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O94941

- RNF37_HUMAN

UniProt

O94941 - RNF37_HUMAN

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Protein

RING finger protein 37

Gene
UBOX5, KIAA0860, RNF37, UBCE7IP5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri483 – 52846RING-typeAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-ubiquitin ligase activity Source: Ensembl
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein polyubiquitination Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi6.3.2.19. 3474.
ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 37
Alternative name(s):
U-box domain-containing protein 5
Ubiquitin-conjugating enzyme 7-interacting protein 5
Gene namesi
Name:UBOX5
Synonyms:KIAA0860, RNF37, UBCE7IP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:17777. UBOX5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. ubiquitin ligase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541RING finger protein 37PRO_0000056076Add
BLAST

Proteomic databases

MaxQBiO94941.
PaxDbiO94941.
PRIDEiO94941.

PTM databases

PhosphoSiteiO94941.

Expressioni

Gene expression databases

ArrayExpressiO94941.
BgeeiO94941.
CleanExiHS_UBOX5.
GenevestigatoriO94941.

Organism-specific databases

HPAiHPA028871.

Interactioni

Subunit structurei

Interacts with UBE2L3 By similarity.

Protein-protein interaction databases

BioGridi116554. 21 interactions.
IntActiO94941. 15 interactions.
STRINGi9606.ENSP00000217173.

Structurei

3D structure databases

ProteinModelPortaliO94941.
SMRiO94941. Positions 256-335.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini258 – 33881U-boxAdd
BLAST

Sequence similaritiesi

Contains 1 U-box domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri483 – 52846RING-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG308766.
HOGENOMiHOG000132931.
HOVERGENiHBG054212.
InParanoidiO94941.
KOiK10600.
OMAiKICITHV.
OrthoDBiEOG7G7KQ8.
PhylomeDBiO94941.
TreeFamiTF329105.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04564. U-box. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00504. Ubox. 1 hit.
[Graphical view]
PROSITEiPS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O94941-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP    50
VYVTVSFPFN VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR 100
TLGPAEPSVP DKEAFTLVGK VLLKNQSQVV FSHRGFKARP PFGAMEATLP 150
SPAVVAQELW NKGALSLSHV AHLRICITHV TGGGIPCIKR LEVWGQPAKT 200
CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP ESQQAPSSLQ 250
KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG 300
RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL 350
AVIPSSIVLP SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA 400
KKMKATNEPS LTHMDCSTGP LSHEQKLSQS LEIALASTLG SMPSFTARLT 450
RGQLQHLGTR GSNTSWRPGT GSEQPGSILG PECASCKRVF SPYFKKEPVY 500
QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH F 541
Length:541
Mass (Da):58,966
Last modified:May 1, 1999 - v1
Checksum:i4AF1A0C5115FAF7B
GO
Isoform 2 (identifier: O94941-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-472: Missing.

Note: No experimental confirmation available.

Show »
Length:487
Mass (Da):53,276
Checksum:i82BE211EECCCFC05
GO

Sequence cautioni

The sequence BAA74883.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961T → M.
Corresponds to variant rs999409 [ dbSNP | Ensembl ].
VAR_046402
Natural varianti479 – 4791L → P.
Corresponds to variant rs34205880 [ dbSNP | Ensembl ].
VAR_046403

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei419 – 47254Missing in isoform 2. VSP_042899Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020667 mRNA. Translation: BAA74883.2. Different initiation.
AK022444 mRNA. Translation: BAG51073.1.
CR457089 mRNA. Translation: CAG33370.1.
AL121891 Genomic DNA. Translation: CAC09908.2.
AL121891 Genomic DNA. Translation: CAC09909.1.
CH471133 Genomic DNA. Translation: EAX10550.1.
CH471133 Genomic DNA. Translation: EAX10551.1.
BC000515 mRNA. Translation: AAH00515.1.
BC046122 mRNA. Translation: AAH46122.1.
CCDSiCCDS13046.1. [O94941-1]
CCDS13047.1. [O94941-2]
RefSeqiNP_055763.1. NM_014948.3. [O94941-1]
NP_955447.1. NM_199415.2. [O94941-2]
UniGeneiHs.654646.

Genome annotation databases

EnsembliENST00000217173; ENSP00000217173; ENSG00000185019. [O94941-1]
ENST00000348031; ENSP00000311726; ENSG00000185019. [O94941-2]
GeneIDi22888.
KEGGihsa:22888.
UCSCiuc002whw.4. human. [O94941-1]
uc002whx.4. human. [O94941-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020667 mRNA. Translation: BAA74883.2 . Different initiation.
AK022444 mRNA. Translation: BAG51073.1 .
CR457089 mRNA. Translation: CAG33370.1 .
AL121891 Genomic DNA. Translation: CAC09908.2 .
AL121891 Genomic DNA. Translation: CAC09909.1 .
CH471133 Genomic DNA. Translation: EAX10550.1 .
CH471133 Genomic DNA. Translation: EAX10551.1 .
BC000515 mRNA. Translation: AAH00515.1 .
BC046122 mRNA. Translation: AAH46122.1 .
CCDSi CCDS13046.1. [O94941-1 ]
CCDS13047.1. [O94941-2 ]
RefSeqi NP_055763.1. NM_014948.3. [O94941-1 ]
NP_955447.1. NM_199415.2. [O94941-2 ]
UniGenei Hs.654646.

3D structure databases

ProteinModelPortali O94941.
SMRi O94941. Positions 256-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116554. 21 interactions.
IntActi O94941. 15 interactions.
STRINGi 9606.ENSP00000217173.

PTM databases

PhosphoSitei O94941.

Proteomic databases

MaxQBi O94941.
PaxDbi O94941.
PRIDEi O94941.

Protocols and materials databases

DNASUi 22888.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000217173 ; ENSP00000217173 ; ENSG00000185019 . [O94941-1 ]
ENST00000348031 ; ENSP00000311726 ; ENSG00000185019 . [O94941-2 ]
GeneIDi 22888.
KEGGi hsa:22888.
UCSCi uc002whw.4. human. [O94941-1 ]
uc002whx.4. human. [O94941-2 ]

Organism-specific databases

CTDi 22888.
GeneCardsi GC20M003088.
HGNCi HGNC:17777. UBOX5.
HPAi HPA028871.
neXtProti NX_O94941.
PharmGKBi PA134991794.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308766.
HOGENOMi HOG000132931.
HOVERGENi HBG054212.
InParanoidi O94941.
KOi K10600.
OMAi KICITHV.
OrthoDBi EOG7G7KQ8.
PhylomeDBi O94941.
TreeFami TF329105.

Enzyme and pathway databases

BRENDAi 6.3.2.19. 3474.
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GeneWikii UBOX5.
GenomeRNAii 22888.
NextBioi 43483.
PROi O94941.

Gene expression databases

ArrayExpressi O94941.
Bgeei O94941.
CleanExi HS_UBOX5.
Genevestigatori O94941.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
InterProi IPR003613. Ubox_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF04564. U-box. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00504. Ubox. 1 hit.
[Graphical view ]
PROSITEi PS51698. U_BOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Mammary gland.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Lymph.

Entry informationi

Entry nameiRNF37_HUMAN
AccessioniPrimary (citable) accession number: O94941
Secondary accession number(s): Q6IAR5, Q86X87, Q9H4J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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