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O94916

- NFAT5_HUMAN

UniProt

O94916 - NFAT5_HUMAN

Protein

Nuclear factor of activated T-cells 5

Gene

NFAT5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi293 – 3008

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cytokine production Source: Ensembl
    2. excretion Source: ProtInc
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. regulation of calcineurin-NFAT signaling cascade Source: Ensembl
    5. signal transduction Source: ProtInc
    6. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear factor of activated T-cells 5
    Short name:
    NF-AT5
    Alternative name(s):
    T-cell transcription factor NFAT5
    Tonicity-responsive enhancer-binding protein
    Short name:
    TonE-binding protein
    Short name:
    TonEBP
    Gene namesi
    Name:NFAT5
    Synonyms:KIAA0827, TONEBP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:7774. NFAT5.

    Subcellular locationi

    Nucleus. Cytoplasm By similarity
    Note: Nuclear distribution increases under hypertonic conditions.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi120 – 1201S → A: Normal nuclear localization. 1 Publication
    Mutagenesisi134 – 1341S → A: Reduced nuclear localization. 1 Publication
    Mutagenesisi135 – 1351T → A: Reduced nuclear localization. 1 Publication
    Mutagenesisi155 – 1551S → A: Increased nuclear localization. 1 Publication

    Organism-specific databases

    PharmGKBiPA31581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15311531Nuclear factor of activated T-cells 5PRO_0000205183Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei120 – 1201Phosphoserine1 Publication
    Modified residuei122 – 1221N6-acetyllysineBy similarity
    Modified residuei134 – 1341Phosphoserine1 Publication
    Modified residuei135 – 1351Phosphothreonine; by CDK51 Publication
    Modified residuei155 – 1551Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO94916.
    PaxDbiO94916.
    PRIDEiO94916.

    PTM databases

    PhosphoSiteiO94916.

    Expressioni

    Tissue specificityi

    Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon.

    Gene expression databases

    ArrayExpressiO94916.
    BgeeiO94916.
    CleanExiHS_NFAT5.
    GenevestigatoriO94916.

    Interactioni

    Subunit structurei

    Homodimer when bound to DNA, completely encircles its DNA target. Interacts with CIDEC; this interaction is direct and retains NFAT5 in the cytoplasm By similarity. Does not bind with Fos and Jun transcription factors.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DDX17Q928413EBI-308320,EBI-746012
    DDX5P178444EBI-308320,EBI-351962

    Protein-protein interaction databases

    BioGridi115949. 3 interactions.
    DIPiDIP-58524N.
    IntActiO94916. 5 interactions.
    STRINGi9606.ENSP00000396538.

    Structurei

    Secondary structure

    1
    1531
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi275 – 2773
    Beta strandi280 – 2867
    Beta strandi310 – 3123
    Beta strandi315 – 3206
    Beta strandi325 – 33713
    Beta strandi342 – 3487
    Beta strandi358 – 3625
    Beta strandi365 – 3728
    Helixi374 – 3763
    Beta strandi379 – 3813
    Beta strandi384 – 3896
    Helixi392 – 3965
    Beta strandi410 – 42011
    Beta strandi422 – 4243
    Beta strandi426 – 4327
    Beta strandi446 – 4516
    Beta strandi454 – 4563
    Beta strandi462 – 4687
    Beta strandi475 – 4828
    Beta strandi489 – 4924
    Helixi496 – 4983
    Beta strandi501 – 5077
    Beta strandi520 – 5289
    Beta strandi537 – 5426

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1IMHX-ray2.86C/D264-544[»]
    ProteinModelPortaliO94916.
    SMRiO94916. Positions 264-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO94916.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini264 – 443180RHDPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi69 – 10032Ser-richAdd
    BLAST
    Compositional biasi739 – 7435Poly-Gln
    Compositional biasi879 – 88810Poly-Gln
    Compositional biasi966 – 9716Poly-Thr
    Compositional biasi1248 – 126619Poly-GlnAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RHD (Rel-like) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG85658.
    HOGENOMiHOG000236245.
    HOVERGENiHBG052612.
    InParanoidiO94916.
    KOiK17335.
    OMAiNNMTLAV.
    OrthoDBiEOG79PJND.
    PhylomeDBiO94916.
    TreeFamiTF326480.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR008366. NFAT.
    IPR015646. NFAT5.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view]
    PANTHERiPTHR12533. PTHR12533. 1 hit.
    PTHR12533:SF7. PTHR12533:SF7. 1 hit.
    PfamiPF00554. RHD. 1 hit.
    [Graphical view]
    PRINTSiPR01789. NUCFACTORATC.
    SMARTiSM00429. IPT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS50254. REL_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform C (identifier: O94916-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPSDFISLLS ADLDLESPKS LYSRESVYDL LPKELQLPPS RETSVASMSQ     50
    TSGGEAGSPP PAVVAADASS APSSSSMGGA CSSFTTSSSP TIYSTSVTDS 100
    KAMQVESCSS AVGVSNRGVS EKQLTSNTVQ QHPSTPKRHT VLYISPPPED 150
    LLDNSRMSCQ DEGCGLESEQ SCSMWMEDSP SNFSNMSTSS YNDNTEVPRK 200
    SRKRNPKQRP GVKRRDCEES NMDIFDADSA KAPHYVLSQL TTDNKGNSKA 250
    GNGTLENQKG TGVKKSPMLC GQYPVKSEGK ELKIVVQPET QHRARYLTEG 300
    SRGSVKDRTQ QGFPTVKLEG HNEPVVLQVF VGNDSGRVKP HGFYQACRVT 350
    GRNTTPCKEV DIEGTTVIEV GLDPSNNMTL AVDCVGILKL RNADVEARIG 400
    IAGSKKKSTR ARLVFRVNIM RKDGSTLTLQ TPSSPILCTQ PAGVPEILKK 450
    SLHSCSVKGE EEVFLIGKNF LKGTKVIFQE NVSDENSWKS EAEIDMELFH 500
    QNHLIVKVPP YHDQHITLPV SVGIYVVTNA GRSHDVQPFT YTPDPAAAGA 550
    LNVNVKKEIS SPARPCSFEE AMKAMKTTGC NLDKVNIIPN ALMTPLIPSS 600
    MIKSEDVTPM EVTAEKRSST IFKTTKSVGS TQQTLENISN IAGNGSFSSP 650
    SSSHLPSENE KQQQIQPKAY NPETLTTIQT QDISQPGTFP AVSASSQLPN 700
    SDALLQQATQ FQTRETQSRE ILQSDGTVVN LSQLTEASQQ QQQSPLQEQA 750
    QTLQQQISSN IFPSPNSVSQ LQNTIQQLQA GSFTGSTASG SSGSVDLVQQ 800
    VLEAQQQLSS VLFSAPDGNE NVQEQLSADI FQQVSQIQSG VSPGMFSSTE 850
    PTVHTRPDNL LPGRAESVHP QSENTLSNQQ QQQQQQQQVM ESSAAMVMEM 900
    QQSICQAAAQ IQSELFPSTA SANGNLQQSP VYQQTSHMMS ALSTNEDMQM 950
    QCELFSSPPA VSGNETSTTT TQQVATPGTT MFQTSSSGDG EETGTQAKQI 1000
    QNSVFQTMVQ MQHSGDNQPQ VNLFSSTKSM MSVQNSGTQQ QGNGLFQQGN 1050
    EMMSLQSGNF LQQSSHSQAQ LFHPQNPIAD AQNLSQETQG SLFHSPNPIV 1100
    HSQTSTTSSE QMQPPMFHSQ STIAVLQGSS VPQDQQSTNI FLSQSPMNNL 1150
    QTNTVAQEAF FAAPNSISPL QSTSNSEQQA AFQQQAPISH IQTPMLSQEQ 1200
    AQPPQQGLFQ PQVALGSLPP NPMPQSQQGT MFQSQHSIVA MQSNSPSQEQ 1250
    QQQQQQQQQQ QQQQQQSILF SNQNTMATMA SPKQPPPNMI FNPNQNPMAN 1300
    QEQQNQSIFH QQSNMAPMNQ EQQPMQFQSQ STVSSLQNPG PTQSESSQTP 1350
    LFHSSPQIQL VQGSPSSQEQ QVTLFLSPAS MSALQTSINQ QDMQQSPLYS 1400
    PQNNMPGIQG ATSSPQPQAT LFHNTAGGTM NQLQNSPGSS QQTSGMFLFG 1450
    IQNNCSQLLT SGPATLPDQL MAISQPGQPQ NEGQPPVTTL LSQQMPENSP 1500
    LASSINTNQN IEKIDLLVSL QNQGNNLTGS F 1531
    Length:1,531
    Mass (Da):165,763
    Last modified:May 1, 1999 - v1
    Checksum:iA68C68088DABF69E
    GO
    Isoform A (identifier: O94916-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-76: Missing.

    Show »
    Length:1,455
    Mass (Da):157,983
    Checksum:i4FA637348EAC0041
    GO
    Isoform B (identifier: O94916-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-47: Missing.

    Show »
    Length:1,484
    Mass (Da):160,556
    Checksum:iF3E61D1947D310D3
    GO
    Isoform D (identifier: O94916-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-24: R → RDSLKLHPSQNFHRAGLLE
         546-546: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,548
    Mass (Da):167,737
    Checksum:i48E5072E004F9C09
    GO
    Isoform E (identifier: O94916-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-24: R → RDSLKLHPSQNFHRAGLLE

    Show »
    Length:1,549
    Mass (Da):167,808
    Checksum:i12DBBD89C630E445
    GO

    Sequence cautioni

    The sequence CAB09693.1 differs from that shown. Reason: Frameshift at position 1164.
    The sequence CAC42765.1 differs from that shown. Reason: Frameshift at position 20.
    The sequence BAA74850.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti666 – 6672QP → HA in AAK91166. (PubMed:11528118)Curated
    Sequence conflicti666 – 6672QP → HA in CAC42764. (PubMed:11528118)Curated
    Sequence conflicti1369 – 13691E → D in CAB09693. (PubMed:10565538)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7676Missing in isoform A. 3 PublicationsVSP_005605Add
    BLAST
    Alternative sequencei1 – 4747Missing in isoform B. 1 PublicationVSP_005606Add
    BLAST
    Alternative sequencei24 – 241R → RDSLKLHPSQNFHRAGLLE in isoform D and isoform E. 2 PublicationsVSP_043840
    Alternative sequencei546 – 5461Missing in isoform D. 1 PublicationVSP_043841

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163836 mRNA. Translation: AAD48441.1.
    AF089824 mRNA. Translation: AAD18136.1.
    AF134870 mRNA. Translation: AAD38360.1.
    AF346509 mRNA. Translation: AAK91166.1.
    AJ243298 mRNA. Translation: CAC42764.1.
    AJ243299 mRNA. Translation: CAC42765.1. Frameshift.
    AB020634 mRNA. Translation: BAA74850.2. Different initiation.
    AC009032 Genomic DNA. No translation available.
    AC012321 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW83281.1.
    BC131509 mRNA. Translation: AAI31510.1.
    BC146765 mRNA. Translation: AAI46766.1.
    Z97016 mRNA. Translation: CAB09693.1. Frameshift.
    CCDSiCCDS10881.1. [O94916-1]
    CCDS10882.1. [O94916-2]
    CCDS45518.1. [O94916-5]
    CCDS45519.1. [O94916-4]
    RefSeqiNP_001106649.1. NM_001113178.2. [O94916-4]
    NP_006590.1. NM_006599.3. [O94916-1]
    NP_619727.2. NM_138713.3. [O94916-5]
    NP_619728.2. NM_138714.3. [O94916-2]
    NP_775321.1. NM_173214.2. [O94916-2]
    NP_775322.1. NM_173215.2. [O94916-2]
    XP_006721188.1. XM_006721125.1. [O94916-3]
    UniGeneiHs.371987.

    Genome annotation databases

    EnsembliENST00000349945; ENSP00000338806; ENSG00000102908. [O94916-2]
    ENST00000354436; ENSP00000346420; ENSG00000102908. [O94916-1]
    ENST00000393742; ENSP00000377343; ENSG00000102908. [O94916-2]
    ENST00000566899; ENSP00000455628; ENSG00000102908. [O94916-2]
    ENST00000567239; ENSP00000457593; ENSG00000102908. [O94916-4]
    GeneIDi10725.
    KEGGihsa:10725.
    UCSCiuc002exi.3. human. [O94916-1]
    uc002exn.2. human. [O94916-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF163836 mRNA. Translation: AAD48441.1 .
    AF089824 mRNA. Translation: AAD18136.1 .
    AF134870 mRNA. Translation: AAD38360.1 .
    AF346509 mRNA. Translation: AAK91166.1 .
    AJ243298 mRNA. Translation: CAC42764.1 .
    AJ243299 mRNA. Translation: CAC42765.1 . Frameshift.
    AB020634 mRNA. Translation: BAA74850.2 . Different initiation.
    AC009032 Genomic DNA. No translation available.
    AC012321 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW83281.1 .
    BC131509 mRNA. Translation: AAI31510.1 .
    BC146765 mRNA. Translation: AAI46766.1 .
    Z97016 mRNA. Translation: CAB09693.1 . Frameshift.
    CCDSi CCDS10881.1. [O94916-1 ]
    CCDS10882.1. [O94916-2 ]
    CCDS45518.1. [O94916-5 ]
    CCDS45519.1. [O94916-4 ]
    RefSeqi NP_001106649.1. NM_001113178.2. [O94916-4 ]
    NP_006590.1. NM_006599.3. [O94916-1 ]
    NP_619727.2. NM_138713.3. [O94916-5 ]
    NP_619728.2. NM_138714.3. [O94916-2 ]
    NP_775321.1. NM_173214.2. [O94916-2 ]
    NP_775322.1. NM_173215.2. [O94916-2 ]
    XP_006721188.1. XM_006721125.1. [O94916-3 ]
    UniGenei Hs.371987.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1IMH X-ray 2.86 C/D 264-544 [» ]
    ProteinModelPortali O94916.
    SMRi O94916. Positions 264-544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115949. 3 interactions.
    DIPi DIP-58524N.
    IntActi O94916. 5 interactions.
    STRINGi 9606.ENSP00000396538.

    PTM databases

    PhosphoSitei O94916.

    Proteomic databases

    MaxQBi O94916.
    PaxDbi O94916.
    PRIDEi O94916.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349945 ; ENSP00000338806 ; ENSG00000102908 . [O94916-2 ]
    ENST00000354436 ; ENSP00000346420 ; ENSG00000102908 . [O94916-1 ]
    ENST00000393742 ; ENSP00000377343 ; ENSG00000102908 . [O94916-2 ]
    ENST00000566899 ; ENSP00000455628 ; ENSG00000102908 . [O94916-2 ]
    ENST00000567239 ; ENSP00000457593 ; ENSG00000102908 . [O94916-4 ]
    GeneIDi 10725.
    KEGGi hsa:10725.
    UCSCi uc002exi.3. human. [O94916-1 ]
    uc002exn.2. human. [O94916-4 ]

    Organism-specific databases

    CTDi 10725.
    GeneCardsi GC16P069599.
    HGNCi HGNC:7774. NFAT5.
    MIMi 604708. gene.
    neXtProti NX_O94916.
    PharmGKBi PA31581.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85658.
    HOGENOMi HOG000236245.
    HOVERGENi HBG052612.
    InParanoidi O94916.
    KOi K17335.
    OMAi NNMTLAV.
    OrthoDBi EOG79PJND.
    PhylomeDBi O94916.
    TreeFami TF326480.

    Miscellaneous databases

    ChiTaRSi NFAT5. human.
    EvolutionaryTracei O94916.
    GeneWikii NFAT5.
    GenomeRNAii 10725.
    NextBioi 40713.
    PROi O94916.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O94916.
    Bgeei O94916.
    CleanExi HS_NFAT5.
    Genevestigatori O94916.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.340. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR008366. NFAT.
    IPR015646. NFAT5.
    IPR008967. p53-like_TF_DNA-bd.
    IPR011539. RHD.
    [Graphical view ]
    PANTHERi PTHR12533. PTHR12533. 1 hit.
    PTHR12533:SF7. PTHR12533:SF7. 1 hit.
    Pfami PF00554. RHD. 1 hit.
    [Graphical view ]
    PRINTSi PR01789. NUCFACTORATC.
    SMARTi SM00429. IPT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS50254. REL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
      Tissue: Brain.
    2. "Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity."
      Miyakawa H., Woo S.K., Dahl S.C., Handler J.S., Kwon H.M.
      Proc. Natl. Acad. Sci. U.S.A. 96:2538-2542(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    3. "NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun."
      Lopez-Rodriguez C., Aramburu J., Rakeman A.S., Rao A.
      Proc. Natl. Acad. Sci. U.S.A. 96:7214-7219(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
      Tissue: Brain.
    4. "Genomic organization of the human NFAT5 gene: exon-intron structure of the 14-kb transcript and CpG-island analysis of the promoter region."
      Dalski A., Schwinger E., Zuhlke C.
      Cytogenet. Cell Genet. 93:239-241(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND E).
    5. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
      Tissue: Brain.
    6. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS C AND D).
    9. "Isolation and characterization of novel CAG repeat containing genes expressed in human brain."
      Zuehlke C., Kiehl R., Johannsmeyer A., Grzeschik K.H., Schwinger E.
      DNA Seq. 10:1-6(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 675-1531.
      Tissue: Brain.
    10. "Mouse TonEBP-NFAT5: expression in early development and alternative splicing."
      Maouyo D., Kim J.Y., Lee S.D., Wu Y., Woo S.K., Kwon H.M.
      Am. J. Physiol. 282:F802-F809(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization."
      Gallazzini M., Heussler G.E., Kunin M., Izumi Y., Burg M.B., Ferraris J.D.
      Mol. Biol. Cell 22:703-714(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-120; SER-134; THR-135 AND SER-155, MUTAGENESIS OF SER-120; SER-134; THR-135 AND SER-155.
    13. "Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor."
      Stroud J.C., Lopez-Rodriguez C., Rao A., Chen L.
      Nat. Struct. Biol. 9:90-94(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 264-544 IN COMPLEX WITH DNA, SUBUNIT.

    Entry informationi

    Entry nameiNFAT5_HUMAN
    AccessioniPrimary (citable) accession number: O94916
    Secondary accession number(s): A2RRB4
    , A6H8V5, E9PHR7, O95693, Q7LA65, Q969Q8, Q96QH3, Q9UN18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 149 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3