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O94952

- FBX21_HUMAN

UniProt

O94952 - FBX21_HUMAN

Protein

F-box only protein 21

Gene

FBXO21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. protein ubiquitination Source: GOC
    2. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box only protein 21
    Gene namesi
    Name:FBXO21
    Synonyms:FBX21, KIAA0875
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13592. FBXO21.

    Subcellular locationi

    GO - Cellular componenti

    1. ubiquitin ligase complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28034.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628F-box only protein 21PRO_0000119903Add
    BLAST

    Proteomic databases

    MaxQBiO94952.
    PaxDbiO94952.
    PRIDEiO94952.

    PTM databases

    PhosphoSiteiO94952.

    Expressioni

    Gene expression databases

    ArrayExpressiO94952.
    BgeeiO94952.
    CleanExiHS_FBXO21.
    GenevestigatoriO94952.

    Interactioni

    Subunit structurei

    Directly interacts with SKP1 and CUL1.By similarity

    Protein-protein interaction databases

    BioGridi116656. 12 interactions.
    IntActiO94952. 1 interaction.
    MINTiMINT-4715904.
    STRINGi9606.ENSP00000328187.

    Structurei

    3D structure databases

    ProteinModelPortaliO94952.
    SMRiO94952. Positions 31-73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 8457F-boxAdd
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.Curated

    Phylogenomic databases

    eggNOGiCOG2912.
    HOGENOMiHOG000065670.
    HOVERGENiHBG051569.
    InParanoidiO94952.
    KOiK10301.
    OMAiLNSYIHQ.
    OrthoDBiEOG73V6JS.
    PhylomeDBiO94952.
    TreeFamiTF313177.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    IPR011722. Hemimethylated_DNA-bd_dom.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF08755. YccV-like. 1 hit.
    [Graphical view]
    SMARTiSM00992. YccV-like. 1 hit.
    [Graphical view]
    SUPFAMiSSF141255. SSF141255. 1 hit.
    SSF81383. SSF81383. 1 hit.
    TIGRFAMsiTIGR02097. yccV. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94952-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAVDSAM EVVPALAEEA APEVAGLSCL VNLPGEVLEY ILCCGSLTAA    50
    DIGRVSSTCR RLRELCQSSG KVWKEQFRVR WPSLMKHYSP TDYVNWLEEY 100
    KVRQKAGLEA RKIVASFSKR FFSEHVPCNG FSDIENLEGP EIFFEDELVC 150
    ILNMEGRKAL TWKYYAKKIL YYLRQQKILN NLKAFLQQPD DYESYLEGAV 200
    YIDQYCNPLS DISLKDIQAQ IDSIVELVCK TLRGINSRHP SLAFKAGESS 250
    MIMEIELQSQ VLDAMNYVLY DQLKFKGNRM DYYNALNLYM HQVLIRRTGI 300
    PISMSLLYLT IARQLGVPLE PVNFPSHFLL RWCQGAEGAT LDIFDYIYID 350
    AFGKGKQLTV KECEYLIGQH VTAALYGVVN VKKVLQRMVG NLLSLGKREG 400
    IDQSYQLLRD SLDLYLAMYP DQVQLLLLQA RLYFHLGIWP EKSFCLVLKV 450
    LDILQHIQTL DPGQHGAVGY LVQHTLEHIE RKKEEVGVEV KLRSDEKHRD 500
    VCYSIGLIMK HKRYGYNCVI YGWDPTCMMG HEWIRNMNVH SLPHGHHQPF 550
    YNVLVEDGSC RYAAQENLEY NVEPQEISHP DVGRYFSEFT GTHYIPNAEL 600
    EIRYPEDLEF VYETVQNIYS AKKENIDE 628

    Note: May be due to a competing acceptor splice site. No experimental confirmation available.

    Length:628
    Mass (Da):72,270
    Last modified:December 16, 2008 - v2
    Checksum:i56144BB92D3CE446
    GO
    Isoform 2 (identifier: O94952-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         442-448: Missing.

    Show »
    Length:621
    Mass (Da):71,479
    Checksum:iD302DD46F3ABB5A3
    GO

    Sequence cautioni

    The sequence CAB66833.2 differs from that shown. Reason: Erroneous termination at position 81. Translated as Trp.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti180 – 1801N → T.
    Corresponds to variant rs11556202 [ dbSNP | Ensembl ].
    VAR_047919

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei442 – 4487Missing in isoform 2. 4 PublicationsVSP_035975

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174601 mRNA. Translation: AAF04522.1.
    AB020682 mRNA. Translation: BAA74898.1.
    AK001699 mRNA. Translation: BAG50962.1.
    AC026364 Genomic DNA. No translation available.
    AC026368 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW98105.1.
    BC091496 mRNA. Translation: AAH91496.1.
    AL136899 mRNA. Translation: CAB66833.2. Sequence problems.
    CCDSiCCDS44989.1. [O94952-1]
    CCDS9184.1. [O94952-2]
    RefSeqiNP_055817.1. NM_015002.2. [O94952-1]
    NP_296373.1. NM_033624.2. [O94952-2]
    UniGeneiHs.740376.

    Genome annotation databases

    EnsembliENST00000330622; ENSP00000328187; ENSG00000135108. [O94952-2]
    ENST00000427718; ENSP00000414468; ENSG00000135108. [O94952-1]
    GeneIDi23014.
    KEGGihsa:23014.
    UCSCiuc001twj.3. human. [O94952-1]
    uc001twk.3. human. [O94952-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174601 mRNA. Translation: AAF04522.1 .
    AB020682 mRNA. Translation: BAA74898.1 .
    AK001699 mRNA. Translation: BAG50962.1 .
    AC026364 Genomic DNA. No translation available.
    AC026368 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW98105.1 .
    BC091496 mRNA. Translation: AAH91496.1 .
    AL136899 mRNA. Translation: CAB66833.2 . Sequence problems.
    CCDSi CCDS44989.1. [O94952-1 ]
    CCDS9184.1. [O94952-2 ]
    RefSeqi NP_055817.1. NM_015002.2. [O94952-1 ]
    NP_296373.1. NM_033624.2. [O94952-2 ]
    UniGenei Hs.740376.

    3D structure databases

    ProteinModelPortali O94952.
    SMRi O94952. Positions 31-73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116656. 12 interactions.
    IntActi O94952. 1 interaction.
    MINTi MINT-4715904.
    STRINGi 9606.ENSP00000328187.

    PTM databases

    PhosphoSitei O94952.

    Proteomic databases

    MaxQBi O94952.
    PaxDbi O94952.
    PRIDEi O94952.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330622 ; ENSP00000328187 ; ENSG00000135108 . [O94952-2 ]
    ENST00000427718 ; ENSP00000414468 ; ENSG00000135108 . [O94952-1 ]
    GeneIDi 23014.
    KEGGi hsa:23014.
    UCSCi uc001twj.3. human. [O94952-1 ]
    uc001twk.3. human. [O94952-2 ]

    Organism-specific databases

    CTDi 23014.
    GeneCardsi GC12M117581.
    HGNCi HGNC:13592. FBXO21.
    MIMi 609095. gene.
    neXtProti NX_O94952.
    PharmGKBi PA28034.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2912.
    HOGENOMi HOG000065670.
    HOVERGENi HBG051569.
    InParanoidi O94952.
    KOi K10301.
    OMAi LNSYIHQ.
    OrthoDBi EOG73V6JS.
    PhylomeDBi O94952.
    TreeFami TF313177.

    Miscellaneous databases

    GenomeRNAii 23014.
    NextBioi 43940.
    PROi O94952.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94952.
    Bgeei O94952.
    CleanExi HS_FBXO21.
    Genevestigatori O94952.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    IPR011722. Hemimethylated_DNA-bd_dom.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF08755. YccV-like. 1 hit.
    [Graphical view ]
    SMARTi SM00992. YccV-like. 1 hit.
    [Graphical view ]
    SUPFAMi SSF141255. SSF141255. 1 hit.
    SSF81383. SSF81383. 1 hit.
    TIGRFAMsi TIGR02097. yccV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-628 (ISOFORM 2).
      Tissue: Testis.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-628 (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiFBX21_HUMAN
    AccessioniPrimary (citable) accession number: O94952
    Secondary accession number(s): B3KMF0, Q5BJG0, Q9H087
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3