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O94906

- PRP6_HUMAN

UniProt

O94906 - PRP6_HUMAN

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Protein

Pre-mRNA-processing factor 6

Gene

PRPF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.1 Publication

GO - Molecular functioni

  1. androgen receptor binding Source: MGI
  2. poly(A) RNA binding Source: UniProtKB
  3. ribonucleoprotein complex binding Source: BHF-UCL
  4. RNA binding Source: MGI
  5. transcription coactivator activity Source: MGI

GO - Biological processi

  1. gene expression Source: Reactome
  2. mRNA splicing, via spliceosome Source: UniProtKB
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  4. RNA localization Source: MGI
  5. RNA splicing Source: UniProtKB
  6. RNA splicing, via transesterification reactions Source: UniProtKB
  7. spliceosomal complex assembly Source: UniProtKB
  8. spliceosomal tri-snRNP complex assembly Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiREACT_1753. mRNA Splicing - Minor Pathway.
REACT_467. mRNA Splicing - Major Pathway.
SignaLinkiO94906.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 6
Alternative name(s):
Androgen receptor N-terminal domain-transactivating protein 1
Short name:
ANT-1
PRP6 homolog
U5 snRNP-associated 102 kDa protein
Short name:
U5-102 kDa protein
Gene namesi
Name:PRPF6
Synonyms:C20orf14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15860. PRPF6.

Subcellular locationi

Nucleusnucleoplasm. Nucleus speckle
Note: Localized in splicing speckles.

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: UniProtKB
  2. membrane Source: UniProtKB
  3. nucleoplasm Source: Reactome
  4. nucleus Source: HPA
  5. spliceosomal complex Source: UniProtKB
  6. U4/U6 snRNP Source: BHF-UCL
  7. U4/U6 x U5 tri-snRNP complex Source: BHF-UCL
  8. U5 snRNP Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Involvement in diseasei

Retinitis pigmentosa 60 (RP60) [MIM:613983]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.1 Publication
Note: The disease may be caused by mutations affecting the gene represented in this entry. Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti729 – 7291R → W in RP60; mislocalized in Cajal bodies; partial loss of localization in splicing speckles. 1 Publication
VAR_065768

Keywords - Diseasei

Disease mutation, Retinitis pigmentosa

Organism-specific databases

MIMi613983. phenotype.
Orphaneti791. Retinitis pigmentosa.
PharmGKBiPA25682.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Pre-mRNA-processing factor 6PRO_0000205759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661Phosphothreonine2 Publications
Modified residuei275 – 2751Phosphothreonine2 Publications
Modified residuei279 – 2791Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94906.
PaxDbiO94906.
PeptideAtlasiO94906.
PRIDEiO94906.

PTM databases

PhosphoSiteiO94906.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiO94906.
CleanExiHS_PRPF6.
GenevestigatoriO94906.

Organism-specific databases

HPAiHPA047106.

Interactioni

Subunit structurei

Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Identified in the spliceosome C complex. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARAFP103984EBI-536755,EBI-365961
CD2BP2O954004EBI-536755,EBI-768015
IKQ131232EBI-536755,EBI-713456
PRPF31Q8WWY32EBI-536755,EBI-1567797

Protein-protein interaction databases

BioGridi117298. 81 interactions.
DIPiDIP-29006N.
IntActiO94906. 25 interactions.
MINTiMINT-260551.
STRINGi9606.ENSP00000266079.

Structurei

3D structure databases

ProteinModelPortaliO94906.
SMRiO94906. Positions 287-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati384 – 41633HAT 1Add
BLAST
Repeati418 – 44427HAT 2Add
BLAST
Repeati445 – 47632HAT 3Add
BLAST
Repeati554 – 58633HAT 4Add
BLAST
Repeati588 – 62033HAT 5Add
BLAST
Repeati622 – 65433HAT 6Add
BLAST
Repeati689 – 72133HAT 7Add
BLAST
Repeati723 – 75533HAT 8Add
BLAST
Repeati855 – 88733HAT 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 726Poly-Asp

Sequence similaritiesi

Contains 9 HAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00550000075016.
HOVERGENiHBG023330.
InParanoidiO94906.
KOiK12855.
OMAiRQRFYAV.
OrthoDBiEOG7RV9FB.
PhylomeDBiO94906.
TreeFamiTF105743.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR003107. HAT.
IPR010491. PRP1_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF06424. PRP1_N. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O94906-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP
60 70 80 90 100
PGKRTVGDQM KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE
110 120 130 140 150
ADAIYAALDK RMDERRKERR EQREKEEIEK YRMERPKIQQ QFSDLKRKLA
160 170 180 190 200
EVTEEEWLSI PEVGDARNKR QRNPRYEKLT PVPDSFFAKH LQTGENHTSV
210 220 230 240 250
DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM RKIGQARNTL
260 270 280 290 300
MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS
310 320 330 340 350
VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA
360 370 380 390 400
RLQPGDTAKA VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV
410 420 430 440 450
PNSVRLWKAA VELEEPEDAR IMLSRAVECC PTSVELWLAL ARLETYENAR
460 470 480 490 500
KVLNKARENI PTDRHIWITA AKLEEANGNT QMVEKIIDRA ITSLRANGVE
510 520 530 540 550
INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK HTWMEDADSC
560 570 580 590 600
VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA
610 620 630 640 650
VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK
660 670 680 690 700
LESENDEYER ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE
710 720 730 740 750
ALRHYEDFPK LWMMKGQIEE QKEMMEKARE AYNQGLKKCP HSTPLWLLLS
760 770 780 790 800
RLEEKIGQLT RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM
810 820 830 840 850
AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD PHVLLAVAKL
860 870 880 890 900
FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR
910 920 930 940
CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F
Length:941
Mass (Da):106,925
Last modified:May 1, 1999 - v1
Checksum:i91C2F1ADCA439BE9
GO
Isoform 2 (identifier: O94906-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-676: Missing.

Note: No experimental confirmation available.

Show »
Length:901
Mass (Da):102,429
Checksum:i23ADD30A75374402
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201G → W in AAD01798. (PubMed:10848612)Curated
Sequence conflicti223 – 2231P → R in AAD01798. (PubMed:10848612)Curated
Sequence conflicti284 – 2841H → R in BAG50938. (PubMed:14702039)Curated
Sequence conflicti421 – 4211I → T in BAG36962. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti477 – 4771N → S Very rare variant found in a family with neuronal ceroid lipofuscinosis carrying a causative mutation in DNAJC5; uncertain role as a disease phenotype modifier. 1 Publication
VAR_069766
Natural varianti729 – 7291R → W in RP60; mislocalized in Cajal bodies; partial loss of localization in splicing speckles. 1 Publication
VAR_065768

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei637 – 67640Missing in isoform 2. 1 PublicationVSP_041857Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019219 mRNA. Translation: BAA37140.1.
AF221842 mRNA. Translation: AAF66128.1.
AF026031 mRNA. Translation: AAD01798.1.
AK001554 mRNA. Translation: BAG50938.1.
AK314310 mRNA. Translation: BAG36962.1.
AL356790, AL118506, AL355803 Genomic DNA. Translation: CAH71582.1.
AL118506, AL355803, AL356790 Genomic DNA. Translation: CAI21906.1.
AL355803, AL118506, AL356790 Genomic DNA. Translation: CAC16610.2.
BC001666 mRNA. Translation: AAH01666.1.
AL137320 mRNA. Translation: CAB70695.1.
CCDSiCCDS13550.1. [O94906-1]
PIRiT46386.
RefSeqiNP_036601.2. NM_012469.3. [O94906-1]
UniGeneiHs.31334.

Genome annotation databases

EnsembliENST00000266079; ENSP00000266079; ENSG00000101161. [O94906-1]
GeneIDi24148.
KEGGihsa:24148.
UCSCiuc002yho.3. human. [O94906-1]
uc002yhp.3. human. [O94906-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019219 mRNA. Translation: BAA37140.1 .
AF221842 mRNA. Translation: AAF66128.1 .
AF026031 mRNA. Translation: AAD01798.1 .
AK001554 mRNA. Translation: BAG50938.1 .
AK314310 mRNA. Translation: BAG36962.1 .
AL356790 , AL118506 , AL355803 Genomic DNA. Translation: CAH71582.1 .
AL118506 , AL355803 , AL356790 Genomic DNA. Translation: CAI21906.1 .
AL355803 , AL118506 , AL356790 Genomic DNA. Translation: CAC16610.2 .
BC001666 mRNA. Translation: AAH01666.1 .
AL137320 mRNA. Translation: CAB70695.1 .
CCDSi CCDS13550.1. [O94906-1 ]
PIRi T46386.
RefSeqi NP_036601.2. NM_012469.3. [O94906-1 ]
UniGenei Hs.31334.

3D structure databases

ProteinModelPortali O94906.
SMRi O94906. Positions 287-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117298. 81 interactions.
DIPi DIP-29006N.
IntActi O94906. 25 interactions.
MINTi MINT-260551.
STRINGi 9606.ENSP00000266079.

PTM databases

PhosphoSitei O94906.

Proteomic databases

MaxQBi O94906.
PaxDbi O94906.
PeptideAtlasi O94906.
PRIDEi O94906.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266079 ; ENSP00000266079 ; ENSG00000101161 . [O94906-1 ]
GeneIDi 24148.
KEGGi hsa:24148.
UCSCi uc002yho.3. human. [O94906-1 ]
uc002yhp.3. human. [O94906-2 ]

Organism-specific databases

CTDi 24148.
GeneCardsi GC20P062612.
GeneReviewsi PRPF6.
HGNCi HGNC:15860. PRPF6.
HPAi HPA047106.
MIMi 613979. gene.
613983. phenotype.
neXtProti NX_O94906.
Orphaneti 791. Retinitis pigmentosa.
PharmGKBi PA25682.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0457.
GeneTreei ENSGT00550000075016.
HOVERGENi HBG023330.
InParanoidi O94906.
KOi K12855.
OMAi RQRFYAV.
OrthoDBi EOG7RV9FB.
PhylomeDBi O94906.
TreeFami TF105743.

Enzyme and pathway databases

Reactomei REACT_1753. mRNA Splicing - Minor Pathway.
REACT_467. mRNA Splicing - Major Pathway.
SignaLinki O94906.

Miscellaneous databases

ChiTaRSi PRPF6. human.
GeneWikii PRPF6.
GenomeRNAii 24148.
NextBioi 46847.
PROi O94906.
SOURCEi Search...

Gene expression databases

Bgeei O94906.
CleanExi HS_PRPF6.
Genevestigatori O94906.

Family and domain databases

Gene3Di 1.25.40.10. 4 hits.
InterProi IPR003107. HAT.
IPR010491. PRP1_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF06424. PRP1_N. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view ]
SMARTi SM00386. HAT. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors."
    Nishikimi A., Mukai J., Kioka N., Yamada M.
    Biochim. Biophys. Acta 1435:147-152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 138-147; 300-309; 352-359; 776-784 AND 891-898, SUBCELLULAR LOCATION.
    Tissue: Cervix carcinoma.
  2. "The human homologue of the yeast splicing factor Prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions."
    Makarov E.M., Makarova O.V., Achsel T., Luehrmann R.
    J. Mol. Biol. 298:567-575(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 324-334; 395-408; 755-768; 871-883 AND 917-924, INTERACTION WITH U5 AND U4/U6 SNRNPS.
    Tissue: Cervix carcinoma.
  3. "Isoform-specific localization of A-RAF in mitochondria."
    Yuryev A., Ono M., Goff S.A., Macaluso F., Wennogle L.P.
    Mol. Cell. Biol. 20:4870-4878(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH ARAF1.
    Tissue: Cervix carcinoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma and Testis.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-941.
    Tissue: Testis.
  8. "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor."
    Zhao Y., Goto K., Saitoh M., Yanase T., Nomura M., Okabe T., Takayanagi R., Nawata H.
    J. Biol. Chem. 277:30031-30039(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AR AND NR3C1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
    Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
    RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
  10. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."
    Liu S., Rauhut R., Vornlocher H.-P., Luehrmann R.
    RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266; THR-275 AND SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266; THR-275 AND SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa."
    Tanackovic G., Ransijn A., Ayuso C., Harper S., Berson E.L., Rivolta C.
    Am. J. Hum. Genet. 88:643-649(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT RP60 TRP-729, SUBCELLULAR LOCATION.
  16. "Mutations in the gene DNAJC5 cause autosomal dominant Kufs disease in a proportion of cases: study of the Parry family and 8 other families."
    Velinov M., Dolzhanskaya N., Gonzalez M., Powell E., Konidari I., Hulme W., Staropoli J.F., Xin W., Wen G.Y., Barone R., Coppel S.H., Sims K., Brown W.T., Zuchner S.
    PLoS ONE 7:E29729-E29729(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-477.

Entry informationi

Entry nameiPRP6_HUMAN
AccessioniPrimary (citable) accession number: O94906
Secondary accession number(s): B2RAR5
, B3KMC6, O95109, Q5VXS5, Q9H3Z1, Q9H4T9, Q9H4U8, Q9NTE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3