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O94956

- SO2B1_HUMAN

UniProt

O94956 - SO2B1_HUMAN

Protein

Solute carrier organic anion transporter family member 2B1

Gene

SLCO2B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.By similarity

    GO - Molecular functioni

    1. bile acid transmembrane transporter activity Source: Ensembl
    2. organic anion transmembrane transporter activity Source: UniProtKB
    3. sodium-independent organic anion transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. liver development Source: Ensembl
    2. sodium-independent icosanoid transport Source: Ensembl
    3. sodium-independent organic anion transport Source: Reactome
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_23988. Transport of organic anions.

    Protein family/group databases

    TCDBi2.A.60.1.20. the organo anion transporter (oat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 2B1
    Alternative name(s):
    Organic anion transporter B
    Short name:
    OATP-B
    Organic anion transporter polypeptide-related protein 2
    Short name:
    OATP-RP2
    Short name:
    OATPRP2
    Solute carrier family 21 member 9
    Gene namesi
    Name:SLCO2B1
    Synonyms:KIAA0880, OATP2B1, OATPB, SLC21A9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10962. SLCO2B1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35845.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 709709Solute carrier organic anion transporter family member 2B1PRO_0000191061Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341PhosphoserineBy similarity
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi489 ↔ 516PROSITE-ProRule annotation
    Disulfide bondi493 ↔ 504PROSITE-ProRule annotation
    Disulfide bondi495 ↔ 520PROSITE-ProRule annotation
    Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO94956.
    PaxDbiO94956.
    PRIDEiO94956.

    PTM databases

    PhosphoSiteiO94956.

    Expressioni

    Tissue specificityi

    Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver.1 Publication

    Gene expression databases

    ArrayExpressiO94956.
    BgeeiO94956.
    CleanExiHS_SLCO2B1.
    GenevestigatoriO94956.

    Organism-specific databases

    HPAiHPA020659.

    Interactioni

    Protein-protein interaction databases

    BioGridi116442. 1 interaction.
    STRINGi9606.ENSP00000289575.

    Structurei

    3D structure databases

    ProteinModelPortaliO94956.
    SMRiO94956. Positions 493-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini70 – 8819ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini110 – 1156CytoplasmicSequence Analysis
    Topological domaini141 – 18545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 23419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 27318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 36668CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini389 – 40820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini433 – 4364CytoplasmicSequence Analysis
    Topological domaini461 – 564104ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini588 – 5969CytoplasmicSequence Analysis
    Topological domaini623 – 65533ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini674 – 70936CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 6920Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei116 – 14025Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei186 – 21530Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29825Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei367 – 38822Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei409 – 43224Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei437 – 46024Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei565 – 58723Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei597 – 62226Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei656 – 67318Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini483 – 54361Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318402.
    HOGENOMiHOG000231269.
    HOVERGENiHBG108345.
    InParanoidiO94956.
    KOiK14352.
    OMAiATMGTEN.
    OrthoDBiEOG7QG43R.
    PhylomeDBiO94956.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF03137. OATP. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 5 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: O94956-1) [UniParc]FASTAAdd to Basket

    Also known as: 1b, FL

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPRIGPAGE VPQVPDKETK ATMGTENTPG GKASPDPQDV RPSVFHNIKL    50
    FVLCHSLLQL AQLMISGYLK SSISTVEKRF GLSSQTSGLL ASFNEVGNTA 100
    LIVFVSYFGS RVHRPRMIGY GAILVALAGL LMTLPHFISE PYRYDNTSPE 150
    DMPQDFKASL CLPTTSAPAS APSNGNCSSY TETQHLSVVG IMFVAQTLLG 200
    VGGVPIQPFG ISYIDDFAHN SNSPLYLGIL FAVTMMGPGL AFGLGSLMLR 250
    LYVDINQMPE GGISLTIKDP RWVGAWWLGF LIAAGAVALA AIPYFFFPKE 300
    MPKEKRELQF RRKVLAVTDS PARKGKDSPS KQSPGESTKK QDGLVQIAPN 350
    LTVIQFIKVF PRVLLQTLRH PIFLLVVLSQ VCLSSMAAGM AIFLPKFLER 400
    QFSITASYAN LLIGCLSFPS VIVGIVVGGV LVKRLHLGPV GCGALCLLGM 450
    LLCLFFSLPL FFIGCSSHQI AGITHQTSAH PGLELSPSCM EACSCPLDGF 500
    NPVCDPSTRV EYITPCHAGC SSWVVQDALD NSQVFYTNCS CVVEGNPVLA 550
    GSCDSTCSHL VVPFLLLVSL GSALACLTHT PSFMLILRGV KKEDKTLAVG 600
    IQFMFLRILA WMPSPVIHGS AIDTTCVHWA LSCGRRAVCR YYNNDLLRNR 650
    FIGLQFFFKT GSVICFALVL AVLRQQDKEA RTKESRSSPA VEQQLLVSGP 700
    GKKPEDSRV 709
    Length:709
    Mass (Da):76,711
    Last modified:November 30, 2010 - v2
    Checksum:i652DB4B70B2D9A2D
    GO
    Isoform 2 (identifier: O94956-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-116: Missing.
         150-260: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:482
    Mass (Da):52,489
    Checksum:iE436FE77E1355157
    GO
    Isoform 3 (identifier: O94956-3) [UniParc]FASTAAdd to Basket

    Also known as: 1e, Short

    The sequence of this isoform differs from the canonical sequence as follows:
         1-22: Missing.

    Note: Functional transporter. Predominant isoform in liver, expression at promoter is regulated by HNF4alpha.

    Show »
    Length:687
    Mass (Da):74,450
    Checksum:i9696809B01FD241D
    GO
    Isoform 4 (identifier: O94956-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         6-149: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:565
    Mass (Da):61,177
    Checksum:iAFFFAD6CD486F466
    GO

    Sequence cautioni

    The sequence BAA74903.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941N → D in BAF82923. (PubMed:14702039)Curated
    Sequence conflicti215 – 2151D → V in AAG42205. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771E → K in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036412
    Natural varianti201 – 2011V → M.
    Corresponds to variant rs35199625 [ dbSNP | Ensembl ].
    VAR_053675
    Natural varianti312 – 3121R → Q.
    Corresponds to variant rs12422149 [ dbSNP | Ensembl ].
    VAR_053676
    Natural varianti392 – 3921I → T.6 Publications
    Corresponds to variant rs1621378 [ dbSNP | Ensembl ].
    VAR_053677
    Natural varianti486 – 4861S → F.1 Publication
    Corresponds to variant rs2306168 [ dbSNP | Ensembl ].
    VAR_020294

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 116116Missing in isoform 2. 1 PublicationVSP_006147Add
    BLAST
    Alternative sequencei1 – 2222Missing in isoform 3. 2 PublicationsVSP_054109Add
    BLAST
    Alternative sequencei6 – 149144Missing in isoform 4. 1 PublicationVSP_054110Add
    BLAST
    Alternative sequencei150 – 260111Missing in isoform 2. 1 PublicationVSP_006148Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026256 mRNA. Translation: BAA78638.1.
    AF205073 mRNA. Translation: AAG42205.1.
    AB020687 mRNA. Translation: BAA74903.2. Different initiation.
    AK290234 mRNA. Translation: BAF82923.1.
    AK294503 mRNA. Translation: BAG57720.1.
    AK300134 mRNA. Translation: BAG61922.1.
    AL117465 mRNA. Translation: CAB55940.1.
    AP001972 Genomic DNA. No translation available.
    BC041095 mRNA. Translation: AAH41095.1.
    CCDSiCCDS44683.1. [O94956-3]
    CCDS53679.1. [O94956-4]
    CCDS8235.1. [O94956-1]
    PIRiT17250.
    RefSeqiNP_001138683.1. NM_001145211.2.
    NP_001138684.1. NM_001145212.2.
    NP_009187.1. NM_007256.4.
    UniGeneiHs.7884.

    Genome annotation databases

    EnsembliENST00000289575; ENSP00000289575; ENSG00000137491. [O94956-1]
    ENST00000428359; ENSP00000388912; ENSG00000137491. [O94956-3]
    ENST00000454962; ENSP00000389653; ENSG00000137491. [O94956-2]
    ENST00000525650; ENSP00000436324; ENSG00000137491. [O94956-4]
    GeneIDi11309.
    KEGGihsa:11309.
    UCSCiuc001owb.3. human. [O94956-1]
    uc001owc.3. human. [O94956-2]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026256 mRNA. Translation: BAA78638.1 .
    AF205073 mRNA. Translation: AAG42205.1 .
    AB020687 mRNA. Translation: BAA74903.2 . Different initiation.
    AK290234 mRNA. Translation: BAF82923.1 .
    AK294503 mRNA. Translation: BAG57720.1 .
    AK300134 mRNA. Translation: BAG61922.1 .
    AL117465 mRNA. Translation: CAB55940.1 .
    AP001972 Genomic DNA. No translation available.
    BC041095 mRNA. Translation: AAH41095.1 .
    CCDSi CCDS44683.1. [O94956-3 ]
    CCDS53679.1. [O94956-4 ]
    CCDS8235.1. [O94956-1 ]
    PIRi T17250.
    RefSeqi NP_001138683.1. NM_001145211.2.
    NP_001138684.1. NM_001145212.2.
    NP_009187.1. NM_007256.4.
    UniGenei Hs.7884.

    3D structure databases

    ProteinModelPortali O94956.
    SMRi O94956. Positions 493-521.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116442. 1 interaction.
    STRINGi 9606.ENSP00000289575.

    Chemistry

    ChEMBLi CHEMBL1743124.
    DrugBanki DB01049. Ergoloid mesylate.
    GuidetoPHARMACOLOGYi 1224.

    Protein family/group databases

    TCDBi 2.A.60.1.20. the organo anion transporter (oat) family.

    PTM databases

    PhosphoSitei O94956.

    Proteomic databases

    MaxQBi O94956.
    PaxDbi O94956.
    PRIDEi O94956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289575 ; ENSP00000289575 ; ENSG00000137491 . [O94956-1 ]
    ENST00000428359 ; ENSP00000388912 ; ENSG00000137491 . [O94956-3 ]
    ENST00000454962 ; ENSP00000389653 ; ENSG00000137491 . [O94956-2 ]
    ENST00000525650 ; ENSP00000436324 ; ENSG00000137491 . [O94956-4 ]
    GeneIDi 11309.
    KEGGi hsa:11309.
    UCSCi uc001owb.3. human. [O94956-1 ]
    uc001owc.3. human. [O94956-2 ]

    Organism-specific databases

    CTDi 11309.
    GeneCardsi GC11P074901.
    HGNCi HGNC:10962. SLCO2B1.
    HPAi HPA020659.
    MIMi 604988. gene.
    neXtProti NX_O94956.
    PharmGKBi PA35845.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318402.
    HOGENOMi HOG000231269.
    HOVERGENi HBG108345.
    InParanoidi O94956.
    KOi K14352.
    OMAi ATMGTEN.
    OrthoDBi EOG7QG43R.
    PhylomeDBi O94956.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_23988. Transport of organic anions.

    Miscellaneous databases

    ChiTaRSi SLCO2B1. human.
    GeneWikii SLCO2B1.
    GenomeRNAii 11309.
    NextBioi 27033476.
    PROi O94956.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94956.
    Bgeei O94956.
    CleanExi HS_SLCO2B1.
    Genevestigatori O94956.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF03137. OATP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 5 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family."
      Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A.
      Biochem. Biophys. Res. Commun. 273:251-260(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-392.
      Tissue: Brain.
    2. "Identification and characterization of novel human OATP family members."
      Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT THR-392.
    3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-392.
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANTS THR-392 AND PHE-486.
      Tissue: Amygdala and Thalamus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-392.
      Tissue: Uterus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-392.
      Tissue: Brain.
    8. "Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1."
      Hanggi E., Grundschober A.F., Leuthold S., Meier P.J., St-Pierre M.V.
      Mol. Pharmacol. 70:806-817(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRESENCE OF DISULFIDE BONDS.
    9. "Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant."
      Knauer M.J., Girdwood A.J., Kim R.B., Tirona R.G.
      Mol. Pharmacol. 83:1218-1228(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-77.

    Entry informationi

    Entry nameiSO2B1_HUMAN
    AccessioniPrimary (citable) accession number: O94956
    Secondary accession number(s): A8K2G9
    , B4DGA9, B4DTB0, E7ERN5, E9PPU8, Q9H2Z0, Q9UFU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3