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Protein

Glutaminase kidney isoform, mitochondrial

Gene

GLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.1 Publication

Enzyme regulationi

Isoform 1 and isoform 3 are activated by phosphate. Inhibited by BPTES. BPTES binds between subunits and favors dissociation of the tetramer into dimers.1 Publication

Kineticsi

  1. KM=1.9 mM for glutamine (isoform 1)1 Publication
  2. KM=1.4 mM for glutamine (isoform 3)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei286Substrate1
    Binding sitei335Substrate1
    Binding sitei381Substrate1
    Binding sitei388Substrate1
    Binding sitei414Substrate1
    Binding sitei466Substrate1
    Binding sitei484Substrate; via amide nitrogen1

    GO - Molecular functioni

    • glutaminase activity Source: UniProtKB

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciZFISH:HS03886-MONOMER.
    BRENDAi3.5.1.2. 2681.
    ReactomeiR-HSA-210500. Glutamate Neurotransmitter Release Cycle.
    R-HSA-5628897. TP53 Regulates Metabolic Genes.
    R-HSA-70614. Amino acid synthesis and interconversion (transamination).
    SABIO-RKO94925.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaminase kidney isoform, mitochondrial (EC:3.5.1.2)
    Short name:
    GLS
    Alternative name(s):
    K-glutaminase
    L-glutamine amidohydrolase
    Gene namesi
    Name:GLS
    Synonyms:GLS1, KIAA0838
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4331. GLS.

    Subcellular locationi

    GO - Cellular componenti

    • cytosol Source: UniProtKB-SubCell
    • mitochondrial matrix Source: GO_Central
    • mitochondrion Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi318F → Y: No effect on catalytic activity. Loss of inhibition by BPTES; when associated with S-322. 1 Publication1
    Mutagenesisi322F → S: No effect on catalytic activity. Loss of inhibition by BPTES; when associated with Y-318. 1 Publication1
    Mutagenesisi394Y → L: No effect on catalytic activity. Loss of inhibition by BPTES. 1 Publication1

    Organism-specific databases

    DisGeNETi2744.
    OpenTargetsiENSG00000115419.
    PharmGKBiPA28734.

    Chemistry databases

    ChEMBLiCHEMBL2146302.
    DrugBankiDB00130. L-Glutamine.
    GuidetoPHARMACOLOGYi2891.

    Polymorphism and mutation databases

    BioMutaiGLS.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transit peptidei1 – 16MitochondrionBy similarityAdd BLAST16
    ChainiPRO_000001162217 – 669Glutaminase kidney isoform, mitochondrialAdd BLAST653

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei130N6-succinyllysineBy similarity1
    Modified residuei164N6-succinyllysineBy similarity1
    Modified residuei311N6-acetyllysineCombined sources1
    Modified residuei652PhosphoserineBy similarity1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    EPDiO94925.
    MaxQBiO94925.
    PaxDbiO94925.
    PeptideAtlasiO94925.
    PRIDEiO94925.
    TopDownProteomicsiO94925-2. [O94925-2]

    PTM databases

    iPTMnetiO94925.
    PhosphoSitePlusiO94925.
    SwissPalmiO94925.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiENSG00000115419.
    CleanExiHS_GLS.
    ExpressionAtlasiO94925. baseline and differential.
    GenevisibleiO94925. HS.

    Organism-specific databases

    HPAiHPA036223.

    Interactioni

    Subunit structurei

    Heterotetramer. Interacts with ATCAY; the interaction is direct and may control GLS localization, negatively regulating its activity.3 Publications

    Protein-protein interaction databases

    BioGridi109006. 41 interactors.
    DIPiDIP-50591N.
    IntActiO94925. 3 interactors.
    MINTiMINT-4096121.
    STRINGi9606.ENSP00000317379.

    Chemistry databases

    BindingDBiO94925.

    Structurei

    Secondary structure

    1669
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi139 – 148Combined sources10
    Beta strandi152 – 155Combined sources4
    Helixi156 – 165Combined sources10
    Helixi173 – 175Combined sources3
    Helixi176 – 188Combined sources13
    Beta strandi194 – 196Combined sources3
    Helixi197 – 204Combined sources8
    Helixi205 – 207Combined sources3
    Helixi208 – 216Combined sources9
    Beta strandi219 – 223Combined sources5
    Helixi224 – 239Combined sources16
    Beta strandi244 – 246Combined sources3
    Helixi251 – 254Combined sources4
    Beta strandi262 – 267Combined sources6
    Beta strandi272 – 277Combined sources6
    Helixi285 – 287Combined sources3
    Helixi288 – 300Combined sources13
    Helixi302 – 305Combined sources4
    Turni306 – 308Combined sources3
    Beta strandi315 – 317Combined sources3
    Beta strandi327 – 330Combined sources4
    Helixi335 – 344Combined sources10
    Turni345 – 348Combined sources4
    Helixi351 – 365Combined sources15
    Turni366 – 368Combined sources3
    Beta strandi371 – 373Combined sources3
    Helixi375 – 384Combined sources10
    Helixi386 – 397Combined sources12
    Helixi407 – 418Combined sources12
    Beta strandi420 – 422Combined sources3
    Helixi424 – 435Combined sources12
    Turni436 – 438Combined sources3
    Turni441 – 443Combined sources3
    Helixi450 – 463Combined sources14
    Helixi466 – 468Combined sources3
    Helixi469 – 475Combined sources7
    Beta strandi480 – 482Combined sources3
    Beta strandi486 – 492Combined sources7
    Turni493 – 495Combined sources3
    Beta strandi496 – 501Combined sources6
    Beta strandi503 – 505Combined sources3
    Beta strandi509 – 511Combined sources3
    Helixi512 – 525Combined sources14

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3CZDX-ray2.40A221-533[»]
    3UNWX-ray2.56A/B/C/D71-597[»]
    3UO9X-ray2.30A/B/C/D71-597[»]
    3VOYX-ray2.20A221-533[»]
    3VOZX-ray2.40A221-533[»]
    3VP0X-ray2.40A221-533[»]
    3VP1X-ray2.30A221-533[»]
    3VP2X-ray2.70A221-533[»]
    3VP3X-ray2.70A221-533[»]
    3VP4X-ray2.45A221-533[»]
    4O7DX-ray2.30A221-531[»]
    5D3OX-ray2.79A/B72-597[»]
    5FI2X-ray2.50A/B/C/D72-597[»]
    5FI6X-ray2.52A/B/C/D72-597[»]
    5FI7X-ray2.50A/B/C/D72-597[»]
    5HL1X-ray2.40A/B/C/D72-597[»]
    5I94X-ray2.98A/B/C/D72-597[»]
    5JYOX-ray2.10A/B/C/D/E/F/G/H221-533[»]
    5JYPX-ray2.74A221-533[»]
    ProteinModelPortaliO94925.
    SMRiO94925.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO94925.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Repeati585 – 614ANK 1Add BLAST30
    Repeati619 – 648ANK 2Add BLAST30

    Sequence similaritiesi

    Belongs to the glutaminase family.Curated
    Contains 2 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiKOG0506. Eukaryota.
    COG2066. LUCA.
    GeneTreeiENSGT00390000010463.
    HOGENOMiHOG000216891.
    HOVERGENiHBG005856.
    InParanoidiO94925.
    KOiK01425.
    OMAiFMNKMAG.
    OrthoDBiEOG091G03YU.
    PhylomeDBiO94925.
    TreeFamiTF313359.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF04960. Glutaminase. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: O94925-1) [UniParc]FASTAAdd to basket
    Also known as: KGA

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MMRLRGSGML RDLLLRSPAG VSATLRRAQP LVTLCRRPRG GGRPAAGPAA
    60 70 80 90 100
    AARLHPWWGG GGWPAEPLAR GLSSSPSEIL QELGKGSTHP QPGVSPPAAP
    110 120 130 140 150
    AAPGPKDGPG ETDAFGNSEG KELVASGENK IKQGLLPSLE DLLFYTIAEG
    160 170 180 190 200
    QEKIPVHKFI TALKSTGLRT SDPRLKECMD MLRLTLQTTS DGVMLDKDLF
    210 220 230 240 250
    KKCVQSNIVL LTQAFRRKFV IPDFMSFTSH IDELYESAKK QSGGKVADYI
    260 270 280 290 300
    PQLAKFSPDL WGVSVCTVDG QRHSTGDTKV PFCLQSCVKP LKYAIAVNDL
    310 320 330 340 350
    GTEYVHRYVG KEPSGLRFNK LFLNEDDKPH NPMVNAGAIV VTSLIKQGVN
    360 370 380 390 400
    NAEKFDYVMQ FLNKMAGNEY VGFSNATFQS ERESGDRNFA IGYYLKEKKC
    410 420 430 440 450
    FPEGTDMVGI LDFYFQLCSI EVTCESASVM AATLANGGFC PITGERVLSP
    460 470 480 490 500
    EAVRNTLSLM HSCGMYDFSG QFAFHVGLPA KSGVAGGILL VVPNVMGMMC
    510 520 530 540 550
    WSPPLDKMGN SVKGIHFCHD LVSLCNFHNY DNLRHFAKKL DPRREGGDQR
    560 570 580 590 600
    VKSVINLLFA AYTGDVSALR RFALSAMDME QRDYDSRTAL HVAAAEGHVE
    610 620 630 640 650
    VVKFLLEACK VNPFPKDRWN NTPMDEALHF GHHDVFKILQ EYQVQYTPQG
    660
    DSDNGKENQT VHKNLDGLL
    Length:669
    Mass (Da):73,461
    Last modified:May 1, 1999 - v1
    Checksum:i4E5E63505E84E0B7
    GO
    Isoform 2 (identifier: O94925-2) [UniParc]FASTAAdd to basket
    Also known as: GAM

    The sequence of this isoform differs from the canonical sequence as follows:
         162-169: ALKSTGLR → VSFYIFLS
         170-669: Missing.

    Show »
    Length:169
    Mass (Da):17,738
    Checksum:i869F0D4A9B2B3AEE
    GO
    Isoform 3 (identifier: O94925-3) [UniParc]FASTAAdd to basket
    Also known as: Glutaminase C, GAC

    The sequence of this isoform differs from the canonical sequence as follows:
         551-669: VKSVINLLFA...TVHKNLDGLL → HSFGPLDYES...YRMESLGEKS

    Show »
    Length:598
    Mass (Da):65,460
    Checksum:i3076ED034A79ABA5
    GO

    Sequence cautioni

    The sequence BAA74861 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti6G → S in AAF00090 (PubMed:11015561).Curated1
    Sequence conflicti66E → D in AAF00090 (PubMed:11015561).Curated1
    Sequence conflicti219F → L in AAG47842 (PubMed:10719215).Curated1
    Sequence conflicti268V → A in AAD47056 (PubMed:11015561).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_049188254A → P.Corresponds to variant rs16833035dbSNPEnsembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_001765162 – 169ALKSTGLR → VSFYIFLS in isoform 2. Curated8
    Alternative sequenceiVSP_001766170 – 669Missing in isoform 2. CuratedAdd BLAST500
    Alternative sequenceiVSP_001767551 – 669VKSVI…LDGLL → HSFGPLDYESLQQELALKET VWKKVSPESNEDISTTVVYR MESLGEKS in isoform 3. 1 PublicationAdd BLAST119

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF158555 mRNA. Translation: AAD47056.1.
    AF097492 mRNA. Translation: AAF00088.1.
    AF097493 mRNA. Translation: AAF00089.1.
    AF097495 mRNA. Translation: AAF00090.1.
    AB020645 mRNA. Translation: BAA74861.2. Different initiation.
    AF223943 mRNA. Translation: AAF33825.1.
    AF327434 mRNA. Translation: AAG47842.1.
    BC038507 mRNA. Translation: AAH38507.2.
    AF279697 mRNA. Translation: AAG17700.1.
    CCDSiCCDS2308.1. [O94925-1]
    CCDS58744.1. [O94925-3]
    RefSeqiNP_001243239.1. NM_001256310.1. [O94925-3]
    NP_055720.3. NM_014905.4. [O94925-1]
    UniGeneiHs.116448.
    Hs.737608.

    Genome annotation databases

    EnsembliENST00000320717; ENSP00000317379; ENSG00000115419. [O94925-1]
    ENST00000338435; ENSP00000340689; ENSG00000115419. [O94925-3]
    GeneIDi2744.
    KEGGihsa:2744.
    UCSCiuc002use.4. human. [O94925-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF158555 mRNA. Translation: AAD47056.1.
    AF097492 mRNA. Translation: AAF00088.1.
    AF097493 mRNA. Translation: AAF00089.1.
    AF097495 mRNA. Translation: AAF00090.1.
    AB020645 mRNA. Translation: BAA74861.2. Different initiation.
    AF223943 mRNA. Translation: AAF33825.1.
    AF327434 mRNA. Translation: AAG47842.1.
    BC038507 mRNA. Translation: AAH38507.2.
    AF279697 mRNA. Translation: AAG17700.1.
    CCDSiCCDS2308.1. [O94925-1]
    CCDS58744.1. [O94925-3]
    RefSeqiNP_001243239.1. NM_001256310.1. [O94925-3]
    NP_055720.3. NM_014905.4. [O94925-1]
    UniGeneiHs.116448.
    Hs.737608.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3CZDX-ray2.40A221-533[»]
    3UNWX-ray2.56A/B/C/D71-597[»]
    3UO9X-ray2.30A/B/C/D71-597[»]
    3VOYX-ray2.20A221-533[»]
    3VOZX-ray2.40A221-533[»]
    3VP0X-ray2.40A221-533[»]
    3VP1X-ray2.30A221-533[»]
    3VP2X-ray2.70A221-533[»]
    3VP3X-ray2.70A221-533[»]
    3VP4X-ray2.45A221-533[»]
    4O7DX-ray2.30A221-531[»]
    5D3OX-ray2.79A/B72-597[»]
    5FI2X-ray2.50A/B/C/D72-597[»]
    5FI6X-ray2.52A/B/C/D72-597[»]
    5FI7X-ray2.50A/B/C/D72-597[»]
    5HL1X-ray2.40A/B/C/D72-597[»]
    5I94X-ray2.98A/B/C/D72-597[»]
    5JYOX-ray2.10A/B/C/D/E/F/G/H221-533[»]
    5JYPX-ray2.74A221-533[»]
    ProteinModelPortaliO94925.
    SMRiO94925.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi109006. 41 interactors.
    DIPiDIP-50591N.
    IntActiO94925. 3 interactors.
    MINTiMINT-4096121.
    STRINGi9606.ENSP00000317379.

    Chemistry databases

    BindingDBiO94925.
    ChEMBLiCHEMBL2146302.
    DrugBankiDB00130. L-Glutamine.
    GuidetoPHARMACOLOGYi2891.

    PTM databases

    iPTMnetiO94925.
    PhosphoSitePlusiO94925.
    SwissPalmiO94925.

    Polymorphism and mutation databases

    BioMutaiGLS.

    Proteomic databases

    EPDiO94925.
    MaxQBiO94925.
    PaxDbiO94925.
    PeptideAtlasiO94925.
    PRIDEiO94925.
    TopDownProteomicsiO94925-2. [O94925-2]

    Protocols and materials databases

    DNASUi2744.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000320717; ENSP00000317379; ENSG00000115419. [O94925-1]
    ENST00000338435; ENSP00000340689; ENSG00000115419. [O94925-3]
    GeneIDi2744.
    KEGGihsa:2744.
    UCSCiuc002use.4. human. [O94925-1]

    Organism-specific databases

    CTDi2744.
    DisGeNETi2744.
    GeneCardsiGLS.
    H-InvDBHIX0161645.
    HGNCiHGNC:4331. GLS.
    HPAiHPA036223.
    MIMi138280. gene.
    neXtProtiNX_O94925.
    OpenTargetsiENSG00000115419.
    PharmGKBiPA28734.
    HUGEiSearch...
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0506. Eukaryota.
    COG2066. LUCA.
    GeneTreeiENSGT00390000010463.
    HOGENOMiHOG000216891.
    HOVERGENiHBG005856.
    InParanoidiO94925.
    KOiK01425.
    OMAiFMNKMAG.
    OrthoDBiEOG091G03YU.
    PhylomeDBiO94925.
    TreeFamiTF313359.

    Enzyme and pathway databases

    BioCyciZFISH:HS03886-MONOMER.
    BRENDAi3.5.1.2. 2681.
    ReactomeiR-HSA-210500. Glutamate Neurotransmitter Release Cycle.
    R-HSA-5628897. TP53 Regulates Metabolic Genes.
    R-HSA-70614. Amino acid synthesis and interconversion (transamination).
    SABIO-RKO94925.

    Miscellaneous databases

    ChiTaRSiGLS. human.
    EvolutionaryTraceiO94925.
    GenomeRNAii2744.
    PROiO94925.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000115419.
    CleanExiHS_GLS.
    ExpressionAtlasiO94925. baseline and differential.
    GenevisibleiO94925. HS.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF04960. Glutaminase. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiGLSK_HUMAN
    AccessioniPrimary (citable) accession number: O94925
    Secondary accession number(s): Q9UL05
    , Q9UL06, Q9UL07, Q9UN40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 1999
    Last modified: November 30, 2016
    This is version 170 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Isoform 3 is predicted to be expressed at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay (PubMed:14759258), but has been shown to be well expressed (PubMed:17940881 and PubMed:11015561) and the encoded protein is detected in mitochondria (PubMed:22228304).2 Publications
    A report observed N-glycosylation at Asn-620 (PubMed:19139490). However, as the protein is mitochondrial, additional evidences are required to confirm this result.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.