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O94964 (K0889_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein KIAA0889
Gene names
Name:KIAA0889
Synonyms:C20orf117
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1423 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence caution

The sequence BAA74912.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O94964-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O94964-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEAPAAEPPV...DEIEELRAEM
Note: No experimental confirmation available. Gene prediction based on EST data.
Isoform 3 (identifier: O94964-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-870: Missing.
     871-922: NRLSQLQKAA...EVELGGNGLK → MWDWAPTTSL...NNDVSSSVLR
     1374-1423: DAVCDCSTQSLTSCFARSSRSAIRHSPSKCRLHPSESSWGGEERALPPSE → VGGWDLSFLLVGGVSI
Isoform 4 (identifier: O94964-4)

The sequence of this isoform differs from the canonical sequence as follows:
     998-1016: RQMQRSYTAPDKTGIRVYY → SQKLPFLLILAPPQPPPIL
     1017-1423: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Sequence conflict9981S → R in BAC86621. Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14231423Uncharacterized protein KIAA0889
PRO_0000050781

Amino acid modifications

Modified residue10171Phosphoserine Ref.5 Ref.7
Modified residue12441Phosphoserine Ref.6
Modified residue13031Phosphoserine Ref.6

Natural variations

Alternative sequence1 – 870870Missing in isoform 3.
VSP_035976
Alternative sequence11M → MEAPAAEPPVRGCGPQPAPA PAPAPERKKSHRAPSPARPK DVAGWSLAKGRRGPGPGSAV ACSAAFSSRPDKKGRAVAPG ARGAGVRVAGVRTGVRAKGR PRSGAGPRPPPPPPSLTDSS SEVSDCASEEARLLGLELAL SSDAESAAGGPAGVRTGQPA QPAPSAQQPPRPPASPDEPS VAASSVGSSRLPLSASLAFS DLTEEMLDCGPSGLVRELEE LRSENDYLKDEIEELRAEM in isoform 2.
VSP_035977
Alternative sequence871 – 92252NRLSQ…GNGLK → MWDWAPTTSLQEVNKTVLVF ALTQHTDQGGRPECALSVIS TNNDVSSSVLR in isoform 3.
VSP_035978
Alternative sequence998 – 101619RQMQR…IRVYY → SQKLPFLLILAPPQPPPIL in isoform 4.
VSP_040825
Alternative sequence1017 – 1423407Missing in isoform 4.
VSP_040826
Alternative sequence1374 – 142350DAVCD…LPPSE → VGGWDLSFLLVGGVSI in isoform 3.
VSP_035979
Natural variant9931Q → H.
Corresponds to variant rs34459518 [ dbSNP | Ensembl ].
VAR_056848

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: EE50F4D144ABD972

FASTA1,423159,760
        10         20         30         40         50         60 
MLEMRDVYME EDVYQLQELR QQLDQASKTC RILQYRLRKA ERRSLRAAQT GQVDGELIRG 

        70         80         90        100        110        120 
LEQDVKVSKD ISMRLHKELE VVEKKRARLE EENEELRQRL IETELAKQVL QTELERPREH 

       130        140        150        160        170        180 
SLKKRGTRSL GKADKKTLVQ EDSADLKCQL HFAKEESALM CKKLTKLAKE NDSMKEELLK 

       190        200        210        220        230        240 
YRSLYGDLDS ALSAEELADA PHSRETELKV HLKLVEEEAN LLSRRIVELE VENRGLRAEM 

       250        260        270        280        290        300 
DDMKDHGGGC GGPEARLAFS ALGGGECGES LAELRRHLQF VEEEAELLRR SSAELEDQNK 

       310        320        330        340        350        360 
LLLNELAKFR SEHELDVALS EDSCSVLSEP SQEELAAAKL QIGELSGKVK KLQYENRVLL 

       370        380        390        400        410        420 
SNLQRCDLAS CQSTRPMLET DAEAGDSAQC VPAPLGETHE SHAVRLCRAR EAEVLPGLRE 

       430        440        450        460        470        480 
QAALVSKAID VLVADANGFT AGLRLCLDNE CADFRLHEAP DNSEGPRDTK LIHAILVRLS 

       490        500        510        520        530        540 
VLQQELNAFT RKADAVLGCS VKEQQESFSS LPPLGSQGLS KEILLAKDLG SDFQPPDFRD 

       550        560        570        580        590        600 
LPEWEPRIRE AFRTGDLDSK PDPSRSFRPY RAEDNDSYAS EIKELQLVLA EAHDSLRGLQ 

       610        620        630        640        650        660 
EQLSQERQLR KEEADNFNQK MVQLKEDQQR ALLRREFELQ SLSLQRRLEQ KFWSQEKNML 

       670        680        690        700        710        720 
VQESQQFKHN FLLLFMKLRW FLKRWRQGKV LPSEGDDFLE VNSMKELYLL MEEEEINAQH 

       730        740        750        760        770        780 
SDNKACTGDS WTQNTPNEYI KTLADMKVTL KELCWLLRDE RRGLTELQQQ FAKAKATWET 

