O94906 (PRP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pre-mRNA-processing factor 6

Alternative name(s):
Androgen receptor N-terminal domain-transactivating protein 1
Short name=ANT-1
PRP6 homolog
U5 snRNP-associated 102 kDa protein
Short name=U5-102 kDa protein

Gene names

Name:	PRPF6
Synonyms:	C20orf14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	941 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Ref.8
Subunit structure	Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Identified in the spliceosome C complex. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones. Ref.2 Ref.3 Ref.8 Ref.9 Ref.10
Subcellular location	Nucleus › nucleoplasm. Nucleus speckle. Note: Localized in splicing speckles. Ref.1 Ref.8 Ref.15
Tissue specificity	Widely expressed. Ref.8
Involvement in disease	Retinitis pigmentosa 60 (RP60) [MIM:613983]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note: The disease may be caused by mutations affecting the gene represented in this entry. Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals. Ref.15
Sequence similarities	Contains 9 HAT repeats.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus Spliceosome
Coding sequence diversity	Alternative splicing
Disease	Disease mutation Retinitis pigmentosa
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	RNA localization Inferred from mutant phenotype PubMed 20797886. Source: MGI assembly of spliceosomal tri-snRNP Inferred from mutant phenotype PubMed 15257298. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 16414017. Source: MGI spliceosomal complex assembly Non-traceable author statement Ref.2. Source: UniProtKB
Cellular_component	U4/U6 snRNP Inferred from direct assay Ref.2. Source: BHF-UCL U4/U6 x U5 tri-snRNP complex Inferred from direct assay Ref.2. Source: BHF-UCL U5 snRNP Inferred from direct assay Ref.2. Source: BHF-UCL catalytic step 2 spliceosome Inferred from direct assay Ref.9. Source: UniProtKB nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	RNA binding Inferred from direct assay PubMed 20797886. Source: MGI ribonucleoprotein complex binding Inferred from direct assay Ref.2. Source: BHF-UCL transcription coactivator activity Inferred from genetic interaction PubMed 16414017. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ARAF	P10398	4	EBI-536755,EBI-365961

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O94906-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O94906-2)

The sequence of this isoform differs from the canonical sequence as follows:
     637-676: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 941	941	Pre-mRNA-processing factor 6		PRO_0000205759
Regions
	Repeat	384 – 416	33	HAT 1
	Repeat	418 – 444	27	HAT 2
	Repeat	445 – 476	32	HAT 3
	Repeat	554 – 586	33	HAT 4
	Repeat	588 – 620	33	HAT 5
	Repeat	622 – 654	33	HAT 6
	Repeat	689 – 721	33	HAT 7
	Repeat	723 – 755	33	HAT 8
	Repeat	855 – 887	33	HAT 9
	Compositional bias	67 – 72	6	Poly-Asp
Amino acid modifications
	Modified residue	266	1	Phosphothreonine Ref.11 Ref.13
	Modified residue	275	1	Phosphothreonine Ref.11 Ref.13
	Modified residue	279	1	Phosphoserine Ref.11 Ref.13
Natural variations
	Alternative sequence	637 – 676	40	Missing in isoform 2.		VSP_041857
	Natural variant	729	1	R → W in RP60; mislocalized in Cajal bodies; partial loss of localization in splicing speckles. Ref.15		VAR_065768
Experimental info
	Sequence conflict	20	1	G → W in AAD01798. Ref.3
	Sequence conflict	223	1	P → R in AAD01798. Ref.3
	Sequence conflict	284	1	H → R in BAG50938. Ref.4
	Sequence conflict	421	1	I → T in BAG36962. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 91C2F1ADCA439BE9	FASTA	941	106,925
	10 20 30 40 50 60 MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP PGKRTVGDQM 70 80 90 100 110 120 KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE ADAIYAALDK RMDERRKERR 130 140 150 160 170 180 EQREKEEIEK YRMERPKIQQ QFSDLKRKLA EVTEEEWLSI PEVGDARNKR QRNPRYEKLT 190 200 210 220 230 240 PVPDSFFAKH LQTGENHTSV DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM 250 260 270 280 290 300 RKIGQARNTL MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS 310 320 330 340 350 360 VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA RLQPGDTAKA 370 380 390 400 410 420 VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV PNSVRLWKAA VELEEPEDAR 430 440 450 460 470 480 IMLSRAVECC PTSVELWLAL ARLETYENAR KVLNKARENI PTDRHIWITA AKLEEANGNT 490 500 510 520 530 540 QMVEKIIDRA ITSLRANGVE INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK 550 560 570 580 590 600 HTWMEDADSC VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA 610 620 630 640 650 660 VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK LESENDEYER 670 680 690 700 710 720 ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE ALRHYEDFPK LWMMKGQIEE 730 740 750 760 770 780 QKEMMEKARE AYNQGLKKCP HSTPLWLLLS RLEEKIGQLT RARAILEKSR LKNPKNPGLW 790 800 810 820 830 840 LESVRLEYRA GLKNIANTLM AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD 850 860 870 880 890 900 PHVLLAVAKL FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR 910 920 930 940 CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F
	Isoform 2 [UniParc]. Checksum: 23ADD30A75374402	FASTA	901	102,429
	10 20 30 40 50 60 MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP PGKRTVGDQM 70 80 90 100 110 120 KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE ADAIYAALDK RMDERRKERR 130 140 150 160 170 180 EQREKEEIEK YRMERPKIQQ QFSDLKRKLA EVTEEEWLSI PEVGDARNKR QRNPRYEKLT 190 200 210 220 230 240 PVPDSFFAKH LQTGENHTSV DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM 250 260 270 280 290 300 RKIGQARNTL MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS 310 320 330 340 350 360 VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA RLQPGDTAKA 370 380 390 400 410 420 VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV PNSVRLWKAA VELEEPEDAR 430 440 450 460 470 480 IMLSRAVECC PTSVELWLAL ARLETYENAR KVLNKARENI PTDRHIWITA AKLEEANGNT 490 500 510 520 530 540 QMVEKIIDRA ITSLRANGVE INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK 550 560 570 580 590 600 HTWMEDADSC VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA 610 620 630 640 650 660 VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQVFMK SVKLEWVQDN IRAAQDLCEE 670 680 690 700 710 720 ALRHYEDFPK LWMMKGQIEE QKEMMEKARE AYNQGLKKCP HSTPLWLLLS RLEEKIGQLT 730 740 750 760 770 780 RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM AKALQECPNS GILWSEAIFL 790 800 810 820 830 840 EARPQRRTKS VDALKKCEHD PHVLLAVAKL FWSQRKITKA REWFHRTVKI DSDLGDAWAF 850 860 870 880 890 900 FYKFELQHGT EEQQEEVRKR CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors." Nishikimi A., Mukai J., Kioka N., Yamada M. Biochim. Biophys. Acta 1435:147-152(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 138-147; 300-309; 352-359; 776-784 AND 891-898, SUBCELLULAR LOCATION. Tissue: Cervix carcinoma.
[2]	"The human homologue of the yeast splicing factor Prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions." Makarov E.M., Makarova O.V., Achsel T., Luehrmann R. J. Mol. Biol. 298:567-575(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 324-334; 395-408; 755-768; 871-883 AND 917-924, INTERACTION WITH U5 AND U4/U6 SNRNPS. Tissue: Cervix carcinoma.
[3]	"Isoform-specific localization of A-RAF in mitochondria." Yuryev A., Ono M., Goff S.A., Macaluso F., Wennogle L.P. Mol. Cell. Biol. 20:4870-4878(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH ARAF1. Tissue: Cervix carcinoma.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Teratocarcinoma and Testis.
[5]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-941. Tissue: Testis.
[8]	"Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor." Zhao Y., Goto K., Saitoh M., Yanase T., Nomura M., Okabe T., Takayanagi R., Nawata H. J. Biol. Chem. 277:30031-30039(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AR AND NR3C1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[9]	"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis." Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J. RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
[10]	"The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP." Liu S., Rauhut R., Vornlocher H.-P., Luehrmann R. RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266; THR-275 AND SER-279, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266; THR-275 AND SER-279, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa." Tanackovic G., Ransijn A., Ayuso C., Harper S., Berson E.L., Rivolta C. Am. J. Hum. Genet. 88:643-649(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT RP60 TRP-729, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB019219 mRNA. Translation: BAA37140.1. AF221842 mRNA. Translation: AAF66128.1. AF026031 mRNA. Translation: AAD01798.1. AK001554 mRNA. Translation: BAG50938.1. AK314310 mRNA. Translation: BAG36962.1. AL356790, AL118506, AL355803 Genomic DNA. Translation: CAH71582.1. AL118506, AL355803, AL356790 Genomic DNA. Translation: CAI21906.1. AL355803, AL118506, AL356790 Genomic DNA. Translation: CAC16610.2. BC001666 mRNA. Translation: AAH01666.1. AL137320 mRNA. Translation: CAB70695.1.
IPI	IPI00305068.
PIR	T46386.
RefSeq	NP_036601.2. NM_012469.3.
UniGene	Hs.31334.
3D structure databases
ProteinModelPortal	O94906.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29006N.
IntAct	O94906. 11 interactions.
MINT	MINT-260551.
STRING	9606.ENSP00000266079.
PTM databases
PhosphoSite	O94906.
Proteomic databases
PaxDb	O94906.
PeptideAtlas	O94906.
PRIDE	O94906.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000266079; ENSP00000266079; ENSG00000101161. ENST00000535781; ENSP00000446216; ENSG00000101161.
GeneID	24148.
KEGG	hsa:24148.
UCSC	uc002yho.3. human.
Organism-specific databases
CTD	24148.
GeneCards	GC20P062612.
HGNC	HGNC:15860. PRPF6.
HPA	HPA047106.
MIM	613979. gene. 613983. phenotype.
neXtProt	NX_O94906.
Orphanet	791. Retinitis pigmentosa.
PharmGKB	PA25682.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0457.
HOVERGEN	HBG023330.
InParanoid	O94906.
KO	K12855.
OMA	IWLRAAY.
OrthoDB	EOG4FTVZW.
PhylomeDB	O94906.
Enzyme and pathway databases
Reactome	REACT_1675. mRNA Processing. REACT_71. Gene Expression.
Gene expression databases
Bgee	O94906.
CleanEx	HS_PRPF6.
Genevestigator	O94906.
GermOnline	ENSG00000101161. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.10. 4 hits.
InterPro	IPR003107. HAT. IPR010491. PRP1_N. IPR027108. Prp6/Prp1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
PANTHER	PTHR11246:SF1. PTHR11246:SF1. 1 hit.
Pfam	PF06424. PRP1_N. 1 hit. PF13181. TPR_8. 1 hit. [Graphical view]
SMART	SM00386. HAT. 13 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PRPF6. human.
GenomeRNAi	24148.
NextBio	46847.
SOURCE	Search...

Entry information

Entry name

PRP6_HUMAN

Accession

Primary (citable) accession number: O94906
Secondary accession number(s): B2RAR5 , B3KMC6, O95109, Q5VXS5, Q9H3Z1, Q9H4T9, Q9H4U8, Q9NTE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.