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Protein

F-box only protein 21

Gene

FBXO21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. protein ubiquitination Source: GOC
  2. ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 21
Gene namesi
Name:FBXO21
Synonyms:FBX21, KIAA0875
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:13592. FBXO21.

Subcellular locationi

GO - Cellular componenti

  1. ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28034.

Polymorphism and mutation databases

BioMutaiFBXO21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628F-box only protein 21PRO_0000119903Add
BLAST

Proteomic databases

MaxQBiO94952.
PaxDbiO94952.
PRIDEiO94952.

PTM databases

PhosphoSiteiO94952.

Expressioni

Gene expression databases

BgeeiO94952.
CleanExiHS_FBXO21.
ExpressionAtlasiO94952. baseline and differential.
GenevestigatoriO94952.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi116656. 26 interactions.
IntActiO94952. 1 interaction.
MINTiMINT-4715904.
STRINGi9606.ENSP00000328187.

Structurei

3D structure databases

ProteinModelPortaliO94952.
SMRiO94952. Positions 31-73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 8457F-boxAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.Curated

Phylogenomic databases

eggNOGiCOG2912.
GeneTreeiENSGT00390000005653.
HOGENOMiHOG000065670.
HOVERGENiHBG051569.
InParanoidiO94952.
KOiK10301.
OMAiSHEKHRD.
OrthoDBiEOG73V6JS.
PhylomeDBiO94952.
TreeFamiTF313177.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR011722. Hemimethylated_DNA-bd_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF08755. YccV-like. 1 hit.
[Graphical view]
SMARTiSM00992. YccV-like. 1 hit.
[Graphical view]
SUPFAMiSSF141255. SSF141255. 1 hit.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR02097. yccV. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94952-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAVDSAM EVVPALAEEA APEVAGLSCL VNLPGEVLEY ILCCGSLTAA
60 70 80 90 100
DIGRVSSTCR RLRELCQSSG KVWKEQFRVR WPSLMKHYSP TDYVNWLEEY
110 120 130 140 150
KVRQKAGLEA RKIVASFSKR FFSEHVPCNG FSDIENLEGP EIFFEDELVC
160 170 180 190 200
ILNMEGRKAL TWKYYAKKIL YYLRQQKILN NLKAFLQQPD DYESYLEGAV
210 220 230 240 250
YIDQYCNPLS DISLKDIQAQ IDSIVELVCK TLRGINSRHP SLAFKAGESS
260 270 280 290 300
MIMEIELQSQ VLDAMNYVLY DQLKFKGNRM DYYNALNLYM HQVLIRRTGI
310 320 330 340 350
PISMSLLYLT IARQLGVPLE PVNFPSHFLL RWCQGAEGAT LDIFDYIYID
360 370 380 390 400
AFGKGKQLTV KECEYLIGQH VTAALYGVVN VKKVLQRMVG NLLSLGKREG
410 420 430 440 450
IDQSYQLLRD SLDLYLAMYP DQVQLLLLQA RLYFHLGIWP EKSFCLVLKV
460 470 480 490 500
LDILQHIQTL DPGQHGAVGY LVQHTLEHIE RKKEEVGVEV KLRSDEKHRD
510 520 530 540 550
VCYSIGLIMK HKRYGYNCVI YGWDPTCMMG HEWIRNMNVH SLPHGHHQPF
560 570 580 590 600
YNVLVEDGSC RYAAQENLEY NVEPQEISHP DVGRYFSEFT GTHYIPNAEL
610 620
EIRYPEDLEF VYETVQNIYS AKKENIDE

Note: May be due to a competing acceptor splice site. No experimental confirmation available.

Length:628
Mass (Da):72,270
Last modified:December 16, 2008 - v2
Checksum:i56144BB92D3CE446
GO
Isoform 2 (identifier: O94952-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     442-448: Missing.

