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O94906

- PRP6_HUMAN

UniProt

O94906 - PRP6_HUMAN

Protein

Pre-mRNA-processing factor 6

Gene

PRPF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.1 Publication

    GO - Molecular functioni

    1. androgen receptor binding Source: MGI
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. ribonucleoprotein complex binding Source: BHF-UCL
    5. RNA binding Source: MGI
    6. transcription coactivator activity Source: MGI

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA splicing, via spliceosome Source: UniProtKB
    3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    4. RNA localization Source: MGI
    5. RNA splicing Source: UniProtKB
    6. RNA splicing, via transesterification reactions Source: UniProtKB
    7. spliceosomal complex assembly Source: UniProtKB
    8. spliceosomal tri-snRNP complex assembly Source: BHF-UCL

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    ReactomeiREACT_1753. mRNA Splicing - Minor Pathway.
    REACT_467. mRNA Splicing - Major Pathway.
    SignaLinkiO94906.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-mRNA-processing factor 6
    Alternative name(s):
    Androgen receptor N-terminal domain-transactivating protein 1
    Short name:
    ANT-1
    PRP6 homolog
    U5 snRNP-associated 102 kDa protein
    Short name:
    U5-102 kDa protein
    Gene namesi
    Name:PRPF6
    Synonyms:C20orf14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15860. PRPF6.

    Subcellular locationi

    Nucleusnucleoplasm. Nucleus speckle
    Note: Localized in splicing speckles.

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: UniProtKB
    2. membrane Source: UniProtKB
    3. nuclear speck Source: UniProtKB-SubCell
    4. nucleoplasm Source: Reactome
    5. nucleus Source: HPA
    6. spliceosomal complex Source: UniProtKB
    7. U4/U6 snRNP Source: BHF-UCL
    8. U4/U6 x U5 tri-snRNP complex Source: BHF-UCL
    9. U5 snRNP Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Involvement in diseasei

    Retinitis pigmentosa 60 (RP60) [MIM:613983]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.1 Publication
    Note: The disease may be caused by mutations affecting the gene represented in this entry. Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti729 – 7291R → W in RP60; mislocalized in Cajal bodies; partial loss of localization in splicing speckles. 1 Publication
    VAR_065768

    Keywords - Diseasei

    Disease mutation, Retinitis pigmentosa

    Organism-specific databases

    MIMi613983. phenotype.
    Orphaneti791. Retinitis pigmentosa.
    PharmGKBiPA25682.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 941941Pre-mRNA-processing factor 6PRO_0000205759Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei266 – 2661Phosphothreonine2 Publications
    Modified residuei275 – 2751Phosphothreonine2 Publications
    Modified residuei279 – 2791Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO94906.
    PaxDbiO94906.
    PeptideAtlasiO94906.
    PRIDEiO94906.

    PTM databases

    PhosphoSiteiO94906.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    BgeeiO94906.
    CleanExiHS_PRPF6.
    GenevestigatoriO94906.

    Organism-specific databases

    HPAiHPA047106.

    Interactioni

    Subunit structurei

    Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Identified in the spliceosome C complex. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARAFP103984EBI-536755,EBI-365961
    CD2BP2O954004EBI-536755,EBI-768015
    IKQ131232EBI-536755,EBI-713456
    PRPF31Q8WWY32EBI-536755,EBI-1567797

    Protein-protein interaction databases

    BioGridi117298. 76 interactions.
    DIPiDIP-29006N.
    IntActiO94906. 25 interactions.
    MINTiMINT-260551.
    STRINGi9606.ENSP00000266079.

    Structurei

    3D structure databases

    ProteinModelPortaliO94906.
    SMRiO94906. Positions 292-348, 412-477, 610-637, 726-788.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati384 – 41633HAT 1Add
    BLAST
    Repeati418 – 44427HAT 2Add
    BLAST
    Repeati445 – 47632HAT 3Add
    BLAST
    Repeati554 – 58633HAT 4Add
    BLAST
    Repeati588 – 62033HAT 5Add
    BLAST
    Repeati622 – 65433HAT 6Add
    BLAST
    Repeati689 – 72133HAT 7Add
    BLAST
    Repeati723 – 75533HAT 8Add
    BLAST
    Repeati855 – 88733HAT 9Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi67 – 726Poly-Asp

    Sequence similaritiesi

    Contains 9 HAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOVERGENiHBG023330.
    InParanoidiO94906.
    KOiK12855.
    OMAiRQRFYAV.
    OrthoDBiEOG7RV9FB.
    PhylomeDBiO94906.
    TreeFamiTF105743.

    Family and domain databases

    Gene3Di1.25.40.10. 4 hits.
    InterProiIPR003107. HAT.
    IPR010491. PRP1_N.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF06424. PRP1_N. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view]
    SMARTiSM00386. HAT. 13 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O94906-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP    50
    PGKRTVGDQM KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE 100
    ADAIYAALDK RMDERRKERR EQREKEEIEK YRMERPKIQQ QFSDLKRKLA 150
    EVTEEEWLSI PEVGDARNKR QRNPRYEKLT PVPDSFFAKH LQTGENHTSV 200
    DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM RKIGQARNTL 250
    MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS 300
    VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA 350
    RLQPGDTAKA VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV 400
    PNSVRLWKAA VELEEPEDAR IMLSRAVECC PTSVELWLAL ARLETYENAR 450
    KVLNKARENI PTDRHIWITA AKLEEANGNT QMVEKIIDRA ITSLRANGVE 500
    INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK HTWMEDADSC 550
    VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA 600
    VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK 650
    LESENDEYER ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE 700
    ALRHYEDFPK LWMMKGQIEE QKEMMEKARE AYNQGLKKCP HSTPLWLLLS 750
    RLEEKIGQLT RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM 800
    AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD PHVLLAVAKL 850
    FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR 900
    CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F 941
    Length:941
    Mass (Da):106,925
    Last modified:May 1, 1999 - v1
    Checksum:i91C2F1ADCA439BE9
    GO
    Isoform 2 (identifier: O94906-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         637-676: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:901
    Mass (Da):102,429
    Checksum:i23ADD30A75374402
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201G → W in AAD01798. (PubMed:10848612)Curated
    Sequence conflicti223 – 2231P → R in AAD01798. (PubMed:10848612)Curated
    Sequence conflicti284 – 2841H → R in BAG50938. (PubMed:14702039)Curated
    Sequence conflicti421 – 4211I → T in BAG36962. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti477 – 4771N → S Very rare variant found in a family with neuronal ceroid lipofuscinosis carrying a causative mutation in DNAJC5; uncertain role as a disease phenotype modifier. 1 Publication
    VAR_069766
    Natural varianti729 – 7291R → W in RP60; mislocalized in Cajal bodies; partial loss of localization in splicing speckles. 1 Publication
    VAR_065768

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei637 – 67640Missing in isoform 2. 1 PublicationVSP_041857Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019219 mRNA. Translation: BAA37140.1.
    AF221842 mRNA. Translation: AAF66128.1.
    AF026031 mRNA. Translation: AAD01798.1.
    AK001554 mRNA. Translation: BAG50938.1.
    AK314310 mRNA. Translation: BAG36962.1.
    AL356790, AL118506, AL355803 Genomic DNA. Translation: CAH71582.1.
    AL118506, AL355803, AL356790 Genomic DNA. Translation: CAI21906.1.
    AL355803, AL118506, AL356790 Genomic DNA. Translation: CAC16610.2.
    BC001666 mRNA. Translation: AAH01666.1.
    AL137320 mRNA. Translation: CAB70695.1.
    CCDSiCCDS13550.1. [O94906-1]
    PIRiT46386.
    RefSeqiNP_036601.2. NM_012469.3. [O94906-1]
    UniGeneiHs.31334.

    Genome annotation databases

    EnsembliENST00000266079; ENSP00000266079; ENSG00000101161. [O94906-1]
    GeneIDi24148.
    KEGGihsa:24148.
    UCSCiuc002yho.3. human. [O94906-1]
    uc002yhp.3. human. [O94906-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019219 mRNA. Translation: BAA37140.1 .
    AF221842 mRNA. Translation: AAF66128.1 .
    AF026031 mRNA. Translation: AAD01798.1 .
    AK001554 mRNA. Translation: BAG50938.1 .
    AK314310 mRNA. Translation: BAG36962.1 .
    AL356790 , AL118506 , AL355803 Genomic DNA. Translation: CAH71582.1 .
    AL118506 , AL355803 , AL356790 Genomic DNA. Translation: CAI21906.1 .
    AL355803 , AL118506 , AL356790 Genomic DNA. Translation: CAC16610.2 .
    BC001666 mRNA. Translation: AAH01666.1 .
    AL137320 mRNA. Translation: CAB70695.1 .
    CCDSi CCDS13550.1. [O94906-1 ]
    PIRi T46386.
    RefSeqi NP_036601.2. NM_012469.3. [O94906-1 ]
    UniGenei Hs.31334.

    3D structure databases

    ProteinModelPortali O94906.
    SMRi O94906. Positions 292-348, 412-477, 610-637, 726-788.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117298. 76 interactions.
    DIPi DIP-29006N.
    IntActi O94906. 25 interactions.
    MINTi MINT-260551.
    STRINGi 9606.ENSP00000266079.

    PTM databases

    PhosphoSitei O94906.

    Proteomic databases

    MaxQBi O94906.
    PaxDbi O94906.
    PeptideAtlasi O94906.
    PRIDEi O94906.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266079 ; ENSP00000266079 ; ENSG00000101161 . [O94906-1 ]
    GeneIDi 24148.
    KEGGi hsa:24148.
    UCSCi uc002yho.3. human. [O94906-1 ]
    uc002yhp.3. human. [O94906-2 ]

    Organism-specific databases

    CTDi 24148.
    GeneCardsi GC20P062612.
    GeneReviewsi PRPF6.
    HGNCi HGNC:15860. PRPF6.
    HPAi HPA047106.
    MIMi 613979. gene.
    613983. phenotype.
    neXtProti NX_O94906.
    Orphaneti 791. Retinitis pigmentosa.
    PharmGKBi PA25682.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0457.
    HOVERGENi HBG023330.
    InParanoidi O94906.
    KOi K12855.
    OMAi RQRFYAV.
    OrthoDBi EOG7RV9FB.
    PhylomeDBi O94906.
    TreeFami TF105743.

    Enzyme and pathway databases

    Reactomei REACT_1753. mRNA Splicing - Minor Pathway.
    REACT_467. mRNA Splicing - Major Pathway.
    SignaLinki O94906.

    Miscellaneous databases

    ChiTaRSi PRPF6. human.
    GeneWikii PRPF6.
    GenomeRNAii 24148.
    NextBioi 46847.
    PROi O94906.
    SOURCEi Search...

    Gene expression databases

    Bgeei O94906.
    CleanExi HS_PRPF6.
    Genevestigatori O94906.

    Family and domain databases

    Gene3Di 1.25.40.10. 4 hits.
    InterProi IPR003107. HAT.
    IPR010491. PRP1_N.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF06424. PRP1_N. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00386. HAT. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors."
      Nishikimi A., Mukai J., Kioka N., Yamada M.
      Biochim. Biophys. Acta 1435:147-152(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 138-147; 300-309; 352-359; 776-784 AND 891-898, SUBCELLULAR LOCATION.
      Tissue: Cervix carcinoma.
    2. "The human homologue of the yeast splicing factor Prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions."
      Makarov E.M., Makarova O.V., Achsel T., Luehrmann R.
      J. Mol. Biol. 298:567-575(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 324-334; 395-408; 755-768; 871-883 AND 917-924, INTERACTION WITH U5 AND U4/U6 SNRNPS.
      Tissue: Cervix carcinoma.
    3. "Isoform-specific localization of A-RAF in mitochondria."
      Yuryev A., Ono M., Goff S.A., Macaluso F., Wennogle L.P.
      Mol. Cell. Biol. 20:4870-4878(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH ARAF1.
      Tissue: Cervix carcinoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Teratocarcinoma and Testis.
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-941.
      Tissue: Testis.
    8. "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor."
      Zhao Y., Goto K., Saitoh M., Yanase T., Nomura M., Okabe T., Takayanagi R., Nawata H.
      J. Biol. Chem. 277:30031-30039(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH AR AND NR3C1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
      RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
    10. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."
      Liu S., Rauhut R., Vornlocher H.-P., Luehrmann R.
      RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266; THR-275 AND SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266; THR-275 AND SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa."
      Tanackovic G., Ransijn A., Ayuso C., Harper S., Berson E.L., Rivolta C.
      Am. J. Hum. Genet. 88:643-649(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT RP60 TRP-729, SUBCELLULAR LOCATION.
    16. "Mutations in the gene DNAJC5 cause autosomal dominant Kufs disease in a proportion of cases: study of the Parry family and 8 other families."
      Velinov M., Dolzhanskaya N., Gonzalez M., Powell E., Konidari I., Hulme W., Staropoli J.F., Xin W., Wen G.Y., Barone R., Coppel S.H., Sims K., Brown W.T., Zuchner S.
      PLoS ONE 7:E29729-E29729(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SER-477.

    Entry informationi

    Entry nameiPRP6_HUMAN
    AccessioniPrimary (citable) accession number: O94906
    Secondary accession number(s): B2RAR5
    , B3KMC6, O95109, Q5VXS5, Q9H3Z1, Q9H4T9, Q9H4U8, Q9NTE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3