DKK1

Functionⁱ

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).1 PublicationBy similarity1 Publication

GO - Molecular functionⁱ

co-receptor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 11433302
- 20093360
growth factor activity
Source: ProtInc
Traceable author statementⁱ
- 10383463
low-density lipoprotein particle receptor binding
Source: MGI
Inferred from direct assayⁱ
- 16263759
receptor antagonist activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 20723538
signal transducer activity
Source: ProtInc
Traceable author statementⁱ
- 10383463

Complete GO annotation...

GO - Biological processⁱ

cell morphogenesis involved in differentiation Source: Ensembl
embryonic limb morphogenesis Source: Ensembl
endoderm formation Source: Ensembl
face morphogenesis Source: Ensembl
forebrain development Source: Ensembl
hair follicle development Source: Ensembl
learning or memory Source: ARUK-UCL
limb development Source: UniProtKB
mesoderm formation Source: Ensembl
modulation of age-related behavioral decline Source: ARUK-UCL
motor learning Source: Ensembl
negative regulation of apoptotic process Source: UniProtKB
negative regulation of BMP signaling pathway Source: Ensembl
negative regulation of canonical Wnt signaling pathway
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
Source: BHF-UCL
Inferred from direct assayⁱ
- 20559569
negative regulation of cardiac muscle cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 20559569
negative regulation of mesodermal cell fate specification
Source: BHF-UCL
Inferred from direct assayⁱ
- 20559569
negative regulation of ossification Source: UniProtKB
negative regulation of pathway-restricted SMAD protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 20559569
negative regulation of peptidyl-serine phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 20723538
negative regulation of protein binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 20093360
negative regulation of skeletal muscle tissue development Source: Ensembl
negative regulation of transcription from RNA polymerase II promoter
Source: BHF-UCL
Inferred from direct assayⁱ
- 20723538
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 20093360
- 11448771
negative regulation of Wnt signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 22615920
positive regulation of cell death
Source: ARUK-UCL
Traceable author statementⁱ
- 23164821
positive regulation of gene expression
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 23164821
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
positive regulation of JUN kinase activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- 23164821
positive regulation of midbrain dopaminergic neuron differentiation Source: Ensembl
positive regulation of neuron death Source: ARUK-UCL
positive regulation of tau-protein kinase activity Source: ARUK-UCL
positive regulation of Wnt signaling pathway, calcium modulating pathway
Source: ARUK-UCL
Traceable author statementⁱ
- 23164821
positive regulation of Wnt signaling pathway, planar cell polarity pathway
Source: ARUK-UCL
Traceable author statementⁱ
- 23164821
regulation of dopaminergic neuron differentiation
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302
regulation of endodermal cell fate specification
Source: BHF-UCL
Inferred from direct assayⁱ
- 20559569
regulation of receptor internalization
Source: BHF-UCL
Inferred from direct assayⁱ
- 17804805
regulation of synapse organization Source: Ensembl
regulation of synaptic transmission, glutamatergic Source: Ensembl
response to retinoic acid Source: Ensembl
synapse disassembly
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24449494
Wnt signaling pathway involved in somitogenesis Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201681. TCF dependent signaling in response to WNT. R-HSA-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists. R-HSA-5339717. Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling.
SignaLinkⁱ	O94907.
SIGNORⁱ	O94907.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dickkopf-related protein 1 Short name: Dickkopf-1 Short name: Dkk-1 Short name: hDkk-1 Alternative name(s): SK
Gene namesⁱ	Name:DKK1 ORF Names:UNQ492/PRO1008
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2891. DKK1.

HGNCⁱ

HGNC:2891. DKK1.

Subcellular locationⁱ

Secreted

GO - Cellular componentⁱ

early endosome membrane Source: Reactome
extracellular region Source: Reactome
extracellular space
Source: BHF-UCL
Inferred from direct assayⁱ
- 11448771
- 11742004
plasma membrane
Source: MGI
Inferred from direct assayⁱ
- 16263759

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	22943.
MalaCards human disease database More...MalaCardsⁱ	DKK1.
Open Targets More...OpenTargetsⁱ	ENSG00000107984.
Orphanetⁱ	85193. Idiopathic juvenile osteoporosis.
PharmGKBⁱ	PA27345.

Chemistry databases

ChEMBLⁱ	CHEMBL6024.

ChEMBLⁱ

CHEMBL6024.

Polymorphism and mutation databases

BioMutaⁱ	DKK1.

