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O94906 (PRP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pre-mRNA-processing factor 6
Alternative name(s):
Androgen receptor N-terminal domain-transactivating protein 1
Short name=ANT-1
PRP6 homolog
U5 snRNP-associated 102 kDa protein
Short name=U5-102 kDa protein
Gene names
Name:PRPF6
Synonyms:C20orf14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length941 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Ref.8

Subunit structure

Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Identified in the spliceosome C complex. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones. Ref.2 Ref.3 Ref.8 Ref.9 Ref.10

Subcellular location

Nucleusnucleoplasm. Nucleus speckle. Note: Localized in splicing speckles. Ref.1 Ref.8 Ref.15

Tissue specificity

Widely expressed. Ref.8

Involvement in disease

Retinitis pigmentosa 60 (RP60) [MIM:613983]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Note: The disease may be caused by mutations affecting the gene represented in this entry. Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals. Ref.15

Sequence similarities

Contains 9 HAT repeats.

Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
Spliceosome
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDisease mutation
Retinitis pigmentosa
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processRNA localization

Inferred from mutant phenotype PubMed 20797886. Source: MGI

RNA splicing

Non-traceable author statement Ref.2. Source: UniProtKB

RNA splicing, via transesterification reactions

Non-traceable author statement Ref.2. Source: UniProtKB

gene expression

Traceable author statement. Source: Reactome

mRNA splicing, via spliceosome

Inferred by curator Ref.9. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16414017. Source: MGI

spliceosomal complex assembly

Non-traceable author statement Ref.2. Source: UniProtKB

spliceosomal tri-snRNP complex assembly

Inferred from mutant phenotype PubMed 15257298. Source: BHF-UCL

   Cellular_componentU4/U6 snRNP

Inferred from direct assay Ref.2. Source: BHF-UCL

U4/U6 x U5 tri-snRNP complex

Inferred from direct assay Ref.2. Source: BHF-UCL

U5 snRNP

Inferred from direct assay Ref.2. Source: BHF-UCL

catalytic step 2 spliceosome

Inferred from direct assay Ref.9. Source: UniProtKB

nuclear speck

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleoplasm

Traceable author statement. Source: Reactome

nucleus

Inferred from direct assay. Source: HPA

spliceosomal complex

Non-traceable author statement Ref.2. Source: UniProtKB

   Molecular_functionRNA binding

Inferred from direct assay PubMed 20797886. Source: MGI

androgen receptor binding

Inferred from physical interaction PubMed 16414017. Source: MGI

poly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 12620389PubMed 15840814PubMed 22365833. Source: IntAct

ribonucleoprotein complex binding

Inferred from direct assay Ref.2. Source: BHF-UCL

transcription coactivator activity

Inferred from genetic interaction PubMed 16414017. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O94906-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O94906-2)

The sequence of this isoform differs from the canonical sequence as follows:
     637-676: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 941941Pre-mRNA-processing factor 6
PRO_0000205759

Regions

Repeat384 – 41633HAT 1
Repeat418 – 44427HAT 2
Repeat445 – 47632HAT 3
Repeat554 – 58633HAT 4
Repeat588 – 62033HAT 5
Repeat622 – 65433HAT 6
Repeat689 – 72133HAT 7
Repeat723 – 75533HAT 8
Repeat855 – 88733HAT 9
Compositional bias67 – 726Poly-Asp

Amino acid modifications

Modified residue2661Phosphothreonine Ref.11 Ref.13
Modified residue2751Phosphothreonine Ref.11 Ref.13
Modified residue2791Phosphoserine Ref.11 Ref.13

Natural variations

Alternative sequence637 – 67640Missing in isoform 2.
VSP_041857
Natural variant4771N → S Very rare variant found in a family with neuronal ceroid lipofuscinosis carrying a causative mutation in DNAJC5; uncertain role as a disease phenotype modifier. Ref.16
VAR_069766
Natural variant7291R → W in RP60; mislocalized in Cajal bodies; partial loss of localization in splicing speckles. Ref.15
VAR_065768

Experimental info

Sequence conflict201G → W in AAD01798. Ref.3
Sequence conflict2231P → R in AAD01798. Ref.3
Sequence conflict2841H → R in BAG50938. Ref.4
Sequence conflict4211I → T in BAG36962. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 91C2F1ADCA439BE9

FASTA941106,925
        10         20         30         40         50         60 
MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP PGKRTVGDQM 

        70         80         90        100        110        120 
KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE ADAIYAALDK RMDERRKERR 

       130        140        150        160        170        180 
EQREKEEIEK YRMERPKIQQ QFSDLKRKLA EVTEEEWLSI PEVGDARNKR QRNPRYEKLT 

       190        200        210        220        230        240 
PVPDSFFAKH LQTGENHTSV DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM 

       250        260        270        280        290        300 
RKIGQARNTL MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS 

       310        320        330        340        350        360 
VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA RLQPGDTAKA 

       370        380        390        400        410        420 
VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV PNSVRLWKAA VELEEPEDAR 

       430        440        450        460        470        480 
IMLSRAVECC PTSVELWLAL ARLETYENAR KVLNKARENI PTDRHIWITA AKLEEANGNT 

       490        500        510        520        530        540 
QMVEKIIDRA ITSLRANGVE INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK 

       550        560        570        580        590        600 
HTWMEDADSC VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA 

       610        620        630        640        650        660 
VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK LESENDEYER 

       670        680        690        700        710        720 
ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE ALRHYEDFPK LWMMKGQIEE 

       730        740        750        760        770        780 
QKEMMEKARE AYNQGLKKCP HSTPLWLLLS RLEEKIGQLT RARAILEKSR LKNPKNPGLW 

       790        800        810        820        830        840 
LESVRLEYRA GLKNIANTLM AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD 

       850        860        870        880        890        900 
PHVLLAVAKL FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR 

       910        920        930        940 
CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F 

« Hide

Isoform 2 [UniParc].

