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Protein

Pre-mRNA cleavage complex 2 protein Pcf11

Gene

PCF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of pre-mRNA cleavage complex II.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72187. mRNA 3'-end processing.
R-HSA-77595. Processing of Intronless Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA cleavage complex 2 protein Pcf11
Alternative name(s):
Pre-mRNA cleavage complex II protein Pcf11
Gene namesi
Name:PCF11
Synonyms:KIAA0824
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30097. PCF11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • mRNA cleavage factor complex Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671196.

Polymorphism and mutation databases

BioMutaiPCF11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 15551554Pre-mRNA cleavage complex 2 protein Pcf11PRO_0000058246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei169 – 1691PhosphoserineCombined sources
Modified residuei182 – 1821PhosphoserineCombined sources
Modified residuei459 – 4591PhosphothreonineCombined sources
Modified residuei489 – 4891PhosphoserineCombined sources
Modified residuei494 – 4941PhosphoserineCombined sources
Modified residuei509 – 5091PhosphoserineCombined sources
Modified residuei511 – 5111PhosphoserineCombined sources
Modified residuei645 – 6451PhosphoserineCombined sources
Modified residuei705 – 7051PhosphoserineCombined sources
Modified residuei728 – 7281PhosphoserineCombined sources
Modified residuei777 – 7771PhosphoserineCombined sources
Modified residuei785 – 7851PhosphothreonineCombined sources
Modified residuei794 – 7941PhosphoserineCombined sources
Modified residuei851 – 8511PhosphoserineCombined sources
Modified residuei1161 – 11611PhosphoserineCombined sources
Cross-linki1511 – 1511Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1530 – 15301PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO94913.
MaxQBiO94913.
PaxDbiO94913.
PeptideAtlasiO94913.
PRIDEiO94913.

PTM databases

iPTMnetiO94913.
PhosphoSiteiO94913.
SwissPalmiO94913.

Expressioni

Gene expression databases

BgeeiENSG00000165494.
CleanExiHS_PCF11.
ExpressionAtlasiO94913. baseline and differential.
GenevisibleiO94913. HS.

Organism-specific databases

HPAiHPA040279.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119622. 43 interactions.
DIPiDIP-56825N.
IntActiO94913. 20 interactions.
MINTiMINT-3002535.
STRINGi9606.ENSP00000298281.

Structurei

3D structure databases

ProteinModelPortaliO94913.
SMRiO94913. Positions 20-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 142129CIDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili202 – 23938Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi328 – 436109Lys-richAdd
BLAST
Compositional biasi703 – 1080378Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 CID domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2071. Eukaryota.
ENOG410Y266. LUCA.
GeneTreeiENSGT00440000034259.
HOGENOMiHOG000290721.
HOVERGENiHBG058882.
InParanoidiO94913.
KOiK14400.
OMAiILIDHNE.
OrthoDBiEOG091G05E7.
PhylomeDBiO94913.
TreeFamiTF350069.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]
PfamiPF04818. CTD_bind. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQTPAEAG AAGAREDACR DYQSSLEDLT FNSKPHINML TILAEENLPF
60 70 80 90 100
AKEIVSLIEA QTAKAPSSEK LPVMYLMDSI VKNVGREYLT AFTKNLVATF
110 120 130 140 150
ICVFEKVDEN TRKSLFKLRS TWDEIFPLKK LYALDVRVNS LDPAWPIKPL
160 170 180 190 200
PPNVNTSSIH VNPKFLNKSP EEPSTPGTVV SSPSISTPPI VPDIQKNLTQ
210 220 230 240 250
EQLIRQQLLA KQKQLLELQQ KKLELELEQA KAQLAVSLSV QQETSNLGPG
260 270 280 290 300
SAPSKLHVSQ IPPMAVKAPH QVPVQSEKSR PGPSLQIQDL KGTNRDPRLN
310 320 330 340 350
RISQHSHGKD QSHRKEFLMN TLNQSDTKTS KTIPSEKLNS SKQEKSKSGE
360 370 380 390 400
KITKKELDQL DSKSKSKSKS PSPLKNKLSH TKDLKNQESE SMRLSDMNKR
410 420 430 440 450
DPRLKKHLQD KTDGKDDDVK EKRKTAEKKD KDEHMKSSEH RLAGSRNKII
460 470 480 490 500
NGIVQKQDTI TEESEKQGTK PGRSSTRKRS RSRSPKSRSP IIHSPKRRDR
510 520 530 540 550
RSPKRRQRSM SPTSTPKAGK IRQSGAKQSH MEEFTPPSRE DRNAKRSTKQ
560 570 580 590 600
DIRDPRRMKK TEEERPQETT NQHSTKSGTE PKENVENWQS SKSAKRWKSG
610 620 630 640 650
WEENKSLQQV DEHSKPPHLR HRESWSSTKG ILSPRAPKQQ QHRLSVDANL
660 670 680 690 700
QIPKELTLAS KRELLQKTSE RLASGEITQD DFLVVVHQIR QLFQYQEGVR
710 720 730 740 750
EEQRSPFNDR FPLKRPRYED SDKPFVDSPA SRFAGLDTNQ RLTALAEDRP
760 770 780 790 800
LFDGPSRPSV ARDGPTKMIF EGPNKLSPRI DGPPTPASLR FDGSPGQMGG
810 820 830 840 850
GGPLRFEGPQ GQLGGGCPLR FEGPPGPVGT PLRFEGPIGQ AGGGGFRFEG
860 870 880 890 900
SPGLRFEGSP GGLRFEGPGG QPVGGLRFEG HRGQPVGGLR FEGPHGQPVG
910 920 930 940 950
GLRFDNPRGQ PVGGLRFEGG HGPSGAAIRF DGPHGQPGGG IRFEGPLLQQ
960 970 980 990 1000
GVGMRFEGPH GQSVAGLRFE GQHNQLGGNL RFEGPHGQPG VGIRFEGPLV
1010 1020 1030 1040 1050
QQGGGMRFEG PSVPGGGLRI EGPLGQGGPR FEGCHALRFD GQPGQPSLLP
1060 1070 1080 1090 1100
RFDGLHGQPG PRFERTPGQP GPQRFDGPPG QQVQPRFDGV PQRFDGPQHQ
1110 1120 1130 1140 1150
QASRFDIPLG LQGTRFDNHP SQRLESVSFN QTGPYNDPPG NAFNAPSQGL
1160 1170 1180 1190 1200
QFQRHEQIFD SPQGPNFNGP HGPGNQSFSN PLNRASGHYF DEKNLQSSQF
1210 1220 1230 1240 1250
GNFGNIPAPM TVGNIQASQQ VLSGVAQPVA FGQGQQFLPV HPQNPGFVQN
1260 1270 1280 1290 1300
PSGALPKAYP DNHLSQVDVN ELFSKLLKTG ILKLSQTDSA TTQVSEVTAQ
1310 1320 1330 1340 1350
PPPEEEEDQN EDQDVPDLTN FTVEELKQRY DSVINRLYTG IQCYSCGMRF
1360 1370 1380 1390 1400
TTSQTDVYAD HLDWHYRQNR TEKDVSRKVT HRRWYYSLTD WIEFEEIADL
1410 1420 1430 1440 1450
EERAKSQFFE KVHEEVVLKT QEAAKEKEFQ SVPAGPAGAV ESCEICQEQF
1460 1470 1480 1490 1500
EQYWDEEEEE WHLKNAIRVD GKIYHPSCYE DYQNTSSFDC TPSPSKTPVE
1510 1520 1530 1540 1550
NPLNIMLNIV KNELQEPCDS PKVKEERIDT PPACTEESIA TPSEIKTEND

TVESV
Length:1,555
Mass (Da):173,050
Last modified:October 23, 2007 - v3
Checksum:i0AEAE04D7CB4A34F
GO

Sequence cautioni

The sequence AAC03107 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAC03107 differs from that shown. Reason: Frameshift at position 712. Curated
The sequence BAA74847 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti783 – 7831P → L in AAC03107 (Ref. 4) Curated
Sequence conflicti784 – 7841P → R in AAC03107 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti651 – 6511Q → H.
Corresponds to variant rs7935175 [ dbSNP | Ensembl ].
VAR_036878
Natural varianti1119 – 11191H → Y.
Corresponds to variant rs17513642 [ dbSNP | Ensembl ].
VAR_036879
Natural varianti1402 – 14021E → K.
Corresponds to variant rs11233510 [ dbSNP | Ensembl ].
VAR_036880

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020631 mRNA. Translation: BAA74847.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW75083.1.
BC065384 mRNA. Translation: AAH65384.2.
BC146778 mRNA. Translation: AAI46779.1.
AF046935 mRNA. Translation: AAC03107.1. Sequence problems.
CCDSiCCDS44689.1.
RefSeqiNP_056969.2. NM_015885.3.
UniGeneiHs.128959.
Hs.731825.

Genome annotation databases

EnsembliENST00000298281; ENSP00000298281; ENSG00000165494.
GeneIDi51585.
KEGGihsa:51585.
UCSCiuc001ozx.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020631 mRNA. Translation: BAA74847.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW75083.1.
BC065384 mRNA. Translation: AAH65384.2.
BC146778 mRNA. Translation: AAI46779.1.
AF046935 mRNA. Translation: AAC03107.1. Sequence problems.
CCDSiCCDS44689.1.
RefSeqiNP_056969.2. NM_015885.3.
UniGeneiHs.128959.
Hs.731825.

3D structure databases

ProteinModelPortaliO94913.
SMRiO94913. Positions 20-135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119622. 43 interactions.
DIPiDIP-56825N.
IntActiO94913. 20 interactions.
MINTiMINT-3002535.
STRINGi9606.ENSP00000298281.

PTM databases

iPTMnetiO94913.
PhosphoSiteiO94913.
SwissPalmiO94913.

Polymorphism and mutation databases

BioMutaiPCF11.

Proteomic databases

EPDiO94913.
MaxQBiO94913.
PaxDbiO94913.
PeptideAtlasiO94913.
PRIDEiO94913.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298281; ENSP00000298281; ENSG00000165494.
GeneIDi51585.
KEGGihsa:51585.
UCSCiuc001ozx.5. human.

Organism-specific databases

CTDi51585.
GeneCardsiPCF11.
HGNCiHGNC:30097. PCF11.
HPAiHPA040279.
MIMi608876. gene.
neXtProtiNX_O94913.
PharmGKBiPA142671196.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2071. Eukaryota.
ENOG410Y266. LUCA.
GeneTreeiENSGT00440000034259.
HOGENOMiHOG000290721.
HOVERGENiHBG058882.
InParanoidiO94913.
KOiK14400.
OMAiILIDHNE.
OrthoDBiEOG091G05E7.
PhylomeDBiO94913.
TreeFamiTF350069.

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72187. mRNA 3'-end processing.
R-HSA-77595. Processing of Intronless Pre-mRNAs.

Miscellaneous databases

ChiTaRSiPCF11. human.
GenomeRNAii51585.
PROiO94913.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165494.
CleanExiHS_PCF11.
ExpressionAtlasiO94913. baseline and differential.
GenevisibleiO94913. HS.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]
PfamiPF04818. CTD_bind. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCF11_HUMAN
AccessioniPrimary (citable) accession number: O94913
Secondary accession number(s): A6H8W7, O43671, Q6P0X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 23, 2007
Last modified: September 7, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.