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Protein

Solute carrier organic anion transporter family member 2B1

Gene

SLCO2B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.By similarity

GO - Molecular functioni

  1. organic anion transmembrane transporter activity Source: UniProtKB
  2. sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. sodium-independent organic anion transport Source: Reactome
  2. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_23988. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.20. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Organic anion transporter B
Short name:
OATP-B
Organic anion transporter polypeptide-related protein 2
Short name:
OATP-RP2
Short name:
OATPRP2
Solute carrier family 21 member 9
Gene namesi
Name:SLCO2B1
Synonyms:KIAA0880, OATP2B1, OATPB, SLC21A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:10962. SLCO2B1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei50 – 6920Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini70 – 8819ExtracellularSequence AnalysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini110 – 1156CytoplasmicSequence Analysis
Transmembranei116 – 14025Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini141 – 18545ExtracellularSequence AnalysisAdd
BLAST
Transmembranei186 – 21530Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini216 – 23419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini256 – 27318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei274 – 29825Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini299 – 36668CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei367 – 38822Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini389 – 40820ExtracellularSequence AnalysisAdd
BLAST
Transmembranei409 – 43224Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini433 – 4364CytoplasmicSequence Analysis
Transmembranei437 – 46024Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini461 – 564104ExtracellularSequence AnalysisAdd
BLAST
Transmembranei565 – 58723Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini588 – 5969CytoplasmicSequence Analysis
Transmembranei597 – 62226Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini623 – 65533ExtracellularSequence AnalysisAdd
BLAST
Transmembranei656 – 67318Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini674 – 70936CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 709709Solute carrier organic anion transporter family member 2B1PRO_0000191061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341PhosphoserineBy similarity
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
Modified residuei318 – 3181Phosphothreonine1 Publication
Modified residuei320 – 3201Phosphoserine1 Publication
Disulfide bondi489 ↔ 516PROSITE-ProRule annotation
Disulfide bondi493 ↔ 504PROSITE-ProRule annotation
Disulfide bondi495 ↔ 520PROSITE-ProRule annotation
Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO94956.
PaxDbiO94956.
PRIDEiO94956.

PTM databases

PhosphoSiteiO94956.

Expressioni

Tissue specificityi

Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver.1 Publication

Gene expression databases

BgeeiO94956.
CleanExiHS_SLCO2B1.
ExpressionAtlasiO94956. baseline and differential.
GenevestigatoriO94956.

Organism-specific databases

HPAiHPA020659.

Interactioni

Protein-protein interaction databases

BioGridi116442. 1 interaction.
STRINGi9606.ENSP00000289575.

Structurei

3D structure databases

ProteinModelPortaliO94956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini483 – 54361Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG318402.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiO94956.
KOiK14352.
OMAiATMGTEN.
OrthoDBiEOG7QG43R.
PhylomeDBiO94956.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94956-1) [UniParc]FASTAAdd to basket

Also known as: 1b, FL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPRIGPAGE VPQVPDKETK ATMGTENTPG GKASPDPQDV RPSVFHNIKL
60 70 80 90 100
FVLCHSLLQL AQLMISGYLK SSISTVEKRF GLSSQTSGLL ASFNEVGNTA
110 120 130 140 150
LIVFVSYFGS RVHRPRMIGY GAILVALAGL LMTLPHFISE PYRYDNTSPE
160 170 180 190 200
DMPQDFKASL CLPTTSAPAS APSNGNCSSY TETQHLSVVG IMFVAQTLLG
210 220 230 240 250
VGGVPIQPFG ISYIDDFAHN SNSPLYLGIL FAVTMMGPGL AFGLGSLMLR
260 270 280 290 300
LYVDINQMPE GGISLTIKDP RWVGAWWLGF LIAAGAVALA AIPYFFFPKE
310 320 330 340 350
MPKEKRELQF RRKVLAVTDS PARKGKDSPS KQSPGESTKK QDGLVQIAPN
360 370 380 390 400
LTVIQFIKVF PRVLLQTLRH PIFLLVVLSQ VCLSSMAAGM AIFLPKFLER
410 420 430 440 450
QFSITASYAN LLIGCLSFPS VIVGIVVGGV LVKRLHLGPV GCGALCLLGM
460 470 480 490 500
LLCLFFSLPL FFIGCSSHQI AGITHQTSAH PGLELSPSCM EACSCPLDGF
510 520 530 540 550
NPVCDPSTRV EYITPCHAGC SSWVVQDALD NSQVFYTNCS CVVEGNPVLA
560 570 580 590 600
GSCDSTCSHL VVPFLLLVSL GSALACLTHT PSFMLILRGV KKEDKTLAVG
610 620 630 640 650
IQFMFLRILA WMPSPVIHGS AIDTTCVHWA LSCGRRAVCR YYNNDLLRNR
660 670 680 690 700
FIGLQFFFKT GSVICFALVL AVLRQQDKEA RTKESRSSPA VEQQLLVSGP

GKKPEDSRV
Length:709
Mass (Da):76,711
Last modified:November 30, 2010 - v2
Checksum:i652DB4B70B2D9A2D
GO
Isoform 2 (identifier: O94956-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     150-260: Missing.

Note: No experimental confirmation available.

Show »
Length:482
Mass (Da):52,489
Checksum:iE436FE77E1355157
GO
Isoform 3 (identifier: O94956-3) [UniParc]FASTAAdd to basket

Also known as: 1e, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Note: Functional transporter. Predominant isoform in liver, expression at promoter is regulated by HNF4alpha.

Show »
Length:687
Mass (Da):74,450
Checksum:i9696809B01FD241D
GO
Isoform 4 (identifier: O94956-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-149: Missing.

Note: No experimental confirmation available.

Show »
Length:565
Mass (Da):61,177
Checksum:iAFFFAD6CD486F466
GO

Sequence cautioni

The sequence BAA74903.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941N → D in BAF82923 (PubMed:14702039).Curated
Sequence conflicti215 – 2151D → V in AAG42205 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771E → K in a breast cancer sample; somatic mutation. 1 Publication
VAR_036412
Natural varianti201 – 2011V → M.
Corresponds to variant rs35199625 [ dbSNP | Ensembl ].
VAR_053675
Natural varianti312 – 3121R → Q.
Corresponds to variant rs12422149 [ dbSNP | Ensembl ].
VAR_053676
Natural varianti392 – 3921I → T.6 Publications
Corresponds to variant rs1621378 [ dbSNP | Ensembl ].
VAR_053677
Natural varianti486 – 4861S → F.1 Publication
Corresponds to variant rs2306168 [ dbSNP | Ensembl ].
VAR_020294

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 116116Missing in isoform 2. 1 PublicationVSP_006147Add
BLAST
Alternative sequencei1 – 2222Missing in isoform 3. 2 PublicationsVSP_054109Add
BLAST
Alternative sequencei6 – 149144Missing in isoform 4. 1 PublicationVSP_054110Add
BLAST
Alternative sequencei150 – 260111Missing in isoform 2. 1 PublicationVSP_006148Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026256 mRNA. Translation: BAA78638.1.
AF205073 mRNA. Translation: AAG42205.1.
AB020687 mRNA. Translation: BAA74903.2. Different initiation.
AK290234 mRNA. Translation: BAF82923.1.
AK294503 mRNA. Translation: BAG57720.1.
AK300134 mRNA. Translation: BAG61922.1.
AL117465 mRNA. Translation: CAB55940.1.
AP001972 Genomic DNA. No translation available.
BC041095 mRNA. Translation: AAH41095.1.
CCDSiCCDS44683.1. [O94956-3]
CCDS53679.1. [O94956-4]
CCDS8235.1. [O94956-1]
PIRiT17250.
RefSeqiNP_001138683.1. NM_001145211.2.
NP_001138684.1. NM_001145212.2.
NP_009187.1. NM_007256.4.
UniGeneiHs.7884.

Genome annotation databases

EnsembliENST00000428359; ENSP00000388912; ENSG00000137491.
ENST00000454962; ENSP00000389653; ENSG00000137491.
GeneIDi11309.
KEGGihsa:11309.
UCSCiuc001owb.3. human. [O94956-1]
uc001owc.3. human. [O94956-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026256 mRNA. Translation: BAA78638.1.
AF205073 mRNA. Translation: AAG42205.1.
AB020687 mRNA. Translation: BAA74903.2. Different initiation.
AK290234 mRNA. Translation: BAF82923.1.
AK294503 mRNA. Translation: BAG57720.1.
AK300134 mRNA. Translation: BAG61922.1.
AL117465 mRNA. Translation: CAB55940.1.
AP001972 Genomic DNA. No translation available.
BC041095 mRNA. Translation: AAH41095.1.
CCDSiCCDS44683.1. [O94956-3]
CCDS53679.1. [O94956-4]
CCDS8235.1. [O94956-1]
PIRiT17250.
RefSeqiNP_001138683.1. NM_001145211.2.
NP_001138684.1. NM_001145212.2.
NP_009187.1. NM_007256.4.
UniGeneiHs.7884.

3D structure databases

ProteinModelPortaliO94956.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116442. 1 interaction.
STRINGi9606.ENSP00000289575.

Chemistry

BindingDBiO94956.
ChEMBLiCHEMBL1743124.
DrugBankiDB03166. Acetic acid.
DB00770. Alprostadil.
DB01076. Atorvastatin.
DB01053. Benzylpenicillin.
DB00286. Conjugated Estrogens.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB01049. Ergoloid mesylate.
DB00783. Estradiol.
DB00655. Estrone.
DB00950. Fexofenadine.
DB01095. Fluvastatin.
DB01016. Glyburide.
DB01050. Ibuprofen.
DB01088. Iloprost.
DB00654. Latanoprost.
DB00471. Montelukast.
DB00627. Niacin.
DB08860. Pitavastatin.
DB00175. Pravastatin.
DB01045. Rifampicin.
DB01098. Rosuvastatin.
DB00936. Salicylic acid.
DB01124. Tolbutamide.
GuidetoPHARMACOLOGYi1224.

Protein family/group databases

TCDBi2.A.60.1.20. the organo anion transporter (oat) family.

PTM databases

PhosphoSiteiO94956.

Proteomic databases

MaxQBiO94956.
PaxDbiO94956.
PRIDEiO94956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000428359; ENSP00000388912; ENSG00000137491.
ENST00000454962; ENSP00000389653; ENSG00000137491.
GeneIDi11309.
KEGGihsa:11309.
UCSCiuc001owb.3. human. [O94956-1]
uc001owc.3. human. [O94956-2]

Organism-specific databases

CTDi11309.
GeneCardsiGC11P074949.
HGNCiHGNC:10962. SLCO2B1.
HPAiHPA020659.
MIMi604988. gene.
neXtProtiNX_O94956.
PharmGKBiPA35845.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG318402.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiO94956.
KOiK14352.
OMAiATMGTEN.
OrthoDBiEOG7QG43R.
PhylomeDBiO94956.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiREACT_23988. Transport of organic anions.

Miscellaneous databases

ChiTaRSiSLCO2B1. human.
GeneWikiiSLCO2B1.
GenomeRNAii11309.
NextBioi27033476.
PROiO94956.
SOURCEiSearch...

Gene expression databases

BgeeiO94956.
CleanExiHS_SLCO2B1.
ExpressionAtlasiO94956. baseline and differential.
GenevestigatoriO94956.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family."
    Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A.
    Biochem. Biophys. Res. Commun. 273:251-260(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-392.
    Tissue: Brain.
  2. "Identification and characterization of novel human OATP family members."
    Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT THR-392.
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-392.
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANTS THR-392 AND PHE-486.
    Tissue: Amygdala and Thalamus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-392.
    Tissue: Uterus.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-392.
    Tissue: Brain.
  8. "Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1."
    Hanggi E., Grundschober A.F., Leuthold S., Meier P.J., St-Pierre M.V.
    Mol. Pharmacol. 70:806-817(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRESENCE OF DISULFIDE BONDS.
  9. "Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant."
    Knauer M.J., Girdwood A.J., Kim R.B., Tirona R.G.
    Mol. Pharmacol. 83:1218-1228(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-318 AND SER-320, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-77.

Entry informationi

Entry nameiSO2B1_HUMAN
AccessioniPrimary (citable) accession number: O94956
Secondary accession number(s): A8K2G9
, B4DGA9, B4DTB0, E7ERN5, E9PPU8, Q9H2Z0, Q9UFU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: March 4, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.