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Protein

HAUS augmin-like complex subunit 5

Gene

HAUS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome cycle Source: UniProtKB
  • ciliary basal body-plasma membrane docking Source: Reactome
  • G2/M transition of mitotic cell cycle Source: Reactome
  • regulation of G2/M transition of mitotic cell cycle Source: Reactome
  • spindle assembly Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-380284. Loss of proteins required for interphase microtubule organization from the centrosome.
R-HSA-380320. Recruitment of NuMA to mitotic centrosomes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 5
Gene namesi
Name:HAUS5
Synonyms:KIAA0841
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000249115.8.
HGNCiHGNC:29130. HAUS5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000249115.
PharmGKBiPA165393415.

Polymorphism and mutation databases

BioMutaiHAUS5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507761 – 633HAUS augmin-like complex subunit 5Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei71PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO94927.
MaxQBiO94927.
PaxDbiO94927.
PeptideAtlasiO94927.
PRIDEiO94927.

PTM databases

iPTMnetiO94927.
PhosphoSitePlusiO94927.

Expressioni

Gene expression databases

BgeeiENSG00000249115.
CleanExiHS_KIAA0841.
ExpressionAtlasiO94927. baseline and differential.
GenevisibleiO94927. HS.

Organism-specific databases

HPAiHPA067250.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HAUS6Q7Z4H73EBI-2558224,EBI-2558196

Protein-protein interaction databases

BioGridi116936. 49 interactors.
CORUMiO94927.
DIPiDIP-48831N.
IntActiO94927. 40 interactors.
MINTiMINT-4995031.
STRINGi9606.ENSP00000439056.

Structurei

3D structure databases

ProteinModelPortaliO94927.
SMRiO94927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili73 – 110Sequence analysisAdd BLAST38
Coiled coili375 – 403Sequence analysisAdd BLAST29
Coiled coili551 – 592Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the HAUS5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJZU. Eukaryota.
ENOG410ZKR5. LUCA.
GeneTreeiENSGT00390000012508.
HOGENOMiHOG000112852.
HOVERGENiHBG081829.
InParanoidiO94927.
KOiK16588.
OMAiHSPGELK.
OrthoDBiEOG091G07CF.
PhylomeDBiO94927.
TreeFamiTF333977.

Family and domain databases

InterProiView protein in InterPro
IPR029131. HAUS5.
IPR026215. HAUS5_metazoa.
PfamiView protein in Pfam
PF14817. HAUS5. 1 hit.
PRINTSiPR02091. HAUSAUGMINL5.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94927-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELAQEAREL GCWAVEEMGV PVAARAPEST LRRLCLGQGA DIWAYILQHV
60 70 80 90 100
HSQRTVKKIR GNLLWYGHQD SPQVRRKLEL EAAVTRLRAE IQELDQSLEL
110 120 130 140 150
MERDTEAQDT AMEQARQHTQ DTQRRALLLR AQAGAMRRQQ HTLRDPMQRL
160 170 180 190 200
QNQLRRLQDM ERKAKVDVTF GSLTSAALGL EPVVLRDVRT ACTLRAQFLQ
210 220 230 240 250
NLLLPQAKRG SLPTPHDDHF GTSYQQWLSS VETLLTNHPP GHVLAALEHL
260 270 280 290 300
AAEREAEIRS LCSGDGLGDT EISRPQAPDQ SDSSQTLPSM VHLIQEGWRT
310 320 330 340 350
VGVLVSQRST LLKERQVLTQ RLQGLVEEVE RRVLGSSERQ VLILGLRRCC
360 370 380 390 400
LWTELKALHD QSQELQDAAG HRQLLLRELQ AKQQRILHWR QLVEETQEQV
410 420 430 440 450
RLLIKGNSAS KTRLCRSPGE VLALVQRKVV PTFEAVAPQS RELLRCLEEE
460 470 480 490 500
VRHLPHILLG TLLRHRPGEL KPLPTVLPSI HQLHPASPRG SSFIALSHKL
510 520 530 540 550
GLPPGKASEL LLPAAASLRQ DLLLLQDQRS LWCWDLLHMK TSLPPGLPTQ
560 570 580 590 600
ELLQIQASQE KQQKENLGQA LKRLEKLLKQ ALERIPELQG IVGDWWEQPG
610 620 630
QAALSEELCQ GLSLPQWRLR WVQAQGALQK LCS
Length:633
Mass (Da):71,682
Last modified:June 7, 2005 - v2
Checksum:i23D8746F2A81ABCB
GO
Isoform 2 (identifier: O94927-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-290: PQAPDQSDSSQTLPSM → RAGGLWVCWSPSGAPS
     291-633: Missing.

Show »
Length:290
Mass (Da):32,638
Checksum:i8E06946A08C011D1
GO

Sequence cautioni

O94927: The sequence AAH13947 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
O94927: The sequence BAA74864 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti556Q → R in AAI57883 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034038213P → L. Corresponds to variant dbSNP:rs2301596Ensembl.1
Natural variantiVAR_034039277A → D. Corresponds to variant dbSNP:rs2285412Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013927275 – 290PQAPD…TLPSM → RAGGLWVCWSPSGAPS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_013928291 – 633Missing in isoform 2. 1 PublicationAdd BLAST343

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020648 mRNA. Translation: BAA74864.1. Different initiation.
BC013947 mRNA. Translation: AAH13947.2. Different initiation.
BC064390 mRNA. Translation: AAH64390.1.
BC157882 mRNA. Translation: AAI57883.1.
CCDSiCCDS42550.1. [O94927-1]
RefSeqiNP_056117.1. NM_015302.1. [O94927-1]
UniGeneiHs.7426.

Genome annotation databases

EnsembliENST00000203166; ENSP00000439056; ENSG00000249115. [O94927-1]
ENST00000587439; ENSP00000466661; ENSG00000249115. [O94927-2]
GeneIDi23354.
KEGGihsa:23354.
UCSCiuc002oam.2. human. [O94927-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHAUS5_HUMAN
AccessioniPrimary (citable) accession number: O94927
Secondary accession number(s): B2RXK1
, Q6P2P7, Q7L3D5, Q96CT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: October 25, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families