Checksum: 23ADD30A75374402
Show »

FASTA901102,429

References

« Hide 'large scale' references
[1]"A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors."
Nishikimi A., Mukai J., Kioka N., Yamada M.
Biochim. Biophys. Acta 1435:147-152(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 138-147; 300-309; 352-359; 776-784 AND 891-898, SUBCELLULAR LOCATION.
Tissue: Cervix carcinoma.
[2]"The human homologue of the yeast splicing factor Prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions."
Makarov E.M., Makarova O.V., Achsel T., Luehrmann R.
J. Mol. Biol. 298:567-575(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 324-334; 395-408; 755-768; 871-883 AND 917-924, INTERACTION WITH U5 AND U4/U6 SNRNPS.
Tissue: Cervix carcinoma.
[3]"Isoform-specific localization of A-RAF in mitochondria."
Yuryev A., Ono M., Goff S.A., Macaluso F., Wennogle L.P.
Mol. Cell. Biol. 20:4870-4878(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH ARAF1.
Tissue: Cervix carcinoma.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Teratocarcinoma and Testis.
[5]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-941.
Tissue: Testis.
[8]"Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor."
Zhao Y., Goto K., Saitoh M., Yanase T., Nomura M., Okabe T., Takayanagi R., Nawata H.
J. Biol. Chem. 277:30031-30039(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AR AND NR3C1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[9]"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
[10]"The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."
Liu S., Rauhut R., Vornlocher H.-P., Luehrmann R.
RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266; THR-275 AND SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[13]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-266; THR-275 AND SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa."
Tanackovic G., Ransijn A., Ayuso C., Harper S., Berson E.L., Rivolta C.
Am. J. Hum. Genet. 88:643-649(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT RP60 TRP-729, SUBCELLULAR LOCATION.
[16]"Mutations in the gene DNAJC5 cause autosomal dominant Kufs disease in a proportion of cases: study of the Parry family and 8 other families."
Velinov M., Dolzhanskaya N., Gonzalez M., Powell E., Konidari I., Hulme W., Staropoli J.F., Xin W., Wen G.Y., Barone R., Coppel S.H., Sims K., Brown W.T., Zuchner S.
PLoS ONE 7:E29729-E29729(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SER-477.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB019219 mRNA. Translation: BAA37140.1.
AF221842 mRNA. Translation: AAF66128.1.
AF026031 mRNA. Translation: AAD01798.1.
AK001554 mRNA. Translation: BAG50938.1.
AK314310 mRNA. Translation: BAG36962.1.
AL356790, AL118506, AL355803 Genomic DNA. Translation: CAH71582.1.
AL118506, AL355803, AL356790 Genomic DNA. Translation: CAI21906.1.
AL355803, AL118506, AL356790 Genomic DNA. Translation: CAC16610.2.
BC001666 mRNA. Translation: AAH01666.1.
AL137320 mRNA. Translation: CAB70695.1.
CCDSCCDS13550.1. [O94906-1]
PIRT46386.
RefSeqNP_036601.2. NM_012469.3. [O94906-1]
UniGeneHs.31334.

3D structure databases

ProteinModelPortalO94906.
SMRO94906. Positions 292-348, 412-477, 610-637, 726-788.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117298. 74 interactions.
DIPDIP-29006N.
IntActO94906. 21 interactions.
MINTMINT-260551.
STRING9606.ENSP00000266079.

PTM databases

PhosphoSiteO94906.

Proteomic databases

MaxQBO94906.
PaxDbO94906.
PeptideAtlasO94906.
PRIDEO94906.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266079; ENSP00000266079; ENSG00000101161. [O94906-1]
ENST00000535781; ENSP00000446216; ENSG00000101161. [O94906-2]
GeneID24148.
KEGGhsa:24148.
UCSCuc002yho.3. human. [O94906-1]
uc002yhp.3. human. [O94906-2]

Organism-specific databases

CTD24148.
GeneCardsGC20P062612.
GeneReviewsPRPF6.
HGNCHGNC:15860. PRPF6.
HPAHPA047106.
MIM613979. gene.
613983. phenotype.
neXtProtNX_O94906.
Orphanet791. Retinitis pigmentosa.
PharmGKBPA25682.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0457.
HOVERGENHBG023330.
InParanoidO94906.
KOK12855.
OMARQRFYAV.
OrthoDBEOG7RV9FB.
PhylomeDBO94906.
TreeFamTF105743.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.
SignaLinkO94906.

Gene expression databases

BgeeO94906.
CleanExHS_PRPF6.
GenevestigatorO94906.

Family and domain databases

Gene3D1.25.40.10. 4 hits.
InterProIPR003107. HAT.
IPR010491. PRP1_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF06424. PRP1_N. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTSM00386. HAT. 13 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPRPF6. human.
GeneWikiPRPF6.
GenomeRNAi24148.
NextBio46847.
PROO94906.
SOURCESearch...

Entry information

Entry namePRP6_HUMAN
AccessionPrimary (citable) accession number: O94906
Secondary accession number(s): B2RAR5 expand/collapse secondary AC list , B3KMC6, O95109, Q5VXS5, Q9H3Z1, Q9H4T9, Q9H4U8, Q9NTE6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM