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O94941

- RNF37_HUMAN

UniProt

O94941 - RNF37_HUMAN

Protein

RING finger protein 37

Gene

UBOX5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri483 – 52846RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ubiquitin-ubiquitin ligase activity Source: Ensembl
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein polyubiquitination Source: Ensembl

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi6.3.2.19. 3474.
    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 37
    Alternative name(s):
    U-box domain-containing protein 5
    Ubiquitin-conjugating enzyme 7-interacting protein 5
    Gene namesi
    Name:UBOX5
    Synonyms:KIAA0860, RNF37, UBCE7IP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:17777. UBOX5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. ubiquitin ligase complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134991794.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541RING finger protein 37PRO_0000056076Add
    BLAST

    Proteomic databases

    MaxQBiO94941.
    PaxDbiO94941.
    PRIDEiO94941.

    PTM databases

    PhosphoSiteiO94941.

    Expressioni

    Gene expression databases

    ArrayExpressiO94941.
    BgeeiO94941.
    CleanExiHS_UBOX5.
    GenevestigatoriO94941.

    Organism-specific databases

    HPAiHPA028871.

    Interactioni

    Subunit structurei

    Interacts with UBE2L3.By similarity

    Protein-protein interaction databases

    BioGridi116554. 21 interactions.
    IntActiO94941. 15 interactions.
    STRINGi9606.ENSP00000217173.

    Structurei

    3D structure databases

    ProteinModelPortaliO94941.
    SMRiO94941. Positions 256-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini258 – 33881U-boxAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 1 U-box domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri483 – 52846RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG308766.
    HOGENOMiHOG000132931.
    HOVERGENiHBG054212.
    InParanoidiO94941.
    KOiK10600.
    OMAiKICITHV.
    OrthoDBiEOG7G7KQ8.
    PhylomeDBiO94941.
    TreeFamiTF329105.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    InterProiIPR003613. Ubox_domain.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF04564. U-box. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00504. Ubox. 1 hit.
    [Graphical view]
    PROSITEiPS51698. U_BOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94941-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP    50
    VYVTVSFPFN VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR 100
    TLGPAEPSVP DKEAFTLVGK VLLKNQSQVV FSHRGFKARP PFGAMEATLP 150
    SPAVVAQELW NKGALSLSHV AHLRICITHV TGGGIPCIKR LEVWGQPAKT 200
    CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP ESQQAPSSLQ 250
    KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG 300
    RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL 350
    AVIPSSIVLP SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA 400
    KKMKATNEPS LTHMDCSTGP LSHEQKLSQS LEIALASTLG SMPSFTARLT 450
    RGQLQHLGTR GSNTSWRPGT GSEQPGSILG PECASCKRVF SPYFKKEPVY 500
    QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH F 541
    Length:541
    Mass (Da):58,966
    Last modified:May 1, 1999 - v1
    Checksum:i4AF1A0C5115FAF7B
    GO
    Isoform 2 (identifier: O94941-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         419-472: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:487
    Mass (Da):53,276
    Checksum:i82BE211EECCCFC05
    GO

    Sequence cautioni

    The sequence BAA74883.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961T → M.
    Corresponds to variant rs999409 [ dbSNP | Ensembl ].
    VAR_046402
    Natural varianti479 – 4791L → P.
    Corresponds to variant rs34205880 [ dbSNP | Ensembl ].
    VAR_046403

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei419 – 47254Missing in isoform 2. 2 PublicationsVSP_042899Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020667 mRNA. Translation: BAA74883.2. Different initiation.
    AK022444 mRNA. Translation: BAG51073.1.
    CR457089 mRNA. Translation: CAG33370.1.
    AL121891 Genomic DNA. Translation: CAC09908.2.
    AL121891 Genomic DNA. Translation: CAC09909.1.
    CH471133 Genomic DNA. Translation: EAX10550.1.
    CH471133 Genomic DNA. Translation: EAX10551.1.
    BC000515 mRNA. Translation: AAH00515.1.
    BC046122 mRNA. Translation: AAH46122.1.
    CCDSiCCDS13046.1. [O94941-1]
    CCDS13047.1. [O94941-2]
    RefSeqiNP_055763.1. NM_014948.3. [O94941-1]
    NP_955447.1. NM_199415.2. [O94941-2]
    UniGeneiHs.654646.

    Genome annotation databases

    EnsembliENST00000217173; ENSP00000217173; ENSG00000185019. [O94941-1]
    ENST00000348031; ENSP00000311726; ENSG00000185019. [O94941-2]
    GeneIDi22888.
    KEGGihsa:22888.
    UCSCiuc002whw.4. human. [O94941-1]
    uc002whx.4. human. [O94941-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020667 mRNA. Translation: BAA74883.2 . Different initiation.
    AK022444 mRNA. Translation: BAG51073.1 .
    CR457089 mRNA. Translation: CAG33370.1 .
    AL121891 Genomic DNA. Translation: CAC09908.2 .
    AL121891 Genomic DNA. Translation: CAC09909.1 .
    CH471133 Genomic DNA. Translation: EAX10550.1 .
    CH471133 Genomic DNA. Translation: EAX10551.1 .
    BC000515 mRNA. Translation: AAH00515.1 .
    BC046122 mRNA. Translation: AAH46122.1 .
    CCDSi CCDS13046.1. [O94941-1 ]
    CCDS13047.1. [O94941-2 ]
    RefSeqi NP_055763.1. NM_014948.3. [O94941-1 ]
    NP_955447.1. NM_199415.2. [O94941-2 ]
    UniGenei Hs.654646.

    3D structure databases

    ProteinModelPortali O94941.
    SMRi O94941. Positions 256-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116554. 21 interactions.
    IntActi O94941. 15 interactions.
    STRINGi 9606.ENSP00000217173.

    PTM databases

    PhosphoSitei O94941.

    Proteomic databases

    MaxQBi O94941.
    PaxDbi O94941.
    PRIDEi O94941.

    Protocols and materials databases

    DNASUi 22888.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000217173 ; ENSP00000217173 ; ENSG00000185019 . [O94941-1 ]
    ENST00000348031 ; ENSP00000311726 ; ENSG00000185019 . [O94941-2 ]
    GeneIDi 22888.
    KEGGi hsa:22888.
    UCSCi uc002whw.4. human. [O94941-1 ]
    uc002whx.4. human. [O94941-2 ]

    Organism-specific databases

    CTDi 22888.
    GeneCardsi GC20M003088.
    HGNCi HGNC:17777. UBOX5.
    HPAi HPA028871.
    neXtProti NX_O94941.
    PharmGKBi PA134991794.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308766.
    HOGENOMi HOG000132931.
    HOVERGENi HBG054212.
    InParanoidi O94941.
    KOi K10600.
    OMAi KICITHV.
    OrthoDBi EOG7G7KQ8.
    PhylomeDBi O94941.
    TreeFami TF329105.

    Enzyme and pathway databases

    BRENDAi 6.3.2.19. 3474.
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    GeneWikii UBOX5.
    GenomeRNAii 22888.
    NextBioi 43483.
    PROi O94941.

    Gene expression databases

    ArrayExpressi O94941.
    Bgeei O94941.
    CleanExi HS_UBOX5.
    Genevestigatori O94941.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    InterProi IPR003613. Ubox_domain.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF04564. U-box. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00504. Ubox. 1 hit.
    [Graphical view ]
    PROSITEi PS51698. U_BOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Mammary gland.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung and Lymph.

    Entry informationi

    Entry nameiRNF37_HUMAN
    AccessioniPrimary (citable) accession number: O94941
    Secondary accession number(s): Q6IAR5, Q86X87, Q9H4J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3