UniProtKB - O94910 (AGRL1_HUMAN)
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Protein
Adhesion G protein-coupled receptor L1
Gene
ADGRL1
Organism
Homo sapiens (Human)
Status
Functioni
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 42 | CarbohydrateBy similarity | 1 |
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- cell adhesion molecule binding Source: UniProtKB
- G-protein coupled receptor activity Source: GDB
- latrotoxin receptor activity Source: UniProtKB
GO - Biological processi
- calcium-mediated signaling using intracellular calcium source Source: UniProtKB
- cell surface receptor signaling pathway Source: InterPro
- G-protein coupled receptor signaling pathway Source: GDB
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- positive regulation of synapse assembly Source: Ensembl
- positive regulation of synapse maturation Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Ligand | Lectin |
Protein family/group databases
MEROPSi | P02.010 |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G protein-coupled receptor L1ImportedAlternative name(s): Calcium-independent alpha-latrotoxin receptor 1By similarity Short name: CIRL-1By similarity Latrophilin-1Imported Lectomedin-2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000072071.16 |
HGNCi | HGNC:20973 ADGRL1 |
MIMi | 616416 gene |
neXtProti | NX_O94910 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 858 | ExtracellularSequence analysisAdd BLAST | 834 | |
Transmembranei | 859 – 879 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 880 – 893 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 894 – 914 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 915 – 920 | ExtracellularSequence analysis | 6 | |
Transmembranei | 921 – 941 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 942 – 964 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 965 – 985 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 986 – 1002 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 1003 – 1023 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1024 – 1050 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 1051 – 1071 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1072 – 1075 | ExtracellularSequence analysis | 4 | |
Transmembranei | 1076 – 1096 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1097 – 1474 | CytoplasmicSequence analysisAdd BLAST | 378 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, Synapse, SynaptosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 22859 |
OpenTargetsi | ENSG00000072071 |
PharmGKBi | PA134868822 |
Polymorphism and mutation databases
BioMutai | LPHN1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_0000012907 | 25 – 1474 | Adhesion G protein-coupled receptor L1Add BLAST | 1450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 41 ↔ 71 | PROSITE-ProRule annotation | ||
Disulfide bondi | 50 ↔ 128 | PROSITE-ProRule annotation | ||
Disulfide bondi | 83 ↔ 115 | PROSITE-ProRule annotation | ||
Disulfide bondi | 96 ↔ 102 | PROSITE-ProRule annotation | ||
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 140 ↔ 322 | PROSITE-ProRule annotation | ||
Disulfide bondi | 480 ↔ 515 | PROSITE-ProRule annotation | ||
Disulfide bondi | 503 ↔ 532 | PROSITE-ProRule annotation | ||
Glycosylationi | 531 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 640 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 742 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 801 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 802 ↔ 833 | PROSITE-ProRule annotation | ||
Glycosylationi | 806 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 821 ↔ 835 | PROSITE-ProRule annotation | ||
Glycosylationi | 827 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1194 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1220 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1473 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 838 – 839 | Cleavage; by autolysisBy similarity | 2 |
Keywords - PTMi
Autocatalytic cleavage, Disulfide bond, Glycoprotein, Methylation, PhosphoproteinProteomic databases
EPDi | O94910 |
MaxQBi | O94910 |
PaxDbi | O94910 |
PeptideAtlasi | O94910 |
PRIDEi | O94910 |
PTM databases
iPTMneti | O94910 |
PhosphoSitePlusi | O94910 |
Expressioni
Gene expression databases
Bgeei | ENSG00000072071 |
CleanExi | HS_LPHN1 |
ExpressionAtlasi | O94910 baseline and differential |
Genevisiblei | O94910 HS |
Organism-specific databases
HPAi | HPA037974 |
Interactioni
Subunit structurei
Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain. Interacts (via extracellular domain) with FLRT1, FLRT2 and FLRT3 (via extracellular domain) (By similarity).By similarity
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
CACNA1A | O00555 | 2 | EBI-3389315,EBI-766279 |
GO - Molecular functioni
- cell adhesion molecule binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 11652830 interactors. |
IntActi | O94910 2 interactors. |
STRINGi | 9606.ENSP00000340688 |
Structurei
3D structure databases
ProteinModelPortali | O94910 |
SMRi | O94910 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 129 | SUEL-type lectinPROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 139 – 398 | Olfactomedin-likePROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 799 – 850 | GPSPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 117 – 120 | Carbohydrate bindingBy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 413 – 416 | Poly-Thr | 4 | |
