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O94941 (RNF37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RING finger protein 37
Alternative name(s):
U-box domain-containing protein 5
Ubiquitin-conjugating enzyme 7-interacting protein 5
Gene names
Name:UBOX5
Synonyms:KIAA0860, RNF37, UBCE7IP5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts with UBE2L3 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 RING-type zinc finger.

Contains 1 U-box domain.

Sequence caution

The sequence BAA74883.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein polyubiquitination

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

ubiquitin ligase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionubiquitin-ubiquitin ligase activity

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O94941-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O94941-2)

The sequence of this isoform differs from the canonical sequence as follows:
     419-472: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 541541RING finger protein 37
PRO_0000056076

Regions

Domain258 – 33881U-box
Zinc finger483 – 52846RING-type

Natural variations

Alternative sequence419 – 47254Missing in isoform 2.
VSP_042899
Natural variant961T → M.
Corresponds to variant rs999409 [ dbSNP | Ensembl ].
VAR_046402
Natural variant4791L → P.
Corresponds to variant rs34205880 [ dbSNP | Ensembl ].
VAR_046403

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 4AF1A0C5115FAF7B

FASTA54158,966
        10         20         30         40         50         60 
MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP VYVTVSFPFN 

        70         80         90        100        110        120 
VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR TLGPAEPSVP DKEAFTLVGK 

       130        140        150        160        170        180 
VLLKNQSQVV FSHRGFKARP PFGAMEATLP SPAVVAQELW NKGALSLSHV AHLRICITHV 

       190        200        210        220        230        240 
TGGGIPCIKR LEVWGQPAKT CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP 

       250        260        270        280        290        300 
ESQQAPSSLQ KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG 

       310        320        330        340        350        360 
RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL AVIPSSIVLP 

       370        380        390        400        410        420 
SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA KKMKATNEPS LTHMDCSTGP 

       430        440        450        460        470        480 
LSHEQKLSQS LEIALASTLG SMPSFTARLT RGQLQHLGTR GSNTSWRPGT GSEQPGSILG 

       490        500        510        520        530        540 
PECASCKRVF SPYFKKEPVY QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH 


F 

« Hide

Isoform 2 [UniParc].

Checksum: 82BE211EECCCFC05
Show »

FASTA48753,276

References

[1]"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Mammary gland.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Lung and Lymph.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB020667 mRNA. Translation: BAA74883.2. Different initiation.
AK022444 mRNA. Translation: BAG51073.1.
CR457089 mRNA. Translation: CAG33370.1.
AL121891 Genomic DNA. Translation: CAC09908.2.
AL121891 Genomic DNA. Translation: CAC09909.1.
CH471133 Genomic DNA. Translation: EAX10550.1.
CH471133 Genomic DNA. Translation: EAX10551.1.
BC000515 mRNA. Translation: AAH00515.1.
BC046122 mRNA. Translation: AAH46122.1.
CCDSCCDS13046.1. [O94941-1]
CCDS13047.1. [O94941-2]
RefSeqNP_055763.1. NM_014948.3. [O94941-1]
NP_955447.1. NM_199415.2. [O94941-2]
UniGeneHs.654646.

3D structure databases

ProteinModelPortalO94941.
SMRO94941. Positions 256-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116554. 21 interactions.
IntActO94941. 15 interactions.
STRING9606.ENSP00000217173.

PTM databases

PhosphoSiteO94941.

Proteomic databases

MaxQBO94941.
PaxDbO94941.
PRIDEO94941.

Protocols and materials databases

DNASU22888.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000217173; ENSP00000217173; ENSG00000185019. [O94941-1]
ENST00000348031; ENSP00000311726; ENSG00000185019. [O94941-2]
GeneID22888.
KEGGhsa:22888.
UCSCuc002whw.4. human. [O94941-1]
uc002whx.4. human. [O94941-2]

Organism-specific databases

CTD22888.
GeneCardsGC20M003088.
HGNCHGNC:17777. UBOX5.
HPAHPA028871.
neXtProtNX_O94941.
PharmGKBPA134991794.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG308766.
HOGENOMHOG000132931.
HOVERGENHBG054212.
InParanoidO94941.
KOK10600.
OMAKICITHV.
OrthoDBEOG7G7KQ8.
PhylomeDBO94941.
TreeFamTF329105.

Enzyme and pathway databases

BRENDA6.3.2.19. 3474.
ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressO94941.
BgeeO94941.
CleanExHS_UBOX5.
GenevestigatorO94941.

Family and domain databases

Gene3D3.30.40.10. 2 hits.
InterProIPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF04564. U-box. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00504. Ubox. 1 hit.
[Graphical view]
PROSITEPS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiUBOX5.
GenomeRNAi22888.
NextBio43483.
PROO94941.

Entry information

Entry nameRNF37_HUMAN
AccessionPrimary (citable) accession number: O94941
Secondary accession number(s): Q6IAR5, Q86X87, Q9H4J2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM