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UniProtKB - O94910 (AGRL1_HUMAN)

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Protein

Adhesion G protein-coupled receptor L1

Gene

ADGRL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42CarbohydrateBy similarity1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLectin

Protein family/group databases

MEROPSiP02.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L1Imported
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 1By similarity
Short name:
CIRL-1By similarity
Latrophilin-1Imported
Lectomedin-2
Gene namesi
Name:ADGRL1Imported
Synonyms:KIAA0821Imported, LEC2By similarity, LPHN1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20973. ADGRL1.

Subcellular locationi

  • Cell membrane; Multi-pass membrane protein
  • Cell projection › axon By similarity
  • Cell projection › growth cone By similarity
  • Cell junction › synapse By similarity
  • Cell junction › synapse › presynaptic cell membrane By similarity
  • Cell junction › synapse › synaptosome By similarity

    • Note: Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 858ExtracellularSequence analysisAdd BLAST834
Transmembranei859 – 879Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini880 – 893CytoplasmicSequence analysisAdd BLAST14
Transmembranei894 – 914Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini915 – 920ExtracellularSequence analysis6
Transmembranei921 – 941Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini942 – 964CytoplasmicSequence analysisAdd BLAST23
Transmembranei965 – 985Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini986 – 1002ExtracellularSequence analysisAdd BLAST17
Transmembranei1003 – 1023Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1024 – 1050CytoplasmicSequence analysisAdd BLAST27
Transmembranei1051 – 1071Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1072 – 1075ExtracellularSequence analysis4
Transmembranei1076 – 1096Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1097 – 1474CytoplasmicSequence analysisAdd BLAST378

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi22859.
OpenTargetsiENSG00000072071.
PharmGKBiPA134868822.

Polymorphism and mutation databases

BioMutaiLPHN1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001290725 – 1474Adhesion G protein-coupled receptor L1Add BLAST1450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 71PROSITE-ProRule annotation
Disulfide bondi50 ↔ 128PROSITE-ProRule annotation
Disulfide bondi83 ↔ 115PROSITE-ProRule annotation
Disulfide bondi96 ↔ 102PROSITE-ProRule annotation
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 322PROSITE-ProRule annotation
Disulfide bondi480 ↔ 515PROSITE-ProRule annotation
Disulfide bondi503 ↔ 532PROSITE-ProRule annotation
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi742N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi801N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi802 ↔ 833PROSITE-ProRule annotation
Glycosylationi806N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi821 ↔ 835PROSITE-ProRule annotation
Glycosylationi827N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1194Omega-N-methylarginineBy similarity1
Modified residuei1220PhosphoserineBy similarity1
Modified residuei1473PhosphoserineBy similarity1

Post-translational modificationi

Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei838 – 839Cleavage; by autolysisBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiO94910.
MaxQBiO94910.
PaxDbiO94910.
PeptideAtlasiO94910.
PRIDEiO94910.

PTM databases

iPTMnetiO94910.
PhosphoSitePlusiO94910.

Expressioni

Gene expression databases

BgeeiENSG00000072071.
CleanExiHS_LPHN1.
ExpressionAtlasiO94910. baseline and differential.
GenevisibleiO94910. HS.

Organism-specific databases

HPAiHPA037974.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain. Interacts (via extracellular domain) with FLRT1, FLRT2 and FLRT3 (via extracellular domain) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CACNA1AO005552EBI-3389315,EBI-766279

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

BioGridi116528. 24 interactors.
IntActiO94910. 2 interactors.
STRINGi9606.ENSP00000340688.

Structurei

3D structure databases

ProteinModelPortaliO94910.
SMRiO94910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 129SUEL-type lectinPROSITE-ProRule annotationAdd BLAST90
Domaini139 – 398Olfactomedin-likePROSITE-ProRule annotationAdd BLAST260
Domaini799 – 850GPSPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 120Carbohydrate bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi413 – 416Poly-Thr4
Compositional biasi1303 – 1314Poly-ProAdd BLAST12
Compositional biasi1315 – 1318Poly-Gly4
Compositional biasi1410 – 1420Poly-ProAdd BLAST11

Domaini

The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000049065.
HOVERGENiHBG052337.
InParanoidiO94910.
KOiK04592.
OMAiLHKMIRN.
OrthoDBiEOG091G00GJ.
PhylomeDBiO94910.
TreeFamiTF351999.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiView protein in SMART
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
PROSITEiView protein in PROSITE
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC 
        60         70         80         90        100
PGSDVIMVEN ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT 
       110        120        130        140        150
QCVVVAGSDA FPDPCPGTYK YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP 
       160        170        180        190        200
TSTHESEHQS GAWCKDPLQA GDRIYVMPWI PYRTDTLTEY ASWEDYVAAR 
       210        220        230        240        250
HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT RIKSGETVIN 
       260        270        280        290        300
TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL 
       310        320        330        340        350
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT 
       360        370        380        390        400
NANREEPVSL TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD 
       410        420        430        440        450
PSAGPATSPP LSTTTTARPT PLTSTASPAA TTPLRRAPLT THPVGAINQL 
       460        470        480        490        500
GPDLPPATAP VPSTRRPPAP NLHVSPELFC EPREVRRVQW PATQQGMLVE 
       510        520        530        540        550
RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV AQKIKSGENA 
       560        570        580        590        600
ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG 
       610        620        630        640        650
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM 
       660        670        680        690        700
LLDVLEEGAF LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE 
       710        720        730        740        750
EYPRKNSIQL SAKTIKQNSR NGVVKVVFIL YNNLGLFLST ENATVKLAGE 
       760        770        780        790        800
AGPGGPGGAS LVVNSQVIAA SINKESSRVF LMDPVIFTVA HLEDKNHFNA 
       810        820        830        840        850
NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN FAVLMAHREI 
       860        870        880        890        900
YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC 
       910        920        930        940        950
INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL 
       960        970        980        990       1000
LLVEVFESEY SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD 
      1010       1020       1030       1040       1050
NYFIWSFIGP VSFVIVVNLV FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA 
      1060       1070       1080       1090       1100
LGAIALLFLL GLTWAFGLLF INKESVVMAY LFTTFNAFQG VFIFVFHCAL 
      1110       1120       1130       1140       1150
QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR YYTGTQSRIR 
      1160       1170       1180       1190       1200
RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY 
      1210       1220       1230       1240       1250
NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN 
      1260       1270       1280       1290       1300
SYSLRSGDFP PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA 
      1310       1320       1330       1340       1350
KGPPPPEPPV PPVPGGGGEE EAGGPGGADR AEIELLYKAL EEPLLLPRAQ 
      1360       1370       1380       1390       1400
SVLYQSDLDE SESCTAEDGA TSRPLSSPPG RDSLYASGAN LRDSPSYPDS 
      1410       1420       1430       1440       1450
SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY YQVRRPSHEG 
      1460       1470 
YLAAPGLEGP GPDGDGQMQL VTSL
Length:1,474
Mass (Da):162,717
Last modified:May 1, 1999 - v1
Checksum:i6152EB2DE1385F5C
GO
Isoform 2 (identifier: O94910-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-137: KVEQKV → I

Show »
Length:1,469
Mass (Da):162,118
Checksum:i4907D329A56E57FF
GO

Sequence cautioni

The sequence BAA74844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1321E → V in AAH02974 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049463595E → Q. Corresponds to variant dbSNP:rs34759320Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010099132 – 137KVEQKV → I in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307079 mRNA. Translation: AAG27461.1.
AB020628 mRNA. Translation: BAA74844.2. Different initiation.
AB065919 Genomic DNA. Translation: BAC06134.1.
BC002974 mRNA. Translation: AAH02974.1.
BC007587 mRNA. Translation: AAH07587.1.
CCDSiCCDS12307.1. [O94910-2]
CCDS32928.1. [O94910-1]
RefSeqiNP_001008701.1. NM_001008701.2. [O94910-1]
NP_055736.2. NM_014921.4. [O94910-2]
UniGeneiHs.94229.

Genome annotation databases

EnsembliENST00000340736; ENSP00000340688; ENSG00000072071. [O94910-1]
ENST00000361434; ENSP00000355328; ENSG00000072071. [O94910-2]
GeneIDi22859.
KEGGihsa:22859.
UCSCiuc010xnn.3. human. [O94910-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307079 mRNA. Translation: AAG27461.1.
AB020628 mRNA. Translation: BAA74844.2. Different initiation.
AB065919 Genomic DNA. Translation: BAC06134.1.
BC002974 mRNA. Translation: AAH02974.1.
BC007587 mRNA. Translation: AAH07587.1.
CCDSiCCDS12307.1. [O94910-2]
CCDS32928.1. [O94910-1]
RefSeqiNP_001008701.1. NM_001008701.2. [O94910-1]
NP_055736.2. NM_014921.4. [O94910-2]
UniGeneiHs.94229.

3D structure databases

ProteinModelPortaliO94910.
SMRiO94910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116528. 24 interactors.
IntActiO94910. 2 interactors.
STRINGi9606.ENSP00000340688.

Protein family/group databases

MEROPSiP02.010.
GPCRDBiSearch...

PTM databases

iPTMnetiO94910.
PhosphoSitePlusiO94910.

Polymorphism and mutation databases

BioMutaiLPHN1.

Proteomic databases

EPDiO94910.
MaxQBiO94910.
PaxDbiO94910.
PeptideAtlasiO94910.
PRIDEiO94910.

Protocols and materials databases

DNASUi22859.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340736; ENSP00000340688; ENSG00000072071. [O94910-1]
ENST00000361434; ENSP00000355328; ENSG00000072071. [O94910-2]
GeneIDi22859.
KEGGihsa:22859.
UCSCiuc010xnn.3. human. [O94910-1]

Organism-specific databases

CTDi22859.
DisGeNETi22859.
GeneCardsiADGRL1.
HGNCiHGNC:20973. ADGRL1.
HPAiHPA037974.
MIMi616416. gene.
neXtProtiNX_O94910.
OpenTargetsiENSG00000072071.
PharmGKBiPA134868822.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3545. Eukaryota.
KOG4193. Eukaryota.
KOG4729. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000049065.
HOVERGENiHBG052337.
InParanoidiO94910.
KOiK04592.
OMAiLHKMIRN.
OrthoDBiEOG091G00GJ.
PhylomeDBiO94910.
TreeFamiTF351999.

Miscellaneous databases

GeneWikiiLPHN1.
GenomeRNAii22859.
PROiPR:O94910.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072071.
CleanExiHS_LPHN1.
ExpressionAtlasiO94910. baseline and differential.
GenevisibleiO94910. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR032471. GAIN_dom_N.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF16489. GAIN. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiView protein in SMART
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
PROSITEiView protein in PROSITE
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGRL1_HUMAN
AccessioniPrimary (citable) accession number: O94910
Secondary accession number(s): Q96IE7, Q9BU07, Q9HAR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 1999
Last modified: May 10, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.