Reviewed, UniProtKB/Swiss-Prot O94907 (DKK1_HUMAN)

Names and origin

Protein names

Recommended name:
    Dickkopf-related protein 1
      Short name=Dickkopf-1
      Short name=Dkk-1
      Short name=hDkk-1
Alternative name(s):
    SK

Gene names

Name:	DKK1
ORF Names:	UNQ492/PRO1008

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibitor of Wnt signaling pathway.
Subcellular location	Secreted.
Tissue specificity	Placenta.
Sequence similarities	Belongs to the dickkopf family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: MGI
Molecular function	growth factor activity Ref.1 Traceable author statement. Source: ProtInc low-density lipoprotein receptor binding Inferred from direct assay. Source: MGI signal transducer activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CORO1A	P31146	1	EBI-742864,EBI-1046676

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Ref.7
	Chain	32 – 266	235	Dickkopf-related protein 1		PRO_0000007218
Regions
	Region	85 – 138	54	DKK-type Cys-1
	Region	189 – 263	75	DKK-type Cys-2
Amino acid modifications
	Glycosylation	256	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O94907-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 5E878B2CCE4236BA	FASTA	266	28,672
	10 20 30 40 50 60 MMALGAAGAT RVFVAMVAAA LGGHPLLGVS ATLNSVLNSN AIKNLPPPLG GAAGHPGSAV 70 80 90 100 110 120 SAAPGILYPG GNKYQTIDNY QPYPCAEDEE CGTDEYCASP TRGGDAGVQI CLACRKRRKR 130 140 150 160 170 180 CMRHAMCCPG NYCKNGICVS SDQNHFRGEI EETITESFGN DHSTLDGYSR RTTLSSKMYH 190 200 210 220 230 240 TKGQEGSVCL RSSDCASGLC CARHFWSKIC KPVLKEGQVC TKHRRKGSHG LEIFQRCYCG 250 260 EGLSCRIQKD HHQASNSSRL HTCQRH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling." Fedi P., Bafico A., Nieto Soria A., Burgess W.H., Miki T., Bottaro D.P., Kraus M.H., Aaronson S.A. J. Biol. Chem. 274:19465-19472(1999) [PubMed: 10383463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leiomyosarcoma.
[2]	"Functional and structural diversity of the human Dickkopf gene family." Krupnik V.E., Sharp J.D., Jiang C., Robison K., Chickering T.W., Amaravadi L., Brown D.E., Guyot D., Mays G., Leiby K., Chang B., Duong T., Goodearl A.D.J., Gearing D.P., Sokol S.Y., McCarthy S.A. Gene 238:301-313(1999) [PubMed: 10570958] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal kidney.
[3]	Tate G., Suzuki T., Mitsuya T. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly." Roessler E., Du Y., Glinka A., Dutra A., Niehrs C., Muenke M. Cytogenet. Cell Genet. 89:220-224(2000) [PubMed: 10965128] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 32-46.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF127563 mRNA. Translation: AAD21087.1. AF177394 mRNA. Translation: AAF02674.1. AB020315 Genomic DNA. Translation: BAA34651.1. AF261158, AF261157 Genomic DNA. Translation: AAG15544.1. AY359005 mRNA. Translation: AAQ89364.1. BC001539 mRNA. Translation: AAH01539.1.
IPI	IPI00016353.
RefSeq	NP_036374.1.
UniGene	Hs.40499
3D structure databases
HSSP	HSSP built from PDB template 1IMT based on UniProtKB P25687.
ModBase	Search...
Protein-protein interaction databases
IntAct	O94907. 2 interactions.
Proteomic databases
PRIDE	O94907.
Genome annotation databases
Ensembl	ENSG00000107984. Homo sapiens. [Contig view]
GeneID	22943.
KEGG	hsa:22943.
Organism-specific databases
GeneCards	GC10P053744.
H-InvDB	HIX0008834.
HGNC	HGNC:2891. DKK1.
HPA	CAB009726.
MIM	605189. gene.
PharmGKB	PA27345.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O94907.
HOVERGEN	O94907.
OMA	O94907. GNYCKNG.
Enzyme and pathway databases
Pathway_Interaction_DB	wnt_canonical_pathway. Canonical Wnt signaling pathway. ps1pathway. Presenilin action in Notch and Wnt signaling.
Gene expression databases
ArrayExpress	O94907.
Bgee	O94907.
CleanEx	HS_DKK1.
GermOnline	ENSG00000107984. Homo sapiens.
Family and domain databases
InterPro	IPR006796. Dickkopf_N. [Graphical view]
Pfam	PF04706. Dickkopf_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	43697.
PMAP-CutDB	O94907.
SOURCE	Search...

Entry information

Entry name

DKK1_HUMAN

Accession

Primary (citable) accession number: O94907

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)