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Protein

Solute carrier organic anion transporter family member 2B1

Gene

SLCO2B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137491-MONOMER.
ReactomeiR-HSA-879518. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.20. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Organic anion transporter B
Short name:
OATP-B
Organic anion transporter polypeptide-related protein 2
Short name:
OATP-RP2
Short name:
OATPRP2
Solute carrier family 21 member 9
Gene namesi
Name:SLCO2B1
Synonyms:KIAA0880, OATP2B1, OATPB, SLC21A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10962. SLCO2B1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 69Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini70 – 88ExtracellularSequence analysisAdd BLAST19
Transmembranei89 – 109Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini110 – 115CytoplasmicSequence analysis6
Transmembranei116 – 140Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini141 – 185ExtracellularSequence analysisAdd BLAST45
Transmembranei186 – 215Helical; Name=4Sequence analysisAdd BLAST30
Topological domaini216 – 234CytoplasmicSequence analysisAdd BLAST19
Transmembranei235 – 255Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini256 – 273ExtracellularSequence analysisAdd BLAST18
Transmembranei274 – 298Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini299 – 366CytoplasmicSequence analysisAdd BLAST68
Transmembranei367 – 388Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini389 – 408ExtracellularSequence analysisAdd BLAST20
Transmembranei409 – 432Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini433 – 436CytoplasmicSequence analysis4
Transmembranei437 – 460Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini461 – 564ExtracellularSequence analysisAdd BLAST104
Transmembranei565 – 587Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini588 – 596CytoplasmicSequence analysis9
Transmembranei597 – 622Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini623 – 655ExtracellularSequence analysisAdd BLAST33
Transmembranei656 – 673Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini674 – 709CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11309.
PharmGKBiPA35845.

Chemistry databases

ChEMBLiCHEMBL1743124.
DrugBankiDB03166. Acetic acid.
DB00770. Alprostadil.
DB01076. Atorvastatin.
DB03793. Benzoic Acid.
DB01053. Benzylpenicillin.
DB00286. Conjugated Estrogens.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB01049. Ergoloid mesylate.
DB00783. Estradiol.
DB00655. Estrone.
DB00950. Fexofenadine.
DB01095. Fluvastatin.
DB01016. Glyburide.
DB01050. Ibuprofen.
DB01088. Iloprost.
DB04398. Lactic Acid.
DB00654. Latanoprost.
DB00471. Montelukast.
DB00627. Niacin.
DB08860. Pitavastatin.
DB00175. Pravastatin.
DB01045. Rifampicin.
DB01098. Rosuvastatin.
DB00936. Salicylic acid.
DB01124. Tolbutamide.
GuidetoPHARMACOLOGYi1224.

Polymorphism and mutation databases

BioMutaiSLCO2B1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910611 – 709Solute carrier organic anion transporter family member 2B1Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Disulfide bondi489 ↔ 516PROSITE-ProRule annotation
Disulfide bondi493 ↔ 504PROSITE-ProRule annotation
Disulfide bondi495 ↔ 520PROSITE-ProRule annotation
Glycosylationi538N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO94956.
PaxDbiO94956.
PeptideAtlasiO94956.
PRIDEiO94956.

PTM databases

iPTMnetiO94956.
PhosphoSitePlusiO94956.

Expressioni

Tissue specificityi

Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver.1 Publication

Gene expression databases

BgeeiENSG00000137491.
CleanExiHS_SLCO2B1.
ExpressionAtlasiO94956. baseline and differential.
GenevisibleiO94956. HS.

Organism-specific databases

HPAiHPA020659.

Interactioni

Protein-protein interaction databases

BioGridi116442. 1 interactor.
STRINGi9606.ENSP00000289575.

Chemistry databases

BindingDBiO94956.

Structurei

3D structure databases

ProteinModelPortaliO94956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini483 – 543Kazal-likePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiO94956.
KOiK14352.
PhylomeDBiO94956.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94956-1) [UniParc]FASTAAdd to basket
Also known as: 1b, FL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPRIGPAGE VPQVPDKETK ATMGTENTPG GKASPDPQDV RPSVFHNIKL
60 70 80 90 100
FVLCHSLLQL AQLMISGYLK SSISTVEKRF GLSSQTSGLL ASFNEVGNTA
110 120 130 140 150
LIVFVSYFGS RVHRPRMIGY GAILVALAGL LMTLPHFISE PYRYDNTSPE
160 170 180 190 200
DMPQDFKASL CLPTTSAPAS APSNGNCSSY TETQHLSVVG IMFVAQTLLG
210 220 230 240 250
VGGVPIQPFG ISYIDDFAHN SNSPLYLGIL FAVTMMGPGL AFGLGSLMLR
260 270 280 290 300
LYVDINQMPE GGISLTIKDP RWVGAWWLGF LIAAGAVALA AIPYFFFPKE
310 320 330 340 350
MPKEKRELQF RRKVLAVTDS PARKGKDSPS KQSPGESTKK QDGLVQIAPN
360 370 380 390 400
LTVIQFIKVF PRVLLQTLRH PIFLLVVLSQ VCLSSMAAGM AIFLPKFLER
410 420 430 440 450
QFSITASYAN LLIGCLSFPS VIVGIVVGGV LVKRLHLGPV GCGALCLLGM
460 470 480 490 500
LLCLFFSLPL FFIGCSSHQI AGITHQTSAH PGLELSPSCM EACSCPLDGF
510 520 530 540 550
NPVCDPSTRV EYITPCHAGC SSWVVQDALD NSQVFYTNCS CVVEGNPVLA
560 570 580 590 600
GSCDSTCSHL VVPFLLLVSL GSALACLTHT PSFMLILRGV KKEDKTLAVG
610 620 630 640 650
IQFMFLRILA WMPSPVIHGS AIDTTCVHWA LSCGRRAVCR YYNNDLLRNR
660 670 680 690 700
FIGLQFFFKT GSVICFALVL AVLRQQDKEA RTKESRSSPA VEQQLLVSGP

GKKPEDSRV
Length:709
Mass (Da):76,711
Last modified:November 30, 2010 - v2
Checksum:i652DB4B70B2D9A2D
GO
Isoform 2 (identifier: O94956-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     150-260: Missing.

Note: No experimental confirmation available.
Show »
Length:482
Mass (Da):52,489
Checksum:iE436FE77E1355157
GO
Isoform 3 (identifier: O94956-3) [UniParc]FASTAAdd to basket
Also known as: 1e, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Note: Functional transporter. Predominant isoform in liver, expression at promoter is regulated by HNF4alpha.
Show »
Length:687
Mass (Da):74,450
Checksum:i9696809B01FD241D
GO
Isoform 4 (identifier: O94956-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-149: Missing.

Note: No experimental confirmation available.
Show »
Length:565
Mass (Da):61,177
Checksum:iAFFFAD6CD486F466
GO

Sequence cautioni

The sequence BAA74903 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94N → D in BAF82923 (PubMed:14702039).Curated1
Sequence conflicti215D → V in AAG42205 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03641277E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053675201V → M.Corresponds to variant rs35199625dbSNPEnsembl.1
Natural variantiVAR_053676312R → Q.Corresponds to variant rs12422149dbSNPEnsembl.1
Natural variantiVAR_053677392I → T.6 PublicationsCorresponds to variant rs1621378dbSNPEnsembl.1
Natural variantiVAR_020294486S → F.1 PublicationCorresponds to variant rs2306168dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0061471 – 116Missing in isoform 2. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_0541091 – 22Missing in isoform 3. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_0541106 – 149Missing in isoform 4. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_006148150 – 260Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026256 mRNA. Translation: BAA78638.1.
AF205073 mRNA. Translation: AAG42205.1.
AB020687 mRNA. Translation: BAA74903.2. Different initiation.
AK290234 mRNA. Translation: BAF82923.1.
AK294503 mRNA. Translation: BAG57720.1.
AK300134 mRNA. Translation: BAG61922.1.
AL117465 mRNA. Translation: CAB55940.1.
AP001972 Genomic DNA. No translation available.
BC041095 mRNA. Translation: AAH41095.1.
CCDSiCCDS44683.1. [O94956-3]
CCDS53679.1. [O94956-4]
CCDS8235.1. [O94956-1]
PIRiT17250.
RefSeqiNP_001138683.1. NM_001145211.2.
NP_001138684.1. NM_001145212.2.
NP_009187.1. NM_007256.4.
UniGeneiHs.7884.

Genome annotation databases

EnsembliENST00000428359; ENSP00000388912; ENSG00000137491.
ENST00000454962; ENSP00000389653; ENSG00000137491.
GeneIDi11309.
KEGGihsa:11309.
UCSCiuc001owc.4. human. [O94956-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026256 mRNA. Translation: BAA78638.1.
AF205073 mRNA. Translation: AAG42205.1.
AB020687 mRNA. Translation: BAA74903.2. Different initiation.
AK290234 mRNA. Translation: BAF82923.1.
AK294503 mRNA. Translation: BAG57720.1.
AK300134 mRNA. Translation: BAG61922.1.
AL117465 mRNA. Translation: CAB55940.1.
AP001972 Genomic DNA. No translation available.
BC041095 mRNA. Translation: AAH41095.1.
CCDSiCCDS44683.1. [O94956-3]
CCDS53679.1. [O94956-4]
CCDS8235.1. [O94956-1]
PIRiT17250.
RefSeqiNP_001138683.1. NM_001145211.2.
NP_001138684.1. NM_001145212.2.
NP_009187.1. NM_007256.4.
UniGeneiHs.7884.

3D structure databases

ProteinModelPortaliO94956.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116442. 1 interactor.
STRINGi9606.ENSP00000289575.

Chemistry databases

BindingDBiO94956.
ChEMBLiCHEMBL1743124.
DrugBankiDB03166. Acetic acid.
DB00770. Alprostadil.
DB01076. Atorvastatin.
DB03793. Benzoic Acid.
DB01053. Benzylpenicillin.
DB00286. Conjugated Estrogens.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB01049. Ergoloid mesylate.
DB00783. Estradiol.
DB00655. Estrone.
DB00950. Fexofenadine.
DB01095. Fluvastatin.
DB01016. Glyburide.
DB01050. Ibuprofen.
DB01088. Iloprost.
DB04398. Lactic Acid.
DB00654. Latanoprost.
DB00471. Montelukast.
DB00627. Niacin.
DB08860. Pitavastatin.
DB00175. Pravastatin.
DB01045. Rifampicin.
DB01098. Rosuvastatin.
DB00936. Salicylic acid.
DB01124. Tolbutamide.
GuidetoPHARMACOLOGYi1224.

Protein family/group databases

TCDBi2.A.60.1.20. the organo anion transporter (oat) family.

PTM databases

iPTMnetiO94956.
PhosphoSitePlusiO94956.

Polymorphism and mutation databases

BioMutaiSLCO2B1.

Proteomic databases

MaxQBiO94956.
PaxDbiO94956.
PeptideAtlasiO94956.
PRIDEiO94956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000428359; ENSP00000388912; ENSG00000137491.
ENST00000454962; ENSP00000389653; ENSG00000137491.
GeneIDi11309.
KEGGihsa:11309.
UCSCiuc001owc.4. human. [O94956-1]

Organism-specific databases

CTDi11309.
DisGeNETi11309.
GeneCardsiSLCO2B1.
HGNCiHGNC:10962. SLCO2B1.
HPAiHPA020659.
MIMi604988. gene.
neXtProtiNX_O94956.
PharmGKBiPA35845.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiO94956.
KOiK14352.
PhylomeDBiO94956.
TreeFamiTF317540.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137491-MONOMER.
ReactomeiR-HSA-879518. Transport of organic anions.

Miscellaneous databases

ChiTaRSiSLCO2B1. human.
GeneWikiiSLCO2B1.
GenomeRNAii11309.
PROiO94956.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137491.
CleanExiHS_SLCO2B1.
ExpressionAtlasiO94956. baseline and differential.
GenevisibleiO94956. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO2B1_HUMAN
AccessioniPrimary (citable) accession number: O94956
Secondary accession number(s): A8K2G9
, B4DGA9, B4DTB0, E7ERN5, E9PPU8, Q9H2Z0, Q9UFU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.