BioMutaⁱ

DKK1.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 31	1 PublicationAdd BLAST		31
ChainⁱPRO_0000007218	32 – 266	Dickkopf-related protein 1Add BLAST		235

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	61	O-linked (GalNAc...) serine1 Publication	1
Disulfide bondⁱ	85 ↔ 97
Disulfide bondⁱ	91 ↔ 111
Disulfide bondⁱ	114 ↔ 128
Disulfide bondⁱ	121 ↔ 133
Disulfide bondⁱ	127 ↔ 138
Disulfide bondⁱ	189 ↔ 201
Disulfide bondⁱ	195 ↔ 210
Disulfide bondⁱ	200 ↔ 237
Disulfide bondⁱ	220 ↔ 245
Disulfide bondⁱ	239 ↔ 263
Glycosylationⁱ	256	N-linked (GlcNAc...) asparagine1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	O94907.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94907.
PaxDbⁱ	O94907.
PeptideAtlas More...PeptideAtlasⁱ	O94907.
PRIDEⁱ	O94907.

PTM databases

iPTMnetⁱ	O94907.
PhosphoSitePlusⁱ	O94907.

Miscellaneous databases

PMAP-CutDBⁱ	O94907.

PMAP-CutDBⁱ

O94907.

Expressionⁱ

Tissue specificityⁱ

Placenta.

Gene expression databases

Bgeeⁱ	ENSG00000107984.
CleanExⁱ	HS_DKK1.
ExpressionAtlasⁱ	O94907. baseline and differential.
Genevisibleⁱ	O94907. HS.

Interactionⁱ

Subunit structureⁱ

Interacts with LRP6 (PubMed:11448771, PubMed:17804805, PubMed:20093360, PubMed:22000856). Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling (PubMed:19746449). Forms a ternary complex with LRP6 and KREM1 (PubMed:27524201). Interacts with KREM1 (PubMed:17804805).6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LRP6	O75581	3	EBI-742864,EBI-910915
MDFI	Q99750	3	EBI-742864,EBI-724076

Show more details

GO - Molecular functionⁱ

co-receptor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 11433302
- 20093360
growth factor activity
Source: ProtInc
Traceable author statementⁱ
- 10383463
low-density lipoprotein particle receptor binding
Source: MGI
Inferred from direct assayⁱ
- 16263759
receptor antagonist activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 20723538

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	116599. 15 interactors.
Database of interacting proteins More...DIPⁱ	DIP-46461N.
IntActⁱ	O94907. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1196808.
STRINGⁱ	9606.ENSP00000363081.

Chemistry databases

BindingDBⁱ

O94907.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	192 – 194	Combined sources	3
Beta strandⁱ	199 – 204	Combined sources	6
Beta strandⁱ	207 – 212	Combined sources	6
Beta strandⁱ	218 – 220	Combined sources	3
Helixⁱ	226 – 231	Combined sources	6
Beta strandⁱ	243 – 247	Combined sources	5
Beta strandⁱ	261 – 265	Combined sources	5

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3S2K	X-ray	2.80	C	178-266	[»]
	3S8V	X-ray	3.10	X	183-266	[»]
	3SOQ	X-ray	1.90	Z	38-44	[»]
	5FWW	X-ray	3.50	C	182-266	[»]
	5GJE	electron microscopy	21.00	C	182-266	[»]
ProteinModelPortalⁱ	O94907.
SMRⁱ	O94907.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	85 – 138	DKK-type Cys-1Add BLAST		54
Regionⁱ	189 – 263	DKK-type Cys-2Add BLAST		75

Domainⁱ

The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.By similarity

Sequence similaritiesⁱ

Belongs to the dickkopf family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IRWP. Eukaryota. ENOG4111FNB. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007000.
HOGENOMⁱ	HOG000246998.
HOVERGENⁱ	HBG000441.
InParanoidⁱ	O94907.
KEGG Orthology (KO) More...KOⁱ	K02165.
OMAⁱ	YHTKGQE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H13.
PhylomeDBⁱ	O94907.
TreeFamⁱ	TF330916.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006796. Dickkopf_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04706. Dickkopf_N. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O94907-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMALGAAGAT RVFVAMVAAA LGGHPLLGVS ATLNSVLNSN AIKNLPPPLG 
        60         70         80         90        100
GAAGHPGSAV SAAPGILYPG GNKYQTIDNY QPYPCAEDEE CGTDEYCASP 
       110        120        130        140        150
TRGGDAGVQI CLACRKRRKR CMRHAMCCPG NYCKNGICVS SDQNHFRGEI 
       160        170        180        190        200
EETITESFGN DHSTLDGYSR RTTLSSKMYH TKGQEGSVCL RSSDCASGLC 
       210        220        230        240        250
CARHFWSKIC KPVLKEGQVC TKHRRKGSHG LEIFQRCYCG EGLSCRIQKD 
       260 
HHQASNSSRL HTCQRH

Length:266

Mass (Da):28,672

Last modified:May 1, 1999 - v1

Checksum:ⁱ5E878B2CCE4236BA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF127563 mRNA. Translation: AAD21087.1. AF177394 mRNA. Translation: AAF02674.1. AB020315 Genomic DNA. Translation: BAA34651.1. AF261158, AF261157 Genomic DNA. Translation: AAG15544.1. AY359005 mRNA. Translation: AAQ89364.1. AK314902 mRNA. Translation: BAG37416.1. CH471083 Genomic DNA. Translation: EAW54144.1. BC001539 mRNA. Translation: AAH01539.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7246.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_036374.1. NM_012242.2.
UniGeneⁱ	Hs.40499.

Genome annotation databases

Ensemblⁱ	ENST00000373970; ENSP00000363081; ENSG00000107984.
GeneIDⁱ	22943.
KEGGⁱ	hsa:22943.
UCSC genome browser More...UCSCⁱ	uc001jjr.4. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF127563 mRNA. Translation: AAD21087.1. AF177394 mRNA. Translation: AAF02674.1. AB020315 Genomic DNA. Translation: BAA34651.1. AF261158, AF261157 Genomic DNA. Translation: AAG15544.1. AY359005 mRNA. Translation: AAQ89364.1. AK314902 mRNA. Translation: BAG37416.1. CH471083 Genomic DNA. Translation: EAW54144.1. BC001539 mRNA. Translation: AAH01539.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7246.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_036374.1. NM_012242.2.
UniGeneⁱ	Hs.40499.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3S2K	X-ray	2.80	C	178-266	[»]
	3S8V	X-ray	3.10	X	183-266	[»]
	3SOQ	X-ray	1.90	Z	38-44	[»]
	5FWW	X-ray	3.50	C	182-266	[»]
	5GJE	electron microscopy	21.00	C	182-266	[»]
ProteinModelPortalⁱ	O94907.
SMRⁱ	O94907.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116599. 15 interactors.
Database of interacting proteins More...DIPⁱ	DIP-46461N.
IntActⁱ	O94907. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1196808.
STRINGⁱ	9606.ENSP00000363081.

Chemistry databases

BindingDBⁱ	O94907.
ChEMBLⁱ	CHEMBL6024.

PTM databases

iPTMnetⁱ	O94907.
PhosphoSitePlusⁱ	O94907.

Polymorphism and mutation databases

BioMutaⁱ	DKK1.

BioMutaⁱ

DKK1.

Proteomic databases

EPDⁱ	O94907.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94907.
PaxDbⁱ	O94907.
PeptideAtlas More...PeptideAtlasⁱ	O94907.
PRIDEⁱ	O94907.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	22943.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373970; ENSP00000363081; ENSG00000107984.
GeneIDⁱ	22943.
KEGGⁱ	hsa:22943.
UCSC genome browser More...UCSCⁱ	uc001jjr.4. human.

Organism-specific databases

CTDⁱ	22943.
DisGeNET More...DisGeNETⁱ	22943.
GeneCardsⁱ	DKK1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2891. DKK1.
MalaCards human disease database More...MalaCardsⁱ	DKK1.
MIMⁱ	605189. gene.
neXtProtⁱ	NX_O94907.
Open Targets More...OpenTargetsⁱ	ENSG00000107984.
Orphanetⁱ	85193. Idiopathic juvenile osteoporosis.
PharmGKBⁱ	PA27345.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IRWP. Eukaryota. ENOG4111FNB. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007000.
HOGENOMⁱ	HOG000246998.
HOVERGENⁱ	HBG000441.
InParanoidⁱ	O94907.
KEGG Orthology (KO) More...KOⁱ	K02165.
OMAⁱ	YHTKGQE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H13.
PhylomeDBⁱ	O94907.
TreeFamⁱ	TF330916.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201681. TCF dependent signaling in response to WNT. R-HSA-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists. R-HSA-5339717. Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling.
SignaLinkⁱ	O94907.
SIGNORⁱ	O94907.

Miscellaneous databases

ChiTaRSⁱ	DKK1. human.
GeneWikiⁱ	DKK1.
GenomeRNAiⁱ	22943.
PMAP-CutDBⁱ	O94907.
Protein Ontology More...PROⁱ	PR:O94907.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107984.
CleanExⁱ	HS_DKK1.
ExpressionAtlasⁱ	O94907. baseline and differential.
Genevisibleⁱ	O94907. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006796. Dickkopf_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04706. Dickkopf_N. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DKK1_HUMAN
Accessionⁱ	O94907Primary (citable) accession number: O94907 Secondary accession number(s): B2RC19
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	May 1, 1999
	Last modified:	July 5, 2017
	This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O94907 (DKK1_HUMAN)

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Dickkopf-related protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