 450 460 470 480 EARAVEKDKS KARSEDTGLD SVATRTPMEH VTPKPETHLA SPKPTCMVPP MPHSPVSGDS 490 500 510 520 530 540 VEEEEEEEKK VCLPGFTGLV NLGNTCFMNS VIQSLSNTRE LRDFFHDRSF EAEINYNNPL 550 560 570 580 590 600 GTGGRLAIGF AVLLRALWKG THHAFQPSKL KAIVASKASQ FTGYAQHDAQ EFMAFLLDGL 610 620 630 640 650 660 HEDLNRIQNK PYTETVDSDG RPDEVVAEEA WQRHKMRNDS FIVDLFQGQY KSKLVCPVCA 670 680 690 700 710 720 KVSITFDPFL YLPVPLPQKQ KVLPVFYFAR EPHSKPIKFL VSVSKENSTA SEVLDSLSQS 730 740 750 760 770 780 VHVKPENLRL AEVIKNRFHR VFLPSHSLDT VSPSDTLLCF ELLSSELAKE RVVVLEVQQR 790 800 810 820 830 840 PQVPSVPISK CAACQRKQQS EDEKLKRCTR CYRVGYCNQL CQKTHWPDHK GLCRPENIGY 850 860 870 880 890 900 PFLVSVPASR LTYARLAQLL EGYARYSVSV FQPPFQPGRM ALESQSPGCT TLLSTGSLEA 910 920 930 940 950 960 GDSERDPIQP PELQLVTPMA EGDTGLPRVW AAPDRGPVPS TSGISSEMLA SGPIEVGSLP 970 980 990 1000 1010 1020 AGERVSRPEA AVPGYQHPSE AMNAHTPQFF IYKIDSSNRE QRLEDKGDTP LELGDDCSLA 1030 1040 1050 1060 1070 1080 LVWRNNERLQ EFVLVASKEL ECAEDPGSAG EAARAGHFTL DQCLNLFTRP EVLAPEEAWY 1090 1100 1110 1120 1130 1140 CPQCKQHREA SKQLLLWRLP NVLIVQLKRF SFRSFIWRDK INDLVEFPVR NLDLSKFCIG 1150 1160 1170 1180 1190 1200 QKEEQLPSYD LYAVINHYGG MIGGHYTACA RLPNDRSSQR SDVGWRLFDD STVTTVDESQ 1210 1220 1230 1240 1250 1260 VVTRYAYVLF YRRRNSPVER PPRAGHSEHH PDLGPAAEAA ASQGLGPGQA PEVAPTRTAP 1270 1280 ERFAPPVDRP APTYSNMEEV D
	Isoform 4 [UniParc]. Checksum: CD9BFE22C20EB03E	FASTA	1,268	140,022
	10 20 30 40 50 60 MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLEPLASGD 70 80 90 100 110 120 PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEE LLLDWRQSAE EVIVKLRVGV 130 140 150 160 170 180 GPLQLEDVDA AFTDTDCVVR FAGGQQWGGV FYAEIKSSCA KVQTRKGSLL HLTLPKKVPM 190 200 210 220 230 240 LTWPSLLVEA DEQLCIPPLN SQTCLLGSEE NLAPLAGEKA VPPGNDPVSP AMVRSRNPGK 250 260 270 280 290 300 DDCAKEEMAV AADAATLVDE PESMVNLAFV KNDSYEKGPD SVVVHVYVKE ICRDTSRVLF 310 320 330 340 350 360 REQDFTLIFQ TRDGNFLRLH PGCGPHTTFR WQVKLRNLIE PEQCTFCFTA SRIDICLRKR 370 380 390 400 410 420 QSQRWGGLEA PAARGAVGGA KVAVPTGPTP LDSTPPGGAP HPLTGQEEAR AVEKDKSKAR 430 440 450 460 470 480 SEDTGLDSVA TRTPMEHVTP KPETHLASPK PTCMVPPMPH SPVSGDSVEE EEEEEKKVCL 490 500 510 520 530 540 PGFTGLVNLG NTCFMNSVIQ SLSNTRELRD FFHDRSFEAE INYNNPLGTG GRLAIGFAVL 550 560 570 580 590 600 LRALWKGTHH AFQPSKLKAI VASKASQFTG YAQHDAQEFM AFLLDGLHED LNRIQNKPYT 610 620 630 640 650 660 ETVDSDGRPD EVVAEEAWQR HKMRNDSFIV DLFQGQYKSK LVCPVCAKVS ITFDPFLYLP 670 680 690 700 710 720 VPLPQKQKVL PVFYFAREPH SKPIKFLVSV SKENSTASEV LDSLSQSVHV KPENLRLAEV 730 740 750 760 770 780 IKNRFHRVFL PSHSLDTVSP SDTLLCFELL SSELAKERVV VLEVQQRPQV PSVPISKCAA 790 800 810 820 830 840 CQRKQQSEDE KLKRCTRCYR VGYCNQLCQK THWPDHKGLC RPENIGYPFL VSVPASRLTY 850 860 870 880 890 900 ARLAQLLEGY ARYSVSVFQP PFQPGRMALE SQSPGCTTLL STGSLEAGDS ERDPIQPPEL 910 920 930 940 950 960 QLVTPMAEGD TGLPRVWAAP DRGPVPSTSG ISSEMLASGP IEVGSLPAGE RVSRPEAAVP 970 980 990 1000 1010 1020 GYQHPSEAMN AHTPQFFIYK IDSSNREQRL EDKGDTPLEL GDDCSLALVW RNNERLQEFV 1030 1040 1050 1060 1070 1080 LVASKELECA EDPGSAGEAA RAGHFTLDQC LNLFTRPEVL APEEAWYCPQ CKQHREASKQ 1090 1100 1110 1120 1130 1140 LLLWRLPNVL IVQLKRFSFR SFIWRDKIND LVEFPVRNLD LSKFCIGQKE EQLPSYDLYA 1150 1160 1170 1180 1190 1200 VINHYGGMIG GHYTACARLP NDRSSQRSDV GWRLFDDSTV TTVDESQVVT RYAYVLFYRR 1210 1220 1230 1240 1250 1260 RNSPVERPPR AGHSEHHPDL GPAAEAAASQ GLGPGQAPEV APTRTAPERF APPVDRPAPT YSNMEEVD
