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O94956 (SO2B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Organic anion transporter B
Short name=OATP-B
Organic anion transporter polypeptide-related protein 2
Short name=OATP-RP2
Short name=OATPRP2
Solute carrier family 21 member 9
Gene names
Name:SLCO2B1
Synonyms:KIAA0880, OATP2B1, OATPB, SLC21A9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length709 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Isoform 1 has it's highest expression in brain, it is the major form expressed in duodenum, kidney, placenta, and skeletal muscle. Isoform 3 predominates in liver. Ref.9

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Sequence caution

The sequence BAA74903.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]
Isoform 1 (identifier: O94956-1)

Also known as: 1b; FL;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O94956-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     150-260: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: O94956-3)

Also known as: 1e; Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
Note: Functional transporter. Predominant isoform in liver, expression at promoter is regulated by HNF4alpha.
Isoform 4 (identifier: O94956-4)

The sequence of this isoform differs from the canonical sequence as follows:
     6-149: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 709709Solute carrier organic anion transporter family member 2B1
PRO_0000191061

Regions

Topological domain1 – 4949Cytoplasmic Potential
Transmembrane50 – 6920Helical; Name=1; Potential
Topological domain70 – 8819Extracellular Potential
Transmembrane89 – 10921Helical; Name=2; Potential
Topological domain110 – 1156Cytoplasmic Potential
Transmembrane116 – 14025Helical; Name=3; Potential
Topological domain141 – 18545Extracellular Potential
Transmembrane186 – 21530Helical; Name=4; Potential
Topological domain216 – 23419Cytoplasmic Potential
Transmembrane235 – 25521Helical; Name=5; Potential
Topological domain256 – 27318Extracellular Potential
Transmembrane274 – 29825Helical; Name=6; Potential
Topological domain299 – 36668Cytoplasmic Potential
Transmembrane367 – 38822Helical; Name=7; Potential
Topological domain389 – 40820Extracellular Potential
Transmembrane409 – 43224Helical; Name=8; Potential
Topological domain433 – 4364Cytoplasmic Potential
Transmembrane437 – 46024Helical; Name=9; Potential
Topological domain461 – 564104Extracellular Potential
Transmembrane565 – 58723Helical; Name=10; Potential
Topological domain588 – 5969Cytoplasmic Potential
Transmembrane597 – 62226Helical; Name=11; Potential
Topological domain623 – 65533Extracellular Potential
Transmembrane656 – 67318Helical; Name=12; Potential
Topological domain674 – 70936Cytoplasmic Potential
Domain483 – 54361Kazal-like

Amino acid modifications

Modified residue341Phosphoserine By similarity
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation5381N-linked (GlcNAc...) Potential
Disulfide bond489 ↔ 516 By similarity
Disulfide bond493 ↔ 504 By similarity
Disulfide bond495 ↔ 520 By similarity

Natural variations

Alternative sequence1 – 116116Missing in isoform 2.
VSP_006147
Alternative sequence1 – 2222Missing in isoform 3.
VSP_054109
Alternative sequence6 – 149144Missing in isoform 4.
VSP_054110
Alternative sequence150 – 260111Missing in isoform 2.
VSP_006148
Natural variant771E → K in a breast cancer sample; somatic mutation. Ref.10
VAR_036412
Natural variant2011V → M.
Corresponds to variant rs35199625 [ dbSNP | Ensembl ].
VAR_053675
Natural variant3121R → Q.
Corresponds to variant rs12422149 [ dbSNP | Ensembl ].
VAR_053676
Natural variant3921I → T. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.7
Corresponds to variant rs1621378 [ dbSNP | Ensembl ].
VAR_053677
Natural variant4861S → F. Ref.4
Corresponds to variant rs2306168 [ dbSNP | Ensembl ].
VAR_020294

Experimental info

Sequence conflict941N → D in BAF82923. Ref.4
Sequence conflict2151D → V in AAG42205. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (1b) (FL) [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: 652DB4B70B2D9A2D

FASTA70976,711
        10         20         30         40         50         60 
MGPRIGPAGE VPQVPDKETK ATMGTENTPG GKASPDPQDV RPSVFHNIKL FVLCHSLLQL 

        70         80         90        100        110        120 
AQLMISGYLK SSISTVEKRF GLSSQTSGLL ASFNEVGNTA LIVFVSYFGS RVHRPRMIGY 

       130        140        150        160        170        180 
GAILVALAGL LMTLPHFISE PYRYDNTSPE DMPQDFKASL CLPTTSAPAS APSNGNCSSY 

       190        200        210        220        230        240 
TETQHLSVVG IMFVAQTLLG VGGVPIQPFG ISYIDDFAHN SNSPLYLGIL FAVTMMGPGL 

       250        260        270        280        290        300 
AFGLGSLMLR LYVDINQMPE GGISLTIKDP RWVGAWWLGF LIAAGAVALA AIPYFFFPKE 

       310        320        330        340        350        360 
MPKEKRELQF RRKVLAVTDS PARKGKDSPS KQSPGESTKK QDGLVQIAPN LTVIQFIKVF 

       370        380        390        400        410        420 
PRVLLQTLRH PIFLLVVLSQ VCLSSMAAGM AIFLPKFLER QFSITASYAN LLIGCLSFPS 

       430        440        450        460        470        480 
VIVGIVVGGV LVKRLHLGPV GCGALCLLGM LLCLFFSLPL FFIGCSSHQI AGITHQTSAH 

       490        500        510        520        530        540 
PGLELSPSCM EACSCPLDGF NPVCDPSTRV EYITPCHAGC SSWVVQDALD NSQVFYTNCS 

       550        560        570        580        590        600 
CVVEGNPVLA GSCDSTCSHL VVPFLLLVSL GSALACLTHT PSFMLILRGV KKEDKTLAVG 

       610        620        630        640        650        660 
IQFMFLRILA WMPSPVIHGS AIDTTCVHWA LSCGRRAVCR YYNNDLLRNR FIGLQFFFKT 

       670        680        690        700 
GSVICFALVL AVLRQQDKEA RTKESRSSPA VEQQLLVSGP GKKPEDSRV 

« Hide

Isoform 2 [UniParc].

Checksum: E436FE77E1355157
Show »

FASTA48252,489
Isoform 3 (1e) (Short) [UniParc].

Checksum: 9696809B01FD241D
Show »

FASTA68774,450
Isoform 4 [UniParc].

Checksum: AFFFAD6CD486F466
Show »

FASTA56561,177

References

« Hide 'large scale' references
[1]"Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family."
Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A.
Biochem. Biophys. Res. Commun. 273:251-260(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-392.
Tissue: Brain.
[2]"Identification and characterization of novel human OATP family members."
Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT THR-392.
[3]"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-392.
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANTS THR-392 AND PHE-486.
Tissue: Amygdala and Thalamus.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-392.
Tissue: Uterus.
[6]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-392.
Tissue: Brain.
[8]"Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1."
Hanggi E., Grundschober A.F., Leuthold S., Meier P.J., St-Pierre M.V.
Mol. Pharmacol. 70:806-817(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PRESENCE OF DISULFIDE BONDS.
[9]"Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant."
Knauer M.J., Girdwood A.J., Kim R.B., Tirona R.G.
Mol. Pharmacol. 83:1218-1228(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY.
[10]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-77.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026256 mRNA. Translation: BAA78638.1.
AF205073 mRNA. Translation: AAG42205.1.
AB020687 mRNA. Translation: BAA74903.2. Different initiation.
AK290234 mRNA. Translation: BAF82923.1.
AK294503 mRNA. Translation: BAG57720.1.
AK300134 mRNA. Translation: BAG61922.1.
AL117465 mRNA. Translation: CAB55940.1.
AP001972 Genomic DNA. No translation available.
BC041095 mRNA. Translation: AAH41095.1.
CCDSCCDS8235.1. [O94956-1]
PIRT17250.
RefSeqNP_001138683.1. NM_001145211.2.
NP_001138684.1. NM_001145212.2.
NP_009187.1. NM_007256.4.
UniGeneHs.7884.

3D structure databases

ProteinModelPortalO94956.
SMRO94956. Positions 493-521.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116442. 1 interaction.
STRING9606.ENSP00000289575.

Chemistry

ChEMBLCHEMBL1743124.
DrugBankDB01049. Ergoloid mesylate.
GuidetoPHARMACOLOGY1224.

Protein family/group databases

TCDB2.A.60.1.20. the organo anion transporter (oat) family.

PTM databases

PhosphoSiteO94956.

Proteomic databases

MaxQBO94956.
PaxDbO94956.
PRIDEO94956.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000289575; ENSP00000289575; ENSG00000137491. [O94956-1]
ENST00000341411; ENSP00000341286; ENSG00000137491. [O94956-2]
ENST00000428359; ENSP00000388912; ENSG00000137491.
ENST00000454962; ENSP00000389653; ENSG00000137491. [O94956-2]
ENST00000525650; ENSP00000436324; ENSG00000137491.
GeneID11309.
KEGGhsa:11309.
UCSCuc001owb.3. human. [O94956-1]
uc001owc.3. human. [O94956-2]

Organism-specific databases

CTD11309.
GeneCardsGC11P074901.
HGNCHGNC:10962. SLCO2B1.
HPAHPA020659.
MIM604988. gene.
neXtProtNX_O94956.
PharmGKBPA35845.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318402.
HOGENOMHOG000231269.
HOVERGENHBG108345.
InParanoidO94956.
KOK14352.
OMAATMGTEN.
OrthoDBEOG7QG43R.
PhylomeDBO94956.
TreeFamTF317540.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressO94956.
BgeeO94956.
CleanExHS_SLCO2B1.
GenevestigatorO94956.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 5 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLCO2B1. human.
GeneWikiSLCO2B1.
GenomeRNAi11309.
NextBio27033476.
PROO94956.
SOURCESearch...

Entry information

Entry nameSO2B1_HUMAN
AccessionPrimary (citable) accession number: O94956
Secondary accession number(s): A8K2G9 expand/collapse secondary AC list , B4DGA9, B4DTB0, E7ERN5, E9PPU8, Q9H2Z0, Q9UFU1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM