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Protein

SLIT and NTRK-like protein 3

Gene

SLITRK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Suppresses neurite outgrowth.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SLIT and NTRK-like protein 3
Gene namesi
Name:SLITRK3
Synonyms:KIAA0848
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23501. SLITRK3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 654626ExtracellularSequence analysisAdd
BLAST
Transmembranei655 – 67521HelicalSequence analysisAdd
BLAST
Topological domaini676 – 977302CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958002.

Polymorphism and mutation databases

BioMutaiSLITRK3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 977951SLIT and NTRK-like protein 3PRO_0000032677Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO94933.
PaxDbiO94933.
PRIDEiO94933.

PTM databases

PhosphoSiteiO94933.

Expressioni

Tissue specificityi

Expressed in the occipital lobe of the cerebral cortex of the brain. Expressed at higher levels in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.1 Publication

Gene expression databases

BgeeiO94933.
CleanExiHS_SLITRK3.
ExpressionAtlasiO94933. baseline and differential.
GenevisibleiO94933. HS.

Organism-specific databases

HPAiHPA017636.

Interactioni

Protein-protein interaction databases

BioGridi116533. 1 interaction.
STRINGi9606.ENSP00000241274.

Structurei

3D structure databases

ProteinModelPortaliO94933.
SMRiO94933. Positions 44-294, 374-612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati78 – 9922LRR 1Add
BLAST
Repeati102 – 12322LRR 2Add
BLAST
Repeati126 – 14722LRR 3Add
BLAST
Repeati150 – 17122LRR 4Add
BLAST
Repeati174 – 19522LRR 5Add
BLAST
Repeati197 – 21822LRR 6Add
BLAST
Domaini232 – 28352LRRCT 1Add
BLAST
Domaini364 – 40643LRRNTAdd
BLAST
Repeati409 – 43022LRR 7Add
BLAST
Repeati433 – 45422LRR 8Add
BLAST
Repeati457 – 47822LRR 9Add
BLAST
Repeati481 – 50222LRR 10Add
BLAST
Repeati505 – 52622LRR 11Add
BLAST
Repeati528 – 54922LRR 12Add
BLAST
Domaini562 – 61352LRRCT 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi712 – 72312Poly-GlyAdd
BLAST

Sequence similaritiesi

Belongs to the SLITRK family.Curated
Contains 12 LRR (leucine-rich) repeats.Curated
Contains 2 LRRCT domains.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JR1Z. Eukaryota.
ENOG410Y1DK. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiO94933.
OMAiHLNAIVQ.
OrthoDBiEOG7W9RT2.
PhylomeDBiO94933.
TreeFamiTF351826.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSIAEMLH RGRMLWIILL STIALGWTTP IPLIEDSEEI DEPCFDPCYC
60 70 80 90 100
EVKESLFHIH CDSKGFTNIS QITEFWSRPF KLYLQRNSMR KLYTNSFLHL
110 120 130 140 150
NNAVSINLGN NALQDIQTGA FNGLKILKRL YLHENKLDVF RNDTFLGLES
160 170 180 190 200
LEYLQADYNV IKRIESGAFR NLSKLRVLIL NDNLIPMLPT NLFKAVSLTH
210 220 230 240 250
LDLRGNRLKV LFYRGMLDHI GRSLMELQLE ENPWNCTCEI VQLKSWLERI
260 270 280 290 300
PYTALVGDIT CETPFHFHGK DLREIRKTEL CPLLSDSEVE ASLGIPHSSS
310 320 330 340 350
SKENAWPTKP SSMLSSVHFT ASSVEYKSSN KQPKPTKQPR TPRPPSTSQA
360 370 380 390 400
LYPGPNQPPI APYQTRPPIP IICPTGCTCN LHINDLGLTV NCKERGFNNI
410 420 430 440 450
SELLPRPLNA KKLYLSSNLI QKIYRSDFWN FSSLDLLHLG NNRISYVQDG
460 470 480 490 500
AFINLPNLKS LFLNGNDIEK LTPGMFRGLQ SLHYLYFEFN VIREIQPAAF
510 520 530 540 550
SLMPNLKLLF LNNNLLRTLP TDAFAGTSLA RLNLRKNYFL YLPVAGVLEH
560 570 580 590 600
LNAIVQIDLN ENPWDCTCDL VPFKQWIETI SSVSVVGDVL CRSPENLTHR
610 620 630 640 650
DVRTIELEVL CPEMLHVAPA GESPAQPGDS HLIGAPTSAS PYEFSPPGGP
660 670 680 690 700
VPLSVLILSL LVLFFSAVFV AAGLFAYVLR RRRKKLPFRS KRQEGVDLTG
710 720 730 740 750
IQMQCHRLFE DGGGGGGGSG GGGRPTLSSP EKAPPVGHVY EYIPHPVTQM
760 770 780 790 800
CNNPIYKPRE EEEVAVSSAQ EAGSAERGGP GTQPPGMGEA LLGSEQFAET
810 820 830 840 850
PKENHSNYRT LLEKEKEWAL AVSSSQLNTI VTVNHHHPHH PAVGGVSGVV
860 870 880 890 900
GGTGGDLAGF RHHEKNGGVV LFPPGGGCGS GSMLLDRERP QPAPCTVGFV
910 920 930 940 950
DCLYGTVPKL KELHVHPPGM QYPDLQQDAR LKETLLFSAG KGFTDHQTQK
960 970
SDYLELRAKL QTKPDYLEVL EKTTYRF
Length:977
Mass (Da):108,934
Last modified:November 25, 2008 - v2
Checksum:i66936B7E00008961
GO

Sequence cautioni

The sequence BAA74871.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti940 – 9401G → E in BAA74871 (PubMed:10048485).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti605 – 6051I → V.
Corresponds to variant rs3828419 [ dbSNP | Ensembl ].
VAR_027757

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020655 mRNA. Translation: BAA74871.2. Different initiation.
AK290024 mRNA. Translation: BAF82713.1.
CH471052 Genomic DNA. Translation: EAW78599.1.
BC114621 mRNA. Translation: AAI14622.1.
CCDSiCCDS3197.1.
RefSeqiNP_001305739.1. NM_001318810.1.
NP_001305740.1. NM_001318811.1.
NP_055741.2. NM_014926.3.
XP_011510852.1. XM_011512550.1.
UniGeneiHs.101745.

Genome annotation databases

EnsembliENST00000241274; ENSP00000241274; ENSG00000121871.
ENST00000475390; ENSP00000420091; ENSG00000121871.
GeneIDi22865.
KEGGihsa:22865.
UCSCiuc003fej.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020655 mRNA. Translation: BAA74871.2. Different initiation.
AK290024 mRNA. Translation: BAF82713.1.
CH471052 Genomic DNA. Translation: EAW78599.1.
BC114621 mRNA. Translation: AAI14622.1.
CCDSiCCDS3197.1.
RefSeqiNP_001305739.1. NM_001318810.1.
NP_001305740.1. NM_001318811.1.
NP_055741.2. NM_014926.3.
XP_011510852.1. XM_011512550.1.
UniGeneiHs.101745.

3D structure databases

ProteinModelPortaliO94933.
SMRiO94933. Positions 44-294, 374-612.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116533. 1 interaction.
STRINGi9606.ENSP00000241274.

PTM databases

PhosphoSiteiO94933.

Polymorphism and mutation databases

BioMutaiSLITRK3.

Proteomic databases

EPDiO94933.
PaxDbiO94933.
PRIDEiO94933.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241274; ENSP00000241274; ENSG00000121871.
ENST00000475390; ENSP00000420091; ENSG00000121871.
GeneIDi22865.
KEGGihsa:22865.
UCSCiuc003fej.4. human.

Organism-specific databases

CTDi22865.
GeneCardsiSLITRK3.
H-InvDBHIX0003827.
HGNCiHGNC:23501. SLITRK3.
HPAiHPA017636.
MIMi609679. gene.
neXtProtiNX_O94933.
PharmGKBiPA134958002.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JR1Z. Eukaryota.
ENOG410Y1DK. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000290667.
HOVERGENiHBG056407.
InParanoidiO94933.
OMAiHLNAIVQ.
OrthoDBiEOG7W9RT2.
PhylomeDBiO94933.
TreeFamiTF351826.

Miscellaneous databases

GenomeRNAii22865.
NextBioi43383.
PROiO94933.
SOURCEiSearch...

Gene expression databases

BgeeiO94933.
CleanExiHS_SLITRK3.
ExpressionAtlasiO94933. baseline and differential.
GenevisibleiO94933. HS.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue."
    Aruga J., Yokota N., Mikoshiba K.
    Gene 315:87-94(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    Tissue: Brain and Brain tumor.

Entry informationi

Entry nameiSLIK3_HUMAN
AccessioniPrimary (citable) accession number: O94933
Secondary accession number(s): Q1RMY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 25, 2008
Last modified: May 11, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.