	Isoform 5 [UniParc]. Checksum: 0FCD06C7B0C80C4E	FASTA	1,419	156,035
	10 20 30 40 50 60 MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLEPLASGD 70 80 90 100 110 120 PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPTPELLLDW 130 140 150 160 170 180 RQSAEEVIVK LRVGVGPLQL EDVDAAFTDT DCVVRFAGGQ QWGGVFYAEI KSSCAKVQTR 190 200 210 220 230 240 KGSLLHLTLP KKVPMLTWPS LLKKPLGTQE LVPGLRCQEN GQELSPIALE PGPEPHRAKQ 250 260 270 280 290 300 EARNQKRAQG RGEVGAGAGP GAQAGPSAKR AVHLCRGPEG DGSRDDPGPR GDAPPFVADP 310 320 330 340 350 360 ATQVEADEQL CIPPLNSQTC LLGSEENLAP LAGEKAVPPG NDPVSPAMVR SRNPGKDDCA 370 380 390 400 410 420 KEEMAVAADA ATLVDEPESM VNLAFVKNDS YEKGPDSVVV HVYVKEICRD TSRVLFREQD 430 440 450 460 470 480 FTLIFQTRDG NFLRLHPGCG PHTTFRWQVK LRNLIEPEQC TFCFTASRID ICLRKRQSQR 490 500 510 520 530 540 WGGLEAPAAR VGGAKVAVPT GPTPLDSTPP GGAPHPLTGQ EEARAVEKDK SKARSEDTGL 550 560 570 580 590 600 DSVATRTPME HVTPKPETHL ASPKPTCMVP PMPHSPVSGD SVEEEEEEEK KVCLPGFTGL 610 620 630 640 650 660 VNLGNTCFMN SVIQSLSNTR ELRDFFHDRS FEAEINYNNP LGTGGRLAIG FAVLLRALWK 670 680 690 700 710 720 GTHHAFQPSK LKAIVASKAS QFTGYAQHDA QEFMAFLLDG LHEDLNRIQN KPYTETVDSD 730 740 750 760 770 780 GRPDEVVAEE AWQRHKMRND SFIVDLFQGQ YKSKLVCPVC AKVSITFDPF LYLPVPLPQK 790 800 810 820 830 840 QKVLPVFYFA REPHSKPIKF LVSVSKENST ASEVLDSLSQ SVHVKPENLR LAEVIKNRFH 850 860 870 880 890 900 RVFLPSHSLD TVSPSDTLLC FELLSSELAK ERVVVLEVQQ RPQVPSVPIS KCAACQRKQQ 910 920 930 940 950 960 SEDEKLKRCT RCYRVGYCNQ LCQKTHWPDH KGLCRPENIG YPFLVSVPAS RLTYARLAQL 970 980 990 1000 1010 1020 LEGYARYSVS VFQPPFQPGR MALESQSPGC TTLLSTGSLE AGDSERDPIQ PPELQLVTPM 1030 1040 1050 1060 1070 1080 AEGDTGLPRV WAAPDRGPVP STSGISSEML ASGPIEVGSL PAGERVSRPE AAVPGYQHPS 1090 1100 1110 1120 1130 1140 EAMNAHTPQF FIYKIDSSNR EQRLEDKGDT PLELGDDCSL ALVWRNNERL QEFVLVASKE 1150 1160 1170 1180 1190 1200 LECAEDPGSA GEAARAGHFT LDQCLNLFTR PEVLAPEEAW YCPQCKQHRE ASKQLLLWRL 1210 1220 1230 1240 1250 1260 PNVLIVQLKR FSFRSFIWRD KINDLVEFPV RNLDLSKFCI GQKEEQLPSY DLYAVINHYG 1270 1280 1290 1300 1310 1320 GMIGGHYTAC ARLPNDRSSQ RSDVGWRLFD DSTVTTVDES QVVTRYAYVL FYRRRNSPVE 1330 1340 1350 1360 1370 1380 RPPRAGHSEH HPDLGPAAEA AASQASRIWQ ELEAEEEPVP EGSGPLGPWG PQDWVGPLPR 1390 1400 1410 GPTTPDEGCL RYFVLGTVAA LVALVLNVFY PLVSQSRWR
	Isoform 6 [UniParc]. Checksum: 7123BB987FCFEF8E	FASTA	1,404	154,239
	10 20 30 40 50 60 MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLEPLASGD 70 80 90 100 110 120 PSASASHAAG ITGSRHRTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPTPELLLDW 130 140 150 160 170 180 RQSAEEVIVK LRVGVGPLQL EDVDAAFTDT DCVVRFAGGQ QWGGVFYAEI KSSCAKVQTR 190 200 210 220 230 240 KGSLLHLTLP KKVPMLTWPS LLKKPLGTQE LVPGLRCQEN GQELSPIALE PGPEPHRAKQ 250 260 270 280 290 300 EARNQKRAQG RGEVGAGAGP GAQAGPSAKR AVHLCRGPEG DGSRDDPGPR GDAPPFVADP 310 320 330 340 350 360 ATQVEADEQL CIPPLNSQTC LLGSEENLAP LAGEKAVPPG NDPVSPAMVR SRNPGKDDCA 370 380 390 400 410 420 KEEMAVAADA ATLVDEPESM VNLAFVKNDS YEKGPDSVVV HVYVKEICRD TSRVLFREQD 430 440 450 460 470 480 FTLIFQTRDG NFLRLHPGCG PHTTFRWQVK LRNLIEPEQC TFCFTASRID ICLRKRQSQR 490 500 510 520 530 540 WGGLEAPAAR GAVGGAKVAV PTGPTPLDST PPGGAPHPLT GQEEARAVEK DKSKARSEDT 550 560 570 580 590 600 GLDSVATRTP MEHVTPKPET HLASPKPTCM VPPMPHSPVS GDSVEEEEEE EKKVCLPGFT 610 620 630 640 650 660 GLVNLGNTCF MNSVIQSLSN TRELRDFFHD RSFEAEINYN NPLGTGGRLA IGFAVLLRAL 670 680 690 700 710 720 WKGTHHAFQP SKLKAIVASK ASQFTGYAQH DAQEFMAFLL DGLHEDLNRI QNKPYTETVD 730 740 750 760 770 780 SDGRPDEVVA EEAWQRHKMR NDSFIVDLFQ GQYKSKLVCP VCAKVSITFD PFLYLPVPLP 790 800 810 820 830 840 QKQKVLPVFY FAREPHSKPI KFLVSVSKEN STASEVLDSL SQSVHVKPEN LRLAEVIKNR 850 860 870 880 890 900 FHRVFLPSHS LDTVSPSDTL LCFELLSSEL AKERVVVLEV QQRPQVPSVP ISKCAACQRK 910 920 930 940 950 960 QQSEDEKLKR CTRCYRVGYC NQLCQKTHWP DHKGLCRPEN IGYPFLVSVP ASRLTYARLA 970 980 990 1000 1010 1020 QLLEGYARYS VSVFQPPFQP GRMALESQSP GCTTLLSTGS LEAGDSERDP IQPPELQLVT 1030 1040 1050 1060 1070 1080 PMAEGDTGLP RVWAAPDRGP VPSTSGISSE MLASGPIEVG SLPAGERVSR PEAAVPGYQH 1090 1100 1110 1120 1130 1140 PSEAMNAHTP QFFIYKIDSS NREQRLEDKG DTPLELGDDC SLALVWRNNE RLQEFVLVAS 1150 1160 1170 1180 1190 1200 KELECAEDPG SAGEAARAGH FTLDQCLNLF TRPEVLAPEE AWYCPQCKQH REASKQLLLW 1210 1220 1230 1240 1250 1260 RLPNVLIVQL KRFSFRSFIW RDKINDLVEF PVRNLDLSKF CIGQKEEQLP SYDLYAVINH 1270 1280 1290 1300 1310 1320 YGGMIGGHYT ACARLPNDRS SQRSDVGWRL FDDSTVTTVD ESQVVTRYAY VLFYRRRNSP 1330 1340 1350 1360 1370 1380 VERPPRAGHS EHHPDLGPAA EAAASQGLGP GQAPEVAPTR TAPERFAPPV DRPAPTYSNM 1390 1400 EEVDALVALV LNVFYPLVSQ SRWR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 846-1318 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-1318 (ISOFORM 4). Tissue: Skin and Testis.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates." Hassink G.C., Zhao B., Sompallae R., Altun M., Gastaldello S., Zinin N.V., Masucci M.G., Lindsten K. EMBO Rep. 10:755-761(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TOPOLOGY, SUBCELLULAR LOCATION.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2." Mei Y., Hahn A.A., Hu S., Yang X. J. Biol. Chem. 286:35380-35387(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH BIRC2/C-IAP1; BIRC3/C-IAP2 AND XIAP/BIRC4.
[10]	"Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes." Iphofer A., Kummer A., Nimtz M., Ritter A., Arnold T., Frank R., van den Heuvel J., Kessler B.M., Jansch L., Franke R. ChemBioChem 13:1416-1420(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, LINKAGE SPECIFICITY.
[11]	"Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia." Altun M., Zhao B., Velasco K., Liu H., Hassink G., Paschke J., Pereira T., Lindsten K. J. Biol. Chem. 287:1962-1969(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH HIF1A.
[12]	"Solution structure of the CS domain of human USP19." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 273-393.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB020698 mRNA. Translation: BAA74914.1. Different initiation.
AK294756 mRNA. Translation: BAG57894.1.
AC135506 Genomic DNA. No translation available.
BC048269 mRNA. Translation: AAH48269.1.
BC065909 mRNA. Translation: AAH65909.1.
BC082241 mRNA. Translation: AAH82241.1.
BC106029 mRNA. Translation: AAI06030.1. Sequence problems.
BC142660 mRNA. Translation: AAI42661.1. Different initiation.
BC146752 mRNA. Translation: AAI46753.1.

IPI

IPI00016589.
IPI00654743.
IPI00797161.
IPI00853489.
IPI00927646.

RefSeq

NP_001186089.1. NM_001199160.1.
NP_001186090.1. NM_001199161.1.
NP_001186091.1. NM_001199162.1.
NP_006668.1. NM_006677.2.

UniGene

Hs.255596.
Hs.734003.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WH0	NMR	-	A	273-393	[»]

ProteinModelPortal

O94966.

ModBase

Search...

Protein-protein interaction databases

IntAct

O94966. 32 interactions.

MINT

MINT-4658026.

STRING

9606.ENSP00000381863.

Protein family/group databases

MEROPS

C19.024.

PTM databases

PhosphoSite

O94966.

Proteomic databases

PaxDb

O94966.

PRIDE

O94966.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000398888; ENSP00000381863; ENSG00000172046.
ENST00000434032; ENSP00000401197; ENSG00000172046.

GeneID

10869.

KEGG

hsa:10869.

UCSC

uc003cwb.3. human.
uc003cwd.2. human.

Organism-specific databases

CTD

10869.

GeneCards

GC03M049120.

HGNC

HGNC:12617. USP19.

MIM

614471. gene.

neXtProt

NX_O94966.

PharmGKB

PA37243.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5560.

HOGENOM

HOG000074206.

HOVERGEN

HBG061889.

KO

K11847.

Gene expression databases

ArrayExpress

O94966.

Bgee

O94966.

CleanEx

HS_USP19.

Genevestigator

O94966.

GermOnline

ENSG00000172046. Homo sapiens.

Family and domain databases

InterPro

IPR007052. CS-like_domain.
IPR017447. CS_domain.
IPR015054. DUF1872.
IPR008978. HSP20-like_chaperone.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
IPR002893. Znf_MYND.
[Graphical view]

Pfam

PF04969. CS. 1 hit.
PF08959. DUF1872. 1 hit.
PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]

SUPFAM

SSF49764. HSP20_chap. 2 hits.

PROSITE

PS51203. CS. 2 hits.
PS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

USP19. human.

EvolutionaryTrace

O94966.

GenomeRNAi

10869.

NextBio

41271.

SOURCE

Search...

Entry information

Entry name

UBP19_HUMAN

Accession

Primary (citable) accession number: O94966
Secondary accession number(s): A5PKX8 , A6H8U2, B4DGT3, E7ETS0, E9PEG8, Q3KQW4, Q641Q9, Q6NZY8, Q86XV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	July 10, 2007
Last modified:	May 1, 2013
This is version 118 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.