       790        800        810        820        830        840 
ERAELKGHTS QMELKTGKGA GERAGPDWKA ALQREREEQQ HLLAESYSAV MELTRQLQIS 

       850        860        870        880        890        900 
ERNWSQEKLQ LVERLQGEKQ QVEQQVKELQ NRLSQLQKAA DPWVLKHSEL EKQDNSWKET 

       910        920        930        940        950        960 
RSEKIHDKEA VSEVELGGNG LKRTKSVSSM SEFESLLDCS PYLAGGDARG KKLPNNPAFG 

       970        980        990       1000       1010       1020 
FVSSEPGDPE KDTKEKPGLS SRDCNHLGAL ACQDPPGRQM QRSYTAPDKT GIRVYYSPPV 

      1030       1040       1050       1060       1070       1080 
ARRLGVPVVH DKEGKIIIEP GFLFTTAKPK ESAEADGLAE SSYGRWLCNF SRQRLDGGSA 

      1090       1100       1110       1120       1130       1140 
GSPSAAGPGF PAALHDFEMS GNMSDDMKEI TNCVRQAMRS GSLERKVKST SSQTVGLASV 

      1150       1160       1170       1180       1190       1200 
GTQTIRTVSV GLQTDPPRSS LHGKAWSPRS SSLVSVRSKQ ISSSLDKVHS RIERPCCSPK 

      1210       1220       1230       1240       1250       1260 
YGSPKLQRRS VSKLDSSKDR SLWNLHQGKQ NGSAWARSTT TRDSPVLRNI NDGLSSLFSV 

      1270       1280       1290       1300       1310       1320 
VEHSGSTESV WKLGMSETRA KPEPPKYGIV QEFFRNVCGR APSPTSSAGE EGTKKPEPLS 

      1330       1340       1350       1360       1370       1380 
PASYHQPEGV ARILNKKAAK LGSSEEVRLT MLPQVGKDGV LRDGDGAVVL PNEDAVCDCS 

      1390       1400       1410       1420 
TQSLTSCFAR SSRSAIRHSP SKCRLHPSES SWGGEERALP PSE 

« Hide

Isoform 2 [UniParc].

Checksum: 95230B6E556F3D03
Show »

FASTA1,661183,858
Isoform 3 [UniParc].

Checksum: 9F9141EDD1CC6005
Show »

FASTA51855,761
Isoform 4 [UniParc].

Checksum: 34E50D41691F15ED
Show »

FASTA1,016115,758

References

[1]"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:355-364(1998) [PubMed: 10048485] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
Tissue: Cerebellum and Embryo.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[5]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1017, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[6]"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis."
Wang B., Malik R., Nigg E.A., Korner R.
Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1244 AND SER-1303, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1017, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB020696 mRNA. Translation: BAA74912.2. Different initiation.
AK022023 mRNA. Translation: BAB13954.1.
AK126630 mRNA. Translation: BAC86621.1.
AL391602, AL079335, AL132768 Genomic DNA. Translation: CAI12788.3.
AL132768, AL079335, AL391602 Genomic DNA. Translation: CAI21460.3.
AL079335, AL132768, AL391602 Genomic DNA. Translation: CAI42289.3.
BC113405 mRNA. Translation: AAI13406.1.
BC113433 mRNA. Translation: AAI13434.1.
IPIIPI00022274.
IPI00797771.
IPI00915294.
IPI00942898.
RefSeqNP_542194.2. NM_080627.2.
NP_954650.2. NM_199181.2.
UniGeneHs.460807.

3D structure databases

ProteinModelPortalO94964.
ModBaseSearch...

Protein-protein interaction databases

IntActO94964. 3 interactions.

PTM databases

PhosphoSiteO94964.

2D gel databases

UCD-2DPAGEO94964.

Proteomic databases

PeptideAtlasO94964.
PRIDEO94964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000237536; ENSP00000237536; ENSG00000149639.
ENST00000279034; ENSP00000279034; ENSG00000149639.
ENST00000357779; ENSP00000350424; ENSG00000149639.
ENST00000456801; ENSP00000413886; ENSG00000149639.
GeneID140710.
KEGGhsa:140710.

Organism-specific databases

CTD140710.
GeneCardsGC20M035406.
HGNCHGNC:16111. KIAA0889.
neXtProtNX_O94964.
PharmGKBPA25657.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG09044.
GeneTreeENSGT00530000063889.
HOGENOMHBG716993.
HOVERGENHBG080205.
OMASDNKACT.
OrthoDBEOG4XSKP1.

Gene expression databases

ArrayExpressO94964.
BgeeO94964.
CleanExHS_C20orf117.
GenevestigatorO94964.
GermOnlineENSG00000149639. Homo sapiens.

Family and domain databases

InterProIPR021507. DUF3166.
[Graphical view]
PfamPF11365. DUF3166. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio84283.

Entry information

Entry nameK0889_HUMAN
AccessionPrimary (citable) accession number: O94964
Secondary accession number(s): A6NK10 expand/collapse secondary AC list , Q14DB2, Q5JW51, Q6ZTG8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: December 16, 2008
Last modified: January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations