Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adhesion G protein-coupled receptor L1

Gene

ADGRL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42CarbohydrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLectin

Protein family/group databases

MEROPSiP02.010

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L1Imported
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 1By similarity
Short name:
CIRL-1By similarity
Latrophilin-1Imported
Lectomedin-2
Gene namesi
Name:ADGRL1Imported
Synonyms:KIAA0821Imported, LEC2By similarity, LPHN1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000072071.16
HGNCiHGNC:20973 ADGRL1
MIMi616416 gene
neXtProtiNX_O94910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 858ExtracellularSequence analysisAdd BLAST834
Transmembranei859 – 879Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini880 – 893CytoplasmicSequence analysisAdd BLAST14
Transmembranei894 – 914Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini915 – 920ExtracellularSequence analysis6
Transmembranei921 – 941Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini942 – 964CytoplasmicSequence analysisAdd BLAST23
Transmembranei965 – 985Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini986 – 1002ExtracellularSequence analysisAdd BLAST17
Transmembranei1003 – 1023Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1024 – 1050CytoplasmicSequence analysisAdd BLAST27
Transmembranei1051 – 1071Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1072 – 1075ExtracellularSequence analysis4
Transmembranei1076 – 1096Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1097 – 1474CytoplasmicSequence analysisAdd BLAST378

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi22859
OpenTargetsiENSG00000072071
PharmGKBiPA134868822

Polymorphism and mutation databases

BioMutaiLPHN1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001290725 – 1474Adhesion G protein-coupled receptor L1Add BLAST1450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 71PROSITE-ProRule annotation
Disulfide bondi50 ↔ 128PROSITE-ProRule annotation
Disulfide bondi83 ↔ 115PROSITE-ProRule annotation
Disulfide bondi96 ↔ 102PROSITE-ProRule annotation
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 322PROSITE-ProRule annotation
Disulfide bondi480 ↔ 515PROSITE-ProRule annotation
Disulfide bondi503 ↔ 532PROSITE-ProRule annotation
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi742N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi801N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi802 ↔ 833PROSITE-ProRule annotation
Glycosylationi806N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi821 ↔ 835PROSITE-ProRule annotation
Glycosylationi827N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1194Omega-N-methylarginineBy similarity1
Modified residuei1220PhosphoserineBy similarity1
Modified residuei1473PhosphoserineBy similarity1

Post-translational modificationi

Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei838 – 839Cleavage; by autolysisBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiO94910
MaxQBiO94910
PaxDbiO94910
PeptideAtlasiO94910
PRIDEiO94910

PTM databases

iPTMnetiO94910
PhosphoSitePlusiO94910

Expressioni

Gene expression databases

BgeeiENSG00000072071
CleanExiHS_LPHN1
ExpressionAtlasiO94910 baseline and differential
GenevisibleiO94910 HS

Organism-specific databases

HPAiHPA037974

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain. Interacts (via extracellular domain) with FLRT1, FLRT2 and FLRT3 (via extracellular domain) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CACNA1AO005552EBI-3389315,EBI-766279

GO - Molecular functioni

Protein-protein interaction databases

BioGridi11652830 interactors.
IntActiO94910 2 interactors.
STRINGi9606.ENSP00000340688

Structurei

3D structure databases

ProteinModelPortaliO94910
SMRiO94910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 129SUEL-type lectinPROSITE-ProRule annotationAdd BLAST90
Domaini139 – 398Olfactomedin-likePROSITE-ProRule annotationAdd BLAST260
Domaini799 – 850GPSPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 120Carbohydrate bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi413 – 416Poly-Thr4
Compositional biasi1303 – 1314Poly-ProAdd BLAST12
Compositional biasi1315 – 1318Poly-Gly4
Compositional biasi1410 – 1420Poly-ProAdd BLAST11

Domaini

The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3545 Eukaryota
KOG4193 Eukaryota
KOG4729 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00900000140800
HOGENOMiHOG000049065
HOVERGENiHBG052337
InParanoidiO94910
KOiK04592
OMAiLHKMIRN
OrthoDBiEOG091G00GJ
PhylomeDBiO94910
TreeFamiTF351999

