Reviewed,
UniProtKB/Swiss-Prot O94907 (DKK1_HUMAN)
Last modified
June 16, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dickkopf-related protein 1 Short name=Dickkopf-1 Short name=Dkk-1 Short name=hDkk-1 Alternative name(s): SK | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 266 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Inhibitor of Wnt signaling pathway. |
| Subcellular location | |
| Tissue specificity | Placenta. |
| Sequence similarities | Belongs to the dickkopf family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Wnt signaling pathway |
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Developmental protein |
| PTM | Glycoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from direct assay. Source: MGI |
| Molecular function | growth factor activity Ref.1 Traceable author statement. Source: ProtInc low-density lipoprotein receptor bindingInferred from direct assay. Source: MGI signal transducer activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 31 | 31 | Ref.7 | ||||||
| Chain | 32 – 266 | 235 | Dickkopf-related protein 1 | PRO_0000007218 | |||||
Regions | |||||||||
| Region | 85 – 138 | 54 | DKK-type Cys-1 | ||||||
| Region | 189 – 263 | 75 | DKK-type Cys-2 | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 256 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling." Fedi P., Bafico A., Nieto Soria A., Burgess W.H., Miki T., Bottaro D.P., Kraus M.H., Aaronson S.A. J. Biol. Chem. 274:19465-19472(1999) [PubMed: 10383463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leiomyosarcoma. |
| [2] | "Functional and structural diversity of the human Dickkopf gene family." Krupnik V.E., Sharp J.D., Jiang C., Robison K., Chickering T.W., Amaravadi L., Brown D.E., Guyot D., Mays G., Leiby K., Chang B., Duong T., Goodearl A.D.J., Gearing D.P., Sokol S.Y., McCarthy S.A. Gene 238:301-313(1999) [PubMed: 10570958] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal kidney. |
| [3] | Tate G., Suzuki T., Mitsuya T. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly." Roessler E., Du Y., Glinka A., Dutra A., Niehrs C., Muenke M. Cytogenet. Cell Genet. 89:220-224(2000) [PubMed: 10965128] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [7] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 32-46. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF127563 mRNA. Translation: AAD21087.1. AF177394 mRNA. Translation: AAF02674.1. AB020315 Genomic DNA. Translation: BAA34651.1. AF261158, AF261157 Genomic DNA. Translation: AAG15544.1. AY359005 mRNA. Translation: AAQ89364.1. BC001539 mRNA. Translation: AAH01539.1. | |
| IPI | IPI00016353. |
| RefSeq | NP_036374.1. |
| UniGene | Hs.40499 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IMT based on UniProtKB P25687. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O94907. 2 interactions. |
Proteomic databases | |
| PRIDE | O94907. |
Genome annotation databases | |
| Ensembl | ENSG00000107984. Homo sapiens. [Contig view] |
| GeneID | 22943. |
| KEGG | hsa:22943. |
Organism-specific databases | |
| GeneCards | GC10P053744. |
| H-InvDB | HIX0008834. |
| HGNC | HGNC:2891. DKK1. |
| HPA | CAB009726. |
| MIM | 605189. gene. |
| PharmGKB | PA27345. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O94907. |
| HOVERGEN | O94907. |
| OMA | O94907. GNYCKNG. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | wnt_canonical_pathway. Canonical Wnt signaling pathway. ps1pathway. Presenilin action in Notch and Wnt signaling. |
Gene expression databases | |
| ArrayExpress | O94907. |
| Bgee | O94907. |
| CleanEx | HS_DKK1. |
| GermOnline | ENSG00000107984. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006796. Dickkopf_N. [Graphical view] |
| Pfam | PF04706. Dickkopf_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 43697. |
| PMAP-CutDB | O94907. |
| SOURCE | Search... |
Entry information
| Entry name | DKK1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O94907 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


