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Protein

Endonuclease domain-containing 1 protein

Gene

ENDOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a DNase and a RNase.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease domain-containing 1 protein (EC:3.1.30.-)
Gene namesi
Name:ENDOD1
Synonyms:KIAA0830
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29129. ENDOD1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485454.

Polymorphism and mutation databases

BioMutaiENDOD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 500479Endonuclease domain-containing 1 proteinPRO_0000019924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei407 – 4071N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO94919.
MaxQBiO94919.
PaxDbiO94919.
PeptideAtlasiO94919.
PRIDEiO94919.

2D gel databases

OGPiO94919.

PTM databases

iPTMnetiO94919.
PhosphoSiteiO94919.
SwissPalmiO94919.

Expressioni

Gene expression databases

BgeeiENSG00000149218.
CleanExiHS_ENDOD1.
GenevisibleiO94919. HS.

Organism-specific databases

HPAiHPA008932.
HPA010517.

Interactioni

Protein-protein interaction databases

BioGridi116689. 21 interactions.
IntActiO94919. 9 interactions.
MINTiMINT-5003939.
STRINGi9606.ENSP00000278505.

Structurei

3D structure databases

ProteinModelPortaliO94919.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1DZ. Eukaryota.
ENOG4111RBI. LUCA.
GeneTreeiENSGT00530000063903.
HOGENOMiHOG000112371.
HOVERGENiHBG081477.
InParanoidiO94919.
KOiK15049.
OMAiSIPWKVL.
OrthoDBiEOG091G05HX.
PhylomeDBiO94919.
TreeFamiTF333322.

Family and domain databases

Gene3Di3.40.570.10. 1 hit.
InterProiIPR001604. DNA/RNA_non-sp_Endonuclease.
IPR020821. Extracellular_endonuc_su_A.
[Graphical view]
PfamiPF01223. Endonuclease_NS. 1 hit.
[Graphical view]
SMARTiSM00892. Endonuclease_NS. 1 hit.
SM00477. NUC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTARWLALG SLFALAGLLE GRLVGEEEAG FGECDKFFYA GTPPAGLAAD
60 70 80 90 100
SHVKICQRAE GAERFATLYS TRDRIPVYSA FRAPRPAPGG AEQRWLVEPQ
110 120 130 140 150
IDDPNSNLEE AINEAEAITS VNSLGSKQAL NTDYLDSDYQ RGQLYPFSLS
160 170 180 190 200
SDVQVATFTL TNSAPMTQSF QERWYVNLHS LMDRALTPQC GSGEDLYILT
210 220 230 240 250
GTVPSDYRVK DKVAVPEFVW LAACCAVPGG GWAMGFVKHT RDSDIIEDVM
260 270 280 290 300
VKDLQKLLPF NPQLFQNNCG ETEQDTEKMK KILEVVNQIQ DEERMVQSQK
310 320 330 340 350
SSSPLSSTRS KRSTLLPPEA SEGSSSFLGK LMGFIATPFI KLFQLIYYLV
360 370 380 390 400
VAILKNIVYF LWCVTKQVIN GIESCLYRLG SATISYFMAI GEELVSIPWK
410 420 430 440 450
VLKVVAKVIR ALLRILCCLL KAICRVLSIP VRVLVDVATF PVYTMGAIPI
460 470 480 490 500
VCKDIALGLG GTVSLLFDTA FGTLGGLFQV VFSVCKRIGY KVTFDNSGEL
Length:500
Mass (Da):55,017
Last modified:July 19, 2004 - v2
Checksum:i5B62754FE2E9AD9C
GO

Sequence cautioni

The sequence BAA74853 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131N → I in BAF84362 (PubMed:14702039).Curated
Sequence conflicti189 – 1891Q → R in BAF84362 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti350 – 3501V → M.
Corresponds to variant rs3740862 [ dbSNP | Ensembl ].
VAR_022044
Natural varianti446 – 4461G → V.
Corresponds to variant rs3740861 [ dbSNP | Ensembl ].
VAR_022045

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020637 mRNA. Translation: BAA74853.1. Different initiation.
AK291673 mRNA. Translation: BAF84362.1.
BC026191 mRNA. Translation: AAH26191.1.
BC071171 mRNA. Translation: AAH71171.1.
CCDSiCCDS41699.1.
RefSeqiNP_055851.1. NM_015036.2.
UniGeneiHs.167115.

Genome annotation databases

EnsembliENST00000278505; ENSP00000278505; ENSG00000149218.
GeneIDi23052.
KEGGihsa:23052.
UCSCiuc001pfh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020637 mRNA. Translation: BAA74853.1. Different initiation.
AK291673 mRNA. Translation: BAF84362.1.
BC026191 mRNA. Translation: AAH26191.1.
BC071171 mRNA. Translation: AAH71171.1.
CCDSiCCDS41699.1.
RefSeqiNP_055851.1. NM_015036.2.
UniGeneiHs.167115.

3D structure databases

ProteinModelPortaliO94919.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116689. 21 interactions.
IntActiO94919. 9 interactions.
MINTiMINT-5003939.
STRINGi9606.ENSP00000278505.

PTM databases

iPTMnetiO94919.
PhosphoSiteiO94919.
SwissPalmiO94919.

Polymorphism and mutation databases

BioMutaiENDOD1.

2D gel databases

OGPiO94919.

Proteomic databases

EPDiO94919.
MaxQBiO94919.
PaxDbiO94919.
PeptideAtlasiO94919.
PRIDEiO94919.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278505; ENSP00000278505; ENSG00000149218.
GeneIDi23052.
KEGGihsa:23052.
UCSCiuc001pfh.4. human.

Organism-specific databases

CTDi23052.
GeneCardsiENDOD1.
HGNCiHGNC:29129. ENDOD1.
HPAiHPA008932.
HPA010517.
neXtProtiNX_O94919.
PharmGKBiPA143485454.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1DZ. Eukaryota.
ENOG4111RBI. LUCA.
GeneTreeiENSGT00530000063903.
HOGENOMiHOG000112371.
HOVERGENiHBG081477.
InParanoidiO94919.
KOiK15049.
OMAiSIPWKVL.
OrthoDBiEOG091G05HX.
PhylomeDBiO94919.
TreeFamiTF333322.

Miscellaneous databases

GenomeRNAii23052.
PROiO94919.

Gene expression databases

BgeeiENSG00000149218.
CleanExiHS_ENDOD1.
GenevisibleiO94919. HS.

Family and domain databases

Gene3Di3.40.570.10. 1 hit.
InterProiIPR001604. DNA/RNA_non-sp_Endonuclease.
IPR020821. Extracellular_endonuc_su_A.
[Graphical view]
PfamiPF01223. Endonuclease_NS. 1 hit.
[Graphical view]
SMARTiSM00892. Endonuclease_NS. 1 hit.
SM00477. NUC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENDD1_HUMAN
AccessioniPrimary (citable) accession number: O94919
Secondary accession number(s): A8K6K8, Q6GQY5, Q8TAQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.