Family and domain databases

Gene3Di4.10.1240.101 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003924 GPCR_2_latrophilin
IPR003334 GPCR_2_latrophilin_rcpt_C
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR031234 Latrophilin-1
IPR000922 Lectin_gal-bd_dom
IPR003112 Olfac-like_dom
PANTHERiPTHR12011:SF62 PTHR12011:SF62, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF02354 Latrophilin, 1 hit
PF02191 OLF, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01444 LATROPHILIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51132 OLF, 1 hit
PS50228 SUEL_LECTIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC
60 70 80 90 100
PGSDVIMVEN ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT
110 120 130 140 150
QCVVVAGSDA FPDPCPGTYK YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP
160 170 180 190 200
TSTHESEHQS GAWCKDPLQA GDRIYVMPWI PYRTDTLTEY ASWEDYVAAR
210 220 230 240 250
HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT RIKSGETVIN
260 270 280 290 300
TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL
310 320 330 340 350
RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT
360 370 380 390 400
NANREEPVSL TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD
410 420 430 440 450
PSAGPATSPP LSTTTTARPT PLTSTASPAA TTPLRRAPLT THPVGAINQL
460 470 480 490 500
GPDLPPATAP VPSTRRPPAP NLHVSPELFC EPREVRRVQW PATQQGMLVE
510 520 530 540 550
RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV AQKIKSGENA
560 570 580 590 600
ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG
610 620 630 640 650
KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM
660 670 680 690 700
LLDVLEEGAF LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE
710 720 730 740 750
EYPRKNSIQL SAKTIKQNSR NGVVKVVFIL YNNLGLFLST ENATVKLAGE
760 770 780 790 800
AGPGGPGGAS LVVNSQVIAA SINKESSRVF LMDPVIFTVA HLEDKNHFNA
810 820 830 840 850
NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN FAVLMAHREI
860 870 880 890 900
YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC
910 920 930 940 950
INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL
960 970 980 990 1000
LLVEVFESEY SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD
1010 1020 1030 1040 1050
NYFIWSFIGP VSFVIVVNLV FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA
1060 1070 1080 1090 1100
LGAIALLFLL GLTWAFGLLF INKESVVMAY LFTTFNAFQG VFIFVFHCAL
1110 1120 1130 1140 1150
QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR YYTGTQSRIR
1160 1170 1180 1190 1200
RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY
1210 1220 1230 1240 1250
NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN
1260 1270 1280 1290 1300
SYSLRSGDFP PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA
1310 1320 1330 1340 1350
KGPPPPEPPV PPVPGGGGEE EAGGPGGADR AEIELLYKAL EEPLLLPRAQ
1360 1370 1380 1390 1400
SVLYQSDLDE SESCTAEDGA TSRPLSSPPG RDSLYASGAN LRDSPSYPDS
1410 1420 1430 1440 1450
SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY YQVRRPSHEG
1460 1470
YLAAPGLEGP GPDGDGQMQL VTSL
Length:1,474
Mass (Da):162,717
Last modified:May 1, 1999 - v1
Checksum:i6152EB2DE1385F5C
GO
Isoform 2 (identifier: O94910-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-137: KVEQKV → I

Show »
Length:1,469
Mass (Da):162,118
Checksum:i4907D329A56E57FF
GO

Sequence cautioni

The sequence BAA74844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1321E → V in AAH02974 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049463595E → Q. Corresponds to variant dbSNP:rs34759320Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010099132 – 137KVEQKV → I in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307079 mRNA Translation: AAG27461.1
AB020628 mRNA Translation: BAA74844.2 Different initiation.
AB065919 Genomic DNA Translation: BAC06134.1
BC002974 mRNA Translation: AAH02974.1
BC007587 mRNA Translation: AAH07587.1
CCDSiCCDS12307.1 [O94910-2]
CCDS32928.1 [O94910-1]
RefSeqiNP_001008701.1, NM_001008701.2 [O94910-1]
NP_055736.2, NM_014921.4 [O94910-2]
UniGeneiHs.94229

Genome annotation databases

EnsembliENST00000340736; ENSP00000340688; ENSG00000072071 [O94910-1]
ENST00000361434; ENSP00000355328; ENSG00000072071 [O94910-2]
GeneIDi22859
KEGGihsa:22859
UCSCiuc010xnn.3 human [O94910-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAGRL1_HUMAN
AccessioniPrimary (citable) accession number: O94910
Secondary accession number(s): Q96IE7, Q9BU07, Q9HAR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome