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Protein

RING finger protein 37

Gene

UBOX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri483 – 528RING-typePROSITE-ProRule annotationAdd BLAST46

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS04943-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 37Curated (EC:6.3.2.-By similarity)
Alternative name(s):
U-box domain-containing protein 5Imported
UbcM4-interacting protein 51 Publication
Short name:
hUIP51 Publication
Ubiquitin-conjugating enzyme 7-interacting protein 5Imported
Gene namesi
Name:UBOX5Imported
Synonyms:KIAA0860Imported, RNF37Curated, UBCE7IP5Imported, UIP51 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:17777. UBOX5.

Subcellular locationi

GO - Cellular componenti

  • nuclear body Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22888.
OpenTargetsiENSG00000185019.
PharmGKBiPA134991794.

Polymorphism and mutation databases

BioMutaiUBOX5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560761 – 541RING finger protein 37Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei451Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiO94941.
MaxQBiO94941.
PaxDbiO94941.
PeptideAtlasiO94941.
PRIDEiO94941.

PTM databases

iPTMnetiO94941.
PhosphoSitePlusiO94941.

Expressioni

Tissue specificityi

Expressed in liver, heart, brain, kidney and testis.1 Publication

Gene expression databases

BgeeiENSG00000185019.
CleanExiHS_UBOX5.
ExpressionAtlasiO94941. baseline and differential.
GenevisibleiO94941. HS.

Organism-specific databases

HPAiHPA028871.

Interactioni

Subunit structurei

Interacts with UBE2L3. Interacts with VCP.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HEL-S-70V9HW803EBI-751901,EBI-10175326
MLH1P406923EBI-751901,EBI-744248

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116554. 21 interactors.
IntActiO94941. 17 interactors.
STRINGi9606.ENSP00000217173.

Structurei

3D structure databases

ProteinModelPortaliO94941.
SMRiO94941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 338U-boxAdd BLAST81

Domaini

The U-box domain mediates interaction with E2 ubiquitin ligases and is required for the ubiquitin-protein ligase activity.1 Publication1 Publication

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 U-box domain.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri483 – 528RING-typePROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2042. Eukaryota.
COG5113. LUCA.
GeneTreeiENSGT00510000049555.
HOGENOMiHOG000132931.
HOVERGENiHBG054212.
InParanoidiO94941.
KOiK10600.
OMAiKICITHV.
OrthoDBiEOG091G0L8V.
PhylomeDBiO94941.
TreeFamiTF329105.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04564. U-box. 1 hit.
[Graphical view]
SMARTiSM00504. Ubox. 1 hit.
[Graphical view]
PROSITEiPS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94941-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP
60 70 80 90 100
VYVTVSFPFN VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR
110 120 130 140 150
TLGPAEPSVP DKEAFTLVGK VLLKNQSQVV FSHRGFKARP PFGAMEATLP
160 170 180 190 200
SPAVVAQELW NKGALSLSHV AHLRICITHV TGGGIPCIKR LEVWGQPAKT
210 220 230 240 250
CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP ESQQAPSSLQ
260 270 280 290 300
KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG
310 320 330 340 350
RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL
360 370 380 390 400
AVIPSSIVLP SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA
410 420 430 440 450
KKMKATNEPS LTHMDCSTGP LSHEQKLSQS LEIALASTLG SMPSFTARLT
460 470 480 490 500
RGQLQHLGTR GSNTSWRPGT GSEQPGSILG PECASCKRVF SPYFKKEPVY
510 520 530 540
QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH F
Length:541
Mass (Da):58,966
Last modified:May 1, 1999 - v1
Checksum:i4AF1A0C5115FAF7B
GO
Isoform 2 (identifier: O94941-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-472: Missing.

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):53,276
Checksum:i82BE211EECCCFC05
GO

Sequence cautioni

The sequence BAA74883 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04640296T → M.Corresponds to variant rs999409dbSNPEnsembl.1
Natural variantiVAR_046403479L → P.Corresponds to variant rs34205880dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042899419 – 472Missing in isoform 2. 2 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020667 mRNA. Translation: BAA74883.2. Different initiation.
AK022444 mRNA. Translation: BAG51073.1.
CR457089 mRNA. Translation: CAG33370.1.
AL121891 Genomic DNA. Translation: CAC09908.2.
AL121891 Genomic DNA. Translation: CAC09909.1.
CH471133 Genomic DNA. Translation: EAX10550.1.
CH471133 Genomic DNA. Translation: EAX10551.1.
BC000515 mRNA. Translation: AAH00515.1.
BC046122 mRNA. Translation: AAH46122.1.
CCDSiCCDS13046.1. [O94941-1]
CCDS13047.1. [O94941-2]
RefSeqiNP_055763.1. NM_014948.3. [O94941-1]
NP_955447.1. NM_199415.2. [O94941-2]
UniGeneiHs.654646.

Genome annotation databases

EnsembliENST00000217173; ENSP00000217173; ENSG00000185019. [O94941-1]
ENST00000348031; ENSP00000311726; ENSG00000185019. [O94941-2]
GeneIDi22888.
KEGGihsa:22888.
UCSCiuc002whw.5. human. [O94941-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020667 mRNA. Translation: BAA74883.2. Different initiation.
AK022444 mRNA. Translation: BAG51073.1.
CR457089 mRNA. Translation: CAG33370.1.
AL121891 Genomic DNA. Translation: CAC09908.2.
AL121891 Genomic DNA. Translation: CAC09909.1.
CH471133 Genomic DNA. Translation: EAX10550.1.
CH471133 Genomic DNA. Translation: EAX10551.1.
BC000515 mRNA. Translation: AAH00515.1.
BC046122 mRNA. Translation: AAH46122.1.
CCDSiCCDS13046.1. [O94941-1]
CCDS13047.1. [O94941-2]
RefSeqiNP_055763.1. NM_014948.3. [O94941-1]
NP_955447.1. NM_199415.2. [O94941-2]
UniGeneiHs.654646.

3D structure databases

ProteinModelPortaliO94941.
SMRiO94941.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116554. 21 interactors.
IntActiO94941. 17 interactors.
STRINGi9606.ENSP00000217173.

PTM databases

iPTMnetiO94941.
PhosphoSitePlusiO94941.

Polymorphism and mutation databases

BioMutaiUBOX5.

Proteomic databases

EPDiO94941.
MaxQBiO94941.
PaxDbiO94941.
PeptideAtlasiO94941.
PRIDEiO94941.

Protocols and materials databases

DNASUi22888.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217173; ENSP00000217173; ENSG00000185019. [O94941-1]
ENST00000348031; ENSP00000311726; ENSG00000185019. [O94941-2]
GeneIDi22888.
KEGGihsa:22888.
UCSCiuc002whw.5. human. [O94941-1]

Organism-specific databases

CTDi22888.
DisGeNETi22888.
GeneCardsiUBOX5.
HGNCiHGNC:17777. UBOX5.
HPAiHPA028871.
neXtProtiNX_O94941.
OpenTargetsiENSG00000185019.
PharmGKBiPA134991794.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2042. Eukaryota.
COG5113. LUCA.
GeneTreeiENSGT00510000049555.
HOGENOMiHOG000132931.
HOVERGENiHBG054212.
InParanoidiO94941.
KOiK10600.
OMAiKICITHV.
OrthoDBiEOG091G0L8V.
PhylomeDBiO94941.
TreeFamiTF329105.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:HS04943-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GeneWikiiUBOX5.
GenomeRNAii22888.
PROiO94941.

Gene expression databases

BgeeiENSG00000185019.
CleanExiHS_UBOX5.
ExpressionAtlasiO94941. baseline and differential.
GenevisibleiO94941. HS.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04564. U-box. 1 hit.
[Graphical view]
SMARTiSM00504. Ubox. 1 hit.
[Graphical view]
PROSITEiPS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNF37_HUMAN
AccessioniPrimary (citable) accession number: O94941
Secondary accession number(s): Q6IAR5, Q86X87, Q9H4J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.