Compositional biasi | 1303 – 1314 | Poly-ProAdd BLAST | 12 | |
Compositional biasi | 1315 – 1318 | Poly-Gly | 4 | |
Compositional biasi | 1410 – 1420 | Poly-ProAdd BLAST | 11 |
Domaini
The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.By similarity
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3545 Eukaryota KOG4193 Eukaryota KOG4729 Eukaryota ENOG410XSD2 LUCA |
GeneTreei | ENSGT00900000140800 |
HOGENOMi | HOG000049065 |
HOVERGENi | HBG052337 |
InParanoidi | O94910 |
KOi | K04592 |
OMAi | LHKMIRN |
OrthoDBi | EOG091G00GJ |
PhylomeDBi | O94910 |
TreeFami | TF351999 |
Family and domain databases
Gene3Di | 4.10.1240.101 hit |
InterProi | View protein in InterPro IPR032471 GAIN_dom_N IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR003924 GPCR_2_latrophilin IPR003334 GPCR_2_latrophilin_rcpt_C IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS IPR000203 GPS IPR031234 Latrophilin-1 IPR000922 Lectin_gal-bd_dom IPR003112 Olfac-like_dom |
PANTHERi | PTHR12011:SF62 PTHR12011:SF62, 1 hit |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF16489 GAIN, 1 hit PF02140 Gal_Lectin, 1 hit PF01825 GPS, 1 hit PF02793 HRM, 1 hit PF02354 Latrophilin, 1 hit PF02191 OLF, 1 hit |
PRINTSi | PR00249 GPCRSECRETIN PR01444 LATROPHILIN |
SMARTi | View protein in SMART SM00303 GPS, 1 hit SM00008 HormR, 1 hit SM00284 OLF, 1 hit |
PROSITEi | View protein in PROSITE PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit PS50221 GPS, 1 hit PS51132 OLF, 1 hit PS50228 SUEL_LECTIN, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: O94910-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC
60 70 80 90 100
PGSDVIMVEN ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT
110 120 130 140 150
QCVVVAGSDA FPDPCPGTYK YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP
160 170 180 190 200
TSTHESEHQS GAWCKDPLQA GDRIYVMPWI PYRTDTLTEY ASWEDYVAAR
210 220 230 240 250
HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT RIKSGETVIN
260 270 280 290 300
TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL
310 320 330 340 350
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT
360 370 380 390 400
NANREEPVSL TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD
410 420 430 440 450
PSAGPATSPP LSTTTTARPT PLTSTASPAA TTPLRRAPLT THPVGAINQL
460 470 480 490 500
GPDLPPATAP VPSTRRPPAP NLHVSPELFC EPREVRRVQW PATQQGMLVE
510 520 530 540 550
RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV AQKIKSGENA
560 570 580 590 600
ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG
610 620 630 640 650
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM
660 670 680 690 700
LLDVLEEGAF LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE
710 720 730 740 750
EYPRKNSIQL SAKTIKQNSR NGVVKVVFIL YNNLGLFLST ENATVKLAGE
760 770 780 790 800
AGPGGPGGAS LVVNSQVIAA SINKESSRVF LMDPVIFTVA HLEDKNHFNA
810 820 830 840 850
NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN FAVLMAHREI
860 870 880 890 900
YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC
910 920 930 940 950
INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL
960 970 980 990 1000
LLVEVFESEY SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD
1010 1020 1030 1040 1050
NYFIWSFIGP VSFVIVVNLV FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA
1060 1070 1080 1090 1100
LGAIALLFLL GLTWAFGLLF INKESVVMAY LFTTFNAFQG VFIFVFHCAL
1110 1120 1130 1140 1150
QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR YYTGTQSRIR
1160 1170 1180 1190 1200
RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY
1210 1220 1230 1240 1250
NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN
1260 1270 1280 1290 1300
SYSLRSGDFP PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA
1310 1320 1330 1340 1350
KGPPPPEPPV PPVPGGGGEE EAGGPGGADR AEIELLYKAL EEPLLLPRAQ
1360 1370 1380 1390 1400
SVLYQSDLDE SESCTAEDGA TSRPLSSPPG RDSLYASGAN LRDSPSYPDS
1410 1420 1430 1440 1450
SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY YQVRRPSHEG
1460 1470
YLAAPGLEGP GPDGDGQMQL VTSL
Sequence cautioni
The sequence BAA74844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1321 | E → V in AAH02974 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049463 | 595 | E → Q. Corresponds to variant dbSNP:rs34759320Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010099 | 132 – 137 | KVEQKV → I in isoform 2. 1 Publication | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF307079 mRNA Translation: AAG27461.1 AB020628 mRNA Translation: BAA74844.2 Different initiation. AB065919 Genomic DNA Translation: BAC06134.1 BC002974 mRNA Translation: AAH02974.1 BC007587 mRNA Translation: AAH07587.1 |
CCDSi | CCDS12307.1 [O94910-2] CCDS32928.1 [O94910-1] |
RefSeqi | NP_001008701.1, NM_001008701.2 [O94910-1] NP_055736.2, NM_014921.4 [O94910-2] |
UniGenei | Hs.94229 |
Genome annotation databases
Ensembli | ENST00000340736; ENSP00000340688; ENSG00000072071 [O94910-1] ENST00000361434; ENSP00000355328; ENSG00000072071 [O94910-2] |
GeneIDi | 22859 |
KEGGi | hsa:22859 |
UCSCi | uc010xnn.3 human [O94910-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | AGRL1_HUMAN | |
Accessioni | O94910Primary (citable) accession number: O94910 Secondary accession number(s): Q96IE7, Q9BU07, Q9HAR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | May 1, 1999 | |
Last modified: | March 28, 2018 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |