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Protein

HAUS augmin-like complex subunit 5

Gene

HAUS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome organization Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: Reactome
  • mitotic nuclear division Source: UniProtKB-KW
  • spindle assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089336-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 5
Gene namesi
Name:HAUS5
Synonyms:KIAA0841
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29130. HAUS5.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytosol Source: Reactome
  • HAUS complex Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000249115.
PharmGKBiPA165393415.

Polymorphism and mutation databases

BioMutaiHAUS5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507761 – 633HAUS augmin-like complex subunit 5Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei71PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO94927.
MaxQBiO94927.
PaxDbiO94927.
PeptideAtlasiO94927.
PRIDEiO94927.

PTM databases

iPTMnetiO94927.
PhosphoSitePlusiO94927.

Expressioni

Gene expression databases

BgeeiENSG00000249115.
CleanExiHS_KIAA0841.
ExpressionAtlasiO94927. baseline and differential.
GenevisibleiO94927. HS.

Organism-specific databases

HPAiHPA067250.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.2 Publications

Protein-protein interaction databases

BioGridi116936. 44 interactors.
DIPiDIP-48831N.
IntActiO94927. 37 interactors.
MINTiMINT-4995031.
STRINGi9606.ENSP00000439056.

Structurei

3D structure databases

ProteinModelPortaliO94927.
SMRiO94927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili73 – 110Sequence analysisAdd BLAST38
Coiled coili375 – 403Sequence analysisAdd BLAST29
Coiled coili551 – 592Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the HAUS5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJZU. Eukaryota.
ENOG410ZKR5. LUCA.
GeneTreeiENSGT00390000012508.
HOGENOMiHOG000112852.
HOVERGENiHBG081829.
InParanoidiO94927.
KOiK16588.
OMAiWAYVLRH.
OrthoDBiEOG091G07CF.
PhylomeDBiO94927.
TreeFamiTF333977.

Family and domain databases

InterProiIPR029131. HAUS5.
IPR026215. HAUS5_metazoa.
[Graphical view]
PfamiPF14817. HAUS5. 1 hit.
[Graphical view]
PRINTSiPR02091. HAUSAUGMINL5.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94927-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELAQEAREL GCWAVEEMGV PVAARAPEST LRRLCLGQGA DIWAYILQHV
60 70 80 90 100
HSQRTVKKIR GNLLWYGHQD SPQVRRKLEL EAAVTRLRAE IQELDQSLEL
110 120 130 140 150
MERDTEAQDT AMEQARQHTQ DTQRRALLLR AQAGAMRRQQ HTLRDPMQRL
160 170 180 190 200
QNQLRRLQDM ERKAKVDVTF GSLTSAALGL EPVVLRDVRT ACTLRAQFLQ
210 220 230 240 250
NLLLPQAKRG SLPTPHDDHF GTSYQQWLSS VETLLTNHPP GHVLAALEHL
260 270 280 290 300
AAEREAEIRS LCSGDGLGDT EISRPQAPDQ SDSSQTLPSM VHLIQEGWRT
310 320 330 340 350
VGVLVSQRST LLKERQVLTQ RLQGLVEEVE RRVLGSSERQ VLILGLRRCC
360 370 380 390 400
LWTELKALHD QSQELQDAAG HRQLLLRELQ AKQQRILHWR QLVEETQEQV
410 420 430 440 450
RLLIKGNSAS KTRLCRSPGE VLALVQRKVV PTFEAVAPQS RELLRCLEEE
460 470 480 490 500
VRHLPHILLG TLLRHRPGEL KPLPTVLPSI HQLHPASPRG SSFIALSHKL
510 520 530 540 550
GLPPGKASEL LLPAAASLRQ DLLLLQDQRS LWCWDLLHMK TSLPPGLPTQ
560 570 580 590 600
ELLQIQASQE KQQKENLGQA LKRLEKLLKQ ALERIPELQG IVGDWWEQPG
610 620 630
QAALSEELCQ GLSLPQWRLR WVQAQGALQK LCS
Length:633
Mass (Da):71,682
Last modified:June 7, 2005 - v2
Checksum:i23D8746F2A81ABCB
GO
Isoform 2 (identifier: O94927-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-290: PQAPDQSDSSQTLPSM → RAGGLWVCWSPSGAPS
     291-633: Missing.

Show »
Length:290
Mass (Da):32,638
Checksum:i8E06946A08C011D1
GO

Sequence cautioni

The sequence AAH13947 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA74864 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti556Q → R in AAI57883 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034038213P → L.Corresponds to variant rs2301596dbSNPEnsembl.1
Natural variantiVAR_034039277A → D.Corresponds to variant rs2285412dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013927275 – 290PQAPD…TLPSM → RAGGLWVCWSPSGAPS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_013928291 – 633Missing in isoform 2. 1 PublicationAdd BLAST343

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020648 mRNA. Translation: BAA74864.1. Different initiation.
BC013947 mRNA. Translation: AAH13947.2. Different initiation.
BC064390 mRNA. Translation: AAH64390.1.
BC157882 mRNA. Translation: AAI57883.1.
CCDSiCCDS42550.1. [O94927-1]
RefSeqiNP_056117.1. NM_015302.1. [O94927-1]
UniGeneiHs.7426.

Genome annotation databases

EnsembliENST00000203166; ENSP00000439056; ENSG00000249115. [O94927-1]
ENST00000587439; ENSP00000466661; ENSG00000249115. [O94927-2]
GeneIDi23354.
KEGGihsa:23354.
UCSCiuc002oam.2. human. [O94927-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020648 mRNA. Translation: BAA74864.1. Different initiation.
BC013947 mRNA. Translation: AAH13947.2. Different initiation.
BC064390 mRNA. Translation: AAH64390.1.
BC157882 mRNA. Translation: AAI57883.1.
CCDSiCCDS42550.1. [O94927-1]
RefSeqiNP_056117.1. NM_015302.1. [O94927-1]
UniGeneiHs.7426.

3D structure databases

ProteinModelPortaliO94927.
SMRiO94927.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116936. 44 interactors.
DIPiDIP-48831N.
IntActiO94927. 37 interactors.
MINTiMINT-4995031.
STRINGi9606.ENSP00000439056.

PTM databases

iPTMnetiO94927.
PhosphoSitePlusiO94927.

Polymorphism and mutation databases

BioMutaiHAUS5.

Proteomic databases

EPDiO94927.
MaxQBiO94927.
PaxDbiO94927.
PeptideAtlasiO94927.
PRIDEiO94927.

Protocols and materials databases

DNASUi23354.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000203166; ENSP00000439056; ENSG00000249115. [O94927-1]
ENST00000587439; ENSP00000466661; ENSG00000249115. [O94927-2]
GeneIDi23354.
KEGGihsa:23354.
UCSCiuc002oam.2. human. [O94927-1]

Organism-specific databases

CTDi23354.
GeneCardsiHAUS5.
HGNCiHGNC:29130. HAUS5.
HPAiHPA067250.
MIMi613432. gene.
neXtProtiNX_O94927.
OpenTargetsiENSG00000249115.
PharmGKBiPA165393415.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJZU. Eukaryota.
ENOG410ZKR5. LUCA.
GeneTreeiENSGT00390000012508.
HOGENOMiHOG000112852.
HOVERGENiHBG081829.
InParanoidiO94927.
KOiK16588.
OMAiWAYVLRH.
OrthoDBiEOG091G07CF.
PhylomeDBiO94927.
TreeFamiTF333977.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089336-MONOMER.
ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

ChiTaRSiHAUS5. human.
GenomeRNAii23354.
PROiO94927.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000249115.
CleanExiHS_KIAA0841.
ExpressionAtlasiO94927. baseline and differential.
GenevisibleiO94927. HS.

Family and domain databases

InterProiIPR029131. HAUS5.
IPR026215. HAUS5_metazoa.
[Graphical view]
PfamiPF14817. HAUS5. 1 hit.
[Graphical view]
PRINTSiPR02091. HAUSAUGMINL5.
ProtoNetiSearch...

Entry informationi

Entry nameiHAUS5_HUMAN
AccessioniPrimary (citable) accession number: O94927
Secondary accession number(s): B2RXK1
, Q6P2P7, Q7L3D5, Q96CT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.