ID   DKK1_HUMAN              Reviewed;         266 AA.
AC   O94907;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   07-JUL-2009, entry version 76.
DE   RecName: Full=Dickkopf-related protein 1;
DE            Short=Dickkopf-1;
DE            Short=Dkk-1;
DE            Short=hDkk-1;
DE   AltName: Full=SK;
DE   Flags: Precursor;
GN   Name=DKK1; ORFNames=UNQ492/PRO1008;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Leiomyosarcoma;
RX   MEDLINE=99315900; PubMed=10383463; DOI=10.1074/jbc.274.27.19465;
RA   Fedi P., Bafico A., Nieto Soria A., Burgess W.H., Miki T.,
RA   Bottaro D.P., Kraus M.H., Aaronson S.A.;
RT   "Isolation and biochemical characterization of the human Dkk-1
RT   homologue, a novel inhibitor of mammalian Wnt signaling.";
RL   J. Biol. Chem. 274:19465-19472(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal kidney;
RX   MEDLINE=20035735; PubMed=10570958; DOI=10.1016/S0378-1119(99)00365-0;
RA   Krupnik V.E., Sharp J.D., Jiang C., Robison K., Chickering T.W.,
RA   Amaravadi L., Brown D.E., Guyot D., Mays G., Leiby K., Chang B.,
RA   Duong T., Goodearl A.D.J., Gearing D.P., Sokol S.Y., McCarthy S.A.;
RT   "Functional and structural diversity of the human Dickkopf gene
RT   family.";
RL   Gene 238:301-313(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Tate G., Suzuki T., Mitsuya T.;
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=20422487; PubMed=10965128;
RA   Roessler E., Du Y., Glinka A., Dutra A., Niehrs C., Muenke M.;
RT   "The genomic structure, chromosome location, and analysis of the human
RT   DKK1 head inducer gene as a candidate for holoprosencephaly.";
RL   Cytogenet. Cell Genet. 89:220-224(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PROTEIN SEQUENCE OF 32-46.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Inhibitor of Wnt signaling pathway.
CC   -!- INTERACTION:
CC       P31146:CORO1A; NbExp=1; IntAct=EBI-742864, EBI-1046676;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Placenta.
CC   -!- SIMILARITY: Belongs to the dickkopf family.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/DKK1ID44007ch10q11.html";
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DR   EMBL; AF127563; AAD21087.1; -; mRNA.
DR   EMBL; AF177394; AAF02674.1; -; mRNA.
DR   EMBL; AB020315; BAA34651.1; -; Genomic_DNA.
DR   EMBL; AF261158; AAG15544.1; -; Genomic_DNA.
DR   EMBL; AF261157; AAG15544.1; JOINED; Genomic_DNA.
DR   EMBL; AY359005; AAQ89364.1; -; mRNA.
DR   EMBL; BC001539; AAH01539.1; -; mRNA.
DR   IPI; IPI00016353; -.
DR   RefSeq; NP_036374.1; -.
DR   UniGene; Hs.40499; -.
DR   HSSP; P25687; 1IMT.
DR   IntAct; O94907; 2.
DR   PRIDE; O94907; -.
DR   Ensembl; ENSG00000107984; Homo sapiens.
DR   GeneID; 22943; -.
DR   KEGG; hsa:22943; -.
DR   UCSC; uc001jjr.1; human.
DR   GeneCards; GC10P053744; -.
DR   H-InvDB; HIX0008834; -.
DR   HGNC; HGNC:2891; DKK1.
DR   HPA; CAB009726; -.
DR   MIM; 605189; gene.
DR   PharmGKB; PA27345; -.
DR   HOGENOM; O94907; -.
DR   HOVERGEN; O94907; -.
DR   OMA; O94907; GNYCKNG.
DR   Pathway_Interaction_DB; wnt_canonical_pathway; Canonical Wnt signaling pathway.
DR   Pathway_Interaction_DB; ps1pathway; Presenilin action in Notch and Wnt signaling.
DR   NextBio; 43697; -.
DR   PMAP-CutDB; O94907; -.
DR   ArrayExpress; O94907; -.
DR   Bgee; O94907; -.
DR   CleanEx; HS_DKK1; -.
DR   GermOnline; ENSG00000107984; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0008083; F:growth factor activity; TAS:ProtInc.
DR   GO; GO:0050750; F:low-density lipoprotein receptor binding; IDA:MGI.
DR   GO; GO:0004871; F:signal transducer activity; TAS:ProtInc.
DR   GO; GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR006796; Dickkopf_N.
DR   Pfam; PF04706; Dickkopf_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; Direct protein sequencing;
KW   Glycoprotein; Secreted; Signal; Wnt signaling pathway.
FT   SIGNAL        1     31
FT   CHAIN        32    266       Dickkopf-related protein 1.
FT                                /FTId=PRO_0000007218.
FT   REGION       85    138       DKK-type Cys-1.
FT   REGION      189    263       DKK-type Cys-2.
FT   CARBOHYD    256    256       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   266 AA;  28672 MW;  5E878B2CCE4236BA CRC64;
     MMALGAAGAT RVFVAMVAAA LGGHPLLGVS ATLNSVLNSN AIKNLPPPLG GAAGHPGSAV
     SAAPGILYPG GNKYQTIDNY QPYPCAEDEE CGTDEYCASP TRGGDAGVQI CLACRKRRKR
     CMRHAMCCPG NYCKNGICVS SDQNHFRGEI EETITESFGN DHSTLDGYSR RTTLSSKMYH
     TKGQEGSVCL RSSDCASGLC CARHFWSKIC KPVLKEGQVC TKHRRKGSHG LEIFQRCYCG
     EGLSCRIQKD HHQASNSSRL HTCQRH
//