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O94910

- LPHN1_HUMAN

UniProt

O94910 - LPHN1_HUMAN

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Protein

Latrophilin-1

Gene
LPHN1, KIAA0821, LEC2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Carbohydrate By similarity
Sitei838 – 8392Cleavage; by autocatalysis By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. cell adhesion molecule binding Source: UniProtKB
  3. G-protein coupled receptor activity Source: GDB
  4. latrotoxin receptor activity Source: UniProtKB
  5. protein binding Source: IntAct

GO - Biological processi

  1. calcium-mediated signaling using intracellular calcium source Source: UniProtKB
  2. G-protein coupled receptor signaling pathway Source: GDB
  3. heterophilic cell-cell adhesion Source: UniProtKB
  4. neuropeptide signaling pathway Source: InterPro
  5. positive regulation of synapse maturation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiS63.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Latrophilin-1
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 1
Short name:
CIRL-1
Lectomedin-2
Gene namesi
Name:LPHN1
Synonyms:KIAA0821, LEC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20973. LPHN1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Cell projectionaxon By similarity. Cell projectiongrowth cone By similarity. Cell junctionsynapse By similarity. Cell junctionsynapsepresynaptic cell membrane By similarity. Cell junctionsynapsesynaptosome By similarity
Note: Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 858834Extracellular Reviewed predictionAdd
BLAST
Transmembranei859 – 87921Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini880 – 89314Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei894 – 91421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini915 – 9206Extracellular Reviewed prediction
Transmembranei921 – 94121Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini942 – 96423Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei965 – 98521Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini986 – 100217Extracellular Reviewed predictionAdd
BLAST
Transmembranei1003 – 102321Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini1024 – 105027Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1051 – 107121Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini1072 – 10754Extracellular Reviewed prediction
Transmembranei1076 – 109621Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini1097 – 1474378Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. growth cone Source: UniProtKB
  4. integral component of membrane Source: GDB
  5. neuron projection Source: UniProtKB
  6. plasma membrane Source: UniProtKB
  7. presynaptic membrane Source: UniProtKB
  8. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 By similarityAdd
BLAST
Chaini25 – 14741450Latrophilin-1PRO_0000012907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 71 By similarity
Disulfide bondi50 ↔ 128 By similarity
Disulfide bondi83 ↔ 115 By similarity
Disulfide bondi96 ↔ 102 By similarity
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi140 ↔ 322 By similarity
Disulfide bondi480 ↔ 515 By similarity
Disulfide bondi503 ↔ 532 By similarity
Glycosylationi531 – 5311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi640 – 6401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi742 – 7421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi801 – 8011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi802 ↔ 833 By similarity
Glycosylationi806 – 8061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi821 ↔ 835 By similarity
Glycosylationi827 – 8271N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO94910.
PaxDbiO94910.
PRIDEiO94910.

PTM databases

PhosphoSiteiO94910.

Expressioni

Gene expression databases

ArrayExpressiO94910.
BgeeiO94910.
CleanExiHS_LPHN1.
GenevestigatoriO94910.

Organism-specific databases

HPAiHPA037974.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
CACNA1AO005552EBI-3389315,EBI-766279

Protein-protein interaction databases

BioGridi116528. 4 interactions.
IntActiO94910. 2 interactions.
STRINGi9606.ENSP00000340688.

Structurei

3D structure databases

ProteinModelPortaliO94910.
SMRiO94910. Positions 29-134, 474-838, 861-1100.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 12990SUEL-type lectinAdd
BLAST
Domaini139 – 398260Olfactomedin-likeAdd
BLAST
Domaini799 – 85052GPSAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 1204Carbohydrate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi413 – 4164Poly-Thr
Compositional biasi1303 – 131412Poly-ProAdd
BLAST
Compositional biasi1315 – 13184Poly-Gly
Compositional biasi1410 – 142011Poly-ProAdd
BLAST

Domaini

The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin By similarity.

Sequence similaritiesi

Contains 1 GPS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253931.
HOGENOMiHOG000049065.
HOVERGENiHBG052337.
InParanoidiO94910.
KOiK04592.
OMAiDRIYVMP.
OrthoDBiEOG76DTRK.
PhylomeDBiO94910.
TreeFamiTF351999.

Family and domain databases

InterProiIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O94910-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC     50
PGSDVIMVEN ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT 100
QCVVVAGSDA FPDPCPGTYK YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP 150
TSTHESEHQS GAWCKDPLQA GDRIYVMPWI PYRTDTLTEY ASWEDYVAAR 200
HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT RIKSGETVIN 250
TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL 300
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT 350
NANREEPVSL TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD 400
PSAGPATSPP LSTTTTARPT PLTSTASPAA TTPLRRAPLT THPVGAINQL 450
GPDLPPATAP VPSTRRPPAP NLHVSPELFC EPREVRRVQW PATQQGMLVE 500
RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV AQKIKSGENA 550
ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG 600
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM 650
LLDVLEEGAF LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE 700
EYPRKNSIQL SAKTIKQNSR NGVVKVVFIL YNNLGLFLST ENATVKLAGE 750
AGPGGPGGAS LVVNSQVIAA SINKESSRVF LMDPVIFTVA HLEDKNHFNA 800
NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN FAVLMAHREI 850
YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC 900
INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL 950
LLVEVFESEY SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD 1000
NYFIWSFIGP VSFVIVVNLV FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA 1050
LGAIALLFLL GLTWAFGLLF INKESVVMAY LFTTFNAFQG VFIFVFHCAL 1100
QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR YYTGTQSRIR 1150
RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY 1200
NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN 1250
SYSLRSGDFP PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA 1300
KGPPPPEPPV PPVPGGGGEE EAGGPGGADR AEIELLYKAL EEPLLLPRAQ 1350
SVLYQSDLDE SESCTAEDGA TSRPLSSPPG RDSLYASGAN LRDSPSYPDS 1400
SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY YQVRRPSHEG 1450
YLAAPGLEGP GPDGDGQMQL VTSL 1474
Length:1,474
Mass (Da):162,717
Last modified:May 1, 1999 - v1
Checksum:i6152EB2DE1385F5C
GO
Isoform 2 (identifier: O94910-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-137: KVEQKV → I

Show »
Length:1,469
Mass (Da):162,118
Checksum:i4907D329A56E57FF
GO

Sequence cautioni

The sequence BAA74844.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti595 – 5951E → Q.
Corresponds to variant rs34759320 [ dbSNP | Ensembl ].
VAR_049463

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei132 – 1376KVEQKV → I in isoform 2. VSP_010099

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1321 – 13211E → V in AAH02974. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF307079 mRNA. Translation: AAG27461.1.
AB020628 mRNA. Translation: BAA74844.2. Different initiation.
AB065919 Genomic DNA. Translation: BAC06134.1.
BC002974 mRNA. Translation: AAH02974.1.
BC007587 mRNA. Translation: AAH07587.1.
CCDSiCCDS12307.1. [O94910-2]
CCDS32928.1. [O94910-1]
RefSeqiNP_001008701.1. NM_001008701.2. [O94910-1]
NP_055736.2. NM_014921.4. [O94910-2]
UniGeneiHs.94229.

Genome annotation databases

EnsembliENST00000340736; ENSP00000340688; ENSG00000072071. [O94910-1]
ENST00000361434; ENSP00000355328; ENSG00000072071. [O94910-2]
GeneIDi22859.
KEGGihsa:22859.
UCSCiuc010xnn.2. human. [O94910-1]
uc010xno.2. human. [O94910-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF307079 mRNA. Translation: AAG27461.1 .
AB020628 mRNA. Translation: BAA74844.2 . Different initiation.
AB065919 Genomic DNA. Translation: BAC06134.1 .
BC002974 mRNA. Translation: AAH02974.1 .
BC007587 mRNA. Translation: AAH07587.1 .
CCDSi CCDS12307.1. [O94910-2 ]
CCDS32928.1. [O94910-1 ]
RefSeqi NP_001008701.1. NM_001008701.2. [O94910-1 ]
NP_055736.2. NM_014921.4. [O94910-2 ]
UniGenei Hs.94229.

3D structure databases

ProteinModelPortali O94910.
SMRi O94910. Positions 29-134, 474-838, 861-1100.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116528. 4 interactions.
IntActi O94910. 2 interactions.
STRINGi 9606.ENSP00000340688.

Protein family/group databases

MEROPSi S63.013.
GPCRDBi Search...

PTM databases

PhosphoSitei O94910.

Proteomic databases

MaxQBi O94910.
PaxDbi O94910.
PRIDEi O94910.

Protocols and materials databases

DNASUi 22859.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340736 ; ENSP00000340688 ; ENSG00000072071 . [O94910-1 ]
ENST00000361434 ; ENSP00000355328 ; ENSG00000072071 . [O94910-2 ]
GeneIDi 22859.
KEGGi hsa:22859.
UCSCi uc010xnn.2. human. [O94910-1 ]
uc010xno.2. human. [O94910-2 ]

Organism-specific databases

CTDi 22859.
GeneCardsi GC19M014258.
HGNCi HGNC:20973. LPHN1.
HPAi HPA037974.
neXtProti NX_O94910.
PharmGKBi PA134868822.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253931.
HOGENOMi HOG000049065.
HOVERGENi HBG052337.
InParanoidi O94910.
KOi K04592.
OMAi DRIYVMP.
OrthoDBi EOG76DTRK.
PhylomeDBi O94910.
TreeFami TF351999.

Miscellaneous databases

GeneWikii LPHN1.
GenomeRNAii 22859.
NextBioi 43351.
PROi O94910.

Gene expression databases

ArrayExpressi O94910.
Bgeei O94910.
CleanExi HS_LPHN1.
Genevestigatori O94910.

Family and domain databases

InterProi IPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTi SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view ]
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Douangpanya J., Puri K., Hayflick J.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 636-1474.
    Tissue: Brain and Lung.
  5. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiLPHN1_HUMAN
AccessioniPrimary (citable) accession number: O94910
Secondary accession number(s): Q96IE7, Q9BU07, Q9HAR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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