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O94910

- LPHN1_HUMAN

UniProt

O94910 - LPHN1_HUMAN

Protein

Latrophilin-1

Gene

LPHN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421CarbohydrateBy similarity
    Sitei838 – 8392Cleavage; by autocatalysisBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. cell adhesion molecule binding Source: UniProtKB
    3. G-protein coupled receptor activity Source: GDB
    4. latrotoxin receptor activity Source: UniProtKB
    5. protein binding Source: IntAct

    GO - Biological processi

    1. calcium-mediated signaling using intracellular calcium source Source: UniProtKB
    2. G-protein coupled receptor signaling pathway Source: GDB
    3. heterophilic cell-cell adhesion Source: UniProtKB
    4. neuropeptide signaling pathway Source: InterPro
    5. positive regulation of synapse maturation Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    MEROPSiS63.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Latrophilin-1
    Alternative name(s):
    Calcium-independent alpha-latrotoxin receptor 1
    Short name:
    CIRL-1
    Lectomedin-2
    Gene namesi
    Name:LPHN1
    Synonyms:KIAA0821, LEC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20973. LPHN1.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Cell projectionaxon By similarity. Cell projectiongrowth cone By similarity. Cell junctionsynapse By similarity. Cell junctionsynapsepresynaptic cell membrane By similarity. Cell junctionsynapsesynaptosome By similarity
    Note: Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cell junction Source: UniProtKB-KW
    3. growth cone Source: UniProtKB
    4. integral component of membrane Source: GDB
    5. neuron projection Source: UniProtKB
    6. plasma membrane Source: UniProtKB
    7. presynaptic membrane Source: UniProtKB
    8. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134868822.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 14741450Latrophilin-1PRO_0000012907Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 71PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 128PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 115PROSITE-ProRule annotation
    Disulfide bondi96 ↔ 102PROSITE-ProRule annotation
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi140 ↔ 322PROSITE-ProRule annotation
    Disulfide bondi480 ↔ 515PROSITE-ProRule annotation
    Disulfide bondi503 ↔ 532PROSITE-ProRule annotation
    Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi640 – 6401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi742 – 7421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi802 ↔ 833PROSITE-ProRule annotation
    Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi821 ↔ 835PROSITE-ProRule annotation
    Glycosylationi827 – 8271N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO94910.
    PaxDbiO94910.
    PRIDEiO94910.

    PTM databases

    PhosphoSiteiO94910.

    Expressioni

    Gene expression databases

    ArrayExpressiO94910.
    BgeeiO94910.
    CleanExiHS_LPHN1.
    GenevestigatoriO94910.

    Organism-specific databases

    HPAiHPA037974.

    Interactioni

    Subunit structurei

    Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CACNA1AO005552EBI-3389315,EBI-766279

    Protein-protein interaction databases

    BioGridi116528. 4 interactions.
    IntActiO94910. 2 interactions.
    STRINGi9606.ENSP00000340688.

    Structurei

    3D structure databases

    ProteinModelPortaliO94910.
    SMRiO94910. Positions 29-134, 474-838, 861-1100.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 858834ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini880 – 89314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini915 – 9206ExtracellularSequence Analysis
    Topological domaini942 – 96423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini986 – 100217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1024 – 105027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1072 – 10754ExtracellularSequence Analysis
    Topological domaini1097 – 1474378CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei859 – 87921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei894 – 91421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei921 – 94121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei965 – 98521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei1003 – 102321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1051 – 107121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1076 – 109621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 12990SUEL-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini139 – 398260Olfactomedin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini799 – 85052GPSPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 1204Carbohydrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi413 – 4164Poly-Thr
    Compositional biasi1303 – 131412Poly-ProAdd
    BLAST
    Compositional biasi1315 – 13184Poly-Gly
    Compositional biasi1410 – 142011Poly-ProAdd
    BLAST

    Domaini

    The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.By similarity

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation
    Contains 1 SUEL-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253931.
    HOGENOMiHOG000049065.
    HOVERGENiHBG052337.
    InParanoidiO94910.
    KOiK04592.
    OMAiDRIYVMP.
    OrthoDBiEOG76DTRK.
    PhylomeDBiO94910.
    TreeFamiTF351999.

    Family and domain databases

    InterProiIPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 1 hit.
    PF02191. OLF. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTiSM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view]
    PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94910-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC     50
    PGSDVIMVEN ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT 100
    QCVVVAGSDA FPDPCPGTYK YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP 150
    TSTHESEHQS GAWCKDPLQA GDRIYVMPWI PYRTDTLTEY ASWEDYVAAR 200
    HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT RIKSGETVIN 250
    TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL 300
    RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT 350
    NANREEPVSL TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD 400
    PSAGPATSPP LSTTTTARPT PLTSTASPAA TTPLRRAPLT THPVGAINQL 450
    GPDLPPATAP VPSTRRPPAP NLHVSPELFC EPREVRRVQW PATQQGMLVE 500
    RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV AQKIKSGENA 550
    ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG 600
    KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM 650
    LLDVLEEGAF LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE 700
    EYPRKNSIQL SAKTIKQNSR NGVVKVVFIL YNNLGLFLST ENATVKLAGE 750
    AGPGGPGGAS LVVNSQVIAA SINKESSRVF LMDPVIFTVA HLEDKNHFNA 800
    NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN FAVLMAHREI 850
    YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC 900
    INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL 950
    LLVEVFESEY SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD 1000
    NYFIWSFIGP VSFVIVVNLV FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA 1050
    LGAIALLFLL GLTWAFGLLF INKESVVMAY LFTTFNAFQG VFIFVFHCAL 1100
    QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR YYTGTQSRIR 1150
    RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY 1200
    NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN 1250
    SYSLRSGDFP PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA 1300
    KGPPPPEPPV PPVPGGGGEE EAGGPGGADR AEIELLYKAL EEPLLLPRAQ 1350
    SVLYQSDLDE SESCTAEDGA TSRPLSSPPG RDSLYASGAN LRDSPSYPDS 1400
    SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY YQVRRPSHEG 1450
    YLAAPGLEGP GPDGDGQMQL VTSL 1474
    Length:1,474
    Mass (Da):162,717
    Last modified:May 1, 1999 - v1
    Checksum:i6152EB2DE1385F5C
    GO
    Isoform 2 (identifier: O94910-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-137: KVEQKV → I

    Show »
    Length:1,469
    Mass (Da):162,118
    Checksum:i4907D329A56E57FF
    GO

    Sequence cautioni

    The sequence BAA74844.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1321 – 13211E → V in AAH02974. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti595 – 5951E → Q.
    Corresponds to variant rs34759320 [ dbSNP | Ensembl ].
    VAR_049463

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei132 – 1376KVEQKV → I in isoform 2. 1 PublicationVSP_010099

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF307079 mRNA. Translation: AAG27461.1.
    AB020628 mRNA. Translation: BAA74844.2. Different initiation.
    AB065919 Genomic DNA. Translation: BAC06134.1.
    BC002974 mRNA. Translation: AAH02974.1.
    BC007587 mRNA. Translation: AAH07587.1.
    CCDSiCCDS12307.1. [O94910-2]
    CCDS32928.1. [O94910-1]
    RefSeqiNP_001008701.1. NM_001008701.2. [O94910-1]
    NP_055736.2. NM_014921.4. [O94910-2]
    UniGeneiHs.94229.

    Genome annotation databases

    EnsembliENST00000340736; ENSP00000340688; ENSG00000072071. [O94910-1]
    ENST00000361434; ENSP00000355328; ENSG00000072071. [O94910-2]
    GeneIDi22859.
    KEGGihsa:22859.
    UCSCiuc010xnn.2. human. [O94910-1]
    uc010xno.2. human. [O94910-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF307079 mRNA. Translation: AAG27461.1 .
    AB020628 mRNA. Translation: BAA74844.2 . Different initiation.
    AB065919 Genomic DNA. Translation: BAC06134.1 .
    BC002974 mRNA. Translation: AAH02974.1 .
    BC007587 mRNA. Translation: AAH07587.1 .
    CCDSi CCDS12307.1. [O94910-2 ]
    CCDS32928.1. [O94910-1 ]
    RefSeqi NP_001008701.1. NM_001008701.2. [O94910-1 ]
    NP_055736.2. NM_014921.4. [O94910-2 ]
    UniGenei Hs.94229.

    3D structure databases

    ProteinModelPortali O94910.
    SMRi O94910. Positions 29-134, 474-838, 861-1100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116528. 4 interactions.
    IntActi O94910. 2 interactions.
    STRINGi 9606.ENSP00000340688.

    Protein family/group databases

    MEROPSi S63.013.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei O94910.

    Proteomic databases

    MaxQBi O94910.
    PaxDbi O94910.
    PRIDEi O94910.

    Protocols and materials databases

    DNASUi 22859.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340736 ; ENSP00000340688 ; ENSG00000072071 . [O94910-1 ]
    ENST00000361434 ; ENSP00000355328 ; ENSG00000072071 . [O94910-2 ]
    GeneIDi 22859.
    KEGGi hsa:22859.
    UCSCi uc010xnn.2. human. [O94910-1 ]
    uc010xno.2. human. [O94910-2 ]

    Organism-specific databases

    CTDi 22859.
    GeneCardsi GC19M014258.
    HGNCi HGNC:20973. LPHN1.
    HPAi HPA037974.
    neXtProti NX_O94910.
    PharmGKBi PA134868822.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253931.
    HOGENOMi HOG000049065.
    HOVERGENi HBG052337.
    InParanoidi O94910.
    KOi K04592.
    OMAi DRIYVMP.
    OrthoDBi EOG76DTRK.
    PhylomeDBi O94910.
    TreeFami TF351999.

    Miscellaneous databases

    GeneWikii LPHN1.
    GenomeRNAii 22859.
    NextBioi 43351.
    PROi O94910.

    Gene expression databases

    ArrayExpressi O94910.
    Bgeei O94910.
    CleanExi HS_LPHN1.
    Genevestigatori O94910.

    Family and domain databases

    InterProi IPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 1 hit.
    PF02191. OLF. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTi SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view ]
    PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Douangpanya J., Puri K., Hayflick J.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 636-1474.
      Tissue: Brain and Lung.
    5. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiLPHN1_HUMAN
    AccessioniPrimary (citable) accession number: O94910
    Secondary accession number(s): Q96IE7, Q9BU07, Q9HAR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3