Show »
Length:621
Mass (Da):71,479
Checksum:iD302DD46F3ABB5A3
GO

Sequence cautioni

The sequence CAB66833.2 differs from that shown. Reason: Erroneous termination at position 81. Translated as Trp.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti180 – 1801N → T.
Corresponds to variant rs11556202 [ dbSNP | Ensembl ].
VAR_047919

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei442 – 4487Missing in isoform 2. 4 PublicationsVSP_035975

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174601 mRNA. Translation: AAF04522.1.
AB020682 mRNA. Translation: BAA74898.1.
AK001699 mRNA. Translation: BAG50962.1.
AC026364 Genomic DNA. No translation available.
AC026368 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98105.1.
BC091496 mRNA. Translation: AAH91496.1.
AL136899 mRNA. Translation: CAB66833.2. Sequence problems.
CCDSiCCDS44989.1. [O94952-1]
CCDS9184.1. [O94952-2]
RefSeqiNP_055817.1. NM_015002.2. [O94952-1]
NP_296373.1. NM_033624.2. [O94952-2]
UniGeneiHs.740376.

Genome annotation databases

EnsembliENST00000330622; ENSP00000328187; ENSG00000135108. [O94952-2]
ENST00000622495; ENSP00000483508; ENSG00000135108. [O94952-1]
GeneIDi23014.
KEGGihsa:23014.
UCSCiuc001twj.3. human. [O94952-1]
uc001twk.3. human. [O94952-2]

Polymorphism and mutation databases

BioMutaiFBXO21.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174601 mRNA. Translation: AAF04522.1.
AB020682 mRNA. Translation: BAA74898.1.
AK001699 mRNA. Translation: BAG50962.1.
AC026364 Genomic DNA. No translation available.
AC026368 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98105.1.
BC091496 mRNA. Translation: AAH91496.1.
AL136899 mRNA. Translation: CAB66833.2. Sequence problems.
CCDSiCCDS44989.1. [O94952-1]
CCDS9184.1. [O94952-2]
RefSeqiNP_055817.1. NM_015002.2. [O94952-1]
NP_296373.1. NM_033624.2. [O94952-2]
UniGeneiHs.740376.

3D structure databases

ProteinModelPortaliO94952.
SMRiO94952. Positions 31-73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116656. 26 interactions.
IntActiO94952. 1 interaction.
MINTiMINT-4715904.
STRINGi9606.ENSP00000328187.

PTM databases

PhosphoSiteiO94952.

Polymorphism and mutation databases

BioMutaiFBXO21.

Proteomic databases

MaxQBiO94952.
PaxDbiO94952.
PRIDEiO94952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330622; ENSP00000328187; ENSG00000135108. [O94952-2]
ENST00000622495; ENSP00000483508; ENSG00000135108. [O94952-1]
GeneIDi23014.
KEGGihsa:23014.
UCSCiuc001twj.3. human. [O94952-1]
uc001twk.3. human. [O94952-2]

Organism-specific databases

CTDi23014.
GeneCardsiGC12M117581.
HGNCiHGNC:13592. FBXO21.
MIMi609095. gene.
neXtProtiNX_O94952.
PharmGKBiPA28034.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2912.
GeneTreeiENSGT00390000005653.
HOGENOMiHOG000065670.
HOVERGENiHBG051569.
InParanoidiO94952.
KOiK10301.
OMAiSHEKHRD.
OrthoDBiEOG73V6JS.
PhylomeDBiO94952.
TreeFamiTF313177.

Miscellaneous databases

ChiTaRSiFBXO21. human.
GenomeRNAii23014.
NextBioi43940.
PROiO94952.
SOURCEiSearch...

Gene expression databases

BgeeiO94952.
CleanExiHS_FBXO21.
ExpressionAtlasiO94952. baseline and differential.
GenevestigatoriO94952.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR011722. Hemimethylated_DNA-bd_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF08755. YccV-like. 1 hit.
[Graphical view]
SMARTiSM00992. YccV-like. 1 hit.
[Graphical view]
SUPFAMiSSF141255. SSF141255. 1 hit.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR02097. yccV. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-628 (ISOFORM 2).
    Tissue: Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-628 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiFBX21_HUMAN
AccessioniPrimary (citable) accession number: O94952
Secondary accession number(s): B3KMF0, Q5BJG0, Q9H087
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 16, 2008
Last modified: